EP4720101A1 - Modifizierte mg53-polypeptide und verfahren zu deren verwendung - Google Patents

Modifizierte mg53-polypeptide und verfahren zu deren verwendung

Info

Publication number
EP4720101A1
EP4720101A1 EP24816223.2A EP24816223A EP4720101A1 EP 4720101 A1 EP4720101 A1 EP 4720101A1 EP 24816223 A EP24816223 A EP 24816223A EP 4720101 A1 EP4720101 A1 EP 4720101A1
Authority
EP
European Patent Office
Prior art keywords
injury
seq
polypeptide
composition
functional fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24816223.2A
Other languages
English (en)
French (fr)
Inventor
Noah Weisleder
Thomas Kwiatkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State Innovation Foundation
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of EP4720101A1 publication Critical patent/EP4720101A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP24816223.2A 2023-05-26 2024-05-24 Modifizierte mg53-polypeptide und verfahren zu deren verwendung Pending EP4720101A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363504538P 2023-05-26 2023-05-26
PCT/US2024/031040 WO2024249315A1 (en) 2023-05-26 2024-05-24 Modified mg53 polypeptides and methods of use thereof

Publications (1)

Publication Number Publication Date
EP4720101A1 true EP4720101A1 (de) 2026-04-08

Family

ID=93658646

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24816223.2A Pending EP4720101A1 (de) 2023-05-26 2024-05-24 Modifizierte mg53-polypeptide und verfahren zu deren verwendung

Country Status (2)

Country Link
EP (1) EP4720101A1 (de)
WO (1) WO2024249315A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008333810B2 (en) * 2007-12-04 2013-01-10 Rutgers, The State University Of New Jersey Compositions and methods to modulate cell membrane resealing
CN103965342B (zh) * 2013-01-25 2015-06-10 北京博雅和瑞科技有限公司 一种mg53突变体及其突变方法和应用
WO2016109638A1 (en) * 2014-12-30 2016-07-07 Rutgers, The State University Of New Jersey Compositions and methods to prevent and repair acute kidney injury
WO2018024110A1 (zh) * 2016-08-01 2018-02-08 北京大学 Mg53突变体及其制备方法和用途

Also Published As

Publication number Publication date
WO2024249315A1 (en) 2024-12-05

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