EP3726993A1 - Formulation de tmad/bit stable au stockage - Google Patents
Formulation de tmad/bit stable au stockageInfo
- Publication number
- EP3726993A1 EP3726993A1 EP18830381.2A EP18830381A EP3726993A1 EP 3726993 A1 EP3726993 A1 EP 3726993A1 EP 18830381 A EP18830381 A EP 18830381A EP 3726993 A1 EP3726993 A1 EP 3726993A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- zinc
- bit
- tmad
- composition according
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 238000009472 formulation Methods 0.000 title description 8
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 claims abstract description 35
- 230000003115 biocidal effect Effects 0.000 claims abstract description 33
- UUGLSEIATNSHRI-UHFFFAOYSA-N 1,3,4,6-tetrakis(hydroxymethyl)-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione Chemical compound OCN1C(=O)N(CO)C2C1N(CO)C(=O)N2CO UUGLSEIATNSHRI-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011701 zinc Substances 0.000 claims abstract description 18
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910001868 water Inorganic materials 0.000 claims abstract description 14
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 11
- 239000011667 zinc carbonate Substances 0.000 claims abstract description 9
- 229910000010 zinc carbonate Inorganic materials 0.000 claims abstract description 9
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims abstract description 9
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims abstract description 8
- -1 alkali metal salts Chemical class 0.000 claims abstract description 8
- 235000004416 zinc carbonate Nutrition 0.000 claims abstract description 8
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims abstract description 8
- 229940007718 zinc hydroxide Drugs 0.000 claims abstract description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 7
- 244000005700 microbiome Species 0.000 claims abstract description 7
- 230000006378 damage Effects 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 21
- 239000003139 biocide Substances 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 3
- 239000012770 industrial material Substances 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- 239000004557 technical material Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 abstract description 9
- 206010061217 Infestation Diseases 0.000 abstract description 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 10
- 239000002904 solvent Substances 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 7
- 229910003002 lithium salt Inorganic materials 0.000 description 7
- 159000000002 lithium salts Chemical class 0.000 description 7
- 229910052700 potassium Inorganic materials 0.000 description 7
- 239000011591 potassium Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 5
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000000976 ink Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- XMKLTEGSALONPH-UHFFFAOYSA-N 1,2,4,5-tetrazinane-3,6-dione Chemical compound O=C1NNC(=O)NN1 XMKLTEGSALONPH-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000002283 diesel fuel Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000001034 iron oxide pigment Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229910052744 lithium Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005555 metalworking Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005553 polystyrene-acrylate Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Definitions
- the present invention relates to a storage-stable aqueous biocide composition in the form of a dispersion comprising the components: (a) 1 to 20 l, 2-benzisothiazolin-3-one (BIT) and / or its alkali metal salts, (b) 10 to 70 wt. -%
- Tetramethylolacetylenediurea (c) 0.5 to 20% by weight of one or more zinc component (s) selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and Mixtures thereof and ad. 100% water.
- the invention further relates to processes for the preparation of these biocidal compositions and their use for the protection of industrial materials and products against attack and destruction by microorganisms.
- 2-Benzisothiazolin-3-one (BIT) or its sodium, potassium and lithium salts is a long-used in practice drug for the preparation of microbicidally active formulations.
- 1,2-Benzisothiazolin-3-one (BIT) is characterized by good chemical and thermal stability and basically has a broad antimicrobial effect against bacteria, fungi and yeasts.
- BIT-containing concentrates or biocidal products are generally formulated in the form of alkali metal salts at high pH.
- co-solvents in the form of water-miscible solvents such as propylene glycol, have to be used in most cases despite the high pH values (compare U.S. 4,188,376).
- BESTATIGUNGSKOPIE To reduce unwanted effects that can be caused by free formaldehyde BIT is usually used in combination with so-called Formaldehyddepotitatien, such as tetramethylolacetylenediurea (TMAD) (see, EP 1 249 166 Al).
- TMAD tetramethylolacetylenediurea
- a disadvantage of these known from the prior art synergistic mixtures of BIT and TMAD is that such mixtures with high active ingredient content can be formulated as storage-stable mixtures either with the aid of co-solvents or at a high pH of pH> 10 (see. W02006 / 102994 Al).
- the corresponding formulations do not have too high a pH. Reasons for this are a less problematic handling and a lower degradation of formaldehyde (Cannizzarro reaction).
- the object of the present invention was therefore to provide long-term stable compositions, in the form of a dispersion, containing BIT and TMAD, which are preferably solvent-free and preferably have a pH in the weakly acidic to slightly alkaline range.
- a storage-stable aqueous biocide composition in the form of a dispersion, comprising the components:
- TMAD tetramethylolacetylenediurea
- (C) 0.5 to 20, preferably 1 to 10 wt .-% of one or more zinc component (s) selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and Mixtures thereof and
- aqueous biocide compositions or dispersions defined above, the 1,2-benzisothiazolin-3-one (BIT) and / or its alkali metal salts and Tetramethylolacetylendihamstoff (TMAD), by the addition of the zinc component (s) have a satisfactory long-term stability during storage.
- the biocidal compositions according to the invention are characterized in that their pH is in the range from 4 to 7, preferably in the range from 5.5 to 6.5.
- such compositions are less problematic because of the almost neutral pH in their handling and are also characterized by a lower degradation of formaldehyde (Cannizzarro reaction).
- the biocide composition is characterized in that the total sum of components (a), (b) and (c) is generally 11.5 to 70% by weight. preferably 15 to 60 wt .-%, particularly preferably 20 to 40 wt .-% is.
- compositions according to the invention contain 1,2-benzisothiazolin-3-one (BIT) and / or its sodium, potassium or lithium salts or mixtures thereof.
- BIT 1,2-benzisothiazolin-3-one
- TMAD tetramethylolacetylenediurea
- the ratio of 1,2-benzisothiazolin-3-one (BIT) and / or its sodium, potassium or lithium salts or mixtures thereof to tetramethylolacetylenediurea (TMAD) in the formulations according to the invention is in a weight ratio of 1: 1 to 1: 50, preferably from 1: 2 to 1: 20, more preferably from 1: 3 to 1:10.
- the biocidal compositions of the invention contain the 1,2-benzisothiazolin-3-one (BIT) and / or its sodium, potassium or lithium metal salts or mixtures thereof.
- the amounts of BIT and / or its alkali metal salts in the compositions are generally from 1 to 20 wt .-%, preferably from 2 to 15 wt .-%, each based on the total weight of the composition.
- the biocide compositions according to the invention generally comprise TMAD in an amount of 10 to 70% by weight, preferably in an amount of 15 to 30% by weight, based in each case on the total weight of the composition.
- the biocidal compositions of the invention further contain the zinc component (s) selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and mixtures thereof, generally in an amount of from 0.5 to 20 wt .-%, preferably in an amount of 1 to 10 wt .-% and particularly preferably in an amount of 2 to 5 wt .-%, each based on the total weight of the composition.
- the zinc component (s) selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and mixtures thereof, generally in an amount of from 0.5 to 20 wt .-%, preferably in an amount of 1 to 10 wt .-% and particularly preferably in an amount of 2 to 5 wt .-%, each based on the total weight of the composition.
- ZnO zinc oxide
- Zn (OH) 2 zinc hydroxide
- ZnC0 3 zinc carbonate
- the biocidal compositions according to the invention are characterized in that they contain zinc oxide as component (c).
- compositions according to the invention are distinguished by good long-term stability. No significant drug degradation was observed during storage, nor did crystal formation or precipitation or stronger pH shifts occur. Furthermore, it was found that the proportion of free formaldehyde in the composition is very low and is generally ⁇ 1%, in particular ⁇ 0.5%, and does not change significantly during storage.
- the biocidal compositions according to the invention contain, in addition to the components (a), (b) and (c) ad. 100% water. That is, in addition to the components (a), (b), (c) and optionally further components such as thickeners, defoamers and dispersants, water is the main solvent of the compositions.
- the biocidal compositions according to the invention contain about 10 to 90% by weight, preferably about 30 to 60 wt .-% water, each based on the total weight of the composition.
- compositions according to the invention are free of co-solvents according to a preferred embodiment.
- the compositions according to the invention may also contain co-solvents in amounts of from 0 to 5% by weight, preferably from 0 to 3% by weight.
- co-solvents are generally used with water-miscible solvents such as alcohols such as butanol, glycerol, glycols and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, and strongly polar solvents such as dimethylformamide, dimethyl sulfoxide and N-methylpyrrolidone ,
- the biocidal compositions according to the invention can be prepared by dissolving (a) BIT and / or its sodium salt and / or its potassium salt and / or its lithium salt in water, if appropriate with the addition of sodium hydroxide, potassium hydroxide, lithium hydroxide or mixtures thereof, and b), a solution of tetramethylol diurea (TMAD) in water and (c) the at least one zinc component selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and mixtures thereof ,
- the zinc component preferably ZnO
- TMAD preferably ZnO
- a commercial solution of TMAD such as Acticide ® F (N)
- the BIT in form of an aqueous dispersion as ACTICIDE ® BW33
- the pH of the biocide composition may be adjusted to a value in the range of pH 4 to pH 9, preferably Ph 4 to pH 7, by adding sodium hydroxide, potassium hydroxide, lithium hydroxide or mixtures thereof or, if appropriate, with the aid of hydrochloric acid become.
- the alkaline 1,2-benzisothiazolin-3-one (BIT) solution used to prepare the biocidal compositions according to the invention can be prepared, for example, by dissolving l, 2-benzisothiazolin-3-one in water, sodium, potassium or lithium salt and optionally NaOH, KOH or LiOH added or by starting from 1,2-benzisothiazolin-3-one and preparing its salts by addition of NaOH, KOH or LiOH, or mixtures thereof in water.
- BIT 1,2-benzisothiazolin-3-one
- TM AD tetramethylolacetylenediurea
- the solution of tetramethylolacetylenediurea (TM AD) used to produce the biocide of the invention can either be prepared analogously to that described in EP 0060471 Al method or adding standard solutions of tetramethylolacetylenediurea (TM AD) as Acticide ® F (N).
- the at least one zinc component selected from the group consisting of zinc oxide (ZnO), zinc hydroxide (Zn (OH) 2 ), zinc carbonate (ZnC0 3 ) and mixtures thereof used in the preparation of the biocidal compositions according to the invention are commercially available chemicals, which are known in the art.
- compositions according to the invention are suitable for the protection of technical materials and products against infestation and destruction by microorganisms.
- the compositions according to the invention can be used to preserve functional fluids and water-containing technical products which are susceptible to microbial attack.
- paints, paints, plasters and other coating compositions such as for example, pressure thickeners, slurries of other raw materials such as color pigments (eg iron oxide pigments, carbon black pigments, titanium dioxide pigments) or slurries of fillers and coating pigments such as kaolin, calcium carbonate or talc, construction chemicals such as concrete additives based on molasses, lignosulfonates or polyacrylates, bituminous emulsions or jointing compounds, glues or adhesives
- polymer dispersions based on, for example, polyacrylate, polystyrene acrylate, styrene butadiene, polyvinyl acetate, etc.
- biocidal compositions according to the invention are known to the person skilled in the art of biocides and can be selected from them depending on the application of the biocidal composition according to the invention.
- the use concentrations of the composition to be used according to the invention depend on the nature and occurrence of the microorganisms to be controlled, the initial microbial load and on the composition of the material to be protected. The optimum amount to be used for a particular application can be determined prior to practical use by means of test series in the laboratory. In general, the use concentrations are in the range of 0.01 to 5 wt .-%, preferably from 0.05 to 1.0 wt .-% of the composition according to the invention, based on the material to be protected.
- biocide compositions according to the invention were prepared and stored at 21 ° C. over a period of 26 weeks.
- storage-stable dispersions or compositions can be obtained by adding the zinc component.
- ACTICIDE BW 33 (aqueous dispersion with 33% BIT)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17002068 | 2017-12-22 | ||
PCT/EP2018/000551 WO2019120602A1 (fr) | 2017-12-22 | 2018-12-11 | Formulation de tmad/bit stable au stockage |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3726993A1 true EP3726993A1 (fr) | 2020-10-28 |
Family
ID=60888076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18830381.2A Withdrawn EP3726993A1 (fr) | 2017-12-22 | 2018-12-11 | Formulation de tmad/bit stable au stockage |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP3726993A1 (fr) |
WO (1) | WO2019120602A1 (fr) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA784934B (en) | 1977-09-30 | 1979-10-31 | Ici Ltd | Solutions of benzisothiazolinones |
DE3109551A1 (de) | 1981-03-13 | 1982-11-04 | Riedel-De Haen Ag, 3016 Seelze | Mikrobiozid und seine verwendung |
DE10112755A1 (de) | 2001-03-16 | 2002-10-02 | Bode Chemie Gmbh & Co Kg | Synergistische biozide Wirkstoffkombinationen, Zusammensetzungen, solche Wirkstoffkombinationen enthaltend, und Verwendung solcher Zusammensetzungen als Konservierungsmittel |
DE10251915A1 (de) * | 2002-11-08 | 2004-05-19 | Bayer Ag | Mikrobizide Mittel |
DE102005013956A1 (de) | 2005-03-26 | 2006-09-28 | Lanxess Deutschland Gmbh | Wasserbasierte BIT/TMAD Formulierungen |
US7585980B2 (en) * | 2006-05-25 | 2009-09-08 | Troy Corporation | Immobilized 1,2-benzisothiazolin-3-one |
EP2020178A1 (fr) * | 2007-08-01 | 2009-02-04 | THOR GmbH | Composition biocide comportant le sel de potassium de 1,2-benzisothiazolin-3-one et éthylène glycol |
CN103627239B (zh) * | 2013-12-12 | 2015-12-30 | 三河市京纳环保技术有限公司 | 一种水性涂料抗菌防霉防藻伴侣及其制备方法 |
US11116217B2 (en) * | 2016-04-05 | 2021-09-14 | Thor Gmbh | Synergistic biocidal compositions containing 5-chloro-2-methylisothiazolin-3-one |
-
2018
- 2018-12-11 WO PCT/EP2018/000551 patent/WO2019120602A1/fr unknown
- 2018-12-11 EP EP18830381.2A patent/EP3726993A1/fr not_active Withdrawn
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