ES2004038A6 - Nucleic acid derivatives having sulphur substitution - Google Patents
Nucleic acid derivatives having sulphur substitutionInfo
- Publication number
- ES2004038A6 ES2004038A6 ES8700012A ES8700012A ES2004038A6 ES 2004038 A6 ES2004038 A6 ES 2004038A6 ES 8700012 A ES8700012 A ES 8700012A ES 8700012 A ES8700012 A ES 8700012A ES 2004038 A6 ES2004038 A6 ES 2004038A6
- Authority
- ES
- Spain
- Prior art keywords
- sulphur
- nucleic acid
- substituted
- acid derivatives
- polymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
The derivatives comprise nucleic acid polymers (e.g. single or double strand ribo or deoxyribo nucleotide polymers) in which some of the purine and/or pyrimidine rings are substituted with sulphur (e.g. by replacement of -NH2 groups by -SH groups), which sulphur substituents may be linked to form disulphide bonds. The sulphur substituted derivatives appear to more stable than non-substituted nucleic and polymers. The derivatives appear to act as immunostimulants and neoplastic proliferation inhibitors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP107686 | 1986-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2004038A6 true ES2004038A6 (en) | 1988-12-01 |
Family
ID=11491410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8700012A Expired ES2004038A6 (en) | 1986-01-06 | 1987-01-05 | Nucleic acid derivatives having sulphur substitution |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS62252798A (en) |
| KR (1) | KR940004076B1 (en) |
| BE (1) | BE906157A (en) |
| CA (1) | CA1315717C (en) |
| CH (1) | CH671960A5 (en) |
| DE (1) | DE3700164A1 (en) |
| ES (1) | ES2004038A6 (en) |
| FR (1) | FR2596762B1 (en) |
| GB (1) | GB2185026B (en) |
| NL (1) | NL8700016A (en) |
| SE (1) | SE469594B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100644172B1 (en) * | 1998-05-25 | 2006-11-10 | 니뽄 신야쿠 가부시키가이샤 | Process for producing composite preparation containing nucleic acid |
| EP1435389A4 (en) * | 2001-09-04 | 2006-02-22 | Nippon Shinyaku Co Ltd | Method of evaluating efficacy of nucleic acid therapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB906851A (en) * | 1960-05-03 | 1962-09-26 | Schwarz Bio Res Inc | Thiolation of polymers |
| DE2041735A1 (en) * | 1970-08-22 | 1972-02-24 | Merck Patent Gmbh | Thio-pyrimidine derivatives |
| GB1364987A (en) * | 1971-06-19 | 1974-08-29 | Merck Patent Gmbh | Biologically active two component complexes |
| GB2038628A (en) * | 1978-11-14 | 1980-07-30 | Searle & Co | Physiological compositions comprising poly(4-thiouridylic acid) or copolymers thereof and the use thereof as anti-viral agents or serum cholesterol lowering agents |
-
1986
- 1986-11-25 JP JP61280452A patent/JPS62252798A/en active Pending
- 1986-12-30 SE SE8605616A patent/SE469594B/en not_active IP Right Cessation
- 1986-12-31 FR FR8618433A patent/FR2596762B1/en not_active Expired - Fee Related
- 1986-12-31 BE BE0/217694A patent/BE906157A/en not_active IP Right Cessation
-
1987
- 1987-01-05 DE DE19873700164 patent/DE3700164A1/en active Granted
- 1987-01-05 ES ES8700012A patent/ES2004038A6/en not_active Expired
- 1987-01-06 GB GB8700183A patent/GB2185026B/en not_active Expired - Fee Related
- 1987-01-06 CH CH23/87A patent/CH671960A5/de not_active IP Right Cessation
- 1987-01-06 KR KR1019870000061A patent/KR940004076B1/en active IP Right Grant
- 1987-01-06 NL NL8700016A patent/NL8700016A/en not_active Application Discontinuation
- 1987-01-06 CA CA000526797A patent/CA1315717C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NL8700016A (en) | 1987-08-03 |
| KR870007198A (en) | 1987-08-17 |
| CH671960A5 (en) | 1989-10-13 |
| GB2185026A (en) | 1987-07-08 |
| SE8605616D0 (en) | 1986-12-30 |
| KR940004076B1 (en) | 1994-05-11 |
| DE3700164C2 (en) | 1993-02-25 |
| FR2596762B1 (en) | 1993-10-08 |
| GB8700183D0 (en) | 1987-02-11 |
| DE3700164A1 (en) | 1987-07-09 |
| GB2185026B (en) | 1990-08-08 |
| JPS62252798A (en) | 1987-11-04 |
| SE469594B (en) | 1993-08-02 |
| CA1315717C (en) | 1993-04-06 |
| BE906157A (en) | 1987-07-01 |
| FR2596762A1 (en) | 1987-10-09 |
| SE8605616L (en) | 1987-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980401 |