EP3745404C0 - Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen - Google Patents

Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen

Info

Publication number
EP3745404C0
EP3745404C0 EP19177387.8A EP19177387A EP3745404C0 EP 3745404 C0 EP3745404 C0 EP 3745404C0 EP 19177387 A EP19177387 A EP 19177387A EP 3745404 C0 EP3745404 C0 EP 3745404C0
Authority
EP
European Patent Office
Prior art keywords
predicting
proteins
protein
coupled receptors
coupling properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19177387.8A
Other languages
English (en)
French (fr)
Other versions
EP3745404B1 (de
EP3745404A1 (de
Inventor
Asuka Inoue
Robert Bruce Russell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Networks GmbH
Original Assignee
Cell Networks GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Networks GmbH filed Critical Cell Networks GmbH
Priority to EP19177387.8A priority Critical patent/EP3745404B1/de
Priority to PCT/EP2020/064937 priority patent/WO2020239967A1/en
Priority to EP24179023.7A priority patent/EP4417702A3/de
Priority to EP20735272.5A priority patent/EP3976639A1/de
Priority to US17/615,000 priority patent/US12612442B2/en
Publication of EP3745404A1 publication Critical patent/EP3745404A1/de
Application granted granted Critical
Publication of EP3745404C0 publication Critical patent/EP3745404C0/de
Publication of EP3745404B1 publication Critical patent/EP3745404B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04011—Phosphoinositide phospholipase C (3.1.4.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/05—Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
    • C12Y306/05002—Small monomeric GTPase (3.6.5.2)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
EP19177387.8A 2019-05-29 2019-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen Active EP3745404B1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP19177387.8A EP3745404B1 (de) 2019-05-29 2019-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen
PCT/EP2020/064937 WO2020239967A1 (en) 2019-05-29 2020-05-29 Method and system for predicting coupling probabilities of g-protein coupled receptors with g-proteins
EP24179023.7A EP4417702A3 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungswahrscheinlichkeiten von g-protein-gekoppelten rezeptoren mit g-proteinen
EP20735272.5A EP3976639A1 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen
US17/615,000 US12612442B2 (en) 2019-05-29 2020-05-29 G12-specific designer receptor exclusively activated by designer drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19177387.8A EP3745404B1 (de) 2019-05-29 2019-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen

Publications (3)

Publication Number Publication Date
EP3745404A1 EP3745404A1 (de) 2020-12-02
EP3745404C0 true EP3745404C0 (de) 2024-04-03
EP3745404B1 EP3745404B1 (de) 2024-04-03

Family

ID=66676434

Family Applications (3)

Application Number Title Priority Date Filing Date
EP19177387.8A Active EP3745404B1 (de) 2019-05-29 2019-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen
EP20735272.5A Withdrawn EP3976639A1 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen
EP24179023.7A Pending EP4417702A3 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungswahrscheinlichkeiten von g-protein-gekoppelten rezeptoren mit g-proteinen

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP20735272.5A Withdrawn EP3976639A1 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungseigenschaften von g-protein-gekoppelten rezeptoren mit g-proteinen
EP24179023.7A Pending EP4417702A3 (de) 2019-05-29 2020-05-29 Verfahren und system zur vorhersage der kopplungswahrscheinlichkeiten von g-protein-gekoppelten rezeptoren mit g-proteinen

Country Status (2)

Country Link
EP (3) EP3745404B1 (de)
WO (1) WO2020239967A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4448562A4 (de) 2021-12-15 2025-12-10 Univ Columbia Regulierung von immunantworten durch selektive neuronale aktivierung
CN114220480B (zh) * 2022-02-17 2022-05-10 武汉宏韧生物医药股份有限公司 一种药物成分分析方法及系统
WO2023159144A2 (en) * 2022-02-17 2023-08-24 The Regents Of The University Of Michigan G-protein coupled receptor assay
CN116631495B (zh) * 2023-07-26 2023-11-21 香港中文大学（深圳） 激动剂分子对gpcr激活能力的预测方法及其系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060008831A1 (en) * 2004-07-09 2006-01-12 Sreekumar Kodangattil R Methods and systems for predicting protein-ligand coupling specificities
US20100120627A1 (en) * 2006-08-02 2010-05-13 Abdelmajid Belouchi Genemap of the human genes associated with psoriasis
EP2220245B1 (de) * 2007-10-17 2015-04-22 The Board of Trustees of The Leland Stanford Junior University Verfahren und zusammensetzung zur kristallisation g-protein-gekoppelter rezeptoren
EP3604498A1 (de) * 2014-04-11 2020-02-05 Université catholique de Louvain Transgene schweineinselzellen und verwendung davon zur behandlung von diabetes

Also Published As

Publication number Publication date
EP3745404B1 (de) 2024-04-03
US20220220185A1 (en) 2022-07-14
WO2020239967A1 (en) 2020-12-03
EP4417702A3 (de) 2025-01-22
EP4417702A2 (de) 2024-08-21
EP3976639A1 (de) 2022-04-06
EP3745404A1 (de) 2020-12-02

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