EP3962441A1 - Composition de soin buccodentaire - Google Patents

Composition de soin buccodentaire

Info

Publication number
EP3962441A1
EP3962441A1 EP19731547.6A EP19731547A EP3962441A1 EP 3962441 A1 EP3962441 A1 EP 3962441A1 EP 19731547 A EP19731547 A EP 19731547A EP 3962441 A1 EP3962441 A1 EP 3962441A1
Authority
EP
European Patent Office
Prior art keywords
oral care
care composition
weight
eugenol
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19731547.6A
Other languages
German (de)
English (en)
Inventor
Shaopeng XU
Dailin CHEN
Neelima UTGIKAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Colgate Palmolive Co
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of EP3962441A1 publication Critical patent/EP3962441A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof

Definitions

  • Gum bleeding is associated with many common oral conditions, such as gingivitis. Gum bleeding may be caused by a buildup of plaque, a soft, sticky, colorless film of bacteria that forms on the teeth and gums, and produces toxins that may inflame or infect the gum tissue to cause gingivitis. Gingivitis is the initial stage of gum disease and, if left untreated, may cause periodontitis.
  • antibacterial agents have been used in oral care products to reduce plaque and gingivitis, and hence reduce gum bleeding.
  • the antibacterial efficacy of compounds may be affected by other active ingredients in the oral care product, or by limits on the amounts of an antibacterial agent that can be used.
  • oral care compositions such as toothpastes and mouthwashes, configured to provide improved antibacterial efficacy. Additionally, it would be useful to develop oral care composition with natural or botanically-based active ingredients.
  • an oral care composition including from 0.04 weight % to 2.80 weight % of a mixture of antibacterial agents, based on a total weight of the oral care composition, wherein the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 weight ratio.
  • Eugenol may include one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
  • the oral care composition may include from 0.10 weight % to 1.0 weight % of the mixture of antibacterial agents.
  • the mixture of antibacterial agents may include oleanic acid and eugenol at a 2: 1 weight ratio.
  • the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2: 1 weight ratio.
  • the oral care composition may include from 0.02 weight % to 2.0 weight % of oleanic acid, based on the total weight of the oral care composition; and from 0.01 weight % to 1.0 weight % of eugenol, based on the total weight of the oral care composition.
  • the oral care composition may include from 0.05 weight % to 0.50 weight % of oleanic acid; and from 0.025 weight % to 0.25 weight % of eugenol.
  • the oral care composition may include 0.10 weight % of oleanic acid; and 0.05 weight % of eugenol.
  • the oral care composition may lack another antibacterial agent.
  • Eugenol may include one or more of eugenol, methyl eugenol, iso-eugenol, or mixtures thereof.
  • the mixture of antibacterial agents may include oleanic acid and eugenol at a 2: 1 weight ratio.
  • the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2: 1 weight ratio.
  • the oral care composition may lack another antibacterial agent.
  • the term“or” is an inclusive operator, and is equivalent to the term “and/or,” unless the context clearly dictates otherwise.
  • the term“based on” is not exclusive and allows for being based on additional factors not described, unless the context clearly dictates otherwise.
  • the recitation of “at least one of A, B, and C,” includes embodiments containing A, B, or C, multiple examples of A, B, or C, or combinations of A/B, A/C, B/C, A/B/B/ B/B/C, A/B/C, etc.
  • the meaning of “a,”“an,” and“the” include plural references.
  • the meaning of“in” includes“in” and“on.”
  • first, second, etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another.
  • a first object, component, or step could be termed a second object, component, or step, and, similarly, a second object, component, or step could be termed a first object, component, or step, without departing from the scope of the invention.
  • the first object, component, or step, and the second object, component, or step are both, objects, components, or steps, respectively, but they are not to be considered the same object, component, or step.
  • the term“if’ may be construed to mean“when” or“upon” or“in response to determining” or“in response to detecting,” depending on the context.
  • any numerical range of values herein are understood to include each and every number and/or fraction between the stated range minimum and maximum, as well as the endpoints.
  • a range of 0.5-6% would expressly include all intermediate values of, for example, 0.6%, 0.7%, and 0.9%, all the way up to and including 5.95%, 5.97%, and 5.99%, among many others.
  • An oral care composition as disclosed herein includes a mixture of antibacterial agents.
  • the mixture of antibacterial agents provides an improved antibacterial effect.
  • the mixture of antibacterial agents includes oleanic acid and eugenol.
  • the mixture of antibacterial agents includes oleanic acid and eugenol at a 2:1 to 3:1 ratio by weight.
  • the mixture of antibacterial agents may include oleanic acid and eugenol at a 2: 1 ratio by weight.
  • the mixture of antibacterial agents consists essentially of oleanic acid and eugenol.
  • the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2:1 to 3:1 ratio by weight.
  • the mixture of antibacterial agents may consist essentially of oleanic acid and eugenol at a 2: 1 ratio by weight.
  • the mixture of antibacterial agents is derived from or based upon compounds or extracts isolated from plants.
  • Formula 1 illustrates a chemical structure of oleanic acid.
  • Oleanic or oleanolic acid (3b- hydroxy-olea-12-en-28-oic) is a pentacyclic triterpenoid that is widely distributed in plants.
  • oleanic acid may be extracted from a number of medicinal plants, such as Calendula officinalis L. (marigold), Ligustrum lucidum Ait (oleaceae), and Hemsleya Chinensis Cogn.
  • Formula 2 illustrates a chemical structure of eugenol.
  • Eugenol (4-allyl-2-methoxyphenol), is a naturally occurring phenol essential oil extracted from, for example, cloves, nutmeg, cinnamon, basil, and bay leaf.
  • Eugenol may also be provided as methyl eugenol or iso-eugenol.
  • the antibacterial effects of oleanic acid combined with eugenol are greater than those of oleanic acid or eugenol separately.
  • the antibacterial effects of oleanic acid combined with eugenol at a 2: 1 ratio are greater than those of oleanic acid combined with eugenol at other ratios, such as 3: 1 or greater.
  • the mixture of antibacterial agents including oleanic acid and eugenol is the only antibacterial agent present in the oral care composition.
  • the oral care composition includes no other antibacterial agents apart from the mixture of antibacterial agents.
  • the oral care composition includes from about 0.04 weight % to about 2.8 weight % mixture of antibacterial agents, based on the total weight of the oral care composition.
  • the oral care composition includes from about 0.05 weight % to about 2.0 weight % mixture of antibacterial agents, from about 0.1 weight % to about 1 weight % mixture of antibacterial agents, or from about 0.1 weight % to about 0.5 weight % mixture of antibacterial agents, based on the total weight of the oral care composition.
  • the oral care composition includes about 0.15 weight % mixture of antibacterial agents.
  • the mixture of antibacterial agents includes oleanic acid and eugenol.
  • Eugenol may also be provided as eugenol, methyl eugenol, iso-eugenol, or combinations thereof.
  • the mixture of antibacterial agents includes oleanic acid and eugenol at a 2: 1 ratio by weight.
  • the mixture of antibacterial agents may include additional antibacterial agents.
  • the mixture of antibacterial agents only includes oleanic acid and eugenol.
  • the oral care composition may include from about 0.02 weight % to about 2.0 weight %, from about 0.05 weight % to about 0.5 weight %, from about 0.1 weight % to about 0.25 weight %, or from about 0.1 weight % to about 0.2 weight % oleanic acid, based on the total weight of the oral care composition.
  • the oral care composition may include 0.10 weight % oleanic acid.
  • the oral care composition may include from 0.01 weight % to 1.0 weight % eugenol, based on the total weight of the oral care composition.
  • the oral care composition includes from about 0.025 weight % to about 0.25 weight
  • the oral care composition may include 0.05 weight % eugenol.
  • the oral care composition may include methyl eugenol and/or iso eugenol instead of or in addition to eugenol.
  • viscosity is an important parameter for oral care compositions, such as toothpastes or whitening gels.
  • oral care compositions such as toothpastes or whitening gels.
  • viscosity of an oral care composition is too low, it may become too runny and physical phase separation may take place. In some cases, this will not only affect the aesthetics of the oral care composition but also the homogeneity of the ingredients in the oral care composition.
  • the viscosity of the oral care compositions is too high, the oral care composition will be difficult to manufacture and package.
  • oral care compositions with high viscosity are very difficult for users to evacuate from commonly used packages, such as tubes or syringes. Accordingly, it’s important to select ingredients for oral care compositions that achieve a desirable range of viscosity to ensure product manufacturability, stability, and quality, as well as consumer acceptance.
  • the viscosity of the oral care composition is from about 10,000 centipoise (cPs) to about 500,000 cPs at 25° C.
  • the viscosity of the oral care composition is from about 50,000 cPs to about 400,000 cPs at 25° C.
  • the viscosity of the oral care composition is from about 125,000 cPs to about 300,000 cPs at 25° C.
  • the oral care composition may include additional ingredients common to oral care compositions, such as carriers, dispersants, whitening agents, flavoring agents, tartar control agents, surfactants, sweeteners, humectants, colorants, antibacterial agents, preservatives, dyes, and pigments.
  • additional ingredients common to oral care compositions such as carriers, dispersants, whitening agents, flavoring agents, tartar control agents, surfactants, sweeteners, humectants, colorants, antibacterial agents, preservatives, dyes, and pigments.
  • All ingredients used in the compositions described herein should be orally acceptable.
  • “Orally acceptable” means an ingredient which is present in the composition as described in an amount and form which does not render the composition unsafe, unpalatable, or otherwise unsuitable for use in the oral cavity.
  • the additional ingredients should not substantially inhibit the efficacy of the mixture of antibacterial agents described above.
  • the oral care composition includes an orally acceptable carrier.
  • an "orally acceptable carrier” refers to a material or combination of materials that are safe for use in the oral care compositions of the present disclosure while retaining significant efficacy for the mixture of antibacterial agents.
  • the carrier is specifically selected to ensure that there is no substantially reduction in efficacy for the mixture of antibacterial agents.
  • the oral care composition may use water as the carrier.
  • the oral care composition includes 90 weight % or less, 70 weight % or less, or 50 weight % or less carrier, based on the total weight of the oral care composition.
  • the oral care composition may include one or more humectants.
  • the humectant is a mixture of humectants, such as glycerin and sorbitol, and a polyhydric alcohol, such as propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol.
  • the oral care composition includes from 5 weight % to 40 weight % or from 10 weight % to 30 weight % humectant, based on a total weight of the oral care composition.
  • the oral care composition may include one or more whitening agent.
  • a “whitening agent” is a material that affects whitening of a tooth surface to which it is applied.
  • the whitening agent is an oxidizing agent.
  • oxidizing agent is intended to include those compounds which can accept an electron from another molecule in the environment of the oral cavity without having a deleterious or unacceptably harmful effect on the oral cavity in normal and accepted use.
  • the whitening agent may include peroxides and hydroperoxides, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, salts thereof, and mixtures thereof.
  • Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
  • Organic peroxy compounds include urea peroxide, carbamide peroxide (also known as urea hydrogen peroxide), glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
  • Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
  • a non peroxide whitening agent may be provided.
  • Whitening agents among those useful herein include non-peroxy compounds, such as chlorine dioxide, chlorites and hypochlorites.
  • Chlorites and hypochlorites include those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium.
  • Non-peroxide whitening agents also include colorants, such as titanium dioxide and hydroxyapatite.
  • the oral care composition includes from about 0.01% to about 50% whitening agent based on a total weight of the oral care composition.
  • the oral care composition includes from about 0.05 weight % to about 40 weight % whitening agent.
  • the oral care composition includes about 0.1 weight % whitening agent based on a total weight of the oral care composition.
  • the oral care composition includes one or more surfactants.
  • the surfactants enhance stability of the composition, help clean the oral cavity surfaces through detergency, and provide foam upon agitation, e.g., during brushing with an oral care composition of the disclosure.
  • Surfactants or surface active agents generally achieve increased whitening action by thoroughly dispersing the whitening agent throughout the oral cavity.
  • suitable surface active agents may function as a surface active agent, emulsifier, and/or foam modulator.
  • Any orally acceptable surfactant most of which are anionic, nonionic, cationic, or amphoteric, may be used.
  • a combination of surfactants may also be used.
  • Suitable anionic surfactants include without limitation water-soluble salts of Cs-20 alkyl sulfates, sulfonated monoglycerides of Cs-20 fatty acids, sarcosinates, taurates and the like.
  • Illustrative examples of these and other classes include sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate.
  • Suitable nonionic surfactants include without limitation poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides and the like.
  • Suitable amphoteric surfactants include, without limitation, derivatives of Cs-20 aliphatic secondary and tertiary amines having an anionic group such as carboxylate, sulfate, sulfonate, phosphate or phosphonate.
  • a suitable example is cocoamidopropyl betaine.
  • the oral care composition includes from about 0.01% to about 20.0% surfactant based on a total weight of the oral care composition.
  • the oral care composition includes from about 1.0 weight % to about 10.0 weight % surfactant.
  • the oral care composition includes about 2 weight % surfactant based on a total weight of the oral care composition.
  • the oral care composition may include about 2 weight % sodium lauryl sulfate.
  • the oral care composition may include thickening agents or thickeners.
  • Any orally acceptable thickening agent may be used, including without limitation carbomers, also known as carboxyvinyl polymers, carrageenans, also known as Irish moss and more particularly carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (such as CARBOWAXTM, available from The Dow Chemical Company), cellulosic polymers such as hydroxyethylcellulose, carboxymethylcellulose (“CMC”) and salts thereof, e.g., CMC sodium, natural gums such as karaya, xanthan, gum arabic and tragacanth, colloidal magnesium aluminum silicate, and colloidal or fumed silica and mixtures of the same.
  • the thickening agent may be a combination of one or more orally acceptable thickening agents.
  • the oral care composition includes from about 0.01% to about 30% thickening agent based on a total weight of the oral care composition.
  • the oral care composition includes from about 0.1 weight % to about 20 weight % thickening agent.
  • the oral care composition includes from about 0.5 weight % to about 10 weight % thickening agent based on a total weight of the oral care composition.
  • the oral care composition may include about 3 weight % fumed silica.
  • the oral care composition includes an antioxidant.
  • Acceptable antioxidants include BHA, BHT, vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin and mixtures thereof.
  • the oral care composition includes from about 0.001% to about 1% antioxidants based on a total weight of the oral care composition. In one embodiment, the oral care composition includes about 0.03 weight % antioxidant by weight.
  • the oral care composition includes one or more flavoring agents.
  • Useful flavoring agents include any material or mixture of materials operable to enhance the taste of the oral care composition. Any orally acceptable natural or synthetic flavoring agent may be used, such as flavoring oils, flavoring aldehydes, esters, alcohols, similar materials, and combinations thereof.
  • Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of wintergreen (methylsalicylate), peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, etc., bean- and nut- derived flavors such as coffee, cocoa, cola, peanut, almond, etc., adsorbed and encapsulated flavorants, and mixtures thereof. Also encompassed within flavoring agents herein are ingredients that provide fragrance and/or other sensory effect in the mouth, including cooling or warming effects.
  • Such ingredients include menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cassia, oxanone, x-irisone, propenyl guaiethol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthan-3-carboxamine, N,2,3-trimethyl-2- isopropylbutanamide, 3-l-menthoxypropane-l,2-diol, cinnamaldehyde glycerol acetal (CGA), methone glycerol acetal (MGA) and mixtures thereof.
  • CGA cinnamaldehyde glycerol acetal
  • MCA methone glycerol acetal
  • the oral care composition includes from about 0.01% to about 5% flavoring agents based on a total weight of the oral care composition.
  • the oral care composition includes from about 0.05 weight % to about 3 weight % flavoring agents.
  • the oral care composition includes from about 0.1 weight % to about 3 weight %, from about 0.2 weight % to about 2.5 weight %, or about 1.5 weight % flavoring agents based on a total weight of the oral care composition.
  • the oral care composition may include about 1.5 weight % of dental cream flavor.
  • the oral care composition may also include one or more sweeteners.
  • Sweeteners among those useful herein include orally acceptable natural or artificial, nutritive or non-nutritive sweeteners.
  • Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and com syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones and mixtures thereof.
  • the oral care composition includes from about 0.005% to about 5% sweeteners based on a total weight of the oral care composition. In other embodiments, the oral care composition includes from about 0.01% to about 1% sweeteners based on a total weight of the oral care composition.
  • the oral care composition may include about 0.5 weight % sodium saccharin and about 0.04 weight % sucralose.
  • the oral care composition may include colorants.
  • Colorants such as dyes or pigments, may be food color additives presently certified under the Food Drug &
  • FD&C Red No. 3 sodium salt of tetraiodofluorescein
  • Food Red 17 disodium salt of 6-hydroxy-5- ⁇ (2-methoxy-5-methyl- 4-sulphophenyl)azo ⁇ -2-naphthalenesulfonic acid
  • Food Yellow 13 sodium salt of a mixture of the mono and disulphonic acids of quinophtalone or 2-(2-quinolyl) indanedione
  • FD&C Yellow No. 5 sodium salt of 4-p-sulfophenylazo-l-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid
  • FD&C Yellow No. 3 sodium salt of 4-p-sulfophenylazo-l-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid
  • the oral care composition may also include one or more pH modifying agents.
  • the pH modifying agents among those useful herein include acidifying agents to lower pH, basifying agents to raise pH and buffering agents to control pH within a desired range.
  • one or more compounds selected from acidifying, basifying and buffering agents can be included to provide a pH of 2 to 10, or in various embodiments from about 2 to about 8, from about 3 to about 9, from about 4 to about 8, from about 5 to about 7, from about 6 to about 10, and from about 7 to about 9.
  • Any orally acceptable pH modifying agent may be used, including without limitation carboxylic, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazole and mixtures thereof.
  • One or more pH modifying agents are optionally present in a total amount effective to maintain the composition in an orally acceptable pH range.
  • the oral care composition includes from about 0.01% to about 10% pH modifier agents based on a total weight of the oral care composition.
  • the oral care composition may include about 0.9 weight % sodium acid pyrophosphate (SAPP) and about 2 weight % tetrasodium pyrophosphate (TSPP) as a pH modifier.
  • the oral care composition may include one or more preservatives.
  • the preservatives improve an antimicrobial characteristic of the oral care composition to improve storage life or prevent decay.
  • the one or more preservatives include at least one of sodium benzoate, methyl paraben, ethyl paraben, zinc citrate, zinc oxide, triclosan, stannum salts, and combinations thereof.
  • the oral care composition may include an effective amount of preservatives.
  • the oral care composition may include an amount of preservatives effective to reduce a spoilage of the oral care composition during storage or use.
  • the oral care composition lacks additional antibacterial agents or preservatives.
  • the oral care composition of the present disclosure may also include one or more additional active ingredients, which are operable for the prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity, the prevention or treatment of a physiological disorder or condition, or to provide a cosmetic benefit.
  • Some embodiments of the present disclosure include a dental abrasive or combination of dental abrasive agents.
  • the term“abrasive” or“abrasive agent” also includes materials commonly referred to as“polishing agents.” Any orally acceptable abrasive may be used, but typically, type, fineness (particle size) and amount of abrasive should be selected so that tooth enamel is not excessively abraded in normal use of the composition.
  • Suitable abrasives include without limitation silica (in the form of silica gel, hydrated silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like.
  • insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates.
  • Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, n-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.
  • Average particle size of an abrasive is generally from about 0.1 to 100 about pm.
  • the particle size may be from about 1 to about 80 pm or from about 5 to about 60 pm.
  • one or more abrasives are present in an amount of from about 0.01 % to about 70% by weight, based on the total weight of the oral care composition.
  • the oral care composition includes from about 0.1 weight % to about 60 weight % abrasives.
  • the abrasive is calcium pyrophosphate.
  • the oral care composition includes from 0.01 weight % to about 70 weight % calcium pyrophosphate based on a total weight of the oral care composition.
  • the oral care composition includes about 20 weight % calcium pyrophosphate.
  • the oral care composition includes an anticalculus agent.
  • Suitable anticalculus agents include without limitation phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates.
  • the anticalculus agent is present in an amount of from about 0.01% to about 30% weight based on the total weight of the oral care composition.
  • the oral care composition includes a mixture of anticalculus agents.
  • tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used as the anticalculus agents.
  • the anticalculus agent includes from 0.1% to 10 weight % TSPP, or about 2 weight % TSPP.
  • the oral care compositions of the present disclosure may also include a synthetic anionic polymeric polycarboxylate.
  • the synthetic anionic polymeric polycarboxylate may act as a stabilizer for the polyphosphate anti-tartar agent and may help to block access of painful or pain- causing materials, such as sugars, to the tooth nerves.
  • the oral care composition optionally includes a source of fluoride ions.
  • the source of fluoride ions is selected from: fluoride, monofluorophosphate (MFP), and fluorosilicate salts.
  • one or more fluoride ion-releasing compounds are optionally present in an amount providing a total of 100 to 20,000 ppm, 200 to 5,000 ppm, or 500 to 2,500 ppm, fluoride ions. If present, in some embodiments, the amount of fluoride source in the oral care composition ranges from about 0.01% to about 10% by weight, based on the total weight of the oral care composition, typically about 0.5% to about 1.5 weight %. For example, the oral care composition may include about 0.76 weight % MFP.
  • the compositions also may include a stannous ion or a stannous ion source to mitigate calcium loss.
  • Suitable stannous ion sources include without limitation stannous fluoride, other stannous halides such as stannous chloride dihydrate, stannous pyrophosphate, organic stannous carboxylate salts such as stannous formate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxide and the like.
  • one or more stannous ion sources are included in the oral care composition.
  • the oral care composition may include from about 0.01% to about 10% stannous ion source by weight, based on the total weight of the oral care composition.
  • the oral care composition includes from about 0.1 weight % to about 7 weight % stannous ion source or from about 0.2 weight % to about 5 weight % stannous ion source.
  • Table 1 illustrates an oral care composition according to embodiments of the present disclosure and three comparative examples.
  • the compositions of Table 1 had the same amount for all ingredients except that Oral Care Composition Example 1 included both oleanic acid and eugenol at a 2: 1 weight ratio, while Comparative Example A and Comparative Example B included only oleanic acid or eugenol, respectively.
  • Comparative Example C included both oleanic acid and eugenol at a 3:1 weight ratio.
  • Table 2 illustrates an antibacterial efficacy of the oral care compositions.
  • the antibacterial composition was measured under the University of Manchester (UoM) biofilm model as follows: dental plaque was collected from 4 healthy volunteers and pooled together as inoculum. The optical density (OD) of the inoculum was matched to 0.3 absorbance at 610nm. Sterile HAP disks were incubated under anaerobic conditions at 37 °C for 24 hours with 1 ml of sterile artificial saliva (with 0.01% sucrose) and 1 ml of pooled saliva in a 24 well microplate. Freshly prepared treatment solutions were prepared for each of the composition of Table 1 comprising 1 part composition and 2 parts sterile distilled water.
  • the treatment solutions were then added to the well and allowed to contact with the HAP disks for 10 mins.
  • the treatment solutions were then replaced with 2 ml of sterile PBS and allowed to contact for 1 min.
  • the liquid phase was then removed and replaced by 2 ml of sterile artificial saliva.
  • the disks were treated in triplicates for each composition of Table 1 for 8 days. At intervals of 2, 4, and 8 days the disks were collected aseptically and transferred into half strength pre-reduced thioglycollate medium. 100 pi of the collected samples were plated in duplicates for each disk on Neomycin- Vancomycin (NV) Agar, for Total Gram negative Anaerobes.
  • NV Neomycin- Vancomycin
  • the UoM number represents the log CFU/mL of bacterial in the sample. The lower the UoM number, the lower the bacterial concentration and the more effective the antibacterial efficacy of the oral care composition.
  • the oral care composition including the mixture of antibacterial agents having a 2: 1 ratio of oleanic acid to eugenol displayed enhanced antibacterial efficacy when compared to comparative compositions including oleanic acid or eugenol separately or including other ratios of oleanic acid to eugenol, such as 3: 1 as in Comparative Composition C.
  • Oral care compositions according to embodiments of the present disclosure provide enhanced antibacterial effects due to the synergistic effects of oleanic acid and eugenol when present at a 2: 1 weight ratio.
  • oleanic acid and eugenol are present at a weight ratio between 2: 1 and 3: 1.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de soin buccodentaire, comprenant un mélange d'agents antibactériens, ce mélange d'agents antibactériens comprenant de l'acide oléanique et de l'eugénol dans un rapport pondéral compris entre 2:1 et 3:1.
EP19731547.6A 2019-05-31 2019-05-31 Composition de soin buccodentaire Pending EP3962441A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/034986 WO2020242499A1 (fr) 2019-05-31 2019-05-31 Composition de soin buccodentaire

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EP3962441A1 true EP3962441A1 (fr) 2022-03-09

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CN (1) CN113873987A (fr)
AU (1) AU2019448167B2 (fr)
CA (1) CA3140627A1 (fr)
MX (1) MX2021014425A (fr)
WO (1) WO2020242499A1 (fr)

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CN116421484A (zh) * 2022-01-04 2023-07-14 高露洁-棕榄公司 口腔护理组合物和用于其的方法

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US20060134025A1 (en) * 2004-12-17 2006-06-22 Colgate-Palmolive Company Oral compositions containing extracts of Rosmarinus and related methods
RU2440821C2 (ru) * 2007-10-01 2012-01-27 Колгейт-Палмолив Компани Композиции для ухода за полостью рта, содержащие растительные экстракты
CA3081541A1 (fr) * 2017-12-01 2019-06-06 Colgate-Palmolive Company Compositions de soins buccaux comprenant un agent hemostatique

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MX2021014425A (es) 2022-01-06
CN113873987A (zh) 2021-12-31
AU2019448167B2 (en) 2023-03-16
CA3140627A1 (fr) 2020-12-03
AU2019448167A1 (en) 2021-11-18
WO2020242499A1 (fr) 2020-12-03

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