EP4220139A3 - Systems and methods for assessing biological samples - Google Patents
Systems and methods for assessing biological samples Download PDFInfo
- Publication number
- EP4220139A3 EP4220139A3 EP23155042.7A EP23155042A EP4220139A3 EP 4220139 A3 EP4220139 A3 EP 4220139A3 EP 23155042 A EP23155042 A EP 23155042A EP 4220139 A3 EP4220139 A3 EP 4220139A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- sensor
- instrument
- biological samples
- sample holder
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012472 biological sample Substances 0.000 title abstract 3
- 230000003287 optical effect Effects 0.000 abstract 6
- 230000005284 excitation Effects 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0332—Cuvette constructions with temperature control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/241—Devices for focusing
- G02B21/244—Devices for focusing using image analysis techniques
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562112910P | 2015-02-06 | 2015-02-06 | |
PCT/US2016/016886 WO2016127128A1 (en) | 2015-02-06 | 2016-02-05 | Systems and methods for assessing biological samples |
EP20171301.3A EP3719481B1 (en) | 2015-02-06 | 2016-02-05 | An optical instrument for biological analysis |
EP16705683.7A EP3254085B1 (en) | 2015-02-06 | 2016-02-05 | An instrument for biological analysis |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16705683.7A Division EP3254085B1 (en) | 2015-02-06 | 2016-02-05 | An instrument for biological analysis |
EP20171301.3A Division-Into EP3719481B1 (en) | 2015-02-06 | 2016-02-05 | An optical instrument for biological analysis |
EP20171301.3A Division EP3719481B1 (en) | 2015-02-06 | 2016-02-05 | An optical instrument for biological analysis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4220139A2 EP4220139A2 (en) | 2023-08-02 |
EP4220139A3 true EP4220139A3 (en) | 2023-08-09 |
Family
ID=55404853
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23155042.7A Pending EP4220139A3 (en) | 2015-02-06 | 2016-02-05 | Systems and methods for assessing biological samples |
EP20171301.3A Active EP3719481B1 (en) | 2015-02-06 | 2016-02-05 | An optical instrument for biological analysis |
EP16705683.7A Active EP3254085B1 (en) | 2015-02-06 | 2016-02-05 | An instrument for biological analysis |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20171301.3A Active EP3719481B1 (en) | 2015-02-06 | 2016-02-05 | An optical instrument for biological analysis |
EP16705683.7A Active EP3254085B1 (en) | 2015-02-06 | 2016-02-05 | An instrument for biological analysis |
Country Status (10)
Country | Link |
---|---|
US (2) | US20160230210A1 (en) |
EP (3) | EP4220139A3 (en) |
JP (3) | JP6985144B2 (en) |
KR (2) | KR102494654B1 (en) |
CN (2) | CN113049553A (en) |
BR (1) | BR112017016937B1 (en) |
ES (1) | ES2943159T3 (en) |
RU (1) | RU2708542C2 (en) |
SG (3) | SG11201706367WA (en) |
WO (1) | WO2016127128A1 (en) |
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US9579655B2 (en) | 2013-01-18 | 2017-02-28 | Biomeme Incorporated | Analytic device |
EP4220139A3 (en) | 2015-02-06 | 2023-08-09 | Life Technologies Corporation | Systems and methods for assessing biological samples |
US10324041B2 (en) * | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
CN206348514U (en) * | 2016-12-23 | 2017-07-21 | 卡尔蔡司医疗技术股份公司 | Surgical operation microscope and the device for making it switch between multiple-working mode |
US11047854B2 (en) | 2017-02-06 | 2021-06-29 | Abbott Japan Llc | Methods for reducing noise in signal-generating digital assays |
CN112326652B (en) * | 2017-09-20 | 2021-09-03 | 深圳市真迈生物科技有限公司 | Imaging method, device and system for controlling sequence determination reaction |
WO2019118343A2 (en) * | 2017-12-15 | 2019-06-20 | Biomeme, Inc. | Portable devices and methods for analyzing samples |
NL2020636B1 (en) * | 2017-12-28 | 2019-07-08 | Illumina Inc | Light energy fluorescence excitation |
KR102133633B1 (en) * | 2018-04-17 | 2020-07-13 | (주)로고스바이오시스템스 | A device for real-time detecting nucleic acids amplification products |
KR102113217B1 (en) * | 2018-07-23 | 2020-05-21 | 광주과학기술원 | Target protein tracing equipment using in laser inducing X-ray |
CN109324024A (en) * | 2018-09-17 | 2019-02-12 | 中国人民解放军陆军军医大学第三附属医院(野战外科研究所) | Small integrated immunofluorescence analysis device |
US10883925B2 (en) * | 2018-09-24 | 2021-01-05 | Hf Scientific, Inc. | Spectrophotometer for use in explosive atmospheres |
USD1016325S1 (en) | 2019-01-04 | 2024-02-27 | Meso Scale Technologies, Llc. | Instrument |
USD921222S1 (en) * | 2019-01-04 | 2021-06-01 | Meso Scale Technologies, Llc. | Instrument |
CN113874708A (en) | 2019-03-21 | 2021-12-31 | 生米公司 | Multifunctional analysis device |
CN110057808A (en) * | 2019-05-27 | 2019-07-26 | 中国人民解放军军事科学院军事医学研究院 | Sample swivel mount and Raman spectrum detector |
KR102220353B1 (en) * | 2019-06-10 | 2021-02-25 | 한국전자기술연구원 | Fluorescence reader system measuring by time control using image sensor |
KR102400907B1 (en) * | 2019-06-30 | 2022-05-24 | 주식회사 진시스템 | Multiplex pcr apparatus |
CN110672550B (en) * | 2019-09-10 | 2021-11-19 | 中国科学院上海技术物理研究所 | Image spectrum analyzer for important biological resources in micro-area |
CN112904013B (en) * | 2019-12-04 | 2023-06-20 | 中国科学院大连化学物理研究所 | High-energy ultraviolet cross-linking instrument for biological sample |
WO2021246745A1 (en) * | 2020-06-03 | 2021-12-09 | Seegene, Inc. | Optical signal detection device for detecting multiple optical signals for multiple target analytes from sample |
CA3186950A1 (en) | 2020-07-23 | 2022-01-27 | Scott Benson | Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same |
CA3186952A1 (en) | 2020-07-23 | 2022-01-27 | Jacob Freudenthal | Systems and methods for biological analysis |
KR102559634B1 (en) * | 2020-08-26 | 2023-07-26 | 한국전자통신연구원 | Apparatus and method for pcr diagnosis based on multiwavelength light source |
KR102380565B1 (en) * | 2020-09-18 | 2022-03-30 | (주)얼라인드제네틱스 | Sample inspection device for detecting fluorescence in the sample |
CA3192080A1 (en) | 2020-09-18 | 2022-03-24 | Marc DEJOHN | Portable devices and methods for analyzing samples |
TW202221310A (en) * | 2020-11-27 | 2022-06-01 | 緯創資通股份有限公司 | Detection device and method thereof |
CN113092424B (en) * | 2021-03-18 | 2023-02-10 | 上海医本医疗器械有限公司 | High-flux biochip analyzer |
WO2023055340A1 (en) * | 2021-09-28 | 2023-04-06 | Hewlett-Packard Development Company, L.P. | Apparatuses with immobilized capture agents in a reaction region of a chamber |
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JP7389095B2 (en) | 2023-11-29 |
EP3719481B1 (en) | 2023-03-29 |
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RU2017131221A3 (en) | 2019-05-29 |
SG10202103903UA (en) | 2021-06-29 |
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JP2022031290A (en) | 2022-02-18 |
CN113049553A (en) | 2021-06-29 |
US20160230210A1 (en) | 2016-08-11 |
SG10201811725SA (en) | 2019-02-27 |
KR20230022450A (en) | 2023-02-15 |
EP3254085A1 (en) | 2017-12-13 |
EP3719481A2 (en) | 2020-10-07 |
JP6985144B2 (en) | 2021-12-22 |
US11920191B2 (en) | 2024-03-05 |
WO2016127128A1 (en) | 2016-08-11 |
EP4220139A2 (en) | 2023-08-02 |
US20210214771A1 (en) | 2021-07-15 |
KR102494654B1 (en) | 2023-01-31 |
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