EP3762060A1 - Vorrichtung und verfahren zur regeneration einer dialyselösung - Google Patents
Vorrichtung und verfahren zur regeneration einer dialyselösungInfo
- Publication number
- EP3762060A1 EP3762060A1 EP19709874.2A EP19709874A EP3762060A1 EP 3762060 A1 EP3762060 A1 EP 3762060A1 EP 19709874 A EP19709874 A EP 19709874A EP 3762060 A1 EP3762060 A1 EP 3762060A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- filter
- container
- circuit
- dialysis solution
- dialysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000385 dialysis solution Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 11
- 230000001172 regenerating effect Effects 0.000 title claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 238000000502 dialysis Methods 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- 239000012141 concentrate Substances 0.000 claims description 12
- 239000013505 freshwater Substances 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910021389 graphene Inorganic materials 0.000 claims description 9
- 238000007872 degassing Methods 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 230000000670 limiting effect Effects 0.000 claims description 4
- 239000012466 permeate Substances 0.000 claims description 4
- 239000012465 retentate Substances 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 3
- 230000008929 regeneration Effects 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 9
- 239000012498 ultrapure water Substances 0.000 description 9
- 239000012528 membrane Substances 0.000 description 8
- 238000001223 reverse osmosis Methods 0.000 description 8
- 238000011282 treatment Methods 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 238000001631 haemodialysis Methods 0.000 description 4
- 230000000322 hemodialysis Effects 0.000 description 4
- 238000000108 ultra-filtration Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- -1 for example Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3624—Level detectors; Level control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/02—Inorganic material
- B01D71/021—Carbon
- B01D71/0211—Graphene or derivates thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/282—Operational modes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3337—Controlling, regulating pressure or flow by means of a valve by-passing a pump
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3386—Low level detectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
Definitions
- the present invention relates to an apparatus and a method for regenerating a dialysis solution.
- the present invention has the object, a device of the type mentioned in such a way that it can be made relatively compact and has a lower compared to known devices water and energy consumption.
- the device comprises a first circuit and a second circuit
- the first circuit comprises a container for receiving the used dialysis solution, the primary side of the container downstream filter and a return line from the primary side of the filter into the container
- the Filter is adapted to produce from the used dialysis solution of purified water, preferably ultrapure water
- the second circuit having the secondary side of the filter, the Dialysatselte a dialyzer and a return line from the Dialysatselte of the dialyzer in the container.
- the purpose of the filter is to produce purified water from the solution in the container, ie water whose content or concentration of impurities and other ingredients, such as ions, molecules is less than in the solution that is fed to the filter.
- the filter is designed to produce Relnstwasser, which is understood in the context of the present invention, water, which is suitable to be used for the production of a ready-dialysis solution.
- the filter can be designed in one or more stages, wherein the several stages are successively flowed through by solution. Also, the use of multiple filters connected in series is conceivable to obtain the desired degree of purity of the water.
- the filter hanndelt it preferably a RO (reverse osmosis) filter, for example in the form of a wound module.
- the device has one or more concentrate lines, which lead into the line leading to the ultrapure water or in a mixing area, so that the ready-to-use dialysis solution can be prepared from the ultrapure water and the concentrate (s) and optionally other additives.
- said filter is a graphene filter.
- This is understood to mean a filter which uses graphene or a graphene derivative, such as, for example, as filter material.
- Graphene oxide or its filter material consists of these substances or contains.
- Graphene or graphene oxide is gas-tight and water-permeable, which in the context of the present invention has the advantage that a gas entry from the first into the second cycle and thus into the ready-to-use dialysis solution does not take place.
- the present invention is not limited to these filters, but also encompasses other filters that are preferably gas impermeable but allow liquid to pass through.
- air can be deposited on the primary side by a degassing throttle, which then can be conveyed back into the container via a valve (preferably a pressure-limiting valve) and thus removed.
- a degassing throttle preferably a pressure-limiting valve
- a pump is arranged to cause a flow of liquid in the first circuit. If this pump is adjustable in its delivery rate or in its discharge pressure, the pump can adjust the throughput of the solution through the first circuit and / or the pressure of the liquid on the primary side of the filter to an optimum filter operating point.
- a pressure limiting device by means of which the pressure on the primary side of the filter is adjustable. This can be, for example, pressure relief valve, which can be adjustable. Also in this way, the pressure conditions on the primary side of the filter can be set to the desired value or in a desired range.
- a bypass line which can be closed by a shut-off element can be provided around the pressure-limiting device. This may be needed to flush the primary side of the filter with the shut-off element open, and where the flow along the primary side of the membrane is there contaminants, e.g. as a coating or layer may be present, removed.
- a sensor preferably a conductivity measuring cell may be arranged to detect the concentration of substances in the first circuit.
- a sensor preferably a conductivity measuring cell
- a sensor can be arranged in front of it, in order to determine the purity of the water of the filter present on the secondary side. If this is not within specified limits or is below a limit value, it can be concluded that the filter has a defect.
- upstream and downstream refer to the position of the components relative to one another when the device is operating, ie, traversed by liquid.
- a pressure measuring device Downstream of the secondary side of the filter, a pressure measuring device can be arranged downstream of the secondary side of the filter. From the pressure measured there can also be clues as to whether the filter is defective. Apart from that, knowing the pressure on the primary side, it is possible to determine how large the transmembrane pressure is, which can then be set to an optimum value for the particular filter used. This can be done for example by a pump arranged on the primary side, which is arranged in the first circuit upstream of the filter.
- a mixing device is provided downstream of the secondary side of the filter, which is designed to supply one or more concentrates to the effluent from the secondary side of the filter water for the production of a ready-to-use dialysis solution.
- one or more concentrate lines can be provided, which lead to the mixing device and which can be connected with concentrate containers or on which concentrate containers are connected.
- the device has an ultrafiltration pump for the removal of dialysis solution, preferably from the return line in order to realize the desired or prescribed by the doctor fluid loss of the patient can.
- the device has a balancing chamber for the balanced feeding and discharging of dialysis solution to and from the dialyzer, as known from the prior art.
- the balance on the container of the 1st cycle for example.
- the filter is gas impermeable. In this case, it is possible to dispense with a degassing device in the second circuit.
- the apparatus comprises a controller configured to partially or completely discard the liquid in the container or in one or both of the circuits or throughout the apparatus and to replace it with fresh water when the sensor reports a value to the controller that exceeds a concentration threshold. This is the case when the solution is so concentrated or has so many impurities that regeneration is not or no longer meaningfully possible.
- a level sensor may be arranged in the container, wherein it is preferably provided that the device has a controller which is designed to issue an error message and / or to stop the operation of the device if the level in the container falls compared to an initial value.
- the first and second circuits are closed, which is a preferred embodiment of the invention, a fall in the level in the container may be due only to leakage of the device.
- the first and / or the second circuit are closed. This is understood to mean that the first circuit leads from the container via the filters back to the container and the second circuit leads from the filter via the dialyzer to the container, from where the solution is returned to the filter.
- the container is designed as a bag, in particular as a flexible bag. This has the advantage that the volume of the container can be made flexible.
- the bag is configured as a disposable, ie as a disposable item. Thus If necessary, the container can be disposed of in a simple manner together with the filter and the dialyzer after completion of the treatment. In the configuration as a bag so only a small amount of waste.
- the device may be part of a dialysis machine or form a dialysis machine, such as a dialysis machine. a peritoneal dialysis machine, a hemodialysis machine or a hemodiafiltration device.
- the present invention further relates to a method for regenerating a dialysis solution with a device according to one of claims 1 to 13, wherein the solution from the container is fed to the primary side of the filter, the retentate is returned to the container and the permeate is mixed the device is supplied, in which by the mixture of the permeate with one or more concentrates a ready-to-use dialysis solution is prepared, which is supplied to a dialyzer.
- a water change is preferably only when the solution is so concentrated that a regeneration is no longer or only with great difficulty possible. This may be necessary if the container is designed to be particularly small, so that a particularly high rate of recycling is required. Such embodiments may be particularly useful in home dialysis. In stationary application of the technical solution, a cyclic exchange of the liquid in the 1st and / or 2nd cycle is possible (so-called fresh water clocking).
- Figure 1 a schematic flow diagram of a device according to the invention
- Figure 2 a schematic flow diagram of another device which is not the subject of the invention.
- FIG. 1 shows a device according to the invention.
- the reference symbol I designates the inlet for fresh water into the container 10, wherein the inlet line can be shut off by a valve V1.
- the flow from the container 10 for used solution is characterized, wherein the drain line is shut off by a valve V2.
- the container 10 is also referred to below as the water inlet chamber.
- a container 10 with a stationary water connection or any other container such as. a bag, e.g. a dialysate bag is used.
- the container 10 may air tight rigid or flexible walls.
- the reference numeral 100 denotes a dialyzer, which preferably has a plurality of membranes, preferably a membrane bundle, which is disposed on a One side D of dialysate and on the other side B are traversed by blood.
- the dialysis solution which has flowed through the dialyzer 100 and is thus loaded with impurities from the blood, is referred to as a used dialysis solution or used dialysate.
- the used dialysate which is passed from the dialyzer 100 back through the line 40 into the water inlet chamber 10, is sucked by a pump 50 and pumped into an upstream circuit, which is the first circuit according to the invention.
- This circuit essentially comprises the pump 50, the container 10, the primary side of the filter 20, i. the section in front of the filter membrane or in front of another filter medium, and the pressure relief valve 60 including the lines connecting these components.
- Reference numeral 30 denotes the return line from the valve 60 to the container 10.
- Reference numeral 60 denotes a pressure limiter valve.
- the pump 50 conveys the used dialysis solution from the container 10 through the primary side 21 of the filter 20 via the valve 60 back into the container 10. This creates a pressure drop across the valve 60 and thus also over the filter 20. This pressure or pressure drop can be adjusted by the valve 60 and thus tuned to the ideal operating point of the filter 20.
- the pressure gradient between the primary 21 and secondary side 22 of the filter 20 causes a flow through the filter membrane or through the other filter medium takes place, which is present on the secondary side 22, ie after the filter medium ultrapure water. It enters the mixing device 200, which can be designed as a mixing circuit, mixing container, line section, etc. In the mixing circuit or mixing vessel, etc., the mixture of Relnstwas- sers with one or more concentrates, such as with a basic and an acidic concentrate. The heating or reheating of the dialysis solution can also take place there, so that as far as possible no heat is withdrawn from the blood in the dialyzer 100 through the dialysis solution.
- the retentate i. the portion of the liquid that is not separated by the filter 20 remains on the primary side and returns via the valve 60 back into the water inlet chamber 10th
- the liquid in the container 10 is gradually further concentrated, thereby increasing its electrical conductivity.
- the first and second circuits are two closed, cascaded water or liquid circuits. In principle, more than two of these circuits may be present.
- the filter 20 may i.a. based on a Graphene filter technology, whereby the ultrapure water can be separated from the filter at the same time without dissolved oxygen. This saves additional components in the dialysis machine, e.g. a separate degassing circuit.
- the filter 20 By "flushing" the filter 20 on its primary side 21 via the valve 60, a high performance can be achieved and the fouling of the filter 20 can be prevented or delayed.This increases the service life of the filter 20.
- the filter 20 can be rinsed with fire by the valve 90 shorting the pressure limiting valve 60. In this case, the liquid, bypassing the valve 60, enters the bypass which contains the valve 90 and from there back into the container This process is advantageous if the filter performance has noticeably decreased , As can be seen further from FIG. 1, a fill level sensor 110 is located in the container 10. If this signal indicates that the fill level in the container 10 has dropped below a limit value, leakage can be inferred since both the first and the second cycle are closed and thus the level should remain the same.
- the valves V1 and V2 are closed during normal operation, ie when there is no water change.
- the presence of a conductivity cell 70 further follows, i. downstream of the pump.
- the concentration of the contaminated liquid due to the circulation operation is measurable and thus it can be deduced when the water in the circuit should be completely replaced (fresh water clocking).
- This replacement can be done by using the valves V1 and V2 and be volumetrically balanced in the container 10 by means of the level sensor 110.
- valves V1 and V2 are closed, whereby the level sensor 10 can be used as shown as leakage monitoring. If one of the two closed circuits lose fluid, this is detectable on the basis of the level in the container 10. This is for patient safety.
- the transmembrane pressure can be monitored via the filter 20, in order to be able to determine a degradation or loss of the performance of the filter. Since the two circuits are closed, the energy required for heating the dialysate drops significantly. As a consequence, smaller heaters can be used than is the case with devices known from the prior art. Although a heat exchanger is still optional for the fresh water timing conceivable, but can also be omitted for cost reasons.
- the ultrapure water accumulating on the secondary side 22 of the filter 20 enters the mixing section 200 of the machine and is there, e.g. with bicarbonate and acid, so that a ready-to-use dialysis fluid is available at the dialyzer 100 for exchange with the patient's blood.
- the reference symbol B / U denotes the balancing unit and / or an ultrafiltration pump which extracts from the used dialysis fluid a partial volume corresponding to the prescription by the physician.
- the two-stage (cascaded) filter approach also allows toxins larger than water to be removed from the patient. These substances, including ions such as Na and CI from the dialysis fluid are then concentrated in the container 10 and discarded in the course of Frischwassertaktung on the outflow O. Ultrafiltration is still done, e.g. via a UF pump in unit B / U, which delivers directly to the drain. Since these are closed circuits, the advantages of volumetric balancing, as it is done today, for example, with the help of a balance chamber, can be maintained.
- the filter 20 Due to the properties of the filter 20 to be impermeable to gases omitted in this structure, the need for additional degassing measures / devices. Alternatively, if necessary, depending on the filter used, but also a degassing throttling / device in the upstream, ie introduced into the first circuit, as shown by the reference numeral E in Figure 1. In this case, the filter module 20 or even a separate air chamber can be used as the air separation chamber. serve deposition chamber, which can be arranged, for example, between 20 and 60 in Figure 1.
- FIG. 2 shows a variant which is not part of the scope of the invention. Identical or functionally identical elements have the same reference numerals as in FIG. 1.
- used dialyzate after flowing through the dialyzer 100, is fed to the filter 20 in order to separate off pure water, which is conveyed back into the water inlet chamber 10.
- the retentate is discarded via the outflow O.
- the pure water is measured in the conductivity sensor 81 for its conductivity and passes with the valve open V3 in the container 10.
- a disadvantage of this concept is that the filter 20 is not permanently flushed, creating the risk that the filter 20 is added significantly faster ie loses performance. If necessary, this can only be avoided by discarding an increased proportion of water via the outlet O, which increases the water consumption and makes mobile applications impossible.
- the concentrated liquid can accumulate only in the filter 20 itself, making it difficult to measure by means of a conductivity cell to monitor the fresh water timing, i. to control the replacement of the liquid in a closed cycle in time.
- the RO system is integrated, thus resulting in a savings of components, i. Costs and size;
- the filter can be rinsed, resulting in increased service life
- the pump does not run in the RO water, which is associated with increased pump life; There is a lower water consumption and thus energy consumption for heating up compared to today's machines;
- the functionality of the filter can be monitored in terms of safety, specifically with a conductivity measuring cell arranged downstream of the filter or the like. This ensures that the correct composition of the dialysate can be achieved in the subsequent mixing device of the machine;
- a timing of when the liquid must be replaced in the circuit is possible with the conductivity cell, which comes into contact with the used solution (fresh water timing); likewise, the rinsing cycle can be determined by means of this conductivity measuring cell;
- the device can be used in or form peritoneal dialysis (PD) and hemodialysis (HD) machines.
- the device may be a dialysis machine or part of it. Also conceivable are various combinations with the components according to Flg.1.
- the pump 50 is optional.
- the senor 70 can be replaced by a fixed control, i. fixed fresh water cycles / flushing of the filter.
- the degassing E may be present or omitted depending on the filter used.
- the pump 50 could also be placed before or after the sensor 80, however, in this configuration no over-purging is possible and thus the problems of Figure 2 would result which would be associated with a performance loss of the filter.
- the heater can be provided both in the first cycle, as well as in the second cycle.
- a pump for conveying the dialysis solution or the ultrapure water is also present in the second circuit.
- Fig. 1 preferably uses the graphene filtering technique, but the invention is not limited to it or any other particular filter.
- Other technologies are also conceivable with the concept in FIG. 1 or according to the invention insofar as these membranes are capable of separating water / ultrapure water from contaminated liquid.
- Known from the prior art RO filter systems are usually based on a different technique. In most cases, these are winding modules with a poor performance in comparison, but these filters are also conceivable as fillers 20.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102018105120.4A DE102018105120A1 (de) | 2018-03-06 | 2018-03-06 | Vorrichtung und Verfahren zur Regeneration einer Dialyselösung |
PCT/EP2019/055338 WO2019170613A1 (de) | 2018-03-06 | 2019-03-04 | Vorrichtung und verfahren zur regeneration einer dialyselösung |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3762060A1 true EP3762060A1 (de) | 2021-01-13 |
Family
ID=65724375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19709874.2A Pending EP3762060A1 (de) | 2018-03-06 | 2019-03-04 | Vorrichtung und verfahren zur regeneration einer dialyselösung |
Country Status (6)
Country | Link |
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US (1) | US11819598B2 (de) |
EP (1) | EP3762060A1 (de) |
JP (1) | JP2021515634A (de) |
CN (1) | CN111818952A (de) |
DE (1) | DE102018105120A1 (de) |
WO (1) | WO2019170613A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11517653B2 (en) | 2019-11-05 | 2022-12-06 | Diality Inc. | Hemodialysis system reservoir level sensor |
DE102020106751B4 (de) | 2020-01-28 | 2021-09-23 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung und Verfahren zur Herstellung von Dialysat |
US20230146806A1 (en) | 2020-01-28 | 2023-05-11 | Fresenius Medical Care Deutschland Gmbh | Apparatus and method for preparing dialyzate |
WO2022214450A1 (en) * | 2021-04-09 | 2022-10-13 | Gambro Lundia Ab | Apparatus and methods for efficient production of dialysis fluid using forward osmosis |
WO2024043193A1 (ja) * | 2022-08-23 | 2024-02-29 | フィジオロガス・テクノロジーズ株式会社 | 対象液処理装置 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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DE19941349A1 (de) * | 1999-08-31 | 2001-03-01 | S Med Medizintechnik Gmbh | Anlage und Verfahren zum Filtern von Flüssigkeiten |
US7169352B1 (en) * | 1999-12-22 | 2007-01-30 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
CN100351006C (zh) * | 2001-05-14 | 2007-11-28 | 沃特海尔斯国际公司 | 强力消毒溶液装置 |
US9700663B2 (en) * | 2005-01-07 | 2017-07-11 | Nxstage Medical, Inc. | Filtration system for preparation of fluids for medical applications |
SE532147C2 (sv) | 2005-02-16 | 2009-11-03 | Triomed Ab | Bärbart dialyssystem |
SE532971C2 (sv) * | 2006-08-16 | 2010-05-25 | Triomed Ab | System för regenerering av en vätska |
US8889004B2 (en) * | 2007-11-16 | 2014-11-18 | Fresenius Medical Care Holdings, Inc. | Dialysis systems and methods |
WO2009083011A2 (en) * | 2007-12-30 | 2009-07-09 | Mohamed Fahim Khaled Mohamed T | A method for dialysis fluid regeneration |
DK177696B1 (en) * | 2013-02-25 | 2014-03-17 | Aquaporin As | Systems for water extraction |
DE102013014751A1 (de) * | 2013-09-06 | 2015-03-12 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum Beeinflussen des Drucks innerhalb eines Heizbeutels während einer medizinischen Behandlung und medizinische Vorrichtung |
US10451591B1 (en) * | 2013-12-19 | 2019-10-22 | Ge Healthcare Bio-Sciences Ab | Remotely actuated valve for a biological liquid treatment system |
DK179128B1 (en) * | 2014-02-24 | 2017-11-20 | Aquaporin As | Systems for utilizing the water content in fluid from a renal replacement therapy process |
EP3827853A1 (de) * | 2015-09-25 | 2021-06-02 | Medtronic, Inc. | Systeme und verfahren zur selektiven sorptionsmittelbasierten regenerationsdialyse |
WO2017116515A1 (en) * | 2015-12-31 | 2017-07-06 | Baxter International Inc. | Methods and apparatuses using urea permselective diffusion through charged membranes |
KR101810470B1 (ko) * | 2016-01-29 | 2017-12-19 | 엘지전자 주식회사 | 혈액 투석용 막 및 그 제조방법 |
EP3413998B1 (de) * | 2016-02-08 | 2024-05-15 | Aquaporin A/S | Trennmembranen mit selbstangeordneten nanostrukturen mit aquaporinwasserkanälen sowie verfahren zur herstellung und verwendung davon |
EP3311861A1 (de) * | 2016-10-18 | 2018-04-25 | Cook Medical Technologies LLC | Dialysatregenerierungsvorrichtung |
US20190225521A1 (en) * | 2018-01-24 | 2019-07-25 | Stephan HEATH | Systems, apparatus, and/or methods for providing liquid treatment comprising at least one of disinfection, filtration and/or purification |
US11260155B2 (en) * | 2018-10-25 | 2022-03-01 | Diality Inc. | Dual reservoir hemodialysis system |
-
2018
- 2018-03-06 DE DE102018105120.4A patent/DE102018105120A1/de active Pending
-
2019
- 2019-03-04 CN CN201980017191.3A patent/CN111818952A/zh active Pending
- 2019-03-04 JP JP2020546491A patent/JP2021515634A/ja active Pending
- 2019-03-04 EP EP19709874.2A patent/EP3762060A1/de active Pending
- 2019-03-04 WO PCT/EP2019/055338 patent/WO2019170613A1/de unknown
- 2019-03-04 US US16/978,247 patent/US11819598B2/en active Active
Also Published As
Publication number | Publication date |
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US11819598B2 (en) | 2023-11-21 |
US20200405938A1 (en) | 2020-12-31 |
CN111818952A (zh) | 2020-10-23 |
DE102018105120A1 (de) | 2019-09-12 |
JP2021515634A (ja) | 2021-06-24 |
WO2019170613A1 (de) | 2019-09-12 |
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