EP4144409A1 - Dispositif de stimulation électrique et système de stimulation électrique - Google Patents

Dispositif de stimulation électrique et système de stimulation électrique Download PDF

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Publication number
EP4144409A1
EP4144409A1 EP22193172.8A EP22193172A EP4144409A1 EP 4144409 A1 EP4144409 A1 EP 4144409A1 EP 22193172 A EP22193172 A EP 22193172A EP 4144409 A1 EP4144409 A1 EP 4144409A1
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EP
European Patent Office
Prior art keywords
terminal
signal
electrical stimulation
circuit
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22193172.8A
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German (de)
English (en)
Inventor
Jian-Hao Pan
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Gimer Medical Co Ltd
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Gimer Medical Co Ltd
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Publication of EP4144409A1 publication Critical patent/EP4144409A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36125—Details of circuitry or electric components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223—Circuits for electromagnetic coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37235—Aspects of the external programmer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3787—Electrical supply from an external energy source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation

Definitions

  • the present disclosure relates to an electrical stimulation device, and, in particular, to an electrical stimulation device and an electrical stimulation system.
  • some of the current implantable electrical stimulation devices use an implantable electrical stimulator without batteries, instead using an external controller to provide electrical energy to the implantable electrical stimulator so that it can provide electrical stimulation in the manner of a wireless power supply.
  • the external controller and the implantable electrical stimulator without batteries must be precisely aligned, otherwise the implantable electrical stimulator may not receive electrical energy.
  • the implantable electrical stimulator when the implantable electrical stimulator is implanted deep, the efficiency of the implantable electrical stimulator to receive electrical energy may be greatly decreased.
  • the implantable electrical stimulator can easily be induced by mistake. As long as the implantable electrical stimulator is close to an unspecified emission source with a similar electromagnetic wave, the implantable electrical stimulator may be immediately induced to perform electrical stimulation, thereby causing trouble for the user. Therefore, how to effectively improve the design of the implantable electrical stimulation device to decrease the complexity of circuit design, decrease the size of the electrical stimulation device and increase the convenience of use has become an important issue.
  • An embodiment of the present disclosure provides an electrical-stimulation device, which includes a signal receiving circuit, a rectifying circuit and a signal processing circuit.
  • the signal receiving circuit is configured to receive and output a frequency signal.
  • the rectifying circuit is configured to receive the frequency signal and rectify the frequency signal to generate a rectifying signal.
  • the signal processing circuit is configured to receive the rectifying signal to generate an electrical stimulation signal.
  • the electrical stimulation device may further comprise at least one electrode.
  • the at least one electrode may be coupled to the signal processing circuit.
  • the signal processing circuit may be an oscillator.
  • the electrical stimulation device may not have a battery.
  • the signal processing circuit may comprise a counter or a pulse width modulation circuit.
  • the electrical stimulation device may further comprise a signal converting circuit, configured to receive the electrical stimulation signal, and to convert the electrical stimulation signal to generate a sine wave electrical stimulation signal.
  • the signal converting circuit may be a passive filter.
  • the signal converting circuit may comprise a first inductor, a first capacitor, a second inductor, a second capacitor, a third capacitor, a third inductor.
  • the first inductor may comprise a first terminal and a second terminal.
  • the first terminal of the first inductor may be coupled to the signal processing circuit and receives the electrical stimulation signal.
  • the first capacitor may comprise a first terminal and a second terminal, wherein the first terminal of the first capacitor may be coupled to the second terminal of the first inductor.
  • the second inductor may comprising a first terminal and a second terminal, wherein the first terminal of the second inductor may be coupled to the second terminal of the first capacitor, and the second terminal of the second inductor may be coupled to a ground terminal.
  • the second capacitor may comprise a first terminal and a second terminal, wherein the first terminal of the second capacitor may be coupled to the first terminal of the second inductor, and the second terminal of the second capacitor may be coupled to the second terminal of the second inductor.
  • the third capacitor may comprising a first terminal and a second terminal, wherein the first terminal of the third capacitor may be is coupled to the second terminal of the first capacitor.
  • the third inductor may comprise a first terminal and a second terminal, wherein the first terminal of the third inductor may be coupled to the second terminal of the third capacitor, and the second terminal of the third inductor may generate the sine wave electrical stimulation signal.
  • the signal converting circuit may be an active filter.
  • the signal converting circuit may comprise a first resistor, a second resistor, a first capacitor, a second capacitor, a third resistor, and an amplifier.
  • the first resistor may comprising a first terminal and a second terminal, wherein the first terminal of the first resistor may be coupled to the signal processing circuit and may receive the electrical stimulation signal.
  • the second resistor may comprise a first terminal and a second terminal, wherein the first terminal of the second resistor may be coupled to the second terminal of the first resistor, and the second terminal of the second resistor may be coupled to a ground.
  • the first capacitor may comprise a first terminal and a second terminal, wherein the first terminal of the first capacitor may be coupled to the second terminal of the first resistor.
  • the second capacitor may comprise a first terminal and a second terminal, wherein the first terminal of the second capacitor may be coupled to the first terminal of the first capacitor.
  • the third resistor may comprise a first terminal and a second terminal, wherein the first terminal of the third resistor may be coupled to the second terminal of the first resistor, and the second terminal of the third resistor may be coupled to the second terminal of the second capacitor.
  • the amplifier may comprise a first input terminal, a second input terminal and an output terminal.
  • the first input terminal of the amplifier may be coupled to the ground terminal
  • the second input terminal of the amplifier may be coupled to the second terminal of the third resistor
  • the output terminal of the amplifier may be coupled to the first terminal of the third resistor and outputs the sine wave electrical stimulation signal.
  • the electrical stimulation device may further comprise a protection circuit, coupled to the signal processing circuit, wherein the protection circuit may be configured to determine whether to output the electrical stimulation signal.
  • the protection circuit may be a Hall switch or a magnetic reed switch.
  • the protection circuit may comprise a processing circuit and a switch.
  • the processing circuit may be coupled to the signal receiving circuit and may be configured to receive a triggering signal to generate a processing signal.
  • the switch may be coupled to the signal processing circuit and the processing circuit, and may be configured to receive the processing signal and determine whether to output the electrical simulation signal according to the processing signal.
  • the processing circuit may be is a near field communication circuit, a radio frequency identification circuit, or an authenticator and security integrated circuit.
  • the electrical stimulation device may further comprise at least one electrode, wherein the at least one electrode may be coupled to the protection circuit.
  • the signal receiving circuit may comprise a coil, an antenna, an ultrasonic circuit, or a combination thereof.
  • a frequency range of the frequency signal may comprise a range of 1 MHz to 1.2 MHz, a range of 9 KHz to 200 KHz, or a range of 6 MHz to 45 MHz.
  • a frequency of the frequency signal may be 13.56 MHz.
  • a frequency range of the electrical simulation signal may be 100 KHz to 2000 KHz.
  • a frequency range of the electrical simulation signal may be 480 KHz to 520 KHz.
  • a voltage range of the electrical stimulation signal may be between -25 V and 25 V.
  • the current range of the electrical simulation signal may be between 0 and 60 mA.
  • an embodiment of the present disclosure provides an electrical-stimulation system, which includes an external controller and an electrical stimulation device.
  • the external controller includes a signal generating circuit and a signal transmitting circuit.
  • the signal generating circuit is configured to generate a frequency signal.
  • the signal transmitting circuit is configured to receive and transmit the frequency signal.
  • the electrical stimulation device includes a signal receiving circuit, a rectifying circuit and a signal processing circuit.
  • the signal receiving circuit is configured to receive and output the frequency signal.
  • the rectifying circuit is configured to receive the frequency signal and rectify the frequency signal to generate a rectifying signal.
  • the signal processing circuit is configured to receive the rectifying signal to generate an electrical stimulation signal.
  • the electrical stimulation system may further comprise a signal converting circuit, configured to receive the electrical stimulation signal, and to convert the electrical stimulation signal to generate a sine wave electrical stimulation signal.
  • the electrical stimulation system may further comprise a protection circuit, coupled to the signal processing circuit, wherein the protection circuit is configured to determine whether to output the electrical stimulation signal.
  • the protection circuit may be a Hall switch or a magnetic reed switch.
  • the protection circuit may comprise a processing circuit, coupled to the signal receiving circuit, and may be configured to receive a triggering signal to generate a processing signal; and a switch, coupled to the signal processing circuit and the processing circuit, and may be configured to receive the processing signal and determine whether to output the electrical simulation signal according to the processing signal.
  • the processing circuit may be a near field communication circuit, a radio frequency identification circuit, or an authenticator and security integrated circuit.
  • the signal transmitting circuit and the signal receiving circuit respectively may comprise a coil, an antenna, an ultrasonic circuit, or a combination thereof.
  • a frequency range of the frequency signal may comprise a range of 1 MHz to 1.2 MHz, a range of 9 KHz to 200 KHz, or a range of 6 MHz to 45 MHz.
  • a frequency range of the electrical simulation signal may be 100 KHz to 2000 KHz.
  • the signal receiving circuit receives and outputs the frequency signal
  • the rectifying circuit receives the frequency signal and rectifies the frequency signal to generate the rectifying signal
  • the signal processing circuit receives the rectifying signal to generate the electrical stimulation signal. Therefore, the complexity of circuit design may be effectively decreased, the size of the electrical stimulation device is decreased, and the convenience of use is increased.
  • FIG. 1 is a schematic view of an electrical stimulation system according to an embodiment of the present disclosure.
  • the electrical stimulation system 100 includes an external controller 110 and an electrical stimulation device 120.
  • the external controller 110 at least includes a signal generating circuit 111 and a signal transmitting circuit 112.
  • the signal generating circuit 111 is configured to generate a frequency signal.
  • the signal transmitting circuit 112 is coupled to the signal generating circuit 111, and configured to transmit or transmit/receive the frequency signal.
  • the signal transmitting circuit 112 may include a coil, an antenna, an ultrasonic circuit, or a combination thereof, but the embodiment of the present disclosure is not limited thereto.
  • the frequency range of the frequency signal may be between 1 MHz to 1.2 MHz, like a general energy transmission frequency, but the embodiment of the present disclosure is not limited thereto. In some embodiments, the frequency range of the frequency signal may be between 9 KHz to 200 KHz, like an extremely low energy transmission frequency, but the embodiment of the present disclosure is not limited thereto. In some embodiments, the frequency range of the frequency signal may be between 6 MHz to 45 MHz, like an industrial scientific medical band (ISM Band) regulated by the federal communications commission (FCC), but the embodiment of the present disclosure is not limited thereto. Furthermore, the frequency of the frequency signal may be 6.78 MHz, 13.56 MHz, 27.12 MHz, or 40.68 MHz, but the embodiment of the present disclosure is not limited thereto.
  • ISM Band industrial scientific medical band
  • FCC federal communications commission
  • the electrical stimulation device 120 is an implanted device and does not have a battery. That is, the electrical stimulation device 120 may be implanted inside the human body, and the external controller 110 may be configured outside the human body. Therefore, the electrical stimulation device 120 of the embodiment does not require any control unit, thereby decreasing the numbers of the circuit components in use and decreasing the complexity of circuit design.
  • the external controller 110 may be configured at a position where the electrical stimulation device 120 may receive the frequency signal, and the external controller 110 does not need to be precisely aligned with the electrical stimulation device 120, thereby increasing the convenience of use.
  • the electrical stimulation device 120 includes a signal receiving circuit 130, a rectifying circuit 140 and a signal processing circuit 150.
  • the signal receiving circuit 130 is configured to receive and output the frequency signal.
  • the signal receiving circuit 130 may include a coil, an antenna, an ultrasonic circuit, or a combination thereof, but the embodiment of the present disclosure is not limited thereto.
  • the signal receiving circuit 130 receives the frequency signal transmitted by the signal transmitting circuit 112 in a wireless manner, and output the received frequency signal.
  • the energy transmission manner of the signal transmitting circuit 112 and the signal receiving circuit 130 may be an electromagnetic induction or an electromagnetic resonance.
  • the energy transmission manner of the signal transmitting circuit 112 and the signal receiving circuit 130 may be in the form of radio wave.
  • the signal transmitting circuit 112 includes an ultrasonic generator and the signal receiving circuit 130 includes an ultrasonic transducer
  • the energy transmission manner of the signal transmitting circuit 112 and the signal receiving circuit 130 may be in the form of ultrasonic energy transmission.
  • the rectifying circuit 140 is coupled to the signal receiving circuit 130.
  • the rectifying circuit 140 is configured to receive the frequency signal and rectify the frequency signal to generate a rectifying signal.
  • the rectifying circuit 140 may be a bridge rectifier, such as a half-bridge rectifier or a full-bridge rectifier, but the embodiment of the present disclosure is not limited thereto.
  • the signal processing circuit 150 is coupled to the rectifying circuit 140.
  • the signal processing circuit 150 is configured to receive the rectifying signal to generate an electrical stimulation signal.
  • the signal processing circuit 150 may include a timer, which is used for frequency multiplication or frequency division, but the embodiment of the present disclosure is not limited thereto.
  • the signal processing circuit 150 may be an oscillator, but the embodiment of the present disclosure is not limited thereto.
  • the above electrical stimulation signal is, for example, a sine wave signal. That is, in some embodiments, the rectifying signal is adjusted through the signal processing circuit 150 to generate the electrical stimulation signal with the sine wave signal output.
  • the electrical stimulation signal may be output to the lead 210, such that the lead 210 may transmit the electrical stimulation signal a target area to be stimulated corresponding to an electrode 221 or an electrode 222 of the lead 210, so as to perform an electrical stimulation operation in the target area, as shown in FIG. 2 .
  • the signal receiving circuit 130, the rectifying circuit 140, the signal processing circuit 150 and the protection circuit 160 in FIG. 1 may be configured in an electrical stimulation device 310 in a packaged manner, and an electrode 321 and an electrode 322 may be configured on one side of the electrical stimulation device 310.
  • the rectifying signal is adjusted through the signal processing circuit 150 to generate the electrical stimulation signal with the sine wave signal output.
  • the electrical stimulation signal may be transmitted to a target area to be stimulated corresponding to the electrode 321 or the electrode 322, so as to perform an electrical stimulation operation in the target area.
  • the electrical stimulation device 310 is a flat rectangular parallelepiped with a length of 3 cm, a width of 1 cm, and a height of 0.5 cm.
  • the electrical stimulation device 310 of FIG. 3 may be applied to nerves in the shallower layer of human tissue, such as tibial nerve.
  • the signal processing circuit 150 is, for example, a counter or a pulse width modulation (PWM) circuit, but the embodiment of the present disclosure is not limited thereto.
  • the above electrical stimulation signal is, for example, a square wave signal. That is, in some embodiments, the rectifying signal is adjusted through the signal processing circuit 150 to generate the electrical stimulation signal with the square wave signal output. Then, the electrical stimulation signal may be output to the lead 210, such that the lead 210 may transmit the electrical stimulation signal the target area to be stimulated corresponding to the electrode 221 or the electrode 222 of the lead 210, , so as to perform the electrical stimulation operation in the target area, as shown in FIG. 2 .
  • the rectifying signal is adjusted through the signal processing circuit 150 to generate the electrical stimulation signal with the square wave signal output, and the electrical stimulation signal is transmitted to the target area to be stimulated corresponding to the electrode 321 or the electrode 322, so as to perform the electrical stimulation operation in the target area, as shown in FIG. 3 .
  • the electrical stimulation signal is the square wave signal as an example, but the embodiment of the present disclosure is not limited thereto. In some embodiments, the electrical stimulation signal may also be a triangular wave, a pulse wave, etc.
  • the frequency range of the above electrical stimulation signal is, for example, 100 KHz to 2000 KHz. In some embodiments, the frequency range of the electrical stimulation signal is, for example, 200 KHz to 800 KHz. In some embodiments, the frequency range of the electrical stimulation signal is, for example, 480 KHz to 520 KHz. In some embodiments, the frequency of the electrical stimulation signal is, for example, 500 KHz. In addition, the frequency of the electrical stimulation signal and the frequency of the frequency signal may be the same or different.
  • the above electrical stimulation signal may be a pulsed radio-frequency (PRF) signal (or referred to as a pulse signal), a continuous sine wave, a continuous triangular wave, etc., but the embodiment of the present disclosure is not limited thereto.
  • PRF pulsed radio-frequency
  • one pulse cycle time T p includes a plurality of pulse signals and at least one rest period of time
  • the pulse cycle time T p is the reciprocal of the pulse repetition frequency.
  • the pulse repetition frequency range (also referred to as the pulse frequency range) is, for example, between 0 and 1 KHz, preferably between 1 and 100 Hz. In the embodiment, the pulse repetition frequency of the electrical stimulation signal is, for example, 2 Hz.
  • the duration time T d of the plurality of pulses in one pulse cycle time is, for example, between 1 and 250 milliseconds (ms), preferably between 10 and 100ms. In the embodiment, the duration time T d is, for example, 25 ms.
  • the frequency of the electrical stimulation signal is 500 KHz, in other words, the cycle time T s of the electrical stimulation signal is about 2 microseconds ( ⁇ s).
  • the frequency of the above electrical stimulation signal is the intra-pulse frequency in each pulse alternating signal of FIG. 4 .
  • the voltage range of the above electrical stimulation signal may be between -25 V and 25 V.
  • the voltage range of the above electrical stimulation signal may further be between -20V and 20V.
  • the current range of the above electrical stimulation signal may be between 0 and 60 mA. Furthermore, the current range of the above electrical stimulation signal may further be between 0 and 50 mA.
  • the electrical stimulation device 120 further includes a protection circuit 160.
  • the protection circuit 160 is coupled to the signal processing circuit 150, and the protection circuit 160 is configured to determine whether to output the electrical stimulation signal generated by the signal processing circuit 150.
  • the protection circuit 160 is, for example, a Hall switch or a magnetic reed switch, but the embodiment of the present disclosure is not limited thereto.
  • the protection circuit 160 may sense the magnetic field generated by the triggering component (such as the magnet) and be turned on, so as to output the electrical stimulation signal.
  • the protection circuit 160 may not sense the triggering component and not be turned on, and the protection circuit 160 does not output the electrical stimulation signal. Therefore, the situation that the electrical stimulation device 120 senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation (for example, directly perform the electrical stimulation operation) may be effectively avoided, so as to increase the safety of the electrical stimulation device 120 and decrease the trouble of the user.
  • the external controller 110 may be configured outside the human body, and the electrical stimulation device 120 may be implanted inside the human body.
  • the electrical stimulation device 120 When the electrical stimulation device 120 is implanted inside the human body, the electrical stimulation device 120 may be placed under the skin of the human body, and one terminal 211 of the lead 210 is connected to the electrical stimulation device 120, and the other terminal 212 of the lead 210 is placed close to a target area to be stimulated.
  • the electrical stimulation system 100 as a spinal cord electrical stimulation system is taken as an example, the other terminal 212 of at least part of the lead 210 is disposed in the epidural space to electrically stimulate the spinal cord, the spinal nerve or the dorsal root ganglia (DRG).
  • DDG dorsal root ganglia
  • the signal processing circuit 150 of the electrical stimulation device 120 transmits the electrical stimulation signal to an output electrode. That is, the signal processing circuit 150 may transmit the electrical stimulation signal to the output electrode (such as the electrode 221 or the electrode 222) of the other terminal 212 of the lead 210 through the terminal 211 of the lead 210, so as to electrically stimulate the target area.
  • the current transmitted by the electrical stimulation device 120 may flow out from one output electrode (such as the electrode 221 or the electrode 222) of the lead 210, and then conducts through the human tissue, and then flow back to the lead 210 from the other electrode (such as the electrode 222 or the electrode 221).
  • the electrode 221 and the electrode 222 may be a pair of electrodes.
  • the electrode 221 may be a positive electrode
  • the electrode 222 may be a negative electrode.
  • the electrode 221 may be the negative electrode
  • the electrode 222 may be the positive electrode.
  • the target nerve area of electrical stimulation may also be in the brain for electrical stimulation of brain cortex or deep brain stimulation (DBS) or abdominal and peripheral nerves.
  • the electrical stimulation system 100 may also be used to relieve or treat diseases, such as pain, overactive bladder (OAB), renal hypertension, spasm, premature ejaculation or carpal tunnel syndrome (CTS), etc.
  • the target nerve area of electrical stimulation may also be a lateral recess or a peripheral nervous system (PNS).
  • the target area of the electrical stimulation may also receive less energy per unit time to ensure the subthreshold stimulation, so that the patient implanted with the electrical-stimulation system may reduce the chance of feeling paresthesia to perform the paresthesia-free treatment.
  • FIG. 5 is a schematic view of an electrical stimulation system according to another embodiment of the present disclosure. Please refer to FIG. 5 .
  • the electrical stimulation system 500 includes an external controller 110 and an electrical stimulation device 510.
  • the external controller 110 in FIG. 5 is the same as or similar to external controller 110 in FIG. 1 . Accordingly, the external controller 110 in FIG. 5 may refer to the description of the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the electrical stimulation device 510 includes a signal receiving circuit 130, a rectifying circuit 140, a signal processing circuit 150 and a protection circuit 520.
  • the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 5 are the same as or similar to the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 1 . Accordingly, the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 5 may refer to the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the protection circuit 520 is coupled to the signal processing circuit 150, and the protection circuit 520 is configured to determine whether to output the electrical stimulation signal generated by the signal processing circuit 150. Furthermore, the protection circuit 520 includes a processing circuit 530 and a switch 540. The processing circuit 530 is coupled to the signal receiving circuit 130. The processing circuit 530 is configured to receive a triggering signal to generate a processing signal. In the embodiment, the processing circuit 530 is, for example, a near field communication (NFC) circuit, a radio frequency identification (RFID) circuit, or an authenticator and security integrated circuit (IC).
  • NFC near field communication
  • RFID radio frequency identification
  • IC authenticator and security integrated circuit
  • the switch 540 is coupled to the signal processing circuit 150 and the processing circuit 530.
  • the switch 540 is configured to receive the processing signal and determine whether to output the electrical simulation signal according to the processing signal.
  • the switch 540 includes a control terminal, a first terminal and a second terminal.
  • the control terminal of the switch 540 is coupled to the processing circuit 530, such that the switch 540 is controlled by the processing signal generated by the processing circuit 530.
  • the first terminal of the switch 540 is coupled to the signal processing circuit 150.
  • the second terminal of the switch 540 is configured to output the electrical stimulation signal.
  • the switch 540 is, for example, a metal oxide semiconductor field effect transistor (MOSFET), a bipolar junction transistor (BJT), etc., but the embodiment of the present disclosure is not limited thereto.
  • MOSFET metal oxide semiconductor field effect transistor
  • BJT bipolar junction transistor
  • the protection circuit 520 may receive the triggering signal through the signal receiving circuit 130 to generate a corresponding processing signal, such as a high logic level. Then, the processing signal with the high logic level may be transmitted to the switch 540, such that the switch 540 is turned on accordingly, so as to output the electrical stimulation signal generated by the signal processing circuit.
  • the protection circuit 520 may not receive the triggering signal to generate a corresponding processing signal, such as a low logic level.
  • the processing signal with the low logic level may be transmitted to the switch 540, such that the switch 540 is not turned on, and the protection circuit 520 does not output the electrical stimulation signal generated by the signal processing circuit 150. Therefore, the situation that the electrical stimulation device 510senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation (for example, directly perform the electrical stimulation operation) may be effectively avoided, so as to increase the safety of the electrical stimulation device 510 and decrease the trouble of the user.
  • FIG. 6 is a schematic view of an electrical stimulation system according to another embodiment of the present disclosure. Please refer to FIG. 6 .
  • the electrical stimulation system 600 includes an external controller 110 and an electrical stimulation device 610.
  • the external controller 110 in FIG. 6 is the same as or similar to external controller 110 in FIG. 1 . Accordingly, the external controller 110 in FIG. 6 may refer to the description of the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the electrical stimulation device 610 includes a signal receiving circuit 130, a rectifying circuit 140, a signal processing circuit 150 and a signal converting circuit 620.
  • the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 6 are the same as or similar to the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 1 . Accordingly, the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 6 may refer to the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the electrical stimulation signal generated by the signal processing circuit 150 is the square wave signal.
  • the signal converting circuit 620 is coupled to the signal processing circuit 150.
  • the signal converting circuit 620 is configured to receive the electrical stimulation signal (i.e., the square wave signal), and converts the electrical stimulation signal to generate a sine wave electrical stimulation signal. That is, sine wave electrical stimulation signal may be an electrical stimulation signal with a sine wave.
  • the signal converting circuit 620 is, for example, a passive filter.
  • the signal converting circuit 620 may include an impedance unit Z1, an impedance unit Z2 and an impedance unit Z3.
  • the impedance unit Z1 includes a first terminal and a second terminal. The first terminal of the impedance unit Z1 is coupled to the signal processing circuit 150 and receives the electrical stimulation signal.
  • the impedance unit Z2 includes a first terminal and a second terminal. The first terminal of the impedance unit Z2 is coupled to the second terminal of the impedance unit Z1.
  • the second terminal of the impedance unit Z2 is coupled to a ground terminal.
  • the impedance unit Z3 includes a first terminal and a second terminal. The first terminal of the impedance unit Z3 is coupled to the second terminal of the impedance unit Z1. The second terminal of the impedance unit Z3 generates the sine wave electrical stimulation signal.
  • the impedance unit Z1 may include an inductor L1 and a capacitor C1.
  • the inductor L1 includes a first terminal and a second terminal.
  • the first terminal of the inductor L1 serves as the first terminal of the impedance unit Z1, is coupled to the signal processing circuit 150 and receives the electrical stimulation signal.
  • the capacitor C1 includes a first terminal and a second terminal.
  • the first terminal of the capacitor C1 is coupled to the second terminal of the inductor L1.
  • the second terminal of the capacitor C1 serves as the second terminal of the impedance unit Z1.
  • the impedance unit Z2 may include an inductor L2 and a capacitor C2.
  • the inductor L2 includes a first terminal and a second terminal.
  • the first terminal of the inductor L2 serves as the first terminal of the impedance unit Z2, and is coupled to the second terminal of the capacitor C1.
  • the second terminal of the inductor L2 serves as the second terminal of the impedance unit Z2, and is coupled to the ground.
  • the capacitor C2 includes a first terminal and a second terminal.
  • the first terminal of the capacitor C2 is coupled to the first terminal of the inductor L2.
  • the second terminal of the capacitor C2 is coupled to the second terminal of the inductor L2.
  • the impedance unit Z3 may include a capacitor C3 and an inductor L3.
  • the capacitor C3 includes a first terminal and a second terminal.
  • the first terminal of the capacitor C3 serves as the first terminal of the impedance unit Z3, and is coupled to the second terminal of the capacitor C1.
  • the inductor L3 includes a first terminal and a second terminal. The first terminal of the inductor L3 is coupled to the second terminal of the capacitor C3.
  • the second terminal of the inductor L3 serves as the second terminal of the impedance unit Z3, and generates the sine wave electrical stimulation signal.
  • the electrical stimulation device 610 of the embodiment converts the electrical stimulation signal with the square wave signal generated by the signal processing circuit 150 into the sine wave electrical stimulation signal through the signal converting circuit 620, so as to increase the electrical stimulation effect of the electrical stimulation device 610 on the target area to be stimulated.
  • the electrical stimulation device 610 may further include a protection circuit 160 as shown in FIG. 1 .
  • the protection circuit 160 may be coupled to the signal converting circuit 620 (such as the second terminal of the impedance unit Z3), and the protection circuit 160 is configured to determine whether to output the sine wave electrical stimulation signal generated by the signal converting circuit 620.
  • the related operation and description of the protection circuit 160 may refer to the embodiment of FIG. 1 , and the description thereof is not repeated herein. Therefore, the situation that the electrical stimulation device 610senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation (for example, directly perform the electrical stimulation operation) may be effectively avoided, so as to increase the safety of the electrical stimulation device 610 and decrease the trouble of the user.
  • the electrical stimulation device 610 may further include a protection circuit 520 as shown in FIG. 5 .
  • the protection circuit 520 may be coupled to the signal converting circuit 620 (such as the second terminal of the impedance unit Z3), and the protection circuit 520 is configured to determine whether to output the sine wave electrical stimulation signal generated by the signal converting circuit 620.
  • the related operation and description of the protection circuit 520 may refer to the embodiment of the FIG. 5 , and the description thereof is not repeated herein.
  • the situation that the electrical stimulation device 610senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation may be effectively avoided, so as to increase the safety of the electrical stimulation device 610 and decrease the trouble of the user.
  • FIG. 7 is a schematic view of an electrical stimulation system according to another embodiment of the present disclosure. Please refer to FIG. 7 .
  • the electrical stimulation system 700 includes an external controller 110 and an electrical stimulation circuit 710.
  • the external controller 110 in FIG. 7 is the same as or similar to external controller 110 in FIG. 1 . Accordingly, the external controller 110 in FIG. 7 may refer to the description of the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the electrical stimulation device 710 includes a signal receiving circuit 130, a rectifying circuit 140, a signal processing circuit 150 and a signal converting circuit 720.
  • the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 7 are the same as or similar to the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 1 . Accordingly, the signal receiving circuit 130, the rectifying circuit 140 and the signal processing circuit 150 in FIG. 7 may refer to the embodiment of FIG. 1 , and the description thereof is not repeated herein.
  • the electrical stimulation signal generated by the signal processing circuit 150 is the square wave signal.
  • the signal converting circuit 720 may be an active filter.
  • the signal converting circuit 720 may include a resistor R1, a resistor R2, a capacitor C4, a capacitor C5, a resistor R3 and an amplifier 730.
  • the resistor R1 includes a first terminal and a second terminal.
  • the first terminal of the resistor R1 is coupled to the signal processing circuit 150, and receives the electrical stimulation signal.
  • the resistor R2 includes a first terminal and a second terminal.
  • the first terminal of the resistor R2 is coupled to the second terminal of the resistor R1.
  • the second terminal of the resistor R2 is coupled to the ground terminal.
  • the capacitor C4 includes a first terminal and a second terminal. The first terminal of the capacitor C4 is coupled to the second terminal of the resistor R1.
  • the capacitor C5 includes a first terminal and a second terminal. The first terminal of the capacitor C5 is coupled to the first terminal of the capacitor C4.
  • the resistor R3 includes a first terminal and a second terminal. The first terminal of the resistor R3 is coupled to the second terminal of the capacitor C4. The second terminal of the resistor R3 is coupled to the second terminal of the capacitor C5.
  • the amplifier 730 includes a first input terminal, a second input terminal and an output terminal.
  • the first input terminal (such as a positive input terminal) of the amplifier 730 is coupled to the ground terminal.
  • the second input terminal (such as a negative input terminal of the amplifier 730 is coupled to the second terminal of the resistor R3.
  • the output terminal of the amplifier 730 is coupled to the first terminal of the resistor R3, and outputs the sine wave electrical stimulation signal.
  • the electrical stimulation device 710 of the embodiment converts the electrical stimulation signal with the square wave signal generated by the signal processing circuit 150 into the sine wave electrical stimulation signal through the signal converting circuit 720, so as to increase the electrical stimulation effect of the electrical stimulation device 710 on the target area to be stimulated.
  • the electrical stimulation device 710 may further include a protection circuit 160 as shown in FIG. 1 .
  • the protection circuit 160 may be coupled to the signal converting circuit 720 (such as the output terminal of the amplifier 730), and the protection circuit 160 is configured to determine whether to output the sine wave electrical stimulation signal generated by the signal converting circuit 720.
  • the related operation and description of the protection circuit 160 may refer to the embodiment of FIG. 1 , and the description thereof is not repeated herein. Therefore, the situation that the electrical stimulation device 710senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation (for example, directly perform the electrical stimulation operation) may be effectively avoided, so as to increase the safety of the electrical stimulation device 710 and decrease the trouble of the user.
  • the electrical stimulation device 710 may further include a protection circuit 520 as shown in FIG. 5 .
  • the protection circuit 520 may be coupled to the signal converting circuit 720 (such as the second input terminal of the amplifier 730), and the protection circuit 520 is configured to determine whether to output the sine wave electrical stimulation signal generated by the signal converting circuit 720.
  • the related operation and description of the protection circuit 520 may refer to the embodiment of the FIG. 5 , and the description thereof is not repeated herein. Therefore, the situation that the electrical stimulation device 710senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation (for example, directly perform the electrical stimulation operation) may be effectively avoided, so as to increase the safety of the electrical stimulation device 710 and decrease the trouble of the user.
  • the signal receiving circuit receives and outputs the frequency signal
  • the rectifying circuit receives the frequency signal and rectifies the frequency signal to generate the rectifying signal
  • the signal processing circuit receives the rectifying signal to generate the electrical stimulation signal. Therefore, the complexity of circuit design may be effectively decreased, the size of the electrical stimulation device is decreased, and the convenience of use is increased.
  • the electrical stimulation device of the embodiment of the present disclosure further includes the signal converting circuit, and the signal converting circuit converts electrical stimulation signal with the square wave signal into the sine wave electrical stimulation signal (i.e., the electrical stimulation signal with the sine wave signal). Therefore, the electrical stimulation effect of the electrical stimulation device on the target area to be stimulated may be effectively increased.
  • the electrical stimulation device of the embodiment of the present disclosure further includes the protection circuit.
  • the protection circuit may be coupled to the signal processing circuit, and is configured to determine whether to output the electrical stimulation signal generated by the signal processing circuit, or the protection circuit may be coupled to the signal converting circuit, and is configured to determine whether to output the sine wave electrical stimulation signal generated by the signal converting circuit.
  • the situation that the electrical stimulation device senses or receives the frequency signal generated by the other devices or emission sources to generate the error operation may be effectively avoided, so as to increase the safety of the electrical stimulation device and decrease the trouble of the user.

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EP22193172.8A 2021-09-03 2022-08-31 Dispositif de stimulation électrique et système de stimulation électrique Pending EP4144409A1 (fr)

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WO2012013360A1 (fr) * 2010-07-30 2012-02-02 Md Start Sa Dispositif d'électrode implantable, en particulier pour détecter un électrogramme intracardiaque
US8457757B2 (en) * 2007-11-26 2013-06-04 Micro Transponder, Inc. Implantable transponder systems and methods
US20140163645A1 (en) * 2012-12-07 2014-06-12 Medtronic, Inc. Minimally invasive implantable neurostimulation system
US20190247664A1 (en) * 2016-06-10 2019-08-15 Jack Williams System for wireless recording and stimulating bioelectric events
US20190275328A1 (en) * 2016-01-20 2019-09-12 Setpoint Medical Corporation Batteryless implantable microstimulators
US10493279B2 (en) * 2014-07-10 2019-12-03 Stimwave Technologies Incorporated Circuit for an implantable device

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US5549658A (en) * 1994-10-24 1996-08-27 Advanced Bionics Corporation Four-Channel cochlear system with a passive, non-hermetically sealed implant
JP7261814B2 (ja) * 2018-04-12 2023-04-20 ニュースペラ メディカル インク 無線の植込まれた装置用のミッドフィールド電源
US10784705B2 (en) * 2018-04-27 2020-09-22 Medtronic, Inc. Recharging power sources of implantable medical devices
CN113117229A (zh) * 2019-12-31 2021-07-16 上海神奕医疗科技有限公司 用于脉冲发生器的电路、脉冲发生器以及脑深部电刺激系统

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Publication number Priority date Publication date Assignee Title
US8457757B2 (en) * 2007-11-26 2013-06-04 Micro Transponder, Inc. Implantable transponder systems and methods
WO2012013360A1 (fr) * 2010-07-30 2012-02-02 Md Start Sa Dispositif d'électrode implantable, en particulier pour détecter un électrogramme intracardiaque
US20140163645A1 (en) * 2012-12-07 2014-06-12 Medtronic, Inc. Minimally invasive implantable neurostimulation system
US10493279B2 (en) * 2014-07-10 2019-12-03 Stimwave Technologies Incorporated Circuit for an implantable device
US20190275328A1 (en) * 2016-01-20 2019-09-12 Setpoint Medical Corporation Batteryless implantable microstimulators
US20190247664A1 (en) * 2016-06-10 2019-08-15 Jack Williams System for wireless recording and stimulating bioelectric events

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TWI824667B (zh) 2023-12-01
TW202310890A (zh) 2023-03-16

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