EP3911403A1

EP3911403A1 - Microarray receiving portion

Info

Publication number: EP3911403A1
Application number: EP19813743.2A
Authority: EP
Inventors: Michael Kulik; Thorsten Fehr; Stefan Erlhofer
Original assignee: LTS Lohmann Therapie Systeme AG
Current assignee: LTS Lohmann Therapie Systeme AG
Priority date: 2019-01-17
Filing date: 2019-11-26
Publication date: 2021-11-24
Also published as: JP2022517650A; CA3125051A1; CN113301943A; CN113301943B; US20220072291A1; WO2020148009A1; JP7507768B2; DE102019200558A1; BR112021012574A2

Abstract

The invention relates to a microarray receiving portion (10) that has a first side (12) and a second side (14). The microarray receiving portion (10) also comprises a carrier structure (16) for connecting the microarray receiving portion (10) to an application point (18). A carrier surface (20) is connected to the carrier structure (16) and is in turn connected to a microarray (22). An articulating device (26) is arranged between the carrier surface (20) and the carrier structure (16), said articulating device (26) allowing the microarray (22) connected to the carrier surface (20) to move relative to the carrier structure (16), along the extension of said microarray (22). The invention also relates to a microarray receiving portion cluster (100) comprising a plurality of such microarray receiving portions (10).

Description

M i kroa rrava take on

The invention relates to a microarray recording and a microarray recording cluster.

Microarrays have a large number of microneedles, which are usually arranged on a carrier surface, such as a patch, a plaster or the like, or are connected to a carrier surface. Such microarrays have a high number of microneedles, for example 500-600 needles per cm ² . The needles have a short length, so that when the microneedles are pressed into the skin of a patient, the needles only penetrate the skin to such an extent that nerve and blood vessels are not touched by needle tips if possible. The microneedles have an active ingredient or a medicament. The corre sponding active ingredient can be applied to a surface of the needle or arranged in the needles. It is preferred that the needles be made from a material that dissolves in the patient's skin.

The problem with the application of microarrays in human skin is that the insertion of the microneedles into the skin must be reproducible, in particular to ensure reliable drug delivery. The insertion of the microneedles must also be independent of the user or patient, since otherwise reproducibility would not be guaranteed.

In particular, the insertion of the microneedles should also be independent of the skin condition, so that a certain depth of penetration is always ensured. Currently, microarrays are often applied manually by a user. Normally, the user takes the microarray out of a standard packaging, for example a blister packaging. On the one hand, the microarray is exposed to contamination from this point on. On the other hand, there is a risk that individual microneedles and / or the entire microarray may be damaged. After removal, the user places the microneedle array on the application site, for example on the skin. The next step is the application. For this purpose, it is common for the user to press the back of the microarray with a finger, for example, and thus to apply the needles into the skin. This means that there is no reproducible application.

A further problem arises if microarrays with a multiplicity of micro needles or a plurality of micro needle arrays are to be applied at an application site or if surfaces are applied to curved skin by the application of a microarray. Here too there is currently no reproducible application.

The object of the invention is to provide a microarray recording that improves the reproducibility of the application of microarrays. Another object of the invention is to provide a microarray recording cluster for the optimized application of a plurality of microarrays.

The object is achieved according to the invention by a microarray recording with the features of claim 1 and by a microarray recording mencluster with the features of claim 15.

The microarray receptacle according to the invention is preferably a microarray receptacle for storage and / or handling and / or guidance when applying a microarray. The microarray receptacle has a first side, the first side preferably being the top of the microarray pickup is. This first page is, in particular, the side that repels the application site, in particular the skin. In addition, the microarray receptacle has a second side, preferably an underside, this side being in particular the side pointing towards the skin. The microarray receptacle has a support structure which is designed to be connected to an application site. The application site is particularly preferably the skin of a user. The carrier structure thus preferably has the contact area of the microarray holder with the skin. This contact surface can in particular be designed to be adhesive. Thus, the micro array recording can be glued to the contact surface of the support structure on the skin. Furthermore, the microarray receptacle has a carrier surface connected to the carrier structure. In a preferred embodiment, this support surface is designed in particular as a round or rectangular plate. Preference is given to the execution of the support surface with an essentially two-dimensional surface. A microarray is connected to the carrier surface. The connection between the microarray and the carrier surface can in particular be carried out in such a way that a patch of the microarray is glued to the carrier surface and / or welded. On the other hand, an embodiment is also possible in which the microarray is formed in one piece with the support surface, also to be referred to as integral. It is possible that the microstructures, preferably the micro needles of the microarray are attached directly to the support surface. It is preferred that the carrier structure is designed and / or connected to the carrier surface in such a way that in the initial state there is a spacing of the carrier surface and the microarray from the application site. The carrier surface can be designed such that it represents a sterile barrier, in particular towards the first side. Furthermore, the microarray holder has a joint device between the support surface and the support structure. The articulation device is designed in such a way that it enables the microarrays connected to the support surface to move relative to the support structure. This relative movement of the microarray relative to the support structure takes place in particular in such a way that the Movement along the extension of the microstructures, preferably with micro needles, of the microarray takes place. In other words, the microarray is connected to the support structure via the joint device in such a way that the spacing of the microarray from the skin is overcome by movement, and thus the microarray is applied to the skin. The articulation device is in this case in particular designed in such a way that it only enables movement along the extent of the microstructures. However, a configuration is also possible in which additional movements, such as tilting or transverse movements in particular, are possible. The joint device can be designed such that it only allows one-sided movement, in particular towards the skin. On the other hand, the joint device can also be designed in such a way that it allows movement on both sides, in particular back and forth. The carrier structure preferably forms a, in particular cylindrical, housing of the microarray receptacle. The cylindrical shape of the housing can preferably have a circular or rectangular, in particular square, or oval base surface.

In a preferred embodiment, the joint device has at least one first solid-state joint. The first solid-state joint is preferably formed in one piece with the support surface. If there is a one-piece design consisting of the solid body joint and the support surface, it is in particular possible that the microarray is connected directly to the solid body joint. Here, a one-piece design of microarray and solid joint is possible.

In addition to the first solid-state joint, the joint device preferably has a second solid-state joint. It is preferred here that the first solid body joint and the second solid body joint are arranged essentially parallel to one another. The second solid body joint forms in particular a Area of action for, preferably external, effects on the microarray image. In particular, the second solid-state joint can be designed such that it can be moved from the outside. It is preferred that the second solid-state joint moved in this way can act on the first solid-state joint. The two solid-state joints are in particular designed or arranged such that the microarray and / or the support surface can only experience a one-dimensional, preferably linear, deflection. This deflection is preferably a deflection along the extent of the microstructures of the microarray. A spacer is preferably provided between the first solid body joint and the second solid body joint.

In a preferred embodiment, the microarray holder has a blocking device for fixing the first solid body joint and the second solid body joint relative to one another. In particular, the blocking device is a latching device which, when latched in, prevents a relative movement of the first solid-state joint to the second solid-state joint. As an alternative or in addition, it is possible for the latching device to prevent a relative movement between the first solid body joint and the support structure during the latching. It is preferred that the snap-in device is designed in such a way that, when it snaps in, it prevents a relative movement between the first solid-state joint, the second solid-body joint and the support structure. The latching device is preferably a latching pin between the first solid-state joint and the second solid-body joint. The latching pin can be configured such that it is already connected to the first or the second solid-state joint in the initial state and engages with the other solid-body joint when it is latched in, thus preventing a relative movement of the two solid-state joints. On the other hand, it is also possible for the latching pin to snap in with both solid bodies when latching. It is also possible that the snap pin also snaps into the support structure. The first solid-state joint and / or the second solid-state joint is, in particular, a linear solid-state joint. Especially preferred is a linear plate solid joint. A linear plate solid-state joint is a rigid plate with at least two regions that are movably connected to one another via webs. The mobility of the areas relative to one another is particularly limited to parallel and / or rectangular movements. The webs and / or the areas are produced in particular by means of punching and / or laser cutting of a rigid plate. A linear plate solid joint is also referred to as a diaphragm solid body joint (English: "diaphragm flexure"). It is preferred that the carrier surface is designed in one piece with the joint device and / or with the microarray. It is also possible for the support surface to be connected in one piece to the support structure.

In a preferred embodiment, the joint device has a degree of freedom of 1. The joint device thus preferably only permits linear deflections, in particular along the extent of the microstructures of the microarray. In other words, the joint device is preferably designed in such a way that it only enables movements along the Z direction. It is particularly preferred that the joint device only allows movements in one direction, preferably in the needle tip direction of the microneedles.

The microarray receptacle preferably has a guide device for guiding the carrier surface in a particularly linear manner. The guide device is preferably designed to guide the joint device. In particular, the guide device is arranged between the first solid body joint and the second solid body joint. The guide device preferably has a, in particular round, guide rod. The guide rod preferably guides the first solid-state joint and / or the second solid-state joint, wherein the first solid body joint and / or the second solid body joint preferably have openings for guidance by means of the guide rod.

On the one hand, it is possible that the joint device is designed such that it automatically moves the carrier surface back into the starting position after a deflection. On the other hand, it is possible that the articulation device holds the support surface in a deflected position. According to this first possible embodiment, the microneedles are subsequently pulled out of the skin, in particular when the microneedles penetrate the skin, as soon as the joint device is no longer deflected, in particular from the outside. According to the possible second embodiment, it is in particular possible that after a first deflection of the joint device, the microneedles penetrate the skin and are preferably deflected out by the joint device and are thus kept penetrated into the skin. For this purpose, it is preferred that the microarray receptacle has a fixing device, in particular a snap-in fixing device, the fixing device blocking or fixing the articulated device and / or the support surface in the deflected position and thus preventing, at least temporarily, the microarray from moving back into the starting position . In particular, the snap-in fixation device is a snap-in hinge having the joint device and / or a snap lock, which acts in particular between the support surface and the support structure. It is preferred that the microarray receptacle, in particular the joint device, has a pretensioning device, such as a spring. The pretensioning device is in particular designed such that it triggers an acceleration of the support surface during the deflection and / or a holding of the support surface in the deflected position.

It is preferred that the microarray receptacle has a force introduction structure that is indirectly or directly connected to the back of the microarray. In particular, the force introduction structure can be connected to the support surface opposite the microarray. It is preferred that the force introduction structure is convex.

The microarray holder has, in particular, a bottom film. The bottom film is preferably arranged on the second side of the microarray holder. In a preferred embodiment, the base film represents a sterile barrier of the microarray on the second side to the surroundings. It is possible that the base film is designed in such a way that the microarray can penetrate it. In particular, microneedles of the microarray can thus pierce the bottom film.

It is preferred that the base film is connected to the support structure. It is particularly preferred here that the base film is detachably or removably connected to the support structure. This peelable connection is made in particular by gluing the base film to the support structure. It is thus possible for a user to detach the base film from the carrier structure, in particular before use, and thus release the microarray.

It is possible that the bottom film has an adhesive layer. In this way it is possible in particular to attach the microarray holder to an application site.

The microarray holder preferably has a cover film. The lid film is in particular connected to the support structure. A firm, non-releasable connection is preferred. In particular, the cover film can be welded to the carrier structure, preferably by ultrasonic welding, or glued. The cover film preferably forms a sterile barrier on the first side of the microarray holder towards the surroundings. The cover film is particularly flexible and / or fragile. In the case of a flexible configuration, in particular an action can take place on the cover film from the outside, so that the cover film yields flexibly. In the case of a fragile, preferably perforated, configuration, the cover film can tear when subjected to external influences and thus allow external influences on the microarray receptacle.

In a preferred embodiment, the microarray holder has a connection device. The connecting device is provided in particular on the first side of the microarray holder. It is particularly preferred that the connecting device is connected to the support structure, preferably in one piece. The connecting device is in particular a connecting device for a microarray applicator. The connecting device preferably has a thread and / or a connector and / or a form-fitting connector and / or an adhesive point and / or a flange and / or a bayonet-type connector and / or a magnetic connector, in particular a magnet.

The microarray recording cluster according to the invention has several microarray recordings according to the invention as defined above. The multiple microarray receptacles can have identical or different microarrays, so that in particular different microarrays with different active substances and / or different numbers of needles, etc. can be present. The support surfaces and / or the base films and / or the cover films and / or the support structures of the plurality of microarray receptacles are preferably connected to one another, with a one-piece connection being preferred in particular. Several microarray recordings can be connected in this way. In particular, several microarray recordings can be produced together, preferably continuously. It is also advantageously possible in this way to take several interconnected microarray recordings together on one body part to be applied, in particular one curved skin area to apply. These multiple microarray recordings can then be applied simultaneously or at different times.

The invention is explained in more detail below with reference to a preferred embodiment with reference to the drawing.

Show it :

FIG. 1 shows a schematic top view of an inventive microarray cluster,

2 shows a detailed view of area II from FIG. 1, which shows an embodiment of a microarray receptacle according to the invention,

3 shows a schematic sectional view of an embodiment of a microarray pickup according to the invention, the microarray pickup essentially corresponding to the microarray pickup from FIG. 2 along section plane III,

4 shows a schematic sectional view of a further embodiment of a microarray holder according to the invention,

5 shows a schematic sectional view of a further embodiment of a microarray holder according to the invention,

6a is a schematic sectional view of a further embodiment of a microarray recording according to the invention in the starting position,

6b shows a schematic sectional view of the microarray image from

FIG. 6a in the applied position, 7 shows a schematic sectional view of a further embodiment of a microarray holder according to the invention,

8a is a schematic sectional view of an application system with a microarray applicator and an embodiment of a microarray recording according to the invention in the starting position, and

8b shows a schematic sectional view of the device from FIG. 7a in the applied position.

Similar or identical components or elements are identified in the figures with the same reference symbols. For better clarity in particular, elements that have already been identified are preferably not provided with reference numerals in all the figures.

Fig. 1 shows a plan view of the underside of an embodiment of a microarray recording cluster 100 according to the invention (with the foil 36 hidden).

The microarray recording cluster 100 shows several embodiments of microarray recordings 10, 10 ', 10 ", 10"' according to the invention which are connected to one another via a cover film 38. For the application of the microarray recording cluster, this is in particular placed on human skin, so that the illustrated side 102 of the microarray recording cluster 100 rests on the skin and is therefore shielded from the cover film 38 from the surroundings. The cover film 38 and / or the microarray receptacles 10, 10 ', 10 ", 10'" are preferably configured flexibly, so that the microarray receptacle cluster 100 clings in particular to a curved skin section. After the microarray recording cluster 100 has been placed on the skin, in particular individual microarray recordings 10 can be applied independently of one another or it is possible to apply all microarray recordings together.

Instead of the embodiment shown, it is possible for the support structures 16, 16 ', 16 ", 16"' to be connected to one another, in particular in one piece.

FIG. 2 shows a detailed view of the microarray receptacle 10 from FIG. 1. FIG. 2 shows the underside 14 of the microarray receptacle 10, which is opposite the top 12 that cannot be seen in the view.

The microarray receptacle 10 has a circumferential support structure 16 which partially projects beyond a support surface 20, the support structure 16 being connected to the support surface 20 by the area overlapping with the support surface 20 (see FIG. 3). The protruding region of the support structure 16 is preferably connected to the cover film 38 (not shown in FIG. 2) (see FIGS. 1 and 3). The connection between cover film 38 and carrier structure 16 is preferably carried out by means of welding and / or gluing, but an integral or other configuration is also possible. The connection between the support structure 16 and the support surface 20 can be made in particular by means of gluing and / or welding, but can also be made in one piece. The carrier surface 20 is connected to a microarray 22 with a plurality of microneedles 24. The microarray 22 is shown as a patch with microneedles 24 arranged thereon, in particular in one piece with it. The microneedles 24 here preferably run conically out of the image plane (in the Z direction). Instead of the embodiment shown, it is also possible to connect the microarray 22 directly to the carrier surface 20, wherein an integral connection is also possible. Accordingly, it is possible to design the carrier surface 20 in one piece with the microarray 22 and / or the microneedles. The carrier structure 16 preferably has one (Outstanding from the image plane in the illustration) height, which in particular ensures a spacing of the carrier surface 20 from an application point.

The microarray receptacle 10 from FIG. 2 also has an articulated device 26. The joint device 26 is designed here as a solid body joint, in particular as a linear plate solid body joint. For this purpose, the support structure 16 has slots 42, 44, which are created in particular by punching a plate, which preferably essentially corresponds to the support surface 20. There are webs 48 between these slots 42, 44. These, preferably flexible webs 48 allow the inner area of the support surface 20 to move with respect to the outer area. The Ge steering device 26 in particular enables movement of the microarray in the Z direction. Due to the design in the illustrated embodiment of the solid-state joint device 26, however, tilting of the microarray 22 is also possible, so that movement about the X and / or Y axis is also possible.

It is possible for the microarray recordings 10 to be designed independently of the microarray recording cluster 100. Accordingly, the microarray receptacles 10 according to the embodiment from FIG. 2 would in particular have a separate cover film 38.

FIG. 3 shows a sectional view of an embodiment of a microarray receptacle 10 according to the invention, the microarray receptacle 10 essentially corresponding to the microarray receptacle from FIG. 2 (independent of the microarray receptacle cluster 100) along section plane III.

In contrast to the embodiment from FIG. 2, a bottom film 36 is shown in FIG. 3. This bottom film 36 is connected to the support structure 16. This Connection between bottom film 36 and support structure 16 is preferably made adhesive. It is particularly preferred that the base film 36 is designed to be removable or removable, so that, in particular, a user can remove the base film 36 from the microarray receptacle 10 before application. As an alternative or in addition, it is possible for the base film 36 to be designed such that it can be pierced by the microarray 22, that is to say in particular the microneedles 24. In particular, the base film 36 can have an adhesive layer, preferably on the underside shown, so that the microarray receptacle 10 can be adhesively connected to an application site via the adhesive layer of the base film 36.

In the form shown, the microarray receptacle 10 is in a non-deflected or non-applied position. The solid body joint 26, which is in particular a linear plate solid body joint, is therefore not deflected. On the back of the microarray 22 or the back of the support surface 20 is a convex force transmission structure 34 verbun the. This convex force introduction structure 34 makes it possible, particularly when force is applied by means of an oppositely convex applicator, for the microarray 22 to be applied in the normal vector to the application site, in particular to the skin. This results in a deflection along the Z axis and an optimal puncturing and application of the microneedles into the skin is possible.

The microarray 22 is protected from the environment via the base film 36 and the cover film 38 and / or the carrier surface 20. In particular, sterile protection from the environment is possible.

FIG. 4 shows a further embodiment of a microarray holder 10 according to the invention. The embodiment from FIG. 4 largely corresponds to the embodiment from FIG. 3. In contrast to the embodiment from FIG. 3, the microarray holder from FIG. 4 has no force introduction structure 34 on. Likewise, in the embodiment from FIG. 4, no cover film 38 is provided. However, it is also possible to provide a cover film 38 in the embodiment from FIG.

In addition, the design of the articulation device 26 from FIG. 4 differs from the embodiment from FIG. 3. The articulation device 26 here has a first solid-state joint 28, this solid-state joint 28 essentially corresponding to the embodiment from FIG . In addition, the microarray receptacle has a second solid body joint 30 above the first solid body joint 28. The second solid-state joint 30 is preferably a plate, in particular made of spring steel, which is bent upwards and is thus in the prestressed state. In other words, the execution of the second solid-state joint 30 corresponds to an execution according to a "pop frog". When pressure is applied to the second solid body joint 30 from above, it deforms and jumps to the opposite side, whereupon the second solid body joint 30 bends downward and remains in this position. Because of this jump in deformation, the second solid-state joint 30 acts on and deflects the first solid-state joint 28 as well. This results in a deflection or application of the microarrays 22 connected to the first solid-state joint.

In the illustrated embodiment, the microarray receptacle 10 has a locking device 60. The snap-in device 60 has a pin 32 and an opening 31 in the second solid-state joint 30. The pin 32 is connected to the first solid-state joint 28, in particular in one piece with the sem. The pin 32 preferably has about half a bone structure, so that a type of hemisphere or thickening 33 is provided at one end. To the other side, connected to the first solid-state joint 28, the pin 32 tapers. When the second solid-body joint 30 is deflected, the second solid-body joint 30 slides over by means of an provided one Opening 31 via the thickening 33 of the, in particular flexible, pin 32. This engages the second solid body joint 30 with the first solid body joint 28, so that subsequent relative movement between the solid body joints 28, 30 is prevented. In other words, the second solid body joint 30 is engaged with the first solid body joint 28. Due to the preload of the second solid-state joint 30, the first solid-state joint 28 and the second solid-state joint 30 remain in the deflected position, so that the microarray 22 is deflected and thus kept applied.

Instead of the embodiment shown here with snap-in device 60, it is also possible to design microarray receptacle 10 without snap-in device and accordingly preferably also without opening 31 of second solid-state joint 30.

Due to the provision of the two, preferably parallel to each other, solid joints 28, 30, in particular in contrast to the embodiment from FIG. 3, no tilting, that is to say no movement of the microarray 22 about the X and / or Y axis is possible. The two solid-state joints 28, 30 arranged relative to one another ensure that only a deflection along the Z-axis is possible.

FIG. 5 shows a further embodiment of a micro array holder 10 according to the invention. The micro array holder 10 has two solid joints 28, 30. The two solid-state joints 28, 30 are in this case based on the solid-state joint 28 from FIG. 3, that is to say in particular as linear plate-solid body joints. Again, the composition of the two solid joints 28, 30 ensure that only a deflection along the Z axis is possible. The first solid body joint 28 has an opening 29 and the second solid body joint 30 has an opening 31. There is an entrance between the openings Detent device 60 is provided, which in the illustrated embodiment is designed as a detent pin 32. The locking pin 32 essentially has a bone shape, so that there are thickenings 33 ′, 33 ″ at the two ends of the locking pin 32. When the second solid body joint 30 is deflected in the positive Z direction, the second solid body joint 30 acts on due to the action of the second solid body joint the first solid-state joint 28 likewise deflects the first solid-state joint 28 and thus an application of the microarray 22 in the Z-direction. In addition, this deflection ensures that the first solid-state joint 28 and the second solid-state joint 30 with the openings 29, 31 slip over the locking pin 32 and remain locked in place in the central region of the locking pin 32. The first solid-state joint 28 snaps in relative to the second solid-body joint 30.

A support structure 16 is provided between the first solid body joint 28 and the second solid body joint 30. Based on the embodiment from FIG. 3, this support structure 16 can also extend below the first solid-state joint 28 and in this way in particular produce a spacing from the application site. In addition, in the embodiment from FIG. 5, based on the embodiment from FIG. 3, the provision of a base film 36 and / or cover film 38 and / or a force introduction structure 34 can also be implemented.

FIG. 6a shows a further embodiment of a microarray recording 10 according to the invention. The embodiment is based on the embodiment from FIG.

In contrast to the embodiment from FIG. 5, the pin 32 is already inserted into the openings 29, 31 in the initial state. The pin 32 corresponds approximately to the design of a shaft with two shaft shoulders 72, 74, with a wide variety of shapes of the pin 32, for example round, rectangular, square, etc. being possible. Shaft shoulder 72 is in opening 31, shaft shoulder 74 in opening 29 plugged in. On the one hand, the pin 32 functions as a spacer between the first solid-state joint 28 and the second solid-state joint 30. Further, the embodiment has a guide device 70 which comprises the shaft shoulders 72, 74 of the pin 32 and the openings 29, 31. The pin 32, as a kind of guide rod, provides for linear guidance of the first solid-state joint 28 and the second solid-state joint 30, so that only a deflection along the z direction is possible. Accordingly, if the first solid-state joint 28 is acted upon in such a way that it would experience a tipping or a moment, the pin 32 takes up this moment and prevents the tipping. Consequently, there is only a linear deflection of the microarray 22 along the z direction.

The embodiment also has a latching device 60. The snap-in device 60 comprises the projection 33 of the pin 32 and the snap-in plate 62. The snap-in plate 62 is shown immovably connected to the support structure 16, in particular designed in one piece, and has an opening 64 provided with a bevel. In the starting position (FIG. 6a), the projection 33, which can also be designed as a bead, bears against the opening 64 of the latching plate 62. When the second solid-state joint 30 is deflected (FIG. 6b), for example due to pressure on the same by a user, along the z-direction, force is transmitted via pin 32 to the first solid-state joint 28 and thus also a deflection of the pin 32 just like the first solid-state joint 28 in the z direction. Here, the jump 33 overcomes the opening 64 of the snap plate 62. As a result, the pin 32 snaps below (in the z direction) of the snap plate 62. This results in fi xation of the first solid 28 in the deflected position, which leads to a kind of re-pressing of the microarray 22 connected to the first solid 28. It is thus possible to keep the microarray 22 applied. In particular, it is due to the slope of the opening 64 after passing the projection 33 through the opening 64 prevents a subsequent opposite passage and thus a return to the starting position.

It is possible for the second solid-state joint 30 to move back into the starting position after an initial deflection. This can be accomplished in particular in that the plug connection between the shaft section 72 and the opening 31 is designed to be detachable. On the other hand, it is possible for shaft shoulder 72 with opening 31 and / or shaft shoulder 74 with opening 29 to be non-detachable, in particular in one piece. It is also possible that pin 32 has no shaft shoulders 72, 74 and / or the solid body joints 28, 30 have no openings 29, 31, but pin 32 directly on one side with the first solid body joint 28 and on the other side with the second solid body joint 30, preferably non-detachable, connected, in particular is designed in one piece.

The projection 33 can be designed to be flexible. Alternatively or additionally, the latch plate 62 or the region of the opening 62 of the latch plate 62 can be configured flexibly.

An embodiment based on the embodiment from FIG. 6a is also possible which has no latching device 60, that is to say in particular no latching plate 62 and / or no projection 33 on pin 32.

FIG. 7 shows a further embodiment of a microarray recording 10 according to the invention. The embodiment essentially corresponds to the embodiment from FIG. 6a.

In contrast to the embodiment from FIG. 6a, the latching device 60 of this embodiment has, in addition to the projection 33 ', a further projection 33 "which is made wider than the projection 33' Passing the protrusion 33 'through the opening 64, the protrusion 33' and protrusion 33 "cause the pin to engage on both sides in the opening 64 on the snap-in plate 62. Because of the width of the protrusion 33" on the snap-in plate 62, a further extension is provided Deflection in the z direction prevented. After a first deflection, this preferably results in permanent engagement and thus in blocking the microarray receptacle.

FIG. 8a shows the microarray receptacle 10 from FIG. 3 arranged on an application site 18, the application site 18 in particular being the skin of a user or patient. For application, the base film 36 was removed or removed.

An essentially cuboidal microarray applicator 50 was placed on the microarray receptacle 10 or connected to the microarray receptacle 10. In addition to the cuboid shape, which can be square or rectangular, for example, other shapes, such as. B. a circular cylindrical shape, etc. possible. The connection of the microarray receptacle 10 to the microarray applicator 50 takes place in particular on a connecting device 40 of the microarray receptacle 10, which is preferably designed as a thread and / or snap-in device and / or the form-fitting connector or flange, the microarray applicator having a corresponding counter-connector. Here, in particular, microarray receptacle 10 has one or more such connection device 40 and the microarray applicator 50 has corresponding counterparts to produce a connection, in particular a separable one.

The microarray applicator 50 has a joint 54 on one side and a predetermined breaking point 52 on the other side. Likewise, the microarray applicator has a convex structure 56, which is designed in the opposite convex manner to the force line structure 34 of the microarray receptacle 10. The microarray receptacle 10 and associated microarray applicator 50 together represent an application system 1000.

FIG. 8b shows the application system 1000 from FIG. 8a in the applied position.

For example, due to pressure by a user on the upper side of the microarray applicator 50 shown, a break occurred at the predetermined breaking point 52, so that the convex structure 56 of the microarray applicator 50 is deflected around the joint 54. The predetermined breaking point is broken in particular when a target load is applied, the target load preferably corresponding to an optimal application force of the microarray. In the deflected position, the convex structure 56 acts on the force introduction structure 34 of the microarray holder. Because of the opposite convex structures, there is a point load between the structures 56, 34 and an application along the normal vector to the skin takes place. Here, the solid body joint 28 with the associated microarray 22 is pierced around the joint device 26 into the application site 18. It is particularly preferred that the predetermined breaking point 52 is designed such that it breaks at a predefined pulse, this pulse corresponding in particular to an optimal application force for the microarray 22.

The microarray applicator 50 preferably has a latching mechanism, which fixes the convex structure 56 in the deflected position. In this way, the convex structure 56 is pressed in a way onto the force introduction structure 34 of the microarray receptacle. This makes continuous application possible in particular.

Instead of triggering or applying the microarray receptacle 10 with a microarray applicator 50, other types of triggering are also possible. Preferably can the microarray 10 take place manually, in particular with a finger of a user. Other microarray applicators can also be used.

Claims

Expectations

1. microarray recording (10), with

a first side (12), preferably an upper side,

a second side (14), preferably an underside,

a support structure (16) for connecting the microarray receptacle (10) to an application site (18),

a support surface (20) connected to the support structure (16), a microarray (22) connected to the support surface (20), and a joint device (26) between the support surface (20) and the support structure (16),

wherein the articulation device (26) enables the microarray (22) connected to the carrier surface (20) to move relative to the carrier structure (16) along the extension of the microarray (22).

2. The microarray receptacle (10) according to claim 1, characterized in that the joint device (26) has at least one first solid-state joint (28), the first solid-state joint (28) in particular being formed in one piece with the support surface (20).

3. microarray holder (10) according to claim 2, characterized in that the joint device (26) has a second solid body joint (30), wherein the first solid body joint (28) and the second solid body joint (30) preferably arranged substantially parallel to each other are.

4. microarray holder (10) according to claim 3, characterized by a snap-in device (60), in particular a snap-in spin (32), preferably between the first solid-state joint (28) and the second Solid-state joint (30), so that when the latching device (60) engages, a relative movement between the solid-state joints (28, 30) and preferably the support structure (16) is prevented.

5. microarray holder (10) according to any one of claims 2 to 4, characterized in that it is the first solid body joint (28) and / or the second solid body joint (30) to linear solid body joints, in particular linear plate solid body joints.

6. microarray holder (10) according to any one of claims 1 to 5, characterized in that the support surface (20) is designed in one piece with the joint device (26) and / or with the microarray (22).

7. Microarray holder (10) according to one of claims 1 to 6, characterized in that the joint device (26) has a degree of freedom of 1.

8. microarray holder (10) according to any one of claims 1 to 7, characterized by a guide device (70), in particular between the first solid body joint (28) and the second solid body joint (30), for, preferably linear, guidance of the support surface (20) , wherein the guide device has in particular a guide rod (72).

9. microarray receptacle (10) according to any one of claims 1 to 8, characterized in that the joint device (26) is designed such that it automatically returns to the starting position after a deflection or is designed such that this after a deflection in the deflected position remains.

10. microarray receptacle (10) according to any one of claims 1 to 9, marked by a with the back of the microarray (22) and / or the support surface (20) directly or indirectly connected, preferably convex starting, force introduction structure (34).

11. microarray holder (10) according to any one of claims 1 to 10, characterized marked by a, preferably from the microarray (22) penetrable bottom film (36), the bottom film (36) the microarray holder (10) on the second side (14) to the environment, especially sterile, from closes.

12. Microarray holder (10) according to claim 11, characterized in that the bottom film (36) with the support structure (16), preferably from removable, is connected.

13. microarray receptacle (10) according to one of claims 1 to 12, characterized marked by a, preferably with the support structure (16) verbun those, cover film (38), the cover film (38) the microarray recording (10) on the first side (12) to the environment, in particular sterile.

14. Microarray holder (10) according to claim 13, characterized in that the cover film (38) is flexible and / or fragile.

15. Microarray holder (10) according to one of claims 1 to 14, characterized in that the microarray holder (10), in particular on the first side (12), has a connecting device (40) for connection to a microarray applicator (50), the Connecting device (40) preferably has: a thread and / or a locking device and / or a form-locking connector and / or a flange.

16. Microarray acquisition cluster (100), with

several microarray receptacles (10) according to one of claims 1 to 15,

in which :

the support surfaces (20) of the plurality of microarray receptacles (10), and / or the bottom foils (36) of the plurality of microarray receptacles (10), and / or the cover foils (38) of the plurality of microarray receptacles (10), and / or the support structures (16 ) of several microarray recordings (10) connected to each other, in particular designed in one piece, are.