EP4752552A2 - Nachweis und quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie - Google Patents

Nachweis und quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie

Info

Publication number
EP4752552A2
EP4752552A2 EP26162420.9A EP26162420A EP4752552A2 EP 4752552 A2 EP4752552 A2 EP 4752552A2 EP 26162420 A EP26162420 A EP 26162420A EP 4752552 A2 EP4752552 A2 EP 4752552A2
Authority
EP
European Patent Office
Prior art keywords
creatine
creatinine
sample
mass
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP26162420.9A
Other languages
English (en)
French (fr)
Other versions
EP4752552A3 (de
Inventor
Thomas C LYNN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quest Diagnostics Investments LLC
Original Assignee
Quest Diagnostics Investments LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Investments LLC filed Critical Quest Diagnostics Investments LLC
Publication of EP4752552A2 publication Critical patent/EP4752552A2/de
Publication of EP4752552A3 publication Critical patent/EP4752552A3/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP26162420.9A 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie Pending EP4752552A3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762545349P 2017-08-14 2017-08-14
PCT/US2018/045790 WO2019036255A1 (en) 2017-08-14 2018-08-08 DETECTION AND QUANTIFICATION OF GUANIDINOACETATE, CREATIN AND CRÉATININE BY MASS SPECTROMETRY
EP23215199.3A EP4310505B1 (de) 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat durch massenspektrometrie
EP18846681.7A EP3669186B1 (de) 2017-08-14 2018-08-08 Verfahren zum nachweis und zur quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP23215199.3A Division EP4310505B1 (de) 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat durch massenspektrometrie
EP18846681.7A Division EP3669186B1 (de) 2017-08-14 2018-08-08 Verfahren zum nachweis und zur quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie

Publications (2)

Publication Number Publication Date
EP4752552A2 true EP4752552A2 (de) 2026-06-03
EP4752552A3 EP4752552A3 (de) 2026-08-05

Family

ID=65362438

Family Applications (3)

Application Number Title Priority Date Filing Date
EP18846681.7A Active EP3669186B1 (de) 2017-08-14 2018-08-08 Verfahren zum nachweis und zur quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie
EP26162420.9A Pending EP4752552A3 (de) 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie
EP23215199.3A Active EP4310505B1 (de) 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat durch massenspektrometrie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18846681.7A Active EP3669186B1 (de) 2017-08-14 2018-08-08 Verfahren zum nachweis und zur quantifizierung von guanidinoacetat, kreatin und kreatinin durch massenspektrometrie

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP23215199.3A Active EP4310505B1 (de) 2017-08-14 2018-08-08 Nachweis und quantifizierung von guanidinoacetat durch massenspektrometrie

Country Status (7)

Country Link
US (3) US11860141B2 (de)
EP (3) EP3669186B1 (de)
JP (1) JP7203086B2 (de)
CN (2) CN111148993A (de)
CA (1) CA3073026A1 (de)
MX (1) MX2020001830A (de)
WO (1) WO2019036255A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11860141B2 (en) * 2017-08-14 2024-01-02 Quest Diagnostics Investments Llc Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry
CN112162028A (zh) * 2020-09-29 2021-01-01 中国农业科学院农业质量标准与检测技术研究所 一种用于草莓组织中维生素c的质谱成像方法
CN112881565B (zh) * 2021-03-05 2022-09-13 山东新华制药股份有限公司 三苯双脒有关物质的hplc检测方法
CN115290770A (zh) * 2022-07-07 2022-11-04 北京君德同创生物技术股份有限公司 一种胍基乙酸含量的测定方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5795469A (en) 1996-01-19 1998-08-18 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US6107623A (en) 1997-08-22 2000-08-22 Micromass Limited Methods and apparatus for tandem mass spectrometry
US6124137A (en) 1993-05-28 2000-09-26 Baylor College Of Medicine Surface-enhanced photolabile attachment and release for desorption and detection of analytes
US6204500B1 (en) 1998-01-23 2001-03-20 Analytica Of Branford, Inc. Mass spectrometry from surfaces
US6268144B1 (en) 1995-03-17 2001-07-31 Sequenom, Inc. DNA diagnostics based on mass spectrometry

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226619C (zh) 2003-03-20 2005-11-09 华中科技大学同济医学院附属同济医院 滤纸片气相色谱－质谱分析检测尿有机酸/氨基酸代谢产物的方法
CA2655933C (en) 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
EP2491400B1 (de) 2009-10-21 2015-10-07 MyCartis N.V. Biomarker zur diagnose, vorhersage und/oder prognose eines akuten herzversagens und verwendungen davon
JP5662182B2 (ja) * 2010-02-08 2015-01-28 地方独立行政法人神奈川県立病院機構 生体試料中のアミンの測定方法およびその方法を用いる患者のスクリーニング方法
CN102980968A (zh) * 2012-12-29 2013-03-20 国家烟草质量监督检验中心 一种尿液中肌酐的液相色谱串联质谱测定方法
US11860141B2 (en) * 2017-08-14 2024-01-02 Quest Diagnostics Investments Llc Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124137A (en) 1993-05-28 2000-09-26 Baylor College Of Medicine Surface-enhanced photolabile attachment and release for desorption and detection of analytes
US6268144B1 (en) 1995-03-17 2001-07-31 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5919368A (en) 1995-11-02 1999-07-06 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5795469A (en) 1996-01-19 1998-08-18 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US5968367A (en) 1996-01-19 1999-10-19 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
US6107623A (en) 1997-08-22 2000-08-22 Micromass Limited Methods and apparatus for tandem mass spectrometry
US6204500B1 (en) 1998-01-23 2001-03-20 Analytica Of Branford, Inc. Mass spectrometry from surfaces

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JEAN MATHIEUJULIAN SCOTT: "An Introduction to Turbulent Flow", 2001, CAMBRIDGE UNIVERSITY PRESS
MERCHANTWEINBERGER, ELECTROPHORESIS, vol. 21, 2000, pages 1164 - 67
POLSON ET AL., JOURNAL OF CHROMATOGRAPHY B, vol. 785, 2003, pages 263 - 275
ROBB ET AL.: "Atmospheric pressure photoionization: An ionization method for liquid chromatography-mass spectrometry", ANAL. CHEM., vol. 72, no. 15, pages 3653 - 3659
SALM ET AL., CLIN. THERAPEUTICS, vol. 22, 2000, pages B71 - B85
TAYLOR ET AL., THERAPEUTIC DRUG MONITORING, vol. 22, 2000, pages 608 - 12
WRIGHT ET AL., PROSTATE CANCER AND PROSTATIC DISEASES, vol. 2, 1999, pages 264 - 76
ZIMMER ET AL., J. CHROMATOGR. A, vol. 854, 1999, pages 23 - 35

Also Published As

Publication number Publication date
US11860141B2 (en) 2024-01-02
US20250208101A1 (en) 2025-06-26
US12276644B2 (en) 2025-04-15
EP3669186B1 (de) 2023-12-13
CN111148993A (zh) 2020-05-12
US20240085386A1 (en) 2024-03-14
EP4310505B1 (de) 2026-03-18
WO2019036255A1 (en) 2019-02-21
EP3669186A1 (de) 2020-06-24
EP3669186A4 (de) 2021-04-07
MX2020001830A (es) 2020-08-17
EP4310505A3 (de) 2024-04-10
EP4752552A3 (de) 2026-08-05
BR112020003057A2 (pt) 2020-08-25
US20190170711A1 (en) 2019-06-06
JP7203086B2 (ja) 2023-01-12
CN119470753A (zh) 2025-02-18
JP2020530904A (ja) 2020-10-29
CA3073026A1 (en) 2019-02-21
EP4310505A2 (de) 2024-01-24

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 4310505

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3669186

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: G01N0033700000

Ipc: G01N0030880000

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 30/88 20060101AFI20260626BHEP

Ipc: G01N 30/72 20060101ALI20260626BHEP

Ipc: G01N 27/62 20210101ALI20260626BHEP

Ipc: G01N 33/70 20060101ALI20260626BHEP