EP3876945A4 - Behandlung und hemmung von fibrose bei patienten mit nicht alkoholbedingter fettleber - Google Patents

Behandlung und hemmung von fibrose bei patienten mit nicht alkoholbedingter fettleber Download PDF

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Publication number
EP3876945A4
EP3876945A4 EP19881364.4A EP19881364A EP3876945A4 EP 3876945 A4 EP3876945 A4 EP 3876945A4 EP 19881364 A EP19881364 A EP 19881364A EP 3876945 A4 EP3876945 A4 EP 3876945A4
Authority
EP
European Patent Office
Prior art keywords
fibrosis
inhibition
treatment
liver disease
fatty liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19881364.4A
Other languages
English (en)
French (fr)
Other versions
EP3876945A1 (de
Inventor
Liat Hayardeny-Nissimov
Tali GORFINE
Allen BAHARAFF
Jose M. Mato De La Paz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galmed Research and Development Ltd
Original Assignee
Galmed Research and Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/182,767 external-priority patent/US20190175619A1/en
Application filed by Galmed Research and Development Ltd filed Critical Galmed Research and Development Ltd
Publication of EP3876945A1 publication Critical patent/EP3876945A1/de
Publication of EP3876945A4 publication Critical patent/EP3876945A4/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19881364.4A 2018-11-07 2019-10-16 Behandlung und hemmung von fibrose bei patienten mit nicht alkoholbedingter fettleber Withdrawn EP3876945A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/182,767 US20190175619A1 (en) 2016-11-10 2018-11-07 Treatment of fibrosis, and inhibition of fibrosis in non-alcoholic fatty liver disease patients
PCT/IL2019/051121 WO2020095293A1 (en) 2018-11-07 2019-10-16 Treatment and inhibition of fibrosis in non-alcoholic fatty liver disease patients

Publications (2)

Publication Number Publication Date
EP3876945A1 EP3876945A1 (de) 2021-09-15
EP3876945A4 true EP3876945A4 (de) 2022-08-24

Family

ID=70611747

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19881364.4A Withdrawn EP3876945A4 (de) 2018-11-07 2019-10-16 Behandlung und hemmung von fibrose bei patienten mit nicht alkoholbedingter fettleber

Country Status (8)

Country Link
EP (1) EP3876945A4 (de)
CN (1) CN113301902A (de)
AU (1) AU2019376907B2 (de)
BR (1) BR112021008896A2 (de)
CA (1) CA3117958A1 (de)
IL (1) IL282854B (de)
MX (1) MX2021005420A (de)
WO (1) WO2020095293A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11197870B2 (en) * 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
US20190175619A1 (en) * 2016-11-10 2019-06-13 Galmed Research And Development Ltd. Treatment of fibrosis, and inhibition of fibrosis in non-alcoholic fatty liver disease patients
CA3152584C (en) * 2016-11-10 2024-02-13 Galmed Research And Development Ltd. Treatment for fibrosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
IL282854A (en) 2021-06-30
IL282854B (en) 2021-12-01
EP3876945A1 (de) 2021-09-15
CA3117958A1 (en) 2020-05-14
AU2019376907A1 (en) 2021-06-24
BR112021008896A2 (pt) 2021-08-10
CN113301902A (zh) 2021-08-24
WO2020095293A1 (en) 2020-05-14
MX2021005420A (es) 2021-09-10
AU2019376907B2 (en) 2024-10-10

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