ES2002325A6 - Un procedimiento para preparar un derivado de dihidropiridina - Google Patents
Un procedimiento para preparar un derivado de dihidropiridinaInfo
- Publication number
- ES2002325A6 ES2002325A6 ES8601837A ES8601837A ES2002325A6 ES 2002325 A6 ES2002325 A6 ES 2002325A6 ES 8601837 A ES8601837 A ES 8601837A ES 8601837 A ES8601837 A ES 8601837A ES 2002325 A6 ES2002325 A6 ES 2002325A6
- Authority
- ES
- Spain
- Prior art keywords
- formula
- pir
- compound
- dihydropyridine derivatives
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIHIDROPIRIDINA DE FORMULA: DONDE RK1 ES METILO, HALOGENO, TRIFLUOROMETILO, NITRO, CIANO O METOXI Y R7 ES BENCILO, ESTANDO UNIDA LA HIDROPIRIDINA A LA POSICION 2, 3 O 4 DE LA PIRIDINA, EN EL QUE SE HACEN REACCIONAR ENTRE SI TRES COMPUESTOS DE FORMULAS DONDE RK1 Y R7 SON COMO ANTES, PARA FORMAR UN COMPUESTO DE FORMULA II'' DONDE RK1 ES COMO ANTES, O EL COMPUESTO DE FORMULA (I), Y CUANDO SE OBTIENE EL COMPUESTO DE FORMULA (II), SE HACE REACCIONAR ESTE CON UNA AMINA SECUNDARIA DE FORMULA: DONDE R7 ES COMO ANTES. LOS COMPUESTOS OBTENIDOS TIENEN ACTIVIDAD ANTAGONISTA DEL CALCIO Y SON UTILES PARA TRATAR DESORDENES VASCULARES TALES COMO ENFERMEDADES DE LAS ARTERIAS CORONARIAS Y LAS ARTERIAS CEREBRALES, HIPERTENSION Y SIMILARES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20393585 | 1985-09-13 | ||
JP26309385 | 1985-11-22 | ||
JP11156086 | 1986-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2002325A6 true ES2002325A6 (es) | 1988-08-01 |
Family
ID=27311989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8601837A Expired ES2002325A6 (es) | 1985-09-13 | 1986-09-12 | Un procedimiento para preparar un derivado de dihidropiridina |
Country Status (6)
Country | Link |
---|---|
US (1) | US4849429A (es) |
EP (1) | EP0216542B1 (es) |
KR (1) | KR870003094A (es) |
CA (1) | CA1295331C (es) |
DE (1) | DE3682857D1 (es) |
ES (1) | ES2002325A6 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8531625D0 (en) * | 1985-12-23 | 1986-02-05 | Shell Int Research | Complex-forming polymers |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
WO1983003249A1 (en) * | 1982-03-17 | 1983-09-29 | Yoshitomi Pharmaceutical | 1,4-dihydropyridine-3,5-dicarboxylate derivatives |
FI853477L (fi) * | 1984-09-14 | 1986-03-15 | Ciba Geigy Ag | Foerfarande foer framstaellning av karbonylfoereningar. |
-
1986
- 1986-09-02 DE DE8686306770T patent/DE3682857D1/de not_active Expired - Lifetime
- 1986-09-02 EP EP86306770A patent/EP0216542B1/en not_active Expired - Lifetime
- 1986-09-05 CA CA000517525A patent/CA1295331C/en not_active Expired - Lifetime
- 1986-09-09 US US06/906,268 patent/US4849429A/en not_active Expired - Fee Related
- 1986-09-12 ES ES8601837A patent/ES2002325A6/es not_active Expired
- 1986-09-13 KR KR1019860007724A patent/KR870003094A/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US4849429A (en) | 1989-07-18 |
CA1295331C (en) | 1992-02-04 |
EP0216542B1 (en) | 1991-12-11 |
EP0216542A1 (en) | 1987-04-01 |
DE3682857D1 (en) | 1992-01-23 |
KR870003094A (ko) | 1987-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-09-12 |
|
FD1A | Patent lapsed |
Effective date: 20000204 |