EP3853354A4 - NK CELLS DERIVED FROM MONONUCLEAR CELLS - Google Patents

NK CELLS DERIVED FROM MONONUCLEAR CELLS Download PDF

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Publication number
EP3853354A4
EP3853354A4 EP19936966.1A EP19936966A EP3853354A4 EP 3853354 A4 EP3853354 A4 EP 3853354A4 EP 19936966 A EP19936966 A EP 19936966A EP 3853354 A4 EP3853354 A4 EP 3853354A4
Authority
EP
European Patent Office
Prior art keywords
cells
cell derived
mononuclear cell
mononuclear
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19936966.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3853354A1 (en
Inventor
Rohit Duggal
Ranjeet SINHA
Wenzhao Li
Jason ISAACSON
Karl MARQUEZ
Patrick Soon-Shiong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunitybio Inc
Original Assignee
Immunitybio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunitybio Inc filed Critical Immunitybio Inc
Publication of EP3853354A1 publication Critical patent/EP3853354A1/en
Publication of EP3853354A4 publication Critical patent/EP3853354A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP19936966.1A 2019-07-08 2019-07-08 NK CELLS DERIVED FROM MONONUCLEAR CELLS Pending EP3853354A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/040867 WO2021006875A1 (en) 2019-07-08 2019-07-08 Mononuclear cell derived nk cells

Publications (2)

Publication Number Publication Date
EP3853354A1 EP3853354A1 (en) 2021-07-28
EP3853354A4 true EP3853354A4 (en) 2022-04-20

Family

ID=74114919

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19936966.1A Pending EP3853354A4 (en) 2019-07-08 2019-07-08 NK CELLS DERIVED FROM MONONUCLEAR CELLS

Country Status (9)

Country Link
EP (1) EP3853354A4 (zh)
JP (2) JP7213976B2 (zh)
KR (1) KR20210080566A (zh)
CN (1) CN113166726A (zh)
AU (1) AU2019456283B2 (zh)
CA (1) CA3120695A1 (zh)
IL (1) IL283998A (zh)
SG (1) SG11202104339WA (zh)
WO (1) WO2021006875A1 (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180355317A1 (en) * 2016-02-15 2018-12-13 Dong Hyuk Shin Method of culturing nk cells and kits containing medium addtions therefore

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101881520B1 (ko) * 2009-03-26 2018-07-24 셀프로텍트 노딕 파머수티컬스 에이비 Ｎｋ 세포의 증식
KR101947588B1 (ko) 2009-12-04 2019-02-14 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 인간 배아줄기세포 유래된 혈액모세포로부터 자연 살해 세포 및 수지상 세포를 생성하는 방법
EP2539442A1 (en) 2010-02-24 2013-01-02 Ingo Schmidt-Wolf Method for the generation of a cik cell and nk cell population
EP4385570A2 (en) 2010-09-21 2024-06-19 Altor BioScience, LLC Multimeric il-15 soluble fusion molecules and methods of making and using same
EP2666466A4 (en) * 2011-01-21 2014-11-05 Biotherapy Inst Of Japan PROCESS FOR THE PRODUCTION OF BLOOD PREPARATION ENRICHED IN NK CELLS
WO2012128622A1 (en) 2011-03-18 2012-09-27 Ipd-Therapeutics B.V. Generation of nk cells and nk-cell progenitors
DK2812011T3 (da) 2012-02-08 2020-02-24 Glycostem Therapeutics B V Differentiering ex vivo af nk-celler fra cd34+ hæmatopoietiske celler
CN102988415B (zh) 2012-08-15 2014-11-19 中航（宁夏）生物有限责任公司 人异基因有核细胞工业化制备自然杀伤性细胞(nk)及注射液
JP6719387B2 (ja) 2014-04-28 2020-07-08 ビババイオセル エスピーエー 自動細胞培養及び回収装置
US20200179447A1 (en) * 2016-09-23 2020-06-11 The Regents Of The University Of California Autologous irradiated whole cell tumor vaccines lentivirally engineered to express cd80, il-15 and il-15 receptor alpha
AU2017342560B2 (en) 2016-10-14 2022-03-17 Xencor, Inc. IL15/IL15Ralpha heterodimeric Fc-fusion proteins
EA201991632A1 (ru) * 2017-02-28 2020-03-12 Аффимед Гмбх Комбинация антитела против cd16a с цитокином
CA3055318A1 (en) 2017-03-06 2018-09-13 Altor Bioscience Corporation Il-15-based fusions to il-12 and il-18
CA3060044A1 (en) * 2017-05-11 2018-11-15 Nantkwest, Inc. Anti-egfr/high affinity nk-cells compositions and methods for chordoma treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180355317A1 (en) * 2016-02-15 2018-12-13 Dong Hyuk Shin Method of culturing nk cells and kits containing medium addtions therefore

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HONG-RAE LEE ET AL: "Expansion of cytotoxic natural killer cells using irradiated autologous peripheral blood mononuclear cells and anti-CD16 antibody", SCIENTIFIC REPORTS, vol. 7, no. 1, 11 September 2017 (2017-09-11), XP055762396, DOI: 10.1038/s41598-017-09259-1 *

Also Published As

Publication number Publication date
CA3120695A1 (en) 2021-01-14
IL283998A (en) 2021-07-29
KR20210080566A (ko) 2021-06-30
JP7213976B2 (ja) 2023-01-27
SG11202104339WA (en) 2021-05-28
EP3853354A1 (en) 2021-07-28
WO2021006875A1 (en) 2021-01-14
CN113166726A (zh) 2021-07-23
AU2019456283A1 (en) 2021-05-20
JP2023040184A (ja) 2023-03-22
JP2022513614A (ja) 2022-02-09
AU2019456283B2 (en) 2023-06-08

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