EP3838410A1 - Pneumatisch betätigcare papier-basierte vorrichtung - Google Patents

Pneumatisch betätigcare papier-basierte vorrichtung Download PDF

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Publication number
EP3838410A1
EP3838410A1 EP20213732.9A EP20213732A EP3838410A1 EP 3838410 A1 EP3838410 A1 EP 3838410A1 EP 20213732 A EP20213732 A EP 20213732A EP 3838410 A1 EP3838410 A1 EP 3838410A1
Authority
EP
European Patent Office
Prior art keywords
membrane
substrate
layer
zone
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20213732.9A
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English (en)
French (fr)
Inventor
Raphaël TROUILLON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
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Publication of EP3838410A1 publication Critical patent/EP3838410A1/de
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/126—Paper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Definitions

  • the present invention relates to a pneumatically actuated device.
  • This device has the particularity of having at least one paper-based substrate.
  • a pneumatically actuated device can be, for example, a mechanical actuator or a fluidic valve.
  • microfluidic devices provided with a paper-based substrate having a hydrophobic surface treatment.
  • Such solutions are in particular described in the patent application WO2013 / 181656A1 and in the patent application EP3053652A1 .
  • the microfluidic circuit produced by embossing can be closed from above with a transparent adhesive film using mainly materials based on poly (ethylene terephthalate) (PET) or ethylene vinyl acetate. (EVA).
  • PET poly (ethylene terephthalate)
  • EVA ethylene vinyl acetate.
  • the aim of the invention is therefore to provide such a device.
  • This device has the particularity of comprising at least one paper-based substrate.
  • the first substrate comprises a recess made on its second layer and into which the said control orifice emerges.
  • the membrane is produced in the form of an integral layer deposited over the entire external surface of the second layer of the first substrate, covering said recess.
  • the first substrate comprises a cavity produced opposite the zone of deformation of the membrane, the membrane and the cavity delimiting a chamber, called the first chamber, of non-zero volume, said control orifice. opening inside said cavity.
  • the membrane is produced in the form of an integral layer deposited on the external surface of the second layer of the first substrate, covering said cavity.
  • the device comprises a plate provided with an opening, said plate being applied against the membrane, its opening being cut out to define said zone of deformation of the membrane.
  • the membrane is made of a material of silicone polymer or polysiloxane type.
  • the invention also relates to an actuation system comprising pneumatic equipment and at least one pneumatically actuated device as defined above, said pneumatic equipment being connected to the control orifice of the device in order to be able to control a deformation of the device. the membrane.
  • the system comprises several juxtaposed pneumatically actuated devices produced in the same substrate, said substrate comprising several juxtaposed cavities, a single membrane common to all the devices covering all of the cavities produced.
  • the system comprises several juxtaposed actuation devices produced in the same substrate, said substrate comprising a common cavity, a single membrane common to all the devices covering said cavity and a plate deposited on said membrane comprising several juxtaposed openings. defining several zones of deformation of the membrane.
  • the membrane is deposited by thermal sealing.
  • the first substrate comprises a cavity produced by embossing said first substrate.
  • the method comprises a step of affixing a plate on said membrane, said plate being provided with an opening cut to define the zone of deformation of the membrane.
  • the pneumatically actuated device of the invention comprises a substrate 2 formed of at least two layers 20, 21, advantageously only two layers.
  • the paper used is sold under the trademark “Powercoat” (registered trademark) having a basis weight of 219 g / m 2 .
  • the second layer 21 of the substrate 2 is deposited on the first layer of “Powercoat”.
  • the second layer 21 is advantageously a vinylidene polymer, advantageously polyvinylidene chloride (hereinafter PVDC) or polyvinylidene fluoride (PVDF), advantageously polyvinylidene chloride. In the remainder of the description, it is chosen to use a second layer 21 based on PVDC.
  • PVDC polyvinylidene chloride
  • PVDF polyvinylidene fluoride
  • PVDC layer 21 can thus be deposited on this new substrate (P5N coated with PVDC at 12 gm -2 ).
  • the figure 1 shows an example of the process for manufacturing substrate 2.
  • the layer 21 of PVDC is deposited on the first layer 20 of paper by coating.
  • the PVDC layer is deposited at a thickness between 5 and 20 ⁇ m, which corresponds to basis weights between 15 and 25 g / m 2 .
  • This technique makes it possible to deposit a preparation based on PVDC on the paper then to scrape the excess to keep only a thin functional layer. Drying is then carried out to evaporate the excess water. Drying can be carried out at room temperature; it is possible to carry it out at temperatures up to 70 ° C or even 90 ° C to speed up the process.
  • the PVDC used can be a commercial aqueous emulsion named Diofan A050 (Solvay-registered trademark).
  • such a two-layer substrate 2 may be referenced 2.1 and 2.2.
  • the figure 2 illustrates an alternative embodiment of the method of figure 1 .
  • This variant embodiment consists in using a mask 28 deposited on the first layer 20, in order to produce a recess at the level of the second layer, over its entire thickness, and to delimit an uncoated zone.
  • step E20 The mask 28 is deposited on the first layer 20.
  • the coating principle is then similar to that described for step E10 above.
  • the figure 3 illustrates the principle of embossing a substrate 2 obtained.
  • This step consists of embossing the substrate 2 in order to functionalize it.
  • the embossing is carried out on the upper face of its second layer 21.
  • the embossing can consist in placing the substrate between two dies of a press, a lower die M1 in hollow and an upper die M2 in relief. During the press, the reliefs are duplicated on said upper face of the substrate so as to form an imprint. Other techniques can of course be considered.
  • a hollow or concavity pattern is produced by embossing said substrate 2, for example forming a cavity 22 as shown in Figure figure 3 .
  • E32 A substrate 2 is thus obtained provided with the cavity 22 obtained by embossing.
  • the cavity 22 may have a hollow shape of constant section over its entire height, with a circular contour. In this case, it may for example have a diameter of 8mm and a depth of 0.5mm.
  • the embossing can thus make it possible to produce a pattern forming a concavity on the upper face of the second layer of the substrate.
  • This concavity can be in any possible form. It will be seen that it can for example take the form of a longitudinal channel, for example with a square section.
  • first substrate 2.1 When the device has only one substrate, the latter is referenced 2.1.
  • second substrate 2.2 When the device comprises two substrates, these are designated first substrate 2.1 and second substrate 2.2.
  • the microfluidic device of the invention may be produced by combining a first substrate 2.1 and a second substrate 2.2 produced according to the different variants shown respectively on the figure. figure 4 for the first substrate 2.1 and on the figure 5 for the second substrate 2.2:
  • the displacement of the membrane 3 can be controlled by pressure and / or vacuum, depending on the operation envisaged;
  • each substrate used may or may not have a concavity.
  • Each concavity can be produced by embossing according to the principle described above in conjunction with the figure 3 .
  • the membrane 3 is for example composed of a film made from a hyper-elastic two-component polymer material, for example a silicone or polysiloxane polymer. It may in particular be an elastomer of PDMS (for Polydimethylsiloxane) or ECOFLEX type (trademark registered by the company “Smooth-On” - for example Ecoflex 00-50). Its thickness can be between 20 and 500 ⁇ m.
  • the membrane 3 may be in the form of an integral layer interposed between the two substrates or of a pellet or disc deposited in a localized manner between the two substrates and coming to adhere to only part of each external surface of the two substrates.
  • the device of the invention is intended for use in a system integrating pneumatic equipment 5.
  • the pneumatic equipment 5 may include a pump capable of sucking or injecting air to control the displacement of the membrane.
  • the system may also include a control unit responsible for controlling said pump.
  • the fixing of the membrane 3 on the second PVDC layer 21 of a substrate and the assembly between two substrates by their second layer can be carried out.
  • any known solution for example by gluing, advantageously by thermal sealing.
  • the thermal sealing will be carried out by keeping the layers against each other, for example substrate + membrane or substrate + substrate, for a determined period (for example 20 minutes) and at a suitable temperature, which can range from 130 ° C and 170 ° C. During the sealing time, the temperature can be kept constant or vary in the range from 130 ° C to 170 ° C.
  • the device is of the mechanical actuator type. It is made from a flat substrate 2.1 (without cavity) provided with a recess 29.1 (V2), and a membrane 3.
  • the membrane 3 is applied by its lower face against the upper face of the second PVDC layer of the substrate 2.1, leaving a zone of the membrane free at the level of the recess 29.1 of the substrate 2.1, this zone forming the deformation zone of the membrane 3.
  • This deformation zone is intended to remain free with respect to the substrate 2.1.
  • the zone of deformation of the membrane can be in the form of a disc.
  • the substrate 2.1 is pierced with the orifice 270.1 forming the control channel, advantageously in the axis of the deformation zone of the membrane 3.
  • a nozzle can be added through the control channel to allow the connection of a connector intended to be connected to the pneumatic equipment 5.
  • the orifice may have a diameter of 3.5mm.
  • the membrane 3 when the pneumatic equipment 5 injects air through the control channel, the membrane 3 is deformed, for example forming a dome at its deformation zone. When the pump is stopped, the membrane 3 returns to its initial position against the upper face of the substrate 2.1, by a simple elastic effect.
  • the device is a variant of that described above in conjunction with the figures 6 and 7 .
  • the device may also include a plate 4 affixed against the upper face of the membrane 3 (V3).
  • This plate 4 can be made of plastic material or any other rigid or semi-rigid material.
  • An advantageous option is to use a plate made of a paper (or any other cellulose-based material) coated with PVDC (according to the principle described in figure 1 ). This plate 4 can then be heat sealed / glued to the upper face of the membrane 2. This approach makes it possible to reduce the mass of plastic polymers in the system.
  • the paper used as the plate can be P5N (industrially coated tracing paper of PVDC at 5 g / m 2 sec) with an additional adhesion layer of PVDC (12 g / m 2 sec).
  • the plate 4 comprises an opening 40, the section of which is configured to define the zone of deformation of the membrane 3 when the latter is actuated.
  • said opening 40 can take all types of shapes. By way of example, it may be a circular opening 40 (variant V100), in the form of a rectangle (variant V200), eight (variant V300), etc.
  • the figure 9 illustrates the operating principle of the device in its second embodiment.
  • the pump of the pneumatic equipment 5 is connected via a hermetic link on the control channel of the diaphragm 3.
  • the pneumatic equipment 5 injects air through the control channel.
  • the membrane 3 is deformed by following the deformation zone defined by the opening 40 made through the plate 4.
  • the membrane 3 deforms into a dome.
  • the device is of the mechanical actuator type and comprises a single substrate 2.1 (V4).
  • the substrate 2.1 has a recess 29.1 and is embossed so as to create a recess 26.1 around the recess 29.1.
  • the recess may have a circular contour and a depth at least equivalent to the thickness of the membrane 3.
  • E101 The membrane 3, for example in the form of a disc, is housed in the recess 26.1.
  • E102 The membrane 3 housed in the recess is fixed to the upper face of the substrate 2.1, to cover the recess 29.1, leaving its deformation zone free.
  • E103 The orifice 270.1 format the control channel is made through the substrate 2.1, advantageously in the axis of the deformation zone of the membrane.
  • the figure 11 illustrates the operating principle of the device in its third embodiment.
  • the pump of the pneumatic equipment 5 is connected via a hermetic link on the control channel of the diaphragm 3.
  • the pneumatic equipment 5 injects air through the control channel. Pressurized, the membrane 3 deforms at its deformation zone, for example forming a dome.
  • the device is a variant of that described above in connection with the figures 10 and 11 .
  • the device may also include a plate 4 affixed against the upper face of the membrane 3. This plate 4 has the same characteristics as those described above.
  • the plate 4 comprises an opening 40, the section of which is configured to define the zone of deformation of the membrane 3 when the latter is actuated.
  • This opening may for example be narrower than the recess 29.1 made below the membrane 3.
  • said opening 40 can take all types of shapes. By way of example, it may be a circular opening 40 (variant V100), in the form of a rectangle (variant V200), eight (variant V300), etc.
  • the figure 13 illustrates the operating principle of the device in its fourth embodiment.
  • the pump of the pneumatic equipment 5 is connected via a hermetic link on the control channel of the diaphragm 3.
  • the pneumatic equipment 5 injects air through the control channel.
  • the membrane 3 is deformed by following the deformation zone defined by the opening 40 made through the plate 4.
  • the membrane 3 deforms into a dome.
  • the device is of the mechanical actuator type and comprises a single substrate 2.1 (V5).
  • Substrate 2.1 has a cavity 22.1.
  • the cavity can be produced by embossing according to the principle described above in conjunction with the figure 3 .
  • the deformable membrane 3 is deposited on the upper face of the second PVDC layer of the substrate 2 so as to cover the opening of the cavity 22.1 and close the latter.
  • the membrane 3 is affixed hermetically to the surface of the substrate.
  • the cavity and the membrane thus define a chamber 23.1 having an internal space of non-zero volume.
  • the substrate 2.1 is provided with the orifice 270.1, forming the control channel of the membrane 3.
  • the control channel opens into the chamber 23.1 delimited by the cavity 22.1 and the membrane 3.
  • a nozzle can be added through this port to allow the connection of a fitting intended to be connected to the pump of the pneumatic equipment.
  • the figure 15 illustrates the operating principle of the device in its fifth embodiment.
  • the pneumatic equipment pump 5 is connected via a hermetic link on the control channel of the diaphragm 3.
  • the pneumatic equipment 5 injects air through the control channel into the chamber. Pressurized, the membrane 3 deforms at its deformation zone, for example forming a dome.
  • the membrane deforms towards the inside of the cavity 22.1 (in dotted lines on the figure 15 ).
  • the device is a variant (V6) of that described above in connection with the figures 14 and 15 .
  • the device may additionally include a plate 4 affixed against the upper face of the membrane 3. This plate 4 may have the same characteristics as that already described above.
  • the plate 4 comprises an opening 40, the section of which is configured to define the zone of deformation of the membrane 3 when the latter is actuated.
  • said opening 40 can take all types of shapes. By way of example, it may be a circular opening 40 (variant V100), in the form of a rectangle (variant V200), eight (variant V300), etc.
  • the figure 17 illustrates the operating principle of the device in its sixth embodiment.
  • the pump of the pneumatic equipment 5 is connected via a hermetic link on the control channel of the diaphragm 3.
  • the pneumatic equipment 5 injects air through the control channel.
  • the membrane 3 is deformed by following the deformation zone defined by the opening 40 made through the plate 4.
  • the membrane 3 deforms into a dome.
  • the membrane deforms towards the inside of the cavity 22.1 (in dotted lines on the figure 17 ).
  • the device is of the fluidic type and comprises two substrates 2.1, 2.2.
  • Two orifices 240.2, 250.2 are for example made through the second substrate, each opening into the chamber 23.2.
  • the operation could be reversed.
  • the control is carried out on the side of the second substrate 2.2 and the fluid is sucked through the first substrate 2.1. A single orifice through each substrate is then sufficient.
  • the device is an evolution of that described above in connection with the figures 18 and 19 (V4 and V10).
  • the device has two substrates 2.1, 2.2.
  • the first substrate 2.1 has a recess 29.1 and is embossed so as to create a recess 26.1 around its recess 29.1.
  • the recess 26.1 may have a circular contour and a depth at least equivalent to the thickness of the membrane 3.
  • the second substrate 2.2 has a cavity 22.2, for example produced by embossing according to the principle described above in connection with the figure 3 .
  • the two PVDC layers of the two substrates 2.1, 2.2 face each other.
  • the membrane 3 for example in the form of a disc or pellet, is housed in the recess 26.1 and covers said recess 29.1.
  • the membrane 3 housed in the recess is fixed by its lower face to the upper face of the second layer of the first substrate 2.1, on a part peripheral to the recess 29.1.
  • the membrane 3 is also affixed by its upper layer to the lower PVDC layer of the second substrate 2.2 at the periphery of its cavity 22.2 to cover the latter and close it hermetically, forming the chamber 23.2.
  • E202 The orifice 270.1, forming the control channel, is made through the first substrate 2.1, advantageously in the axis of the deformation zone of the membrane 3.
  • Two orifices 240.2, 250.2 are for example made through the second substrate 2.2, each opening into the chamber 23.2.
  • the device could be reversed.
  • the control is then carried out on the side of the second substrate 2.2 and the fluid is sucked through the first substrate 2.1. A single orifice through each substrate would then be sufficient.
  • This realization is a variant of that of figures 20 and 21 . It has two substrates 2.1, 2.2 (V2 and V11).
  • the device has two substrates 2.1, 2.2.
  • the first substrate 2.1 is flat and provided with a recess 29.1.
  • the second substrate 2.2 has a cavity 22.2, for example produced by embossing according to the principle described above in connection with the figure 3 as well as an annular counterbore 27.2 produced at the periphery of the cavity 22.2 and on which the membrane 3 will bear support.
  • the counterbore can also be produced by embossing according to the same principle.
  • the counterbore may have a depth at least equivalent to the thickness of the membrane 3.
  • the two PVDC layers of the two substrates 2.1, 2.2 face each other.
  • the membrane 3 for example in the form of a disc, comes to bear and is fixed by its periphery on the counterbore 27.2, thus covering the cavity 22.2 and closing it hermetically, forming the chamber 23.2.
  • the membrane 3 thus housed is fixed to the upper face of the first substrate 2.1, by a zone peripheral to its recess 29.1, leaving its deformation zone free.
  • E221 The membrane 3 is thus held between the two substrates 2.1, 2.2, while retaining its free deformation zone towards the interior of the cavity 22.2.
  • E222 The orifice 270.1, forming the control channel, is made through the first substrate 2.1, advantageously in the axis of the deformation zone of the membrane 3.
  • Two orifices 240.2, 250.2 are for example made through the second substrate 2.2, each opening into the chamber 23.2.
  • this counterboring principle to house the membrane 3 can be applied to other embodiments described, to replace the full deposition of the membrane 3 over the entire substrate.
  • a membrane is then used in the form of a pellet or a disc which is positioned on the edge of the cavity.
  • the device could be reversed.
  • the control is then carried out on the side of the second substrate 2.2 via an orifice and the fluid is sucked through the first substrate 2.1. A single orifice through each substrate would then be sufficient.
  • the device is of the fluidic valve type and comprises two substrates 2.1, 2.2 (V6 and V10).
  • the first substrate 2.1 and the second substrate 2.2 are each provided with a cavity 22.1, 22.2, for example produced by embossing according to the principle described above in connection with the figure 3 .
  • the second embossed substrate 2.2 is turned over with respect to the first substrate 2.1 so as to present its second layer 21.2 of PVDC facing the second layer 21.1 of PVDC of the first substrate 2.1.
  • the membrane 3 is in the form of an integral layer interposed between the two substrates.
  • E242 The three elements are assembled together.
  • the membrane 3 thus adheres to the two layers of PVDC around the two cavities and thus delimits two spaces 230.1, 230.2 which are hermetic with respect to one another.
  • the second substrate 2.2 is pierced with two orifices 240.2, 250.2 each opening independently into the second space 230.2. Each orifice forms a fluid inlet / outlet channel. A nipple can be fitted through each port to connect a hose to it.
  • the first substrate 2.1 is pierced with a single orifice 270.1 opening into the first space 230.1. This orifice forms the control fluid inlet / outlet control channel making it possible to actuate the membrane 3.
  • a nozzle can be added through this orifice to allow the connection of a fitting intended to be connected to pneumatic equipment.
  • the figure 26 illustrates the production of several actuator-type devices in accordance with the invention on the same paper-based substrate 2. Each device can for example be addressed individually by the pneumatic equipment 5. The same membrane 3 can be used for all the devices and the same plate 4 provided with several openings 40 can be used to cover the entire membrane 3.
  • state E260 all actuators are at rest.
  • state E261 the pneumatic equipment 5 controls the actuation of the membrane at the level of the actuator A2 and the actuator A3.
  • the figure 27 is an alternative embodiment of the solution of the figure 26 .
  • a single cavity 23.1 is made in the first substrate. Air injection is common and makes it possible to actuate several actuators A1, A2, A2 at once.
  • the plate 4 and its openings 40a, 40b, 40c make it possible to define the zones of deformation of the membrane 3. In state E270, all the actuators are at rest. In state E271, all actuators are active. The membrane 3 is deformed at the level of the three openings 40a, 40b, 40c made through the plate 4.
  • the figure 28 illustrates the production on the same support of several devices of the microfluidic valve type.
  • the support of all the valves is composed of two substrates 2.1, 2.2 only, each embossed with several cavities to form each valve.
  • a membrane common to all the valves is interposed between the two substrates.
  • Each valve can for example be addressed individually by the pneumatic equipment 5.
  • the figure 30 illustrates an example of application of a device of the invention used as a mechanical actuator. This application consists for example in switching an electric switch 6.
  • E301 The membrane 3 is deformed and pushes the switch 6 to its closed position, allowing the electrical circuit to be closed.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reciprocating Pumps (AREA)
  • Delivering By Means Of Belts And Rollers (AREA)
EP20213732.9A 2019-12-20 2020-12-14 Pneumatisch betätigcare papier-basierte vorrichtung Pending EP3838410A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1915056A FR3105024B1 (fr) 2019-12-20 2019-12-20 Dispositif à actionnement pneumatique à substrats à base de papier

Publications (1)

Publication Number Publication Date
EP3838410A1 true EP3838410A1 (de) 2021-06-23

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FR (1) FR3105024B1 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181656A1 (en) 2012-06-01 2013-12-05 President And Fellows Of Harvard College Microfluidic devices formed from hydrophobic paper
EP3053652A1 (de) 2015-02-03 2016-08-10 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Mikrofluidik-vorrichtung und verfahren zur realisierung einer mikrofluidik-vorrichtung
WO2018197814A1 (fr) * 2017-04-27 2018-11-01 bioMérieux Plaque d'analyse maldi-tof a support papier et son utilisation
EP3488929A1 (de) * 2017-11-28 2019-05-29 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Injektionsvorrichtung für eine flüssige probe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181656A1 (en) 2012-06-01 2013-12-05 President And Fellows Of Harvard College Microfluidic devices formed from hydrophobic paper
EP3053652A1 (de) 2015-02-03 2016-08-10 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Mikrofluidik-vorrichtung und verfahren zur realisierung einer mikrofluidik-vorrichtung
WO2018197814A1 (fr) * 2017-04-27 2018-11-01 bioMérieux Plaque d'analyse maldi-tof a support papier et son utilisation
EP3488929A1 (de) * 2017-11-28 2019-05-29 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Injektionsvorrichtung für eine flüssige probe

Also Published As

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FR3105024B1 (fr) 2022-04-15
FR3105024A1 (fr) 2021-06-25

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