EP3980069A4 - METHODS OF TREATMENT OF SPLENOMEGALY - Google Patents

METHODS OF TREATMENT OF SPLENOMEGALY Download PDF

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Publication number
EP3980069A4
EP3980069A4 EP21738476.7A EP21738476A EP3980069A4 EP 3980069 A4 EP3980069 A4 EP 3980069A4 EP 21738476 A EP21738476 A EP 21738476A EP 3980069 A4 EP3980069 A4 EP 3980069A4
Authority
EP
European Patent Office
Prior art keywords
splenomegaly
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21738476.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3980069A1 (en
Inventor
Wayne Philip Rothbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telios Pharma Inc
Original Assignee
Telios Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telios Pharma Inc filed Critical Telios Pharma Inc
Priority to EP22150344.4A priority Critical patent/EP4000624A1/en
Publication of EP3980069A1 publication Critical patent/EP3980069A1/en
Publication of EP3980069A4 publication Critical patent/EP3980069A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processing Of Solid Wastes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
EP21738476.7A 2020-01-08 2021-01-08 METHODS OF TREATMENT OF SPLENOMEGALY Pending EP3980069A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22150344.4A EP4000624A1 (en) 2020-01-08 2021-01-08 Btk inhibitors for treating splenomegaly

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062958632P 2020-01-08 2020-01-08
PCT/US2021/012696 WO2021142257A1 (en) 2020-01-08 2021-01-08 Methods of treating splenomegaly

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP22150344.4A Division EP4000624A1 (en) 2020-01-08 2021-01-08 Btk inhibitors for treating splenomegaly
EP22150344.4A Division-Into EP4000624A1 (en) 2020-01-08 2021-01-08 Btk inhibitors for treating splenomegaly

Publications (2)

Publication Number Publication Date
EP3980069A1 EP3980069A1 (en) 2022-04-13
EP3980069A4 true EP3980069A4 (en) 2022-08-17

Family

ID=76788747

Family Applications (2)

Application Number Title Priority Date Filing Date
EP21738476.7A Pending EP3980069A4 (en) 2020-01-08 2021-01-08 METHODS OF TREATMENT OF SPLENOMEGALY
EP22150344.4A Pending EP4000624A1 (en) 2020-01-08 2021-01-08 Btk inhibitors for treating splenomegaly

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP22150344.4A Pending EP4000624A1 (en) 2020-01-08 2021-01-08 Btk inhibitors for treating splenomegaly

Country Status (15)

Country Link
EP (2) EP3980069A4 (https=)
JP (2) JP7771064B2 (https=)
KR (1) KR20220130151A (https=)
CN (1) CN114423457A (https=)
AU (1) AU2021205484A1 (https=)
BR (1) BR112022013646A2 (https=)
CA (1) CA3164063A1 (https=)
CO (1) CO2022010592A2 (https=)
CR (1) CR20220374A (https=)
IL (1) IL294582A (https=)
JO (1) JOP20220168A1 (https=)
MA (3) MA63848B1 (https=)
MX (1) MX2022008490A (https=)
TN (1) TN2022000185A1 (https=)
WO (1) WO2021142257A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3980069A4 (en) * 2020-01-08 2022-08-17 Telios Pharma, Inc. METHODS OF TREATMENT OF SPLENOMEGALY
US20240024314A1 (en) 2020-01-08 2024-01-25 Telios Pharma, Inc. Methods of Treating Splenomegaly
IL309238A (en) * 2021-06-16 2024-02-01 Telios Pharma Inc Treatment of symptoms associated with myeloproliferative tumors
WO2023071973A1 (en) * 2021-10-26 2023-05-04 Shenzhen Targetrx, Inc. Fused bicyclic compound for inhibiting activity of tyrosine kinase
CN119677518A (zh) * 2022-08-25 2025-03-21 百济神州(苏州)生物科技有限公司 包含(s)-7-(1-丙烯酰基哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺和草酸的固体形式、其组合物及其使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015057992A1 (en) * 2013-10-16 2015-04-23 Izumi Raquel Btk inhibitors for hematopoietic mobilization
WO2016024230A1 (en) * 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor
US20160122365A1 (en) * 2014-10-03 2016-05-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2019243223A1 (en) * 2018-06-19 2019-12-26 Merck Patent Gmbh Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain
WO2021097213A1 (en) * 2019-11-14 2021-05-20 Quogue Ip Holdings Llc Combination of a btk inhibitor and an mdm2 inhibitor for cancer treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015081127A2 (en) 2013-11-26 2015-06-04 Gilead Sciences, Inc. Therapies for treating myeloproliferative disorders
CN109942835A (zh) * 2019-03-27 2019-06-28 广州楹鼎生物科技有限公司 一种催化分解木质纤维原料的方法
EP3980069A4 (en) * 2020-01-08 2022-08-17 Telios Pharma, Inc. METHODS OF TREATMENT OF SPLENOMEGALY

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015057992A1 (en) * 2013-10-16 2015-04-23 Izumi Raquel Btk inhibitors for hematopoietic mobilization
WO2016024230A1 (en) * 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor
US20160122365A1 (en) * 2014-10-03 2016-05-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2019243223A1 (en) * 2018-06-19 2019-12-26 Merck Patent Gmbh Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain
WO2021097213A1 (en) * 2019-11-14 2021-05-20 Quogue Ip Holdings Llc Combination of a btk inhibitor and an mdm2 inhibitor for cancer treatment

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ASHANGARI CHANDRALEKHA ET AL: "Hairy Cell Leukemia Variant", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 132, 29 November 2018 (2018-11-29), pages 5562, XP086591091, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2018-99-110192 *
JAMIE L DARGART ET AL: "Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 95, no. 1, 7 May 2012 (2012-05-07), pages 49 - 56, XP028491144, ISSN: 0166-3542, [retrieved on 20120516], DOI: 10.1016/J.ANTIVIRAL.2012.05.003 *
MICHAEL L. WANG ET AL: "Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 369, no. 6, 8 August 2013 (2013-08-08), US, pages 507 - 516, XP055484912, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1306220 *
ON BEHALF OF THE INVESTIGATORS OF THE ITALIAN REGISTRY OF MYELOFIBROSIS WITH MYELOID METAPLASIA AND THE MYELOPROLIFERATIVE DISORDE: "The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia", BLOOD CELLS, MOLECULES & DISEASES, LAJOLLA, US, vol. 38, no. 3, 4 April 2007 (2007-04-04), pages 280 - 286, XP022014560, ISSN: 1079-9796, DOI: 10.1016/J.BCMD.2007.01.003 *
See also references of WO2021142257A1 *

Also Published As

Publication number Publication date
EP4000624A1 (en) 2022-05-25
AU2021205484A1 (en) 2022-08-18
JP2026027353A (ja) 2026-02-18
MA57226B1 (fr) 2023-06-28
CR20220374A (es) 2023-01-25
MA57226A1 (fr) 2023-02-28
EP3980069A1 (en) 2022-04-13
JOP20220168A1 (ar) 2023-01-30
CO2022010592A2 (es) 2022-10-31
MX2022008490A (es) 2022-10-13
MA63848A1 (fr) 2024-04-30
JP2023509968A (ja) 2023-03-10
MA63848B1 (fr) 2024-10-31
TN2022000185A1 (en) 2024-04-01
MA69153A1 (fr) 2025-07-31
KR20220130151A (ko) 2022-09-26
CA3164063A1 (en) 2021-07-15
WO2021142257A1 (en) 2021-07-15
JP7771064B2 (ja) 2025-11-17
BR112022013646A2 (pt) 2022-10-04
IL294582A (en) 2022-09-01
CN114423457A (zh) 2022-04-29

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