EP4777486A1 - Polymorphe und zusammensetzungen damit - Google Patents

Polymorphe und zusammensetzungen damit

Info

Publication number
EP4777486A1
EP4777486A1 EP24754914.0A EP24754914A EP4777486A1 EP 4777486 A1 EP4777486 A1 EP 4777486A1 EP 24754914 A EP24754914 A EP 24754914A EP 4777486 A1 EP4777486 A1 EP 4777486A1
Authority
EP
European Patent Office
Prior art keywords
bhb
salt form
crystalline
peaks
xrpd pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24754914.0A
Other languages
English (en)
French (fr)
Inventor
Labdhi PARIKH
Wang XIAOYANG
Philippe Delerive
Li MEIQI
Fan JUN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Publication of EP4777486A1 publication Critical patent/EP4777486A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/07—Monoamines containing one, two or three alkyl groups, each having the same number of carbon atoms in excess of three
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP24754914.0A 2023-09-11 2024-08-05 Polymorphe und zusammensetzungen damit Pending EP4777486A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363581718P 2023-09-11 2023-09-11
PCT/EP2024/072112 WO2025056246A1 (en) 2023-09-11 2024-08-05 Polymorphs and compositions comprising same

Publications (1)

Publication Number Publication Date
EP4777486A1 true EP4777486A1 (de) 2026-07-22

Family

ID=92302703

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24754914.0A Pending EP4777486A1 (de) 2023-09-11 2024-08-05 Polymorphe und zusammensetzungen damit

Country Status (4)

Country Link
EP (1) EP4777486A1 (de)
CN (1) CN122070272A (de)
AU (1) AU2024343036A1 (de)
WO (1) WO2025056246A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20260165989A1 (en) * 2024-11-22 2026-06-18 Société des Produits Nestlé S.A. D-bhb (d-beta-hydroxybutyrate) for treatment of multiple acyl-coa dehydrogenase deficiency (madd)
WO2026109941A1 (en) * 2024-11-22 2026-05-28 Société des Produits Nestlé S.A. D-bhb (d-beta-hydroxybutyrate) for use in the treatment of long chain fatty acid oxydation deficiency (lc-faod)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
CN107162893A (zh) * 2017-07-11 2017-09-15 洛阳华荣生物技术有限公司 (r)‑3‑羟基丁酸及其盐的合成工艺
CN110862316A (zh) * 2018-08-27 2020-03-06 浙江华睿生物技术有限公司 一种（r）-3-羟基丁酸的晶型及其应用
CN110372487B (zh) * 2019-07-22 2021-03-19 音芙医药科技(上海)有限公司 一种3-羟基丁酸钠产品及其制备方法
CN112778123A (zh) * 2021-01-19 2021-05-11 宁波酶赛生物工程有限公司 一种3-羟基丁酸钠晶型及其制备方法和应用
CN114573444A (zh) * 2022-03-19 2022-06-03 宁波酶赛生物工程有限公司 一种3-羟基丁酸钠盐及钾盐的制备工艺

Also Published As

Publication number Publication date
AU2024343036A1 (en) 2026-02-12
WO2025056246A1 (en) 2025-03-20
CN122070272A (zh) 2026-05-19

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20260205

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR