EP3765472A4 - High-purity steviol glycosides - Google Patents

High-purity steviol glycosides Download PDF

Info

Publication number
EP3765472A4
EP3765472A4 EP19766689.4A EP19766689A EP3765472A4 EP 3765472 A4 EP3765472 A4 EP 3765472A4 EP 19766689 A EP19766689 A EP 19766689A EP 3765472 A4 EP3765472 A4 EP 3765472A4
Authority
EP
European Patent Office
Prior art keywords
steviol glycosides
purity steviol
purity
glycosides
steviol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19766689.4A
Other languages
German (de)
French (fr)
Other versions
EP3765472A1 (en
Inventor
Avetik Markosyan
Saravanan A/L RAMANDACH
Mohamad AFZAAL BIN HASIM
Khairul NIZAM BIN NAWI
Siew Yin CHOW
Siddhartha Purkayastha
Marcia Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PureCircle USA Inc
Original Assignee
PureCircle USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2018/026920 external-priority patent/WO2019177634A1/en
Application filed by PureCircle USA Inc filed Critical PureCircle USA Inc
Publication of EP3765472A1 publication Critical patent/EP3765472A1/en
Publication of EP3765472A4 publication Critical patent/EP3765472A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
EP19766689.4A 2018-03-16 2019-03-15 High-purity steviol glycosides Pending EP3765472A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862644065P 2018-03-16 2018-03-16
US201862644407P 2018-03-17 2018-03-17
PCT/US2018/026920 WO2019177634A1 (en) 2018-03-16 2018-04-10 High-purity steviol glycosides
US201962802111P 2019-02-06 2019-02-06
PCT/US2019/022581 WO2019178541A1 (en) 2018-03-16 2019-03-15 High-purity steviol glycosides

Publications (2)

Publication Number Publication Date
EP3765472A1 EP3765472A1 (en) 2021-01-20
EP3765472A4 true EP3765472A4 (en) 2022-01-19

Family

ID=67908464

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19766689.4A Pending EP3765472A4 (en) 2018-03-16 2019-03-15 High-purity steviol glycosides

Country Status (9)

Country Link
EP (1) EP3765472A4 (en)
JP (2) JP7432533B2 (en)
KR (1) KR20200132940A (en)
CN (1) CN112513059A (en)
AU (2) AU2019236279B2 (en)
BR (1) BR112020018972A2 (en)
CA (1) CA3094205A1 (en)
MX (1) MX2020009635A (en)
WO (1) WO2019178541A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220232860A1 (en) * 2019-05-17 2022-07-28 Purecircle Usa Inc. Stevia flavor compositions
US20230172235A1 (en) * 2020-05-07 2023-06-08 The Coca-Cola Company Beverages comprising rebaudioside am and rebaudioside m with enhanced flavor
CN114045273B (en) * 2021-11-15 2022-07-22 四川大学 Glycosyl transferase OsUGT91C1 mutant and application thereof
CN114315926B (en) * 2022-01-04 2024-02-06 东台市浩瑞生物科技有限公司 Technological method for producing steviolbioside by multiple high-temperature pyrolysis
WO2024010442A1 (en) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd High-purity steviol glycosides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3592157A1 (en) * 2017-03-06 2020-01-15 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
EP3644758A1 (en) * 2017-06-30 2020-05-06 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101527237B1 (en) * 2007-01-22 2015-06-08 카아길, 인코포레이팃드 Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
WO2016073740A1 (en) * 2014-11-05 2016-05-12 Manus Biosynthesis, Inc. Microbial production of steviol glycosides
US10058112B2 (en) * 2014-11-21 2018-08-28 Eco Sweeteners Llc Sweetener composition including enzymatically processed stevia and method of manufacturing
JP6793957B2 (en) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド Production of non-caloric sweeteners using modified whole cell catalysts
US20200308616A1 (en) * 2015-11-30 2020-10-01 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
ES2964976T3 (en) 2016-10-14 2024-04-10 Conagen Inc Biosynthetic production of steviol glycosides and processes for the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3592157A1 (en) * 2017-03-06 2020-01-15 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
EP3644758A1 (en) * 2017-06-30 2020-05-06 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019178541A1 *

Also Published As

Publication number Publication date
JP7432533B2 (en) 2024-02-16
AU2019236279A1 (en) 2020-10-08
MX2020009635A (en) 2021-02-16
EP3765472A1 (en) 2021-01-20
AU2024201079A1 (en) 2024-03-07
JP2021518163A (en) 2021-08-02
KR20200132940A (en) 2020-11-25
CN112513059A (en) 2021-03-16
WO2019178541A1 (en) 2019-09-19
CA3094205A1 (en) 2019-09-19
AU2019236279B2 (en) 2023-11-23
BR112020018972A2 (en) 2021-01-05
JP2024033006A (en) 2024-03-12

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RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 9/10 20060101ALI20211216BHEP

Ipc: A23L 27/00 20160101ALI20211216BHEP

Ipc: C12P 19/56 20060101ALI20211216BHEP

Ipc: C12G 3/04 20190101ALI20211216BHEP

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