ES2002204A6 - Procedimiento de preparacion de nuevos derivados de 5-amino pentano-nitrilo - Google Patents

Procedimiento de preparacion de nuevos derivados de 5-amino pentano-nitrilo

Info

Publication number
ES2002204A6
ES2002204A6 ES8602393A ES8602393A ES2002204A6 ES 2002204 A6 ES2002204 A6 ES 2002204A6 ES 8602393 A ES8602393 A ES 8602393A ES 8602393 A ES8602393 A ES 8602393A ES 2002204 A6 ES2002204 A6 ES 2002204A6
Authority
ES
Spain
Prior art keywords
image
alkoxy
alkyl
hydrogen
pentanenitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602393A
Other languages
English (en)
Inventor
Gilbert Regnier
Yves-Michel Gargouil
Jean-Paul Vilaine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES2002204A6 publication Critical patent/ES2002204A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LOS DERIVADOS DE FORMULA (I) EN LA QUE REPRESENTAN CON R1 F HIDROGENO, HALOGENO, TRIFLUOROMETILO O ALCOXILO INFERIOR. R2 Y R3 F HIDROGENO O ALCOXILO INFERIOR, O CONJUNTAMENTE: -O-CHFCH-O- O -O-CH2-O-, O CONJUNTAMENTE CON FENILO AL QUE ESTAN UNIDOS: ALCOXIFENILO, BENZOXAZOLILO, BENZOTIAZOLILO, BENZOTIADIAZOLILO O QUINOLEINO R - ALCOHILO DE 3 A 15 CARBONOS O CON XFS O SO2 Y ZFCL, ALCOHILO O ALCOXILO INFERIOR RK - ALCOHILO INFERIOR; ARK - TIENE FORMULA GENERAL II O III CON RL1 Y RK2 ALCOHILOS INFERIORES SE OBTIENEN HACIENDO REACCIONAR: SIENDO M SODIO O LITIO Y AR, R, RK, HAL Y ARK SEGUN SE HA DEFINIDO ANTERIORMENTE. APLICACION EN MEDICAMENTOS MODULADORES DEL CALCIO.
ES8602393A 1985-10-04 1986-10-03 Procedimiento de preparacion de nuevos derivados de 5-amino pentano-nitrilo Expired ES2002204A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8514756A FR2588258B1 (fr) 1985-10-04 1985-10-04 Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2002204A6 true ES2002204A6 (es) 1988-07-16

Family

ID=9323550

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602393A Expired ES2002204A6 (es) 1985-10-04 1986-10-03 Procedimiento de preparacion de nuevos derivados de 5-amino pentano-nitrilo

Country Status (8)

Country Link
US (1) US4792559A (es)
EP (1) EP0220104B1 (es)
JP (1) JPS6287557A (es)
AT (1) ATE74909T1 (es)
CA (1) CA1263862A (es)
DE (1) DE3684867D1 (es)
ES (1) ES2002204A6 (es)
FR (1) FR2588258B1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
US5387685A (en) * 1993-07-16 1995-02-07 American Cyanamid Co MDR reversal agents
CN110240554B (zh) * 2019-06-27 2021-02-23 上海大学 α-硫醚芳基乙腈类化合物及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1154810B (de) * 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
NL148312B (nl) * 1965-03-10 1976-01-15 Pfizer Werkwijze voor het bereiden van een geneesmiddel dat een of een aantal 1-chinolyl-2-alkylaminoethanolderivaten en/of de zuuradditiezouten daarvan bevat en de onder toepassing van deze werkwijze verkregen gevormde geneesmiddelen, alsmede werkwijze voor het bereiden van deze geneeskrachtige derivaten en de zuuradditiezouten daarvan.
DE3144150A1 (de) * 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
ZA822416B (en) * 1981-04-10 1983-03-30 Basf Ag Omega-cyano-1,omega-diphenyl-azaalkane derivatives,their preparation and drugs containing them

Also Published As

Publication number Publication date
JPH0329790B2 (es) 1991-04-25
FR2588258B1 (fr) 1989-12-15
EP0220104A3 (en) 1989-04-05
DE3684867D1 (de) 1992-05-21
EP0220104B1 (fr) 1992-04-15
EP0220104A2 (fr) 1987-04-29
FR2588258A1 (fr) 1987-04-10
ATE74909T1 (de) 1992-05-15
CA1263862A (fr) 1989-12-12
JPS6287557A (ja) 1987-04-22
US4792559A (en) 1988-12-20

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-10-03

FD1A Patent lapsed

Effective date: 20001009