EP4424693A4 - Herstellungsverfahren für hochreine arabinosekristalle - Google Patents

Herstellungsverfahren für hochreine arabinosekristalle

Info

Publication number
EP4424693A4
EP4424693A4 EP23892745.3A EP23892745A EP4424693A4 EP 4424693 A4 EP4424693 A4 EP 4424693A4 EP 23892745 A EP23892745 A EP 23892745A EP 4424693 A4 EP4424693 A4 EP 4424693A4
Authority
EP
European Patent Office
Prior art keywords
manufacturing process
purity
arabinose crystals
crystals
purity arabinose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23892745.3A
Other languages
English (en)
French (fr)
Other versions
EP4424693A1 (de
Inventor
Xinfeng Han
Dongxu Li
Minqian Yang
Chengjun Liao
Shufang Qin
Jiaxing Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Huakang Pharmaceutical Co Ltd
Original Assignee
Zhejiang Huakang Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Huakang Pharmaceutical Co Ltd filed Critical Zhejiang Huakang Pharmaceutical Co Ltd
Publication of EP4424693A1 publication Critical patent/EP4424693A1/de
Publication of EP4424693A4 publication Critical patent/EP4424693A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/28—Evaporating with vapour compression
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0022—Evaporation of components of the mixture to be separated by reducing pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0031—Evaporation of components of the mixture to be separated by heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/211—Measuring of the operational parameters
    • B01F35/2115—Temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02834—Pore size more than 0.1 and up to 1 µm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/004—Fractional crystallisation; Fractionating or rectifying columns
    • B01D9/0045—Washing of crystals, e.g. in wash columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0063—Control or regulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Filtration Of Liquid (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
EP23892745.3A 2022-12-17 2023-05-25 Herstellungsverfahren für hochreine arabinosekristalle Pending EP4424693A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202211628377.2A CN115785174A (zh) 2022-12-17 2022-12-17 一种高纯度阿拉伯糖晶体的制备方法
PCT/CN2023/096370 WO2024124812A1 (zh) 2022-12-17 2023-05-25 一种高纯度阿拉伯糖晶体的制备方法

Publications (2)

Publication Number Publication Date
EP4424693A1 EP4424693A1 (de) 2024-09-04
EP4424693A4 true EP4424693A4 (de) 2026-01-14

Family

ID=85426057

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23892745.3A Pending EP4424693A4 (de) 2022-12-17 2023-05-25 Herstellungsverfahren für hochreine arabinosekristalle

Country Status (5)

Country Link
US (1) US20240279261A1 (de)
EP (1) EP4424693A4 (de)
JP (1) JP7751111B2 (de)
CN (1) CN115785174A (de)
WO (1) WO2024124812A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785174A (zh) * 2022-12-17 2023-03-14 浙江华康药业股份有限公司 一种高纯度阿拉伯糖晶体的制备方法
CN116196691B (zh) * 2023-04-27 2024-01-12 山东归源生物科技有限公司 一种长链二元酸的精制系统和方法
CN116732252A (zh) * 2023-06-28 2023-09-12 山东星光糖业有限公司 一种高纯度糖浆、糖粉的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659854A (zh) * 2012-03-15 2012-09-12 济南圣泉唐和唐生物科技有限公司 一种l-阿拉伯糖的提纯方法
CN111205338A (zh) * 2020-02-11 2020-05-29 浙江华康药业股份有限公司 一种从阿拉伯糖母液中回收阿拉伯糖的方法
CN112079886A (zh) * 2020-09-17 2020-12-15 甘肃赫原生物制品有限公司 一种经色谱分离提高木糖和阿拉伯糖纯度的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20002148L (fi) 2000-09-29 2002-03-30 Xyrofin Oy Menetelmä tuotteiden talteenottamiseksi
JP2004261039A (ja) 2003-02-28 2004-09-24 Unitika Ltd Ｌ−アラビノース含有結晶性粉末糖組成物およびその製造方法
CN102351916A (zh) * 2011-08-24 2012-02-15 山东福田药业有限公司 一种制备d-阿拉伯糖的方法
CN104892688B (zh) * 2015-06-05 2018-02-09 山东福田药业有限公司 利用l‑阿拉伯糖结晶母液回收l‑阿拉伯糖的方法
CN106349296B (zh) * 2016-08-24 2019-08-27 山东福洋生物科技股份有限公司 一种高浓度d-阿拉伯糖的制备方法
CN115785174A (zh) * 2022-12-17 2023-03-14 浙江华康药业股份有限公司 一种高纯度阿拉伯糖晶体的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659854A (zh) * 2012-03-15 2012-09-12 济南圣泉唐和唐生物科技有限公司 一种l-阿拉伯糖的提纯方法
CN111205338A (zh) * 2020-02-11 2020-05-29 浙江华康药业股份有限公司 一种从阿拉伯糖母液中回收阿拉伯糖的方法
CN112079886A (zh) * 2020-09-17 2020-12-15 甘肃赫原生物制品有限公司 一种经色谱分离提高木糖和阿拉伯糖纯度的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2024124812A1 *

Also Published As

Publication number Publication date
WO2024124812A1 (zh) 2024-06-20
US20240279261A1 (en) 2024-08-22
CN115785174A (zh) 2023-03-14
EP4424693A1 (de) 2024-09-04
JP7751111B2 (ja) 2025-10-07
JP2025501886A (ja) 2025-01-24

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