ES2001420A6 - Procedimiento para la preparacion de derivados de naftaleno. - Google Patents

Procedimiento para la preparacion de derivados de naftaleno.

Info

Publication number
ES2001420A6
ES2001420A6 ES8601712A ES8601712A ES2001420A6 ES 2001420 A6 ES2001420 A6 ES 2001420A6 ES 8601712 A ES8601712 A ES 8601712A ES 8601712 A ES8601712 A ES 8601712A ES 2001420 A6 ES2001420 A6 ES 2001420A6
Authority
ES
Spain
Prior art keywords
optionally substituted
substituted phenyl
alkyl
lower alkyl
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601712A
Other languages
English (en)
Inventor
Krishna Murthy
Michael C Venuti
John M Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES2001420A6 publication Critical patent/ES2001420A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C07C69/635—Halogen-containing esters of saturated acids containing rings in the acid moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Organic Insulating Materials (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE NAFTALENO. EL INVENTO CONCIERNE A UN PROCEDIMIENTO PARA LA PREPARACION DE NAFTALENO DE FORMULA: EN QUE: R1 Y R2 SON IGUALES Y SON ALCOXI INFERIOR O FENOXI OPCIONALMENTE SUSTITUIDO; R3 ES ALQUILO INFERIOR, ALCOXI INFERIOR, O HALO, Y M ES 0, 1 O 2 O R3 ES FENILO OPCIONALMENTE SUSTITUIDO, FENIL-ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, FENIL-ALCOXI INFERIOR OPCIONALMENTE SUSTITUIDO, AMINO, ALQUIL INFERIOR-AMINO, DI-ALQUIL INFERIOR-AMINO, CIANDO O S(O)NR EN DONDE R ES ALQUILO INFERIOR; FENILO OPCIONALMENTE SUSTITUIDO; FENIL-ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO; O ARILO HETEROCICLICO OPCIONALMENTE SUSTITUIDO DE TRES A NUEVE ATOMOS EN EL ANILLO QUE CONTIENE UNO O DOS HETEROATOMOS SELECCIONADOS DEL GRUPO CONSISTENTE EN NITROGENO, OXIGENO Y AZUFRE, Y LAS SALES POR ADICION DE ACIDOS, FARMACEUTICAMENTE ACEPTABLES DEL MISMO; Y M ES 1, Y N ES 0, 1 O 2; AL MENOS UNO DE LOS X O Y ES C(O)W Y EL OTRO X O Y ES DIFERENTE, Y ES HIDROGENO, C(O)W O R4, ENQUE W ES ALQUILO DE UNO A SIETE ATOMOS DE CARBONO, FENILO OPCIONALMENTE SUSTITUIDO O BENCILO OPCIONALMENTE SUSTITUIDO; Y R4 ES ALQUILO INFERIOR - FENIL-ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO; CUYO COMPUESTO ES UTILIZADO PARA EL TRATAMIENTO DE LA PSORIASIS EN MAMIFEROS.
ES8601712A 1985-09-09 1986-09-09 Procedimiento para la preparacion de derivados de naftaleno. Expired ES2001420A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77391285A 1985-09-09 1985-09-09
US06/856,929 US4792556A (en) 1985-09-09 1986-04-28 Naphthalene anti-psoriatic agents

Publications (1)

Publication Number Publication Date
ES2001420A6 true ES2001420A6 (es) 1988-05-16

Family

ID=27118816

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601712A Expired ES2001420A6 (es) 1985-09-09 1986-09-09 Procedimiento para la preparacion de derivados de naftaleno.

Country Status (8)

Country Link
US (1) US4792556A (es)
EP (1) EP0215622B1 (es)
AT (1) ATE77362T1 (es)
AU (1) AU603994B2 (es)
DE (1) DE3685702T2 (es)
DK (1) DK428686A (es)
ES (1) ES2001420A6 (es)
NZ (1) NZ217488A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089657A (en) * 1987-03-11 1992-02-18 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
JP3042156B2 (ja) * 1992-02-20 2000-05-15 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE463409A (es) 1944-11-01
US3592930A (en) 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
US4017615A (en) 1970-10-29 1977-04-12 Syntex Corporation Propylene carbonate ointment vehicle
US3924004A (en) 1971-11-24 1975-12-02 Syntex Corp Fatty alcohol-propylene carbonate-glycol solvent cream vehicle
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition
US4593120A (en) * 1982-10-27 1986-06-03 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
US4466981A (en) * 1982-10-27 1984-08-21 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
DK35885A (da) * 1984-01-27 1985-07-28 Syntex Inc Naphthalenderivater

Also Published As

Publication number Publication date
AU6243586A (en) 1987-03-12
ATE77362T1 (de) 1992-07-15
NZ217488A (en) 1990-07-26
DK428686A (da) 1987-03-10
EP0215622B1 (en) 1992-06-17
DE3685702T2 (de) 1993-01-21
DE3685702D1 (de) 1992-07-23
EP0215622A2 (en) 1987-03-25
US4792556A (en) 1988-12-20
EP0215622A3 (en) 1988-07-06
DK428686D0 (da) 1986-09-08
AU603994B2 (en) 1990-12-06

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Publication Publication Date Title
ZA837983B (en) Naphthalene anti-psoriatic agents
ES8600730A1 (es) Procedimiento para la preparacion de agentes anti-psoriaticos del tipo naftalenico
ES8601089A1 (es) Procedimiento para la preparacion de compuestos antipsoria- ticos naftalenicos
ES2001420A6 (es) Procedimiento para la preparacion de derivados de naftaleno.