EP3725315A4 - Médicament améliorant un dysfonctionnement rénal comprenant un isomère optique de dérivé de 1-oxyde de 1,4-benzothiazépine - Google Patents

Médicament améliorant un dysfonctionnement rénal comprenant un isomère optique de dérivé de 1-oxyde de 1,4-benzothiazépine Download PDF

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Publication number
EP3725315A4
EP3725315A4 EP18887948.0A EP18887948A EP3725315A4 EP 3725315 A4 EP3725315 A4 EP 3725315A4 EP 18887948 A EP18887948 A EP 18887948A EP 3725315 A4 EP3725315 A4 EP 3725315A4
Authority
EP
European Patent Office
Prior art keywords
benzothiazepine
optical isomer
oxide derivative
renal dysfunction
improving drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18887948.0A
Other languages
German (de)
English (en)
Other versions
EP3725315B1 (fr
EP3725315A1 (fr
Inventor
Noboru Kaneko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aetas Pharma Co Ltd
Original Assignee
Aetas Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aetas Pharma Co Ltd filed Critical Aetas Pharma Co Ltd
Publication of EP3725315A1 publication Critical patent/EP3725315A1/fr
Publication of EP3725315A4 publication Critical patent/EP3725315A4/fr
Application granted granted Critical
Publication of EP3725315B1 publication Critical patent/EP3725315B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18887948.0A 2017-12-11 2018-12-11 Médicament améliorant un dysfonctionnement rénal comprenant un isomère optique de dérivé de 1-oxyde de 1,4-benzothiazépine Active EP3725315B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017236833 2017-12-11
PCT/JP2018/045416 WO2019117116A1 (fr) 2017-12-11 2018-12-11 Médicament améliorant un dysfonctionnement rénal comprenant un isomère optique de dérivé de 1-oxyde de 1,4-benzothiazépine

Publications (3)

Publication Number Publication Date
EP3725315A1 EP3725315A1 (fr) 2020-10-21
EP3725315A4 true EP3725315A4 (fr) 2021-08-11
EP3725315B1 EP3725315B1 (fr) 2023-10-04

Family

ID=66819257

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18887948.0A Active EP3725315B1 (fr) 2017-12-11 2018-12-11 Médicament améliorant un dysfonctionnement rénal comprenant un isomère optique de dérivé de 1-oxyde de 1,4-benzothiazépine

Country Status (6)

Country Link
US (1) US11844803B2 (fr)
EP (1) EP3725315B1 (fr)
JP (1) JP7228529B2 (fr)
CN (1) CN111447932A (fr)
TW (1) TWI741240B (fr)
WO (1) WO2019117116A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4019089A4 (fr) * 2019-07-22 2023-11-01 Aetas Pharma Co. Ltd. Procédé de production d'un dérivé de 1,4-benzothiazépine-1-oxyde optiquement actif

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010114562A1 (fr) * 2009-04-03 2010-10-07 Sequel Pharmaceuticals, Inc. Procedes d'administration ameliores de k201 (jtv-519) (4-[3-{1-(4-benzyl) piperidinyl}propionyl]-7-methoxy 2, 3, 4, 5-tetrahydro-1, 4-benzothiazepine monochlorhydrate)
WO2010114563A1 (fr) * 2009-04-03 2010-10-07 Sequel Pharmaceuticals, Inc. Metabolites de k201 (jtv-519) (4- [3-{1- (4- benzyl) piperidinyl} propionyl] -7 -methoxy 2, 3, 4, 5-tetrahydro-1,4-benzothiazepine monochlorhydrate
EP2402333A1 (fr) * 2009-02-25 2012-01-04 Noboru Kaneko Dérivé de 1-oxyde de 1,4-benzothiazépine et composition pharmaceutique l'utilisant
EP3176164A1 (fr) * 2014-07-30 2017-06-07 Aetas Pharma Co. Ltd. Isomère optique de dérivé de 1,4-benzothiazépine-1-oxyde, et composition pharmaceutique préparée à l'aide de celui-ci

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0737388B2 (ja) * 1987-02-10 1995-04-26 田辺製薬株式会社 腎機能改善剤
JP2703408B2 (ja) 1990-12-28 1998-01-26 麒麟麦酒株式会社 １，４‐ベンゾチアゼピン誘導体
JP4064027B2 (ja) 1998-12-28 2008-03-19 金子 昇 心房細動治療薬
DE69929362T2 (de) 1998-12-28 2006-09-28 Kaneko, Noboru verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION
JP4041642B2 (ja) 1999-05-19 2008-01-30 昇 金子 制癌剤耐性克服剤および制癌剤効果増強剤
JP2003095977A (ja) 2001-09-21 2003-04-03 Masafumi Yano 筋肉収縮・弛緩機能障害関連疾患の治療又は予防剤
PL1687006T3 (pl) * 2003-11-18 2008-01-31 Solvay Pharm Gmbh Kompozycje farmaceutyczne do leczenia zaburzeń czynności nerek
EP1743895A4 (fr) 2004-04-28 2010-06-16 Aetas Pharma Co Ltd Accélérateur du relachement des muscles et agent thérapeutique pour des maladies des tissus musculaires telles qu'une insuffisance du relâchement des muscles
JP2008273859A (ja) * 2007-04-26 2008-11-13 Japan Health Science Foundation 腎機能障害を持つ心不全患者を治療するためのコハク酸シベンゾリンを有効成分とする不整脈治療剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2402333A1 (fr) * 2009-02-25 2012-01-04 Noboru Kaneko Dérivé de 1-oxyde de 1,4-benzothiazépine et composition pharmaceutique l'utilisant
WO2010114562A1 (fr) * 2009-04-03 2010-10-07 Sequel Pharmaceuticals, Inc. Procedes d'administration ameliores de k201 (jtv-519) (4-[3-{1-(4-benzyl) piperidinyl}propionyl]-7-methoxy 2, 3, 4, 5-tetrahydro-1, 4-benzothiazepine monochlorhydrate)
WO2010114563A1 (fr) * 2009-04-03 2010-10-07 Sequel Pharmaceuticals, Inc. Metabolites de k201 (jtv-519) (4- [3-{1- (4- benzyl) piperidinyl} propionyl] -7 -methoxy 2, 3, 4, 5-tetrahydro-1,4-benzothiazepine monochlorhydrate
EP3176164A1 (fr) * 2014-07-30 2017-06-07 Aetas Pharma Co. Ltd. Isomère optique de dérivé de 1,4-benzothiazépine-1-oxyde, et composition pharmaceutique préparée à l'aide de celui-ci

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ONDREJ LISY ET AL: "New Cardioprotective Agent K201 Is Natriuretic and Glomerular Filtration Rate Enhancing", CIRCULATION, vol. 113, no. 2, 17 January 2006 (2006-01-17), US, pages 246 - 251, XP055617652, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.105.558213 *

Also Published As

Publication number Publication date
JP7228529B2 (ja) 2023-02-24
US11844803B2 (en) 2023-12-19
CN111447932A (zh) 2020-07-24
TWI741240B (zh) 2021-10-01
EP3725315B1 (fr) 2023-10-04
US20200390782A1 (en) 2020-12-17
JPWO2019117116A1 (ja) 2020-12-03
TW201927307A (zh) 2019-07-16
WO2019117116A1 (fr) 2019-06-20
EP3725315A1 (fr) 2020-10-21

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