EP3883642C0 - Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements - Google Patents
Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elementsInfo
- Publication number
- EP3883642C0 EP3883642C0 EP19809920.2A EP19809920A EP3883642C0 EP 3883642 C0 EP3883642 C0 EP 3883642C0 EP 19809920 A EP19809920 A EP 19809920A EP 3883642 C0 EP3883642 C0 EP 3883642C0
- Authority
- EP
- European Patent Office
- Prior art keywords
- ttfields
- arrays
- elements
- selectively addressable
- tumor treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000003491 array Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Developmental Disabilities (AREA)
- Psychiatry (AREA)
- Social Psychology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Electrotherapy Devices (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21188977.9A EP3922301B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP22150741.1A EP4019080A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188976.1A EP3922300B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862769319P | 2018-11-19 | 2018-11-19 | |
PCT/IB2019/059895 WO2020104921A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Related Child Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21188976.1A Division EP3922300B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188976.1A Division-Into EP3922300B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188977.9A Division-Into EP3922301B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188977.9A Division EP3922301B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP22150741.1A Division-Into EP4019080A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP22150741.1A Division EP4019080A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3883642A1 EP3883642A1 (en) | 2021-09-29 |
EP3883642C0 true EP3883642C0 (en) | 2024-02-21 |
EP3883642B1 EP3883642B1 (en) | 2024-02-21 |
Family
ID=68699487
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22150741.1A Pending EP4019080A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP19809920.2A Active EP3883642B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188977.9A Active EP3922301B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188976.1A Active EP3922300B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22150741.1A Pending EP4019080A1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21188977.9A Active EP3922301B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP21188976.1A Active EP3922300B1 (en) | 2018-11-19 | 2019-11-18 | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
Country Status (10)
Country | Link |
---|---|
US (1) | US11395916B2 (en) |
EP (4) | EP4019080A1 (en) |
JP (2) | JP7451511B2 (en) |
KR (1) | KR20210094579A (en) |
CN (1) | CN113015553A (en) |
CA (1) | CA3110448C (en) |
IL (1) | IL280843A (en) |
MX (1) | MX2021002624A (en) |
PL (1) | PL3922301T3 (en) |
WO (1) | WO2020104921A1 (en) |
Families Citing this family (45)
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US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
WO2018002879A1 (en) | 2016-06-30 | 2018-01-04 | Zeev Bomzon | Arrays for longitudinal delivery of ttfields to a body |
CN110178029B (en) | 2017-01-19 | 2021-11-16 | 诺沃库勒有限责任公司 | System for observing cell cultures under a microscope while applying TTfields |
US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
WO2020075537A1 (en) * | 2018-10-12 | 2020-04-16 | 株式会社村田製作所 | Temperature sensor device |
US11154707B2 (en) | 2018-10-15 | 2021-10-26 | Novocure Gmbh | Generating tumor treating fields (TTFields) with high uniformity throughout the brain |
PL3922301T3 (en) | 2018-11-19 | 2024-06-10 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP3886978B1 (en) | 2018-11-29 | 2024-04-03 | Novocure GmbH | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
CN113573774A (en) | 2019-02-26 | 2021-10-29 | 诺沃库勒有限责任公司 | Determining frequency of TTfield therapy based on electrical properties of targeted cancer cells |
EP3917423A1 (en) | 2019-02-27 | 2021-12-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
EP3988099B1 (en) | 2019-03-29 | 2023-06-07 | Novocure GmbH | Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors |
WO2020212824A1 (en) | 2019-04-17 | 2020-10-22 | Yoram Wasserman | Uploading data from an isolated system without compromising isolation |
US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
JP2022545794A (en) | 2019-08-30 | 2022-10-31 | ノボキュア ゲーエムベーハー | Application of tumor therapeutic fields (TTFields) to the neck |
JP2023507464A (en) | 2019-12-20 | 2023-02-22 | ノボキュア ゲーエムベーハー | Treatment assembly for providing a tumor therapeutic electric field to an animal test subject |
DK4074367T3 (en) | 2019-12-31 | 2023-05-22 | Novocure Gmbh | ARRAYS FOR DELIVERY OF TUMOR TREATMENT FIELDS (TT FIELDS) WITH INDIVIDUALLY AVAILABLE ELECTRODE ELEMENTS AND TEMPERATURE SENSORS |
IL294284A (en) | 2019-12-31 | 2022-08-01 | Novocure Gmbh | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
WO2022064339A1 (en) * | 2020-09-25 | 2022-03-31 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
EP4182009A1 (en) * | 2020-09-30 | 2023-05-24 | Novocure Gmbh | Connector for detachable array |
TW202214317A (en) * | 2020-09-30 | 2022-04-16 | 瑞士商諾沃庫勒有限責任公司 | Connector for detachable array |
US20220096829A1 (en) * | 2020-09-30 | 2022-03-31 | Novocure Gmbh | Method and apparatus for delivering tumor treating fields to a torso, and method for determining locations for transducers to deliver tumor treating fields |
WO2022130183A2 (en) * | 2020-12-17 | 2022-06-23 | Novocure Gmbh | Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields) |
EP4282465A3 (en) * | 2020-12-21 | 2024-02-28 | Novocure GmbH | Optimization of composite electrode |
US20220241603A1 (en) * | 2021-02-03 | 2022-08-04 | Novocure Gmbh | Varying Parameters of Tumor Treating Fields (TTFields) Treatment to Overcome Treatment Resistance |
WO2022175803A1 (en) * | 2021-02-17 | 2022-08-25 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
WO2022201060A1 (en) | 2021-03-23 | 2022-09-29 | Novocure Gmbh | Method and apparatus for detecting and responding to changes in subjects |
CN117615816A (en) * | 2021-06-30 | 2024-02-27 | 诺沃库勒有限责任公司 | System for delivering Tumor Treatment Field (TTFIELD) and measuring impedance |
WO2023275749A1 (en) * | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using capacitors to regulate current in transducer arrays for applying tumor treating fields (ttfields) |
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WO2020086753A1 (en) | 2018-10-23 | 2020-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields |
EP3870271A1 (en) | 2018-10-25 | 2021-09-01 | Zeev Bomzon | Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy |
US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
PL3922301T3 (en) | 2018-11-19 | 2024-06-10 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP3886978B1 (en) | 2018-11-29 | 2024-04-03 | Novocure GmbH | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
EP3909015A1 (en) | 2019-01-08 | 2021-11-17 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
CN113613628A (en) | 2019-02-22 | 2021-11-05 | 诺沃库勒有限责任公司 | Treatment of gastric cancer using TTfields in combination with XELOX or FOLFOX |
CN113573774A (en) | 2019-02-26 | 2021-10-29 | 诺沃库勒有限责任公司 | Determining frequency of TTfield therapy based on electrical properties of targeted cancer cells |
EP3917423A1 (en) | 2019-02-27 | 2021-12-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
EP3988099B1 (en) | 2019-03-29 | 2023-06-07 | Novocure GmbH | Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors |
US20210177492A1 (en) | 2019-12-16 | 2021-06-17 | Loyalty Based Innovations, LLC | Apparatus and method for optimizing and adapting treatment of multiple tumors in patients with metastatic disease by electric field |
-
2019
- 2019-11-18 PL PL21188977.9T patent/PL3922301T3/en unknown
- 2019-11-18 CN CN201980076291.3A patent/CN113015553A/en active Pending
- 2019-11-18 KR KR1020217018534A patent/KR20210094579A/en not_active Application Discontinuation
- 2019-11-18 WO PCT/IB2019/059895 patent/WO2020104921A1/en unknown
- 2019-11-18 EP EP22150741.1A patent/EP4019080A1/en active Pending
- 2019-11-18 CA CA3110448A patent/CA3110448C/en active Active
- 2019-11-18 EP EP19809920.2A patent/EP3883642B1/en active Active
- 2019-11-18 MX MX2021002624A patent/MX2021002624A/en unknown
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- 2019-11-18 US US16/686,918 patent/US11395916B2/en active Active
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EP3922300A1 (en) | 2021-12-15 |
JP7451511B2 (en) | 2024-03-18 |
US20220409893A1 (en) | 2022-12-29 |
KR20210094579A (en) | 2021-07-29 |
EP3922300C0 (en) | 2024-03-06 |
US20200155835A1 (en) | 2020-05-21 |
CA3110448A1 (en) | 2020-05-28 |
JP2022505028A (en) | 2022-01-14 |
PL3922301T3 (en) | 2024-06-10 |
EP3883642A1 (en) | 2021-09-29 |
WO2020104921A1 (en) | 2020-05-28 |
EP3922301A1 (en) | 2021-12-15 |
JP2024055977A (en) | 2024-04-19 |
MX2021002624A (en) | 2021-05-12 |
CA3110448C (en) | 2023-12-19 |
EP3883642B1 (en) | 2024-02-21 |
US11395916B2 (en) | 2022-07-26 |
IL280843A (en) | 2021-04-29 |
EP4019080A1 (en) | 2022-06-29 |
EP3922301B1 (en) | 2024-02-21 |
EP3922300B1 (en) | 2024-03-06 |
CN113015553A (en) | 2021-06-22 |
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