Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
  • A61Q1/02—Preparations containing skin colorants, e.g. pigments
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
  • A61Q1/02—Preparations containing skin colorants, e.g. pigments
  • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
  • A61Q1/02—Preparations containing skin colorants, e.g. pigments
  • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
  • A61Q1/06—Lipsticks
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/001—Preparations for care of the lips
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/49—Solubiliser, Solubilising system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/59—Mixtures
  • A61K2800/592—Mixtures of compounds complementing their respective functions
  • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/59—Mixtures
  • A61K2800/594—Mixtures of polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
  • A61K2800/95—Involves in-situ formation or cross-linking of polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0216—Solid or semisolid forms
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/042—Gels
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/062—Oil-in-water emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions

Definitions

• composition for smoothing the skin and/or the lips are Composition for smoothing the skin and/or the lips
• the present invention relates to the cosmetic field and in particular to smoothing compositions for the skin and/or the lips.
• the Applicant has demonstrated that the use of at least two cosmetic ingredients comprising one or more polyglycerols having from 3 to 10 glycerol units, said cosmetic ingredients having average molecular weights distinct from each other of at least 100 g/mol, or even at least 200 g/mol, advantageously in association with a polyol and optionally in addition a propenetrating agent, made it possible to meet this need.
• the polyglycerols and any other ingredients or hydrophilic active ingredients in the composition penetrate the first layers of the skin to provide volume and material to fill wrinkles "from the inside", effectively and durably.
• a first object of the invention is therefore a cosmetic composition for caring for and/or making up the skin and/or the lips comprising, in a physiologically acceptable medium, an aqueous phase and: a first cosmetic ingredient comprising one or more polyglycerols having from 3 to
• a second cosmetic ingredient distinct from the first comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000 g/mol
• a third cosmetic ingredient, distinct from the first and from the second comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 1000 g/mol
• the average molecular weight of the polyglycerols of second cosmetic ingredient is higher by at least 100 g/mol, or even by at least 200 g/mol with respect to the average molecular weight of the polyglycerols of the first cosmetic ingredient.
• composition of the invention is a non-rinse-out care composition, distinct from the rinse-out compositions, which are hygiene or cleaning compositions.
• Another object relates to a cosmetic process comprising the application to the skin and/or the lips of a composition as defined according to the invention, in particular for smoothing the skin and/or the lips, and/or restoring the volumes of the face. and/or lips, provide firmness and/or elasticity, and/or reduce and/or fill in wrinkles.
• the invention also relates to a non-therapeutic cosmetic use of at least:
• a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 600 g/mol, and
• a second cosmetic ingredient distinct from the first comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to
• the invention relates to a cosmetic process for smoothing the skin and/or the lips, and/or restoring the volumes of the face and/or the lips, and/or reducing and/or filling in the wrinkles comprising the application to the skin and/or lips of a composition as defined according to the invention.
• a cosmetic process for smoothing the skin and/or the lips, and/or restoring the volumes of the face and/or the lips, and/or reducing and/or filling in the wrinkles comprising the application to the skin and/or lips of a composition as defined according to the invention.
• the present invention therefore relates to a cosmetic composition for caring for and/or making up the skin and/or the lips comprising, in a physiologically acceptable medium, an aqueous phase and: a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 600 g/mol, a second cosmetic ingredient distinct from the first, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000 g/mol, and optionally in addition a third cosmetic ingredient, distinct from the first and the second, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 1000 g/mol, it being understood that the average molecular weight of the polyglycerols of the second cosmetic ingredient is higher by at least 100 g/mol, or even by at least 200 g/mol with respect to the average molecular
• a cosmetic process for smoothing the skin and/or the lips, and/or restoring the volumes of the face and/or the lips, and/or reducing and/or filling in wrinkles comprising the application to the skin and/or lips, of a cosmetic care and/or makeup composition
• a cosmetic care and/or makeup composition comprising, in a physiologically acceptable medium, an aqueous phase and: a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, by weight average molecular weight ranging from 200 to 600 g/mol, a second cosmetic ingredient distinct from the first, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000 g/mol, and optionally also a third ingredient cosmetic, distinct from the first and the second, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 1000 g/mol, it being
• cosmetic composition is meant any composition for cosmetic purposes, that is to say aesthetic, which can be brought into contact with the superficial parts of the human body and more particularly with keratin materials, in particular the skin and / or the human lips.
• skin is meant the skin of the face and/or the neck and the skin of the body.
• physiologically acceptable medium any excipient suitable for topical use, in contact with keratin materials, without risk of toxicity, incompatibility, instability and/or allergic response.
• polyglycerols comprising from 3 to 10 glycerol units constituting the cosmetic ingredients based on polyglycerols which can be used according to the invention are in particular the following compounds:
• composition of the invention comprises at least two cosmetic ingredients each comprising one or more polyglycerols having from 3 to 10 glycerol units and optionally an aqueous solvent, in particular water.
• each cosmetic ingredient based on polyglycerols consists essentially or even exclusively of one or more polyglycerols having from 3 to 10 glycerol units.
• the cosmetic ingredient based on polyglycerols comprises at least 95%, or better 98%, or even better 99%, or even comprises 100% by weight of polyglycerols.
• the cosmetic ingredient consists of one or more polyglycerols having from 3 to 10 glycerol units and of a hydrophilic solvent, preferably water.
• the polyglycerol content in such a cosmetic ingredient comprising a hydrophilic solvent will generally range from 70 to 90%, preferably from 80 to 90% by weight relative to the total weight of the cosmetic ingredient.
• the INCI name for such an ingredient will be: Polyglycerin-x and aqua (water) with x ranging from 3 to 10.
• the term “average molecular weight” of said cosmetic ingredient means the average molecular weight of said polyglycerols taking into account their proportions respective properties in said ingredient, the value of this average molecular weight determining the corresponding INCI name, as explained below.
• the cosmetic ingredient marketed by the Sakamoto company under the name PGL-S comprises polyglycerol-3 (predominantly), polyglycerol-4 and polyglycerol-5, and the average molecular weight of the molecular weights of the polyglycerols constituting this cosmetic ingredient is close to the molecular weight of polyglycerol-3.
• the INCI name of this cosmetic ingredient made up of a mixture of polyglycerols is POLYGLYCERIN-3.
• cosmetic ingredient with INCI name comprising POLYGLYCERIN-x with x ranging from 3 to 10
• covers according to the invention a) a cosmetic ingredient with INCI name POLYGLYCERIN-x (without solvent) and b) a cosmetic ingredient of INCI name POLYGLYCERIN-x and aqua (water) (with solvent), in the case the polyglycerol(s) are dissolved in a hydrophilic solvent, preferably water.
• the composition of the invention comprises at least two cosmetic ingredients consisting of one or more polyglycerols having from 3 to 10 glycerol units and optionally of a hydrophilic solvent, with distinct INCI names, chosen from the group consisting of the INCI names including polyglycerin-3, polyglycerin-4, polyglycerin-6, polyglycerin-10, polyglycerin -6 and water, or polyglycerin-10 and water.
• At least two cosmetic ingredients will be used consisting of one or more polyglycerols having from 3 to 10 glycerol units, said ingredients having average molecular weights distinct from each other of at least 100 g/mol, even at least 200 g/mol.
• the combined use of two cosmetic ingredients consisting essentially of one or more polyglycerols and having average molecular weights distinct from each other of at least 100 g/mol, or even at least 200 g/mol makes it possible to have prolonged penetration kinetics in the time in the superficial layers of the skin, for an immediate and lasting effect over time.
• the average molecular weight of the polyglycerols of the second cosmetic ingredient is greater by at least 100 g/mol, or even at least 200 g/mol compared to the average molecular weight of the polyglycerols of the first cosmetic ingredient.
• the cosmetic composition for caring for and/or making up the skin and/or the lips comprises, in a physiologically acceptable medium, an aqueous phase and: a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 600 g/mol, preferably from 200 to 500 g/mol, a second cosmetic ingredient distinct from the first, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000g/mol, preferably from 400 to 800g/mol, and optionally in addition a third cosmetic ingredient, distinct from the first and from the second, comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 1000 g/mol, it being understood that the average molecular weight of the polyglycerols of the second cosmetic ingredient is higher by at least 100 g/mol, or even by at least
• the composition of the invention comprises an aqueous phase and: a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, and whose INCI name comprises polyglycerin-3, or polyglycerin-4, or polyglycerin-6 or polyglycerin-10, a second cosmetic ingredient comprising one or more polyglycerols having 3 to 10 glycerol units, and whose INCI name includes polyglycerin-4, or polyglycerin-6 or polyglycerin-10, distinct from the INCI name of polyglycerols of the first cosmetic ingredient, and optionally in addition a third cosmetic ingredient, distinct from the first and from the second ingredient, and comprising one or more polyglycerols having from 3 to 10 glycerol units, and whose INCI name includes polyglycerin-3, or polyglycerin-4 , or polyglycerin-6 or polyglycerin-10.
• the composition of the invention comprises at least one first cosmetic ingredient with INCI name comprising polyglycerin-6 or polyglycerin-6 and water and one or more other cosmetic ingredients with INCI name comprising polyglycerin-3, or polyglycerin-4 , or polyglycerin-10 or polyglycerin-10 and water.
• composition of the invention comprises an aqueous phase and:
• the composition of the invention will comprise a cosmetic ingredient with the INCI name polyglycerin-6 or polyglycerin-6 (and) water and a cosmetic ingredient with the INCI name polyglycerin-10 or polyglycerin-10 (and) water .
• the composition of the invention will comprise a cosmetic ingredient with the INCI name polyglycerin-3 and a cosmetic ingredient with the INCI name polyglycerin-10 or polyglycerin-10 (and) water.
• the composition of the invention will comprise a cosmetic ingredient with the INCI name polyglycerin-3, a cosmetic ingredient with the INCI name polyglycerin-6 or polyglycerin-6 (and) water and a cosmetic ingredient with the INCI name polyglycerin -10 or polyglycerin-10 (and) water.
• Other combinations comprising at least two cosmetic ingredients with INCI names can be made within the scope of the invention as illustrated in the following table 1 which describes combinations two by two (INCI name of each of the two cosmetic ingredients, symbolized by PG3 for Polyglycerin-3, PG4 for Polyglycerin-4, PG6 for Polyglycerin-6, PG10 for Polyglycerin-10):
• non-preferred combination in the context of the invention because the difference between the average molecular weights of the polyglycerols between the two cosmetic ingredients is less than 100 g/mol.
• triple combinations falling within the scope of the invention are easily deducible from the double combinations described in table 1 above, with the addition of a third cosmetic ingredient, distinct from the first and the second ingredient, and comprising a or more polyglycerols having 3 to 10 glycerol units, and whose INCI name includes polyglycerin-3 (PG3), polyglycerin-4 (PG4), polyglycerin-6 (PG6) or polyglycerin-10 (PG10).
• PG3 polyglycerin-3
• PG4 polyglycerin-4
• PG6 polyglycerin-6
• PG10 polyglycerin-10
• the total content of polyglycerols having from 3 to 10 glycerol units in the composition of the invention will in particular range from 0.5 to 20% by weight, preferably from 1 to 15% by weight relative to the total weight of the composition.
• composition of the invention may also advantageously comprise additional agents other than the polyglycerols described above and chosen from the group consisting of moisturizing agents, pro-penetrating agents, smoothing or exfoliating agents, film-forming or tightening agents, antioxidants, gelling and/or structuring agents, fillers, pigments, and mixtures thereof.
• the composition of the invention will comprise one or more polyol(s) distinct from the polyglycerols described above, as a moisturizing agent, a propenetrating agent, and optionally in addition a smoothing agent or a film-forming agent, and their mixtures.
• the composition also comprises at least one hydrating agent, in particular at least one polyol distinct from the polyglycerols described above.
• hydrating agent in particular at least one polyol distinct from the polyglycerols described above.
• the polyol can be chosen from sugars such as trehalose, mannitol, xylitol, sorbitol, and mixtures thereof.
• composition of the invention will comprise trehalose, sorbitol or their mixture.
• a polyol suitable for the invention can be a compound of the alkyl type, linear, branched or cyclic, saturated or unsaturated, bearing on the alkyl chain at least two -OH functions, in particular at least three -OH functions, and more particularly least four -OH functions.
• the polyols advantageously suitable for the formulation of a composition according to the present invention are C2-C8 glycols.
• the C2-C8 glycol may for example be chosen from ethylene glycol, propylene glycol, 1,3 propanediol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, glycerol (or glycerin ), diglycerol (or diglycerin), and mixtures thereof.
• the composition of the invention comprises glycerol, diglycerol or their mixture.
• the composition of the invention comprises at least glycerol, diglycerol or their mixture and optionally additionally trehalose, sorbitol or their mixture.
• the composition of the invention will also comprise at least one moisturizing agent, preferably at least one polyol distinct from the polyglycerols described above and chosen from the group consisting of sugars such as trehalose, mannitol , xylitol, sorbitol and their mixtures and C2-C8 glycols, such as ethylene glycol, propylene glycol, 1,3 propanediol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, glycerol, diglycerol and their mixtures, preferably glycerol, diglycerol and their mixture.
• at least one moisturizing agent preferably at least one polyol distinct from the polyglycerols described above and chosen from the group consisting of sugars such as trehalose, mannitol , xylitol, sorbitol and their mixtures and C2-C8 glycols, such as ethylene glycol, propylene glycol,
• the total content of polyols, distinct from the polyglycerols described above, in the composition of the invention will generally range from 2 to 25% by weight, preferably from 5 to 20% by weight relative to the total weight of the composition.
• the total content of glycerol and diglycerol in the composition of the invention will generally range from 2 to 12% by weight, preferably from 3 to 10% by weight relative to the total weight of the composition.
• composition of the invention will comprise a pro-penetrating agent.
• pro-penetrating agent is meant a cosmetic agent making it possible to improve and/or promote the penetration of targeted cosmetic raw materials into the different layers of the skin.
• composition of the invention will advantageously also comprise a propenetrating agent to improve and/or promote the penetration of the cosmetic ingredients and in particular of the polyglycerols and any polyols of the composition, into the skin.
• this pro-penetrating agent is chosen from the group consisting of:
• Hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine); these small hydrophilic molecules penetrate the different layers of the skin, and thus promote the penetration of hydrophilic ingredients or active ingredients present in the composition (polyglycerols, polyols, etc.);
• Fatty substance solubilizers chosen, for example, from dimethylisosorbide and ethanol; these agents solubilize the fatty substances of the intercellular cement and therefore promote the penetration of hydrophilic ingredients or active agents present in the composition (polyglycerols, polyols, etc.);
• Surfactants in particular nonionic, preferably: o glycerolated surfactants such as esters of mono- or polyglycerols and C6-C24 fatty acids, such as PG10-myristate and glyceryl stearate, and o alcohols alkoxylated C6-C24 fatty acids, preferably ethoxylated, such as the surfactants with INCI names Steareth-2 and Steareth-20; and their mixtures.
• the composition of the invention also comprises at least one propenetrating agent chosen from the group consisting of: hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine),
• glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids, and alkoxylated C6-C24 fatty alcohols, preferably ethoxylated, preferably glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids;
• the composition of the invention will comprise a pro-penetrating agent chosen from the group consisting of (i) hydrophilic molecules such as urea and betaine, (ii) nonionic surfactants chosen from esters of mono- or polyglycerols and C6-C24 fatty acids and alkoxylated, preferably ethoxylated C6-C24 fatty alcohols, and mixtures thereof.
• a pro-penetrating agent chosen from the group consisting of (i) hydrophilic molecules such as urea and betaine, (ii) nonionic surfactants chosen from esters of mono- or polyglycerols and C6-C24 fatty acids and alkoxylated, preferably ethoxylated C6-C24 fatty alcohols, and mixtures thereof.
• composition of the invention will comprise a pro-penetrating agent chosen from the group consisting of (i) hydrophilic molecules such as urea and betaine, (ii) esters of mono- or poly-glycerols and C6-C24 fatty acids, and mixtures thereof.
• a pro-penetrating agent chosen from the group consisting of (i) hydrophilic molecules such as urea and betaine, (ii) esters of mono- or poly-glycerols and C6-C24 fatty acids, and mixtures thereof.
• the composition of the invention will comprise a pro-penetrating agent chosen from urea, trimethylglycine (betaine), PG10-myristate and glyceryl stearate, or Steareth-2 and Steareth-20, and their mixtures.
• a pro-penetrating agent chosen from urea, trimethylglycine (betaine), PG10-myristate and glyceryl stearate, or Steareth-2 and Steareth-20, and their mixtures.
• composition of the invention will comprise a pro-penetrating agent chosen from urea, trimethylglycine (betaine), PG 10-myristate and glyceryl stearate, and mixtures thereof.
• a pro-penetrating agent chosen from urea, trimethylglycine (betaine), PG 10-myristate and glyceryl stearate, and mixtures thereof.
• the total content of pro-penetrating agent(s) in the composition of the invention will generally range from 1 to 20% by weight, preferably from 2 to 15% by weight relative to the total weight of the composition.
• the total content of hydrophilic molecules may range from 1 to 12% by weight, preferably from 2 to 10% by weight relative to the total weight of the composition.
• the total content of fat-solubilizing agents may range from 0.1 to 10% by weight, preferably from 0.5 to 5% by weight, relative to the total weight of the composition.
• the total content of surfactants may range from 0.1 to 10% by weight, preferably from 0.5 to 5% by weight relative to the total weight of the composition.
• the composition of the skin also advantageously comprises a skin-smoothing agent, in particular one or more hyaluronic acids or one of their salts, and a mixture thereof; in particular their sodium, potassium or magnesium salts, preferably their sodium salts.
• a skin-smoothing agent in particular one or more hyaluronic acids or one of their salts, and a mixture thereof; in particular their sodium, potassium or magnesium salts, preferably their sodium salts.
• Said hyaluronic acids can be in the form of a gel or in the form of a powder.
• the hyaluronic acid(s) (or their salts) used according to the invention can be cross-linked or not, and/or acetylated or not.
• the composition of the invention comprises at least one sodium salt of hyaluronic acid chosen from a sodium salt of acetylated hyaluronic acid, a sodium salt of non-acetylated nor cross-linked hyaluronic acid, a salt of cross-linked hyaluronic acid sodium, and mixtures thereof.
• the composition of the invention comprises a sodium salt of acetylated hyaluronic acid.
• the acetylated hyaluronic acid used in the present invention is that described in patent application WO2018/162672.
• said acetylated hyaluronic acid, or its sodium salt has an average degree of acetylation greater than 3.6, determined by quantitative 2D nuclear magnetic resonance (NMR).
• the acetylated hyaluronic acid or its sodium salt used in the present invention has an average molecular weight of approximately 50 kDa or less, more particularly about 30 kDa or less, and a dispersion index of less than 2n3, more particularly less than 2.0, more particularly less than 1.5.
• the acetylated hyaluronic acid used in the present invention is a sodium salt of acetylated hyaluronic acid, in particular the product marketed under the name “PrimalhyalTM Ultrafiller” by the company Givaudan.
• the “PrimalhyalTM Ultrafiller” product is referenced under the international nomenclature, INCI: SODIUM ACETYLATED HYALURONATE.
• acetylated hyaluronic acid or its sodium salt preferably the product marketed under the name “PrimalhyalTM Ultrafiller”, is present in a content ranging from 0.01% to 10%, in particular 0.05% to 5%, and in particular from 0.1 to 1% by weight of raw material (weight of product) relative to the total weight of the composition.
• Non-acetylated or cross-linked hyaluronic acids or their salts
• the composition comprises a sodium salt of hyaluronic acid that is neither acetylated nor crosslinked.
• the non-crosslinked hyaluronic acid has a molecular weight less than or equal to 500 KDa, preferably less than or equal to 300 KDa or one of its salts
• the non-crosslinked low molecular weight hyaluronic acid used in the present invention is the product marketed under the name “Bashyal powder” by the company Soliance.
• the product "Bashyal powder” is a hyaluronic acid in powder form, 100% pure, that is to say composed of 100% active ingredient.
• the hyaluronic acid polymers used in the composition of this product have a molar mass ranging from 100 KDa to 300 KDa.
• the "Bashyal powder” is referenced under the international nomenclature, INCI: SODIUM HYALURONATE.
• the non-crosslinked low molecular weight hyaluronic acid used in the present invention is the product marketed under the name “Oligo HA” by the company Sochibo.
• the product "Oligo HA” is a hyaluronic acid in powder form, 100% pure, that is to say composed of 100% active ingredient.
• the hyaluronic acid polymers used in the composition of this product have a molar mass ranging from 5 KDa to 10 KDa.
• the “HA oligo” is referenced under the international nomenclature, INCI: HYALURONIC ACID.
• the raw materials used as sources of hyaluronic acids comprise polymers of hyaluronic acids, the molar mass of which may vary slightly.
• variations in the molecular mass are in particular linked to the fact that the number of base units (ie, of disaccharide monomers) included in the molecule of hyaluronic acid at the time of its polymerization varies slightly.
• the molar mass of hyaluronic acid' or 'average molar mass of hyaluronic acid' is “approximately” the indicated mass.
• the molar mass of hyaluronic acid indicated can vary by ⁇ 20%, preferably ⁇ 15% and more preferably ⁇ 10%.
• the high molecular weight cross-linked hyaluronic acid used in the present invention is in the form of a gel.
• the high molecular weight cross-linked hyaluronic acid used in the present invention is preferably the product marketed under the name “Phylcare® HyacrossTM TL 100” by Bloomage Freda Biopharm Co., Ltd.
• “Phylcare® HyacrossTM TL 100” is a hyaluronic acid gel comprising 1% to 5% by weight of active ingredient relative to the total weight of the product.
• the hyaluronic acid polymers used in the composition of this product have a molar mass ranging from 1000 KDa to 1800 KDa.
• the high molecular weight cross-linked hyaluronic acid used in the present invention is in the form of a powder.
• the high molecular weight cross-linked hyaluronic acid used in the present invention is preferably the product with the trade name “Phylcare® HyacrossTM TL 200” produced by Bloomage Freda Biopharm Co., Ltd.
• “Phylcare® HyacrossTM TL 200” is hyaluronic acid in powder form, 100% pure, ie composed of 100% active ingredient.
• the hyaluronic acid polymers used in the composition of this product have a molar mass greater than or equal to 3000 KDa.
• the product “Phylcare® HyacrossTM TL 200” is referenced under the international nomenclature, INCI: SODIUM HYALURONATE CROSSPOLYMER, Pentylene Glycol, Aqua.
• the composition of the invention comprises a sodium salt of acetylated hyaluronic acid and a sodium salt of non-acetylated or cross-linked hyaluronic acid.
• the composition comprises a cross-linked hyaluronic acid having a molecular weight greater than or equal to 1000 KDa, preferably greater than or equal to 2000 KDa or even greater than or equal to 3000 KDa or one of its salts, and an acid non-crosslinked hyaluronic acid having a molecular weight less than or equal to 500 KDa, preferably less than or equal to 200 KDa or one of its salts, and their mixture.
• the total content of hyaluronic acid(s) or one of their salts may range from 0.01% to 10%, preferably from 0.05% to 5%, more preferably from 0.01% to 1% by weight of raw material ( weight of product) relative to the total weight of the composition.
• composition may also comprise alpha-hydroxy acids (AHAs).
• AHAs alpha-hydroxy acids
• the composition of the invention further comprises a film-forming agent or agent with a tensing effect on the surface of the skin, in particular a film-forming polymer.
• agent with a tensor effect an agent capable of smoothing the surface of the skin in order to attenuate the wrinkles of the skin, by a mechanical effect linked to the elastic properties of the film formed on the surface of the skin.
• film-forming polymer means a polymer capable of forming a continuous film on a support, from a solution, a dispersion or a suspension of this film-forming polymer, applied to said support.
• the evaporation of the solvent in which it is dispersed allows this film-forming polymer to form a film on the surface of the skin and/or the lips and thus to prolong the effect provided by the composition on the restoration of the volumes of the face and/or or lips, and/or reduction and/or filling of wrinkles.
• the film formed on the skin can also act as a reservoir of molecules dispersed in said film, which will gradually penetrate into the superficial layers of the skin and produce the desired cosmetic effect, for example a moisturizing effect.
• These film-forming polymers can be natural or synthetic, fat-soluble or water-soluble.
• water-soluble polymers and advantageously of natural origin will be used.
• vinyl polymers eg polyvinyl alcohol
• vinylpyrrolidone polymers and copolymers polyacrylates
• polyurethanes latices, and mixtures thereof.
• polysaccharides chosen in particular from pullulans, pectins, carrageenans, galactomanans, xanthans, alginates, starches, and mixtures thereof.
• Polysaccharides can also be in the form of an algae extract, in particular an extract from algae of the Laminariacae family.
• a pullulan will be used.
• a polysaccharide of natural origin having a molecular weight of less than 600,000 Daltons, preferably less than 400,000 Daltons and even more preferably less than 200,000 Daltons, in particular in the form of an extract of Laminaria flexicaulis as described in the applicant's application FR 2 828 810.
• a starch optionally modified.
• the starch is preferably a native starch, chosen in particular from corn starches, pea starches, tapioca starches, potato starches, rice starches, cassava starches and wheat starches.
• a tapioca starch will be used.
• Starches are described in particular in application FR 2 990 348 of the applicant.
• the composition comprises a film-forming polymer chosen from the group consisting of synthetic polymers or polymers of natural origin, in particular vinyl polymers, polyacrylates, polyurethanes, celluloses and their derivatives, polysaccharides and their derivatives, and their mixtures.
• the total content of film-forming polymer(s), when they are present in the composition of the invention will generally range from 0.1 to 10% by weight, preferably from 0.2 to 5% by weight relative to the total weight of the composition.
• composition of the invention may comprise, in addition to the two cosmetic ingredients based on polyglycerols:
• polyol preferably a C2-C8 glycol, preferably a glycerol and optionally in addition a diglycerol;
• a pro-penetrating agent preferably chosen from urea, trimethylglycine (betaine), nonionic surfactants of the ester type of mono- or poly-glycerols and C6-C24 fatty acids, such as PG10-myristate and glyceryl stearate, or alkoxylated, preferably ethoxylated C6-C24 fatty alcohols, and mixtures thereof;
• a film-forming polymer preferably chosen from a vinyl polymer, a polyacrylate, a polyurethane, a polysaccharide and mixtures thereof;
• a smoothing agent preferably chosen from hyaluronic acid or one of its salts, or AHAs; and their mixtures.
• the cosmetic composition for care and/or makeup of the skin and/or of the lips according to the invention comprises, in a physiologically acceptable medium, an aqueous phase and:
• a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 600 g/mol,
• a second cosmetic ingredient distinct from the first comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000 g/mol,
• a third cosmetic ingredient distinct from the first and from the second comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 1000 g/mol, it being understood that the average molecular weight of the polyglycerols of second cosmetic ingredient is higher by at least 100g/mol, or even at least 200g/mol relative to the average molecular weight of the polyglycerols of the first cosmetic ingredient,
• pro-penetrating agent chosen from the group consisting of: - hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine),
• glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids, and alkoxylated C6-C24 fatty alcohols, preferably ethoxylated, preferably glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids;
• the pro-penetrating agent is chosen from hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine).
• the cosmetic composition according to the invention comprises:
• composition of the invention comprises:
• pro-penetrating agent chosen from hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine), preferably betaine.
• composition of this particular and preferred embodiment may also comprise, as film-forming agent, a water-soluble polymer of natural origin, and in particular a pullulan.
• composition of the invention comprises:
• pro-penetrating agent chosen from hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine), preferably urea.
• composition of the invention may also comprise an oily phase comprising oils and optionally fatty substances, such as waxes, pasty compounds and mixtures thereof.
• Mention may in particular be made of waxes of vegetable origin, butters and triglycerides of fatty acids and their derivatives.
• the composition may also comprise a filler.
• fillers means particles of platelet, spherical or oblong, colorless or white form, of mineral or organic, natural or synthetic nature, which are in an insoluble form and dispersed in the medium of the composition. These fillers serve in particular to modify the rheology or the texture of the composition and/or confer a mattifying effect.
• blue effect filler is meant an effect which camouflages the micro-reliefs of the skin and thus makes it possible to attenuate, by optical correction effect, imperfections in relief and/or color, such as wrinkles, fine lines, pores and tasks.
• the care and/or make-up composition for the skin and/or the lips is in the form of a lotion, a gel, a cream, for example a water-in-oil emulsion or oil-in-water, of a serum, preferably in the form of a gelled aqueous phase.
• the composition may in particular have a liquid, fluid or thick consistency.
• the composition is a care composition for the skin and/or the lips.
• the composition is a make-up composition for the skin and/or the lips.
• a skin care in particular an anti-aging care for the skin of the face or a make-up composition for the skin such as a smoothing foundation for the skin of the face .
• it may be a care product for the lips, in particular a care product that smooths and/or volumizes the lips or a makeup composition for the lips such as a lipstick with a smoothing and/or volumizing.
• the invention also relates to a cosmetic process comprising the application to the skin and/or the lips of a composition according to the invention, in particular for smoothing the skin, restoring the volumes of the face and/or the lips, and/or reduce and/or fill in wrinkles.
• the invention relates to a cosmetic process for smoothing the skin and/or the lips, and/or restoring the volumes of the face and/or the lips, and/or reducing and/or filling in the wrinkles comprising the application to the skin and/or the lips of a composition as defined according to the invention.
• composition of the invention is applied to healthy skin and/or lips, that is to say not showing any disorders or disorders that would be a pathological condition. (“unhealthy” subjects, affected by a pathology). Reference will be made indiscriminately to healthy skin and/or lips or to healthy skin and/or lips in the remainder of the description.
• composition also promotes hydration of the skin and/or the lips.
• compositions of the invention will be applied to healthy subjects exhibiting a loss of volume in the face.
• compositions of the invention will be applied to healthy subjects exhibiting signs associated with aging of the skin, in particular wrinkles.
• compositions of the invention will be applied to healthy subjects with dry skin.
• compositions of the invention will be applied to healthy subjects exhibiting a loss of firmness and/or elasticity of the skin.
• compositions of the invention will be applied to healthy subjects having dry lips and/or thin lips and/or lips with streaks.
• the present invention also relates to a non-therapeutic cosmetic use of at least:
• a first cosmetic ingredient comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 200 to 600 g/mol, and
• a second cosmetic ingredient distinct from the first comprising one or more polyglycerols having from 3 to 10 glycerol units, with an average molecular weight ranging from 300 to 1000 g/mol, as an active combination for smoothing the skin, restoring facial volumes and/or lips, provide firmness and/or elasticity, and/or reduce and/or fill in wrinkles.
• the active combination according to the invention further comprises a pro-penetrating agent chosen from the group consisting of:
• hydrophilic molecules chosen from urea and its derivatives, glycine, trimethylglycine (betaine), - fat-solubilizing agents chosen from dimethylisosorbide and ethanol,
• glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids, and alkoxylated C6-C24 fatty alcohols, preferably ethoxylated, preferably glycerolated surfactants such as esters of mono or polyglycerols and C6-C24 fatty acids;
• the active combination will also advantageously comprise a film-forming agent, in particular a water-soluble polymer of natural origin, and in particular a pullulan.
• POLYGLYCERIN -4 marketed under the name POLYGLYCERIN 310 by SAKAMOTO
• POLYGLYCERIN -6 marketed under the name POLYGLYCERIN-500 MB by SAKAMOTO
• POLYGLYCERIN-10 marketed under the name POLYGLYCERIN-750 MB by SAKAMOTO.
• Example 1 Kinetics of penetration of polyglycerols into the superficial layers of the skin
• polyglycerol-4 penetrates faster but remains in the superficial dermis, compared to polyglycerol-3 which penetrates quickly and reaches the superficial dermis very quickly.
• Polyglycerol-5 and -6 penetrate less deeply than polyglycerol-3 or polyglycerol-4.
• These compounds can act at different levels of the superficial layers of the skin and more or less quickly, and produce their effect, in particular moisturizing and/or smoothing by swelling or filling in the superficial layers of the skin, with a lasting effect thanks to kinetics controlled penetration.
• Combinations of polyglycerols are particularly preferred in cosmetic compositions comprising an aqueous phase, such as gelled aqueous compositions or compositions of the emulsion type, in which the aqueous phase is dispersed in a fatty phase (water-in-oil emulsion) or constitutes the continuous phase (oil-in-water emulsion).
• an aqueous phase such as gelled aqueous compositions or compositions of the emulsion type, in which the aqueous phase is dispersed in a fatty phase (water-in-oil emulsion) or constitutes the continuous phase (oil-in-water emulsion).
• composition according to the invention comprises glycerol, a mixture of polyglycerols and a pro-penetrating agent (urea).
• composition is prepared according to the process below:
• phase D Incorporate phase D and stir until homogenization and formation of a gel. Add phase A with stirring, then phase B.
• phase C Add phase C to the aqueous phase with vigorous stirring to form the emulsion.
• the study method is based on making replicas (or impressions) of a skin area of interest.
• the area studied is that of the corner of the eye also called "crow's feet".
• an adhesive ring 24 mm in diameter is applied to the test area. Then, using a spatula, a Silflo silicone casting resin (Flexico) plus a catalyst (Flexico) is spread inside the ring. After drying, the replica is peeled off from the surface of the skin.
• Flexico Silflo silicone casting resin
• Flexico catalyst
• a second impression is made four hours after application of the cosmetic composition (control or invention).
• the protocol is reproduced for each cosmetic composition of the study.
• Each replica is positioned on a support and illuminated using a grazing illumination lamp with an incident angle of 35 degrees (35°) in order to generate shadows behind each line of the skin surface.
• a MONADERM video imaging system is used to acquire high resolution images of the impression made and digital values representing the shades of gray of each point (pixel) analyzed on the images.
• the replicas taken after application of the cosmetic composition tested are strictly repositioned relative to those taken before application, corresponding to the TO.
• the QUANTITRIDES software calculates the following parameters: number of wrinkles, total surface area of wrinkles in mm 2 ; total length of wrinkles in mm; average wrinkle length in mm; mean depth of wrinkles in pm.
• composition of the invention a significant reduction in the number of wrinkles in the total surface of the wrinkles and in the total length of the wrinkles is observed, four hours after application.
• Example 3 Smoothing effect optimized by adding a film-forming agent to the combination of the invention
• composition according to the invention comprises glycerol, a mixture of polyglycerols, a pro-penetrating agent (trimethylglycine, otherwise called betaine) and a film-forming agent (pullulan).
• glycerol a mixture of polyglycerols
• a pro-penetrating agent trimethylglycine, otherwise called betaine
• a film-forming agent pulpulan
• polyglycerols and pro-penetrating agent are lower than those used in example 2 above, and the formula of the invention also contains a film-forming agent pullulan.
• the formulas of the two compositions tested are described in Table 4 below (percentages expressed as a percentage relative to the final formula):
• composition of the invention produces a significant improved smoothing effect, thanks to the presence of the film-forming agent (pullulan) combined with the combination of polyglycerols, on the wrinkles of the contour of the eye four hours after application, compared to T0.
• control formula shows no significant smoothing effect on wrinkles in the same study area four hours after application, compared to T0.
• Example 4 Fluid cream according to the invention
• composition below is a fluid cream in the form of a gelled aqueous oil-in-water emulsion, comprising a combination of polyglycerols of different molecular weights, glycerol and pro-penetrating agents (urea, PG-10 myristate and glyceryl stearate). The percentages are expressed as percentage by weight relative to the final formula (Table 6).
• composition of Table 6 above is tested according to the method described in Example 2 on a number of volunteers equal to 15.
• the composition has a smoothing action on wrinkles in the corner of the eye area.
• the number of wrinkles and the total length of wrinkles decreased significantly (from -15% to -
• Example 5 Thick cream according to the invention
• composition below is a thick eye contour cream in the form of an oil-in-water emulsion, comprising a combination of polyglycerols of different molecular weights, glycerol and pro-penetrating agents (urea, steareth-21 and steareth-2).
• composition of Table 7 above is tested according to the method described in Example 2 on a number of volunteers equal to 15.
• the composition has a smoothing action on wrinkles in the corner of the eye area.
• the total surface area of wrinkles and the total length of wrinkles decreased significantly (from ⁇ 15% to ⁇ 20%), four hours after application of the composition to the zone studied.
• composition below is a composition for the lips, comprising a combination of polyglycerols of different molecular weights, glycerol and smoothing agents (hyaluronic acids).
• composition below is a fluid cream in the form of a gelled aqueous oil-in-water emulsion, comprising a combination of polyglycerols of different molecular weights, glycerol and pro-penetrating agents (betaine, PG-10 myristate and glyceryl stearate). The percentages are expressed as percentage by weight relative to the final formula (Table 9).
• composition exhibits a smoothing action on wrinkles in the area of the corner of the eye.
• the penetration of polyglycerols (PG3, PG6) is facilitated by the combination of pro-penetrating agents (glycerol esters and betaine).

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• 2021
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