EP3821911A4 - Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé - Google Patents

Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé Download PDF

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Publication number
EP3821911A4
EP3821911A4 EP19833361.9A EP19833361A EP3821911A4 EP 3821911 A4 EP3821911 A4 EP 3821911A4 EP 19833361 A EP19833361 A EP 19833361A EP 3821911 A4 EP3821911 A4 EP 3821911A4
Authority
EP
European Patent Office
Prior art keywords
doxorubicin
drug
preparation
nucleic acid
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19833361.9A
Other languages
German (de)
English (en)
Other versions
EP3821911A1 (fr
Inventor
Liyuan Wang
Meng Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bai Yao Zhi Da Beijing Nanobio Tech Co Ltd
Bai Yao Zhi Da Beijing Nanobio Technology Co Ltd
Original Assignee
Bai Yao Zhi Da Beijing Nanobio Tech Co Ltd
Bai Yao Zhi Da Beijing Nanobio Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bai Yao Zhi Da Beijing Nanobio Tech Co Ltd, Bai Yao Zhi Da Beijing Nanobio Technology Co Ltd filed Critical Bai Yao Zhi Da Beijing Nanobio Tech Co Ltd
Publication of EP3821911A1 publication Critical patent/EP3821911A1/fr
Publication of EP3821911A4 publication Critical patent/EP3821911A4/fr
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
EP19833361.9A 2018-07-12 2019-07-12 Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé Pending EP3821911A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810765976 2018-07-12
CN201810766003 2018-07-12
PCT/CN2019/095766 WO2020011248A1 (fr) 2018-07-12 2019-07-12 Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé

Publications (2)

Publication Number Publication Date
EP3821911A1 EP3821911A1 (fr) 2021-05-19
EP3821911A4 true EP3821911A4 (fr) 2022-03-09

Family

ID=69142279

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19833361.9A Pending EP3821911A4 (fr) 2018-07-12 2019-07-12 Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé

Country Status (7)

Country Link
US (1) US20220409742A1 (fr)
EP (1) EP3821911A4 (fr)
JP (1) JP7267416B2 (fr)
KR (1) KR102656600B1 (fr)
AU (1) AU2019302604B2 (fr)
TW (1) TWI743518B (fr)
WO (1) WO2020011248A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020064017A1 (fr) * 2018-09-30 2020-04-02 百药智达（北京）纳米生物技术有限公司 Médicament nanoporteur d'acide nucléique, son procédé de préparation, composition pharmaceutique associée, et utilisation correspondante
US20220047617A1 (en) * 2018-10-16 2022-02-17 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. Nucleic acid nanocarrier drug, preparation method, pharmaceutical composition and use thereof
CN111920947B (zh) * 2020-08-17 2022-09-13 福州大学 一种花菁染料介导的核酸/抗癌药物复合物的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170372A2 (fr) * 2011-06-08 2012-12-13 University Of Cincinnati Domaine de jonction multivalente d'arnp pour l'utilisation dans des nanoparticules multivalentes stables d'arn
WO2016145003A1 (fr) * 2015-03-09 2016-09-15 University Of Kentucky Research Foundation Nanoparticules d'arn pour le traitement du cancer gastrique
WO2017147557A1 (fr) * 2016-02-26 2017-08-31 The Board Of Regents Of The University Of Oklahoma Nouvelles jonctions trois voies d'arnp
WO2020064017A1 (fr) * 2018-09-30 2020-04-02 百药智达（北京）纳米生物技术有限公司 Médicament nanoporteur d'acide nucléique, son procédé de préparation, composition pharmaceutique associée, et utilisation correspondante
WO2020078216A1 (fr) * 2018-10-19 2020-04-23 百药智达（北京）纳米生物技术有限公司 Médicament nanoporteur d'acide nucléique et procédé de préparation associé
WO2020078219A1 (fr) * 2018-10-16 2020-04-23 百药智达（北京）纳米生物技术有限公司 Médicament à nanosupport d'acide nucléique, procédé de préparation associé et composition pharmaceutique et application correspondantes

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US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
JP2003522524A (ja) * 1999-11-13 2003-07-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 高次核酸型構造体

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170372A2 (fr) * 2011-06-08 2012-12-13 University Of Cincinnati Domaine de jonction multivalente d'arnp pour l'utilisation dans des nanoparticules multivalentes stables d'arn
WO2016145003A1 (fr) * 2015-03-09 2016-09-15 University Of Kentucky Research Foundation Nanoparticules d'arn pour le traitement du cancer gastrique
WO2017147557A1 (fr) * 2016-02-26 2017-08-31 The Board Of Regents Of The University Of Oklahoma Nouvelles jonctions trois voies d'arnp
WO2020064017A1 (fr) * 2018-09-30 2020-04-02 百药智达（北京）纳米生物技术有限公司 Médicament nanoporteur d'acide nucléique, son procédé de préparation, composition pharmaceutique associée, et utilisation correspondante
EP3858846A1 (fr) * 2018-09-30 2021-08-04 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. Médicament nanoporteur d'acide nucléique, son procédé de préparation, composition pharmaceutique associée, et utilisation correspondante
WO2020078219A1 (fr) * 2018-10-16 2020-04-23 百药智达（北京）纳米生物技术有限公司 Médicament à nanosupport d'acide nucléique, procédé de préparation associé et composition pharmaceutique et application correspondantes
EP3926047A1 (fr) * 2018-10-16 2021-12-22 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. Médicament à nanosupport d'acide nucléique, procédé de préparation associé et composition pharmaceutique et application correspondantes
WO2020078216A1 (fr) * 2018-10-19 2020-04-23 百药智达（北京）纳米生物技术有限公司 Médicament nanoporteur d'acide nucléique et procédé de préparation associé
EP3851533A1 (fr) * 2018-10-19 2021-07-21 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. Médicament nanoporteur d'acide nucléique et procédé de préparation associé

Non-Patent Citations (2)

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Title
WU DANDAN ET AL: "DNA nanostructure-based drug delivery nanosystems in cancer therapy", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 533, no. 1, 18 September 2017 (2017-09-18), pages 169 - 178, XP085228334, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2017.09.032 *
ZENG YUN ET AL: "Time-lapse live cell imaging to monitor doxorubicin release from DNA origami nanostructures", JOURNAL OF MATERIALS CHEMISTRY. B, vol. 6, no. 11, 21 March 2018 (2018-03-21), GB, pages 1605 - 1612, XP055881837, ISSN: 2050-750X, DOI: 10.1039/C7TB03223D *

Also Published As

Publication number Publication date
KR20210031494A (ko) 2021-03-19
KR102656600B1 (ko) 2024-04-15
TWI743518B (zh) 2021-10-21
AU2019302604A1 (en) 2021-03-11
TW202005638A (zh) 2020-02-01
AU2019302604B2 (en) 2023-11-02
WO2020011248A1 (fr) 2020-01-16
JP7267416B2 (ja) 2023-05-01
JP2021532175A (ja) 2021-11-25
US20220409742A1 (en) 2022-12-29
EP3821911A1 (fr) 2021-05-19

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