EP4713345A2 - Rekombinante aavs mit verbessertem tropismus und verbesserter spezifität - Google Patents
Rekombinante aavs mit verbessertem tropismus und verbesserter spezifitätInfo
- Publication number
- EP4713345A2 EP4713345A2 EP24734324.7A EP24734324A EP4713345A2 EP 4713345 A2 EP4713345 A2 EP 4713345A2 EP 24734324 A EP24734324 A EP 24734324A EP 4713345 A2 EP4713345 A2 EP 4713345A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- capsid protein
- seq
- aav capsid
- independently selected
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363502595P | 2023-05-16 | 2023-05-16 | |
| PCT/US2023/072424 WO2024040193A2 (en) | 2022-08-17 | 2023-08-17 | Recombinant aavs with improved tropism and specificity |
| US202463625790P | 2024-01-26 | 2024-01-26 | |
| US202463643890P | 2024-05-07 | 2024-05-07 | |
| PCT/US2024/029714 WO2024238807A2 (en) | 2023-05-16 | 2024-05-16 | Recombinant aavs with improved tropism and specificity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4713345A2 true EP4713345A2 (de) | 2026-03-25 |
Family
ID=91585889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP24734324.7A Pending EP4713345A2 (de) | 2023-05-16 | 2024-05-16 | Rekombinante aavs mit verbessertem tropismus und verbesserter spezifität |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4713345A2 (de) |
| AU (1) | AU2024271851A1 (de) |
| IL (1) | IL324687A (de) |
| WO (1) | WO2024238807A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121090489B (zh) * | 2025-09-08 | 2026-03-03 | 河北科技师范学院 | 一种水污染溯源与应急决策联动方法及系统 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| PT733103E (pt) | 1993-11-09 | 2004-07-30 | Targeted Genetics Corp | Criacao de elevados titulos de vectores de aav recombinantes |
| ATE272123T1 (de) | 1993-11-09 | 2004-08-15 | Ohio Med College | Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren |
| US5656785A (en) | 1995-08-07 | 1997-08-12 | The Charles Stark Draper Laboratory, Inc. | Micromechanical contact load force sensor for sensing magnitude and distribution of loads and tool employing micromechanical contact load force sensor |
| JP4397972B2 (ja) | 1996-11-19 | 2010-01-13 | サージックス コーポレイション | 過渡電圧保護素子およびその製造方法 |
| US6541258B2 (en) | 1996-12-18 | 2003-04-01 | Targeted Genetics Corporation | AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors |
| BRPI1011236A2 (pt) | 2009-06-15 | 2019-07-09 | 4S3 Bioscience Inc | métodos e composições para tratamento de miopatia miotubular usando polipeptídeos quiméricos compreendendo polipeptídeos miotubularesih 1 (mtm1) |
| NZ718926A (en) | 2013-10-11 | 2021-12-24 | Massachusetts Eye & Ear Infirmary | Methods of predicting ancestral virus sequences and uses thereof |
| EP3875593A1 (de) | 2015-12-11 | 2021-09-08 | California Institute of Technology | Zielpeptide zum leiten von adeno-assoziierten viren (aavs) |
| JP7122091B2 (ja) | 2017-07-24 | 2022-08-19 | 株式会社Fuji | ストッカ、ストッカ管理装置およびストッカ管理方法 |
| TWI832036B (zh) | 2017-08-03 | 2024-02-11 | 美商航海家醫療公司 | 用於aav之遞送之組合物及方法 |
| CA3097375A1 (en) | 2018-04-27 | 2019-10-31 | Universitat Heidelberg | Modified aav capsid polypeptides for treatment of muscular diseases |
| JP7438981B2 (ja) | 2018-05-11 | 2024-02-27 | マサチューセッツ アイ アンド イヤー インファーマリー | アデノ随伴ウイルスの肝臓特異的向性 |
| EP3861010A1 (de) | 2018-10-02 | 2021-08-11 | Voyager Therapeutics, Inc. | Umlenkung des tropismus von aav-kapsiden |
| TW202102526A (zh) * | 2019-04-04 | 2021-01-16 | 美商銳進科斯生物股份有限公司 | 重組腺相關病毒及其用途 |
| CN110675371A (zh) | 2019-09-05 | 2020-01-10 | 北京达佳互联信息技术有限公司 | 一种场景切换的检测方法、装置、电子设备及存储介质 |
| US12570998B2 (en) | 2019-09-09 | 2026-03-10 | Massachusetts Eye & Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (AAV) and the AAV receptor (AAVR) for altered bio-distribution of AAV |
| JP2022547570A (ja) | 2019-09-12 | 2022-11-14 | ザ・ブロード・インスティテュート・インコーポレイテッド | 操作済みのアデノ随伴ウイルスキャプシド |
| CA3153902A1 (en) | 2019-10-16 | 2021-04-22 | Pardis SABETI | Engineered muscle targeting compositions |
| JP2023524061A (ja) | 2020-05-01 | 2023-06-08 | ザ・ブロード・インスティテュート・インコーポレイテッド | 操作された中枢神経系用組成物 |
| US20240197918A1 (en) * | 2021-04-23 | 2024-06-20 | Locanabio, Inc. | Tissue-targeted modified aav capsids and methods of use thereof |
| WO2023015297A1 (en) * | 2021-08-05 | 2023-02-09 | The Broad Institute, Inc. | Engineered muscle targeting compositions |
| WO2024040193A2 (en) * | 2022-08-17 | 2024-02-22 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
-
2024
- 2024-05-16 EP EP24734324.7A patent/EP4713345A2/de active Pending
- 2024-05-16 WO PCT/US2024/029714 patent/WO2024238807A2/en not_active Ceased
- 2024-05-16 AU AU2024271851A patent/AU2024271851A1/en active Pending
- 2024-05-16 IL IL324687A patent/IL324687A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2024271851A1 (en) | 2025-12-18 |
| WO2024238807A3 (en) | 2024-12-26 |
| WO2024238807A2 (en) | 2024-11-21 |
| IL324687A (en) | 2026-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20251212 |
|
| AK | Designated contracting states |
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