EP3946487A1 - Implant doté d'une efficacité antimicrobienne intrinsèque et procédé de sa production - Google Patents

Implant doté d'une efficacité antimicrobienne intrinsèque et procédé de sa production

Info

Publication number
EP3946487A1
EP3946487A1 EP20702614.7A EP20702614A EP3946487A1 EP 3946487 A1 EP3946487 A1 EP 3946487A1 EP 20702614 A EP20702614 A EP 20702614A EP 3946487 A1 EP3946487 A1 EP 3946487A1
Authority
EP
European Patent Office
Prior art keywords
implant
particles
mixture
granulate
metal particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20702614.7A
Other languages
German (de)
English (en)
Inventor
Adem Aksu
Frank Reinauer
Tobias Wolfram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karl Leibinger Medizintechnik GmbH and Co KG
Original Assignee
Karl Leibinger Medizintechnik GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Leibinger Medizintechnik GmbH and Co KG filed Critical Karl Leibinger Medizintechnik GmbH and Co KG
Publication of EP3946487A1 publication Critical patent/EP3946487A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • certain metallic ions such as, for example, are used to produce an antimicrobially active coating.
  • Other materials that implants with antimicrobial activity can have are, for example, PEEK, PPSU with included additives, such as hydroxyapatite (HA), calcium carbonate (CaCCb), strontium (Sr), ⁇ - or ß-tricalcium phosphate (a- or ß-TCP ), Bioglass particles / particles made of bioactive glass, a polyester material such as PDLLA, PLGA, PLA, PGA, chitosan fibers or chitosan particles.
  • a porous implant achieves a better result than a non-porous / solid implant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un implant (1) doté d'une activité antimicrobienne, présentant un mélange d'implant (IM) qui possède un granulé de base (2) à partir d'un mélange de matière première issu de polymères biocompatibles et/ou d'un granulé en céramique, le mélange d'implant (IM) présentant en outre au moins un type de métal particulaire (3), qui est approprié à libérer des ions, les particules de métal (3) se présentant sous la forme de particules d'argent et/ou de cuivre. Les particules de métal (3) sont réparties dans le volume de l'implant (1). L'invention concerne en outre un procédé de fabrication d'un tel implant (1).
EP20702614.7A 2019-03-29 2020-01-28 Implant doté d'une efficacité antimicrobienne intrinsèque et procédé de sa production Pending EP3946487A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019108327.3A DE102019108327A1 (de) 2019-03-29 2019-03-29 Implantat mit intrinsischer antimikrobieller Wirksamkeit und Verfahren zu dessen Herstellung
PCT/EP2020/052068 WO2020200538A1 (fr) 2019-03-29 2020-01-28 Implant doté d'une efficacité antimicrobienne intrinsèque et procédé de sa production

Publications (1)

Publication Number Publication Date
EP3946487A1 true EP3946487A1 (fr) 2022-02-09

Family

ID=69375349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20702614.7A Pending EP3946487A1 (fr) 2019-03-29 2020-01-28 Implant doté d'une efficacité antimicrobienne intrinsèque et procédé de sa production

Country Status (8)

Country Link
US (1) US20220168473A1 (fr)
EP (1) EP3946487A1 (fr)
JP (1) JP2022526567A (fr)
CN (1) CN113631202A (fr)
AU (1) AU2020252747A1 (fr)
BR (1) BR112021019442A2 (fr)
DE (1) DE102019108327A1 (fr)
WO (1) WO2020200538A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021201695A1 (de) 2021-02-23 2022-08-25 Karl Leibinger Medizintechnik Gmbh & Co. Kg Mehrteiliges Implantat mit Stützelement und Funktionselement
CN115896670B (zh) * 2021-09-30 2024-07-02 银微子有限公司 包含银铜微粒的抗微生物制品

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411648A (en) * 1981-06-11 1983-10-25 Board Of Regents, The University Of Texas System Iontophoretic catheter device
ATE155649T1 (de) * 1994-02-01 1997-08-15 Theodor Krall Verfahren zur herstellung von bakteriziden/fungiziden kunststoffkörpern
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
DE10323676A1 (de) 2003-05-15 2004-12-02 Aesculap Ag & Co. Kg Implantat mit antibiotischer Langzeitwirkung
DE102004036399A1 (de) * 2004-07-23 2006-02-16 Biotronik Vi Patent Ag Biokompatibles und bioabsorbierbares Naht- und Klammermaterial für chirurgische Zwecke
EP1976459A4 (fr) * 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Prothese osseuse poreuse
US20090030504A1 (en) * 2007-07-27 2009-01-29 Boston Scientific Scimed, Inc. Medical devices comprising porous inorganic fibers for the release of therapeutic agents
DE102008002601A1 (de) * 2008-02-05 2009-08-06 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Eisenlegierung
ES2376539T3 (es) 2009-01-05 2012-03-14 Dot Gmbh Procedimiento para la fabricación de un recubrimiento antiinfeccioso sobre implantes.
WO2011056422A1 (fr) * 2009-11-03 2011-05-12 Howmedica Osteonics Corp Plateforme pour fixation de partie molle
AU2011231630B2 (en) * 2010-03-25 2014-05-22 Biotronik Ag Implant made of a biodegradable magnesium alloy
EP2382960A1 (fr) * 2010-04-19 2011-11-02 DERU GmbH Entwicklung von medizinischen Produkten Implant doté d'un revêtement antimicrobien
EP3488875A1 (fr) * 2013-03-14 2019-05-29 Prosidyan, Inc. Implants pour greffe osseuse composites, poreux et bioactifs
EP3424877A4 (fr) * 2016-02-29 2019-11-13 Tokyo Institute of Technology Corps fritté en phosphate de calcium contenant de l'argent et son procédé de production

Also Published As

Publication number Publication date
CN113631202A (zh) 2021-11-09
JP2022526567A (ja) 2022-05-25
WO2020200538A1 (fr) 2020-10-08
DE102019108327A1 (de) 2020-10-01
AU2020252747A1 (en) 2021-09-16
BR112021019442A2 (pt) 2021-11-30
US20220168473A1 (en) 2022-06-02

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