EP4463166A4 - Irak4-abbauer und verwendungen davon - Google Patents

Irak4-abbauer und verwendungen davon

Info

Publication number
EP4463166A4
EP4463166A4 EP23740879.4A EP23740879A EP4463166A4 EP 4463166 A4 EP4463166 A4 EP 4463166A4 EP 23740879 A EP23740879 A EP 23740879A EP 4463166 A4 EP4463166 A4 EP 4463166A4
Authority
EP
European Patent Office
Prior art keywords
democraft
iraq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23740879.4A
Other languages
English (en)
French (fr)
Other versions
EP4463166A1 (de
Inventor
Reginald Ewesuedo
Chris Ho
William Leong
Jared Gollob
Jeffrey Davis
Ashwin Gollerkeri
Alice Mcdonald
Vashali Dixit
Shu-Pei Wu
Michele Mayo
Haojing Rong
Sagar Agarwal
Bradley Enerson
Patrick Henrick
Rachelle Perea
Duncan Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kymera Therapeutics Inc
Original Assignee
Kymera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymera Therapeutics Inc filed Critical Kymera Therapeutics Inc
Publication of EP4463166A1 publication Critical patent/EP4463166A1/de
Publication of EP4463166A4 publication Critical patent/EP4463166A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP23740879.4A 2022-01-14 2023-01-13 Irak4-abbauer und verwendungen davon Pending EP4463166A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263299653P 2022-01-14 2022-01-14
US202263267465P 2022-02-02 2022-02-02
US202263387274P 2022-12-13 2022-12-13
PCT/US2023/060645 WO2023137439A1 (en) 2022-01-14 2023-01-13 Irak4 degraders and uses thereof

Publications (2)

Publication Number Publication Date
EP4463166A1 EP4463166A1 (de) 2024-11-20
EP4463166A4 true EP4463166A4 (de) 2025-12-31

Family

ID=87279804

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23740879.4A Pending EP4463166A4 (de) 2022-01-14 2023-01-13 Irak4-abbauer und verwendungen davon

Country Status (4)

Country Link
US (1) US20230277519A1 (de)
EP (1) EP4463166A4 (de)
TW (1) TW202345827A (de)
WO (1) WO2023137439A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
MX2021015995A (es) 2019-06-28 2022-03-11 Kymera Therapeutics Inc Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
US12558427B2 (en) 2019-07-17 2026-02-24 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
US12551564B2 (en) 2019-12-10 2026-02-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
CN115052627A (zh) 2019-12-17 2022-09-13 凯麦拉医疗公司 Irak降解剂和其用途
CA3202360A1 (en) 2020-12-30 2022-07-07 Nello Mainolfi Irak degraders and uses thereof
US11773103B2 (en) 2021-02-15 2023-10-03 Kymera Therapeutics, Inc. IRAK4 degraders and uses thereof
US12091411B2 (en) 2022-01-31 2024-09-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
IL320297A (en) * 2022-10-13 2025-06-01 Kymera Therapeutics Inc Salt forms of IRAK4 joints
WO2024191788A1 (en) * 2023-03-10 2024-09-19 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021127190A1 (en) * 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215801A1 (en) * 2017-05-26 2018-11-29 Cancer Research Technology Limited Benzimidazolone derived inhibitors of bcl6
IL315310A (en) * 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2020010227A1 (en) * 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021127190A1 (en) * 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof

Also Published As

Publication number Publication date
WO2023137439A1 (en) 2023-07-20
US20230277519A1 (en) 2023-09-07
EP4463166A1 (de) 2024-11-20
TW202345827A (zh) 2023-12-01

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Legal Events

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DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20251203

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/5386 20060101AFI20251127BHEP

Ipc: A61K 31/44 20060101ALI20251127BHEP

Ipc: A61K 31/33 20060101ALI20251127BHEP

Ipc: A61K 31/395 20060101ALI20251127BHEP

Ipc: A61K 31/4725 20060101ALI20251127BHEP

Ipc: A61P 35/00 20060101ALI20251127BHEP