ES2003642A6 - Production of 1,5-benzothiazepine derivative - Google Patents
Production of 1,5-benzothiazepine derivativeInfo
- Publication number
- ES2003642A6 ES2003642A6 ES8603613A ES8603613A ES2003642A6 ES 2003642 A6 ES2003642 A6 ES 2003642A6 ES 8603613 A ES8603613 A ES 8603613A ES 8603613 A ES8603613 A ES 8603613A ES 2003642 A6 ES2003642 A6 ES 2003642A6
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- diseases
- cerebral
- alkylating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To economically obtain the titled compound useful as a hypotensor, a cerebral or coronary vasodilator and a platelet coagulation inhibitor, by alkylating 4-hydroxyphenyl group of a compound corresponding to the titled compound to 4-alkoxyphenyl group. CONSTITUTION:The compound of formula II (R<1> is lower alkyl R<2> is H or lower alkanoyl X<1> is H or lower alkyl) or its salt useful for the remedy amelio ration or prevention of cerebral diseases such as hypertension, cerebrovascular contraction, etc., cardiac diseases such as stenocardia or thromotic diseases such as cerebral thrombosis, etc., can be produced by alkylating the compound of formula I (R<3> is H or lower alkanoyl X<2> is H, alkyl or protecting group), removing X<2> when it is a protecting group, optionally removing R<3> when it is lower alkanolyl group and optionally converting the product to its salt. Since the reaction can be performed without causing racemization, an optical isomer can be produced by using an optically active raw material.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61001845A JPS62161776A (en) | 1986-01-07 | 1986-01-07 | Production of 1,5-benzothiazepine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2003642A6 true ES2003642A6 (en) | 1988-11-01 |
Family
ID=11512884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8603613A Expired ES2003642A6 (en) | 1986-01-07 | 1986-12-29 | Production of 1,5-benzothiazepine derivative |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS62161776A (en) |
| KR (1) | KR910002879B1 (en) |
| CN (1) | CN1030388C (en) |
| AT (1) | AT394367B (en) |
| BG (1) | BG46747A3 (en) |
| CA (1) | CA1291134C (en) |
| DD (1) | DD257426A5 (en) |
| ES (1) | ES2003642A6 (en) |
| FI (1) | FI865343A (en) |
| HU (1) | HU198031B (en) |
| IE (1) | IE59359B1 (en) |
| IL (1) | IL81039A (en) |
| PT (1) | PT84036B (en) |
| SU (1) | SU1544187A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580867A (en) * | 1994-09-09 | 1996-12-03 | Universite De Montreal | Myocardial protection during ischemia and reperfusion |
| RU2736671C1 (en) * | 2020-05-19 | 2020-11-19 | федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский горный университет» | Blocking hydrophobic-emulsion solution with marble chips |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57169476A (en) * | 1981-04-13 | 1982-10-19 | Hamari Yakuhin Kogyo Kk | Novel preparation of benzothiazepine derivative |
| JPS57175182A (en) * | 1981-04-22 | 1982-10-28 | Hamari Yakuhin Kogyo Kk | Novel preparation of benzothiazepin derivative |
| JPS58113186A (en) * | 1981-12-28 | 1983-07-05 | Hamari Yakuhin Kogyo Kk | Novel preparation of benzothiazepin derivative |
| JPS58116476A (en) * | 1981-12-29 | 1983-07-11 | Hamari Yakuhin Kogyo Kk | Novel preparation of benzothiazepine derivative |
| US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
| US4585768A (en) * | 1984-04-10 | 1986-04-29 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and processes for preparing the same |
-
1986
- 1986-01-07 JP JP61001845A patent/JPS62161776A/en active Granted
- 1986-12-15 IE IE326986A patent/IE59359B1/en not_active IP Right Cessation
- 1986-12-19 IL IL81039A patent/IL81039A/en not_active IP Right Cessation
- 1986-12-29 ES ES8603613A patent/ES2003642A6/en not_active Expired
- 1986-12-29 PT PT84036A patent/PT84036B/en not_active IP Right Cessation
- 1986-12-30 FI FI865343A patent/FI865343A/en not_active Application Discontinuation
-
1987
- 1987-01-06 SU SU874028773A patent/SU1544187A3/en active
- 1987-01-06 CA CA000526793A patent/CA1291134C/en not_active Expired - Fee Related
- 1987-01-06 BG BG077954A patent/BG46747A3/en unknown
- 1987-01-06 DD DD87299117A patent/DD257426A5/en not_active IP Right Cessation
- 1987-01-06 KR KR1019870000022A patent/KR910002879B1/en not_active IP Right Cessation
- 1987-01-07 CN CN87100139A patent/CN1030388C/en not_active Expired - Fee Related
- 1987-01-07 AT AT0001687A patent/AT394367B/en not_active IP Right Cessation
- 1987-01-07 HU HU8752A patent/HU198031B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL81039A (en) | 1991-07-18 |
| FI865343A0 (en) | 1986-12-30 |
| HUT45242A (en) | 1988-06-28 |
| ATA1687A (en) | 1991-09-15 |
| IL81039A0 (en) | 1987-03-31 |
| FI865343A (en) | 1987-07-08 |
| AT394367B (en) | 1992-03-25 |
| KR870007147A (en) | 1987-08-17 |
| CA1291134C (en) | 1991-10-22 |
| SU1544187A3 (en) | 1990-02-15 |
| PT84036A (en) | 1987-01-01 |
| CN87100139A (en) | 1987-08-12 |
| HU198031B (en) | 1989-07-28 |
| CN1030388C (en) | 1995-11-29 |
| DD257426A5 (en) | 1988-06-15 |
| BG46747A3 (en) | 1990-02-15 |
| JPH0573749B2 (en) | 1993-10-15 |
| IE59359B1 (en) | 1994-02-09 |
| KR910002879B1 (en) | 1991-05-09 |
| IE863269L (en) | 1987-07-07 |
| PT84036B (en) | 1989-01-17 |
| JPS62161776A (en) | 1987-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-12-29 |