EP4200274A4 - Beta-hydroxybuttersäure-zusammensetzungen und verfahren zur oralen verabreichung von ketonkörpern - Google Patents

Beta-hydroxybuttersäure-zusammensetzungen und verfahren zur oralen verabreichung von ketonkörpern Download PDF

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Publication number
EP4200274A4
EP4200274A4 EP21859286.3A EP21859286A EP4200274A4 EP 4200274 A4 EP4200274 A4 EP 4200274A4 EP 21859286 A EP21859286 A EP 21859286A EP 4200274 A4 EP4200274 A4 EP 4200274A4
Authority
EP
European Patent Office
Prior art keywords
beta
methods
oral administration
hydroxybutyric acid
acid compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21859286.3A
Other languages
English (en)
French (fr)
Other versions
EP4200274A2 (de
Inventor
Gary MILLET
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axcess Global Sciences LLC
Original Assignee
Axcess Global Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/996,509 external-priority patent/US10973786B2/en
Priority claimed from US17/210,646 external-priority patent/US11806324B2/en
Application filed by Axcess Global Sciences LLC filed Critical Axcess Global Sciences LLC
Publication of EP4200274A2 publication Critical patent/EP4200274A2/de
Publication of EP4200274A4 publication Critical patent/EP4200274A4/de
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
EP21859286.3A 2020-08-18 2021-09-14 Beta-hydroxybuttersäure-zusammensetzungen und verfahren zur oralen verabreichung von ketonkörpern Pending EP4200274A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/996,509 US10973786B2 (en) 2016-03-11 2020-08-18 R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions
US17/210,646 US11806324B2 (en) 2018-04-18 2021-03-24 Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
PCT/US2021/050302 WO2022040644A2 (en) 2020-08-18 2021-09-14 Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies

Publications (2)

Publication Number Publication Date
EP4200274A2 EP4200274A2 (de) 2023-06-28
EP4200274A4 true EP4200274A4 (de) 2024-10-23

Family

ID=80323202

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21859286.3A Pending EP4200274A4 (de) 2020-08-18 2021-09-14 Beta-hydroxybuttersäure-zusammensetzungen und verfahren zur oralen verabreichung von ketonkörpern

Country Status (3)

Country Link
EP (1) EP4200274A4 (de)
AU (1) AU2021327408A1 (de)
WO (1) WO2022040644A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US20230346721A1 (en) 2018-04-18 2023-11-02 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies
US12533346B2 (en) 2016-04-19 2026-01-27 Axcess Global Sciences, Llc Administration of berberine metabolites
US12496283B2 (en) 2016-04-19 2025-12-16 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US11026929B2 (en) 2016-04-19 2021-06-08 Keto Patent Group, Inc. Administration of berberine metabolites
US12521378B2 (en) 2016-04-19 2026-01-13 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans
US12171735B2 (en) 2017-04-19 2024-12-24 Axcess Global Sciences, Llc Administration of butyrate, beta-hydroxybutyrate, cannabidiol, and related compounds in humans
US20230346699A1 (en) * 2022-04-28 2023-11-02 Axcess Global Sciences, Llc Administration of r-beta-hydroxybutyrate and related compounds in veterinary applications

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5030553B2 (ja) * 2006-11-24 2012-09-19 有限会社ノーベル医学研究所 ドライマウスおよび／または唾液分泌障害を処置するための医薬
JP2018158897A (ja) * 2017-03-22 2018-10-11 大阪瓦斯株式会社 コラゲナーゼｍｍｐ１及び３の産生抑制剤
WO2019237185A1 (en) * 2018-06-12 2019-12-19 Ketofibe (9211-3133 Quebec Inc.) Novel ketogenic compounds, compositions, methods and use thereof
US20200030266A1 (en) * 2016-09-21 2020-01-30 Chain Biotechnology Limited Compositions and uses thereof for treating inflammatory diseases and probiotic compositions
CN111867576A (zh) * 2017-11-22 2020-10-30 阿克塞斯全球科学有限责任公司 富含R-对映体的非外消旋β-羟基丁酸化合物和组合物及其使用方法
CN112262936A (zh) * 2020-10-22 2021-01-26 珠海麦得发生物科技股份有限公司 一种含3-羟基丁酸的饮品及其制备方法和应用
US20210205241A1 (en) * 2018-04-18 2021-07-08 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositionsand methods for oral delivery of ketone bodies
WO2021178547A1 (en) * 2020-03-05 2021-09-10 Devon Price COMPOSITION OF (D)-β-HYDROXYBUTYRIC ACID, (D)-β-HYDROXYVALERIC ACID, AND (D)-1,3 BUTANEDIOL AS A NUTRITIONAL SUPPLEMENT AND THERAPEUTIC AGENT

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012147899A (ru) * 2010-05-24 2014-06-27 Америлаб Текнолоджиз, Инк. Шипучая композиция для формирования желатинизированной композиции, таблетка для формирования желатинизированной композиции и способ изготовления желатинизированной композиции
US10925843B2 (en) * 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
AU2018250146B2 (en) * 2017-04-04 2020-11-05 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Preparation of (R)-3-hydroxybutyric acid or its salts by one-step fermentation
US11760963B2 (en) * 2017-08-23 2023-09-19 KetoneAid Inc. Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5030553B2 (ja) * 2006-11-24 2012-09-19 有限会社ノーベル医学研究所 ドライマウスおよび／または唾液分泌障害を処置するための医薬
US20200030266A1 (en) * 2016-09-21 2020-01-30 Chain Biotechnology Limited Compositions and uses thereof for treating inflammatory diseases and probiotic compositions
JP2018158897A (ja) * 2017-03-22 2018-10-11 大阪瓦斯株式会社 コラゲナーゼｍｍｐ１及び３の産生抑制剤
CN111867576A (zh) * 2017-11-22 2020-10-30 阿克塞斯全球科学有限责任公司 富含R-对映体的非外消旋β-羟基丁酸化合物和组合物及其使用方法
US20210205241A1 (en) * 2018-04-18 2021-07-08 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositionsand methods for oral delivery of ketone bodies
WO2019237185A1 (en) * 2018-06-12 2019-12-19 Ketofibe (9211-3133 Quebec Inc.) Novel ketogenic compounds, compositions, methods and use thereof
WO2021178547A1 (en) * 2020-03-05 2021-09-10 Devon Price COMPOSITION OF (D)-β-HYDROXYBUTYRIC ACID, (D)-β-HYDROXYVALERIC ACID, AND (D)-1,3 BUTANEDIOL AS A NUTRITIONAL SUPPLEMENT AND THERAPEUTIC AGENT
CN112262936A (zh) * 2020-10-22 2021-01-26 珠海麦得发生物科技股份有限公司 一种含3-羟基丁酸的饮品及其制备方法和应用

Also Published As

Publication number Publication date
WO2022040644A3 (en) 2022-04-07
WO2022040644A2 (en) 2022-02-24
EP4200274A2 (de) 2023-06-28
AU2021327408A1 (en) 2023-04-20

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