ES2002325A6 - Dihydropyridine derivatives. - Google Patents

Dihydropyridine derivatives.

Info

Publication number
ES2002325A6
ES2002325A6 ES8601837A ES8601837A ES2002325A6 ES 2002325 A6 ES2002325 A6 ES 2002325A6 ES 8601837 A ES8601837 A ES 8601837A ES 8601837 A ES8601837 A ES 8601837A ES 2002325 A6 ES2002325 A6 ES 2002325A6
Authority
ES
Spain
Prior art keywords
formula
pir
compound
dihydropyridine derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601837A
Other languages
Spanish (es)
Inventor
Chikara Fukaya
Atsuyuki Ashimori
Taizo Ono
Kazumasa Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of ES2002325A6 publication Critical patent/ES2002325A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDURE FOR PREPARING DIHYDROPYRIDINE DERIVATIVES FROM FORMULA: WHERE RK1 IS METHYL, HALOGEN, TRIFLUOROMETHYL, NITRO, CYAN, OR METOXY AND R7 IS BENCIL, HYDROPYRIDINE LINKED TO POSITION 2, 3 OR 4 OF LA PIR IN LA PIR BETWEEN THREE COMPOUNDS OF FORMULAS WHERE RK1 AND R7 ARE LIKE BEFORE, TO FORM A COMPOUND OF FORMULA II'' WHERE RK1 IS LIKE BEFORE, OR WHEN THE COMPOUND OF FORMULA (II) IS OBTAINED, THIS IS REACTED WITH A SECONDARY AMINE OF FORMULA: WHERE R7 IS LIKE BEFORE. THE COMPOUNDS OBTAINED ARE ANTAGONISTIC ACTIVITY OF CALCIUM AND ARE USEFUL TO TREAT VASCULAR DISORDERS SUCH AS DISEASES OF THE CORONARY ARTERIES AND THE CEREBRAL ARTERIES, HYPERTENSION AND THE LIKE. (Machine-translation by Google Translate, not legally binding)
ES8601837A 1985-09-13 1986-09-12 Dihydropyridine derivatives. Expired ES2002325A6 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20393585 1985-09-13
JP26309385 1985-11-22
JP11156086 1986-05-14

Publications (1)

Publication Number Publication Date
ES2002325A6 true ES2002325A6 (en) 1988-08-01

Family

ID=27311989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601837A Expired ES2002325A6 (en) 1985-09-13 1986-09-12 Dihydropyridine derivatives.

Country Status (6)

Country Link
US (1) US4849429A (en)
EP (1) EP0216542B1 (en)
KR (1) KR870003094A (en)
CA (1) CA1295331C (en)
DE (1) DE3682857D1 (en)
ES (1) ES2002325A6 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531625D0 (en) * 1985-12-23 1986-02-05 Shell Int Research Complex-forming polymers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (en) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4- (2'-nitrophenyl) -2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine
DE2218644C3 (en) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basic esters of 1,4-dihydropyridines, processes for their preparation and their use as pharmaceuticals
US3985758A (en) * 1973-02-20 1976-10-12 Yamanouchi Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives
WO1983003249A1 (en) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical 1,4-dihydropyridine-3,5-dicarboxylate derivatives
IL76366A (en) * 1984-09-14 1989-07-31 Ciba Geigy Ag 2,6-dialkyl-4-aryl-3,5-diacyl-1,4-dihydropyridine derivatives,processes for their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
EP0216542B1 (en) 1991-12-11
US4849429A (en) 1989-07-18
DE3682857D1 (en) 1992-01-23
CA1295331C (en) 1992-02-04
EP0216542A1 (en) 1987-04-01
KR870003094A (en) 1987-04-15

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-12

FD1A Patent lapsed

Effective date: 20000204