EP3700936A4 - ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES - Google Patents

ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES Download PDF

Info

Publication number
EP3700936A4
EP3700936A4 EP17929557.1A EP17929557A EP3700936A4 EP 3700936 A4 EP3700936 A4 EP 3700936A4 EP 17929557 A EP17929557 A EP 17929557A EP 3700936 A4 EP3700936 A4 EP 3700936A4
Authority
EP
European Patent Office
Prior art keywords
glyco
muc1 antibodies
muc1
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17929557.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3700936A1 (en
Inventor
Thayer White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Go Therapeutics Inc
Original Assignee
Go Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Go Therapeutics Inc filed Critical Go Therapeutics Inc
Publication of EP3700936A1 publication Critical patent/EP3700936A1/en
Publication of EP3700936A4 publication Critical patent/EP3700936A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4725—Mucins, e.g. human intestinal mucin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
EP17929557.1A 2017-10-24 2017-10-24 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES Pending EP3700936A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/058036 WO2019083506A1 (en) 2017-10-24 2017-10-24 ANTI-GLYCO-MUC1 ANTIBODIES AND USES THEREOF

Publications (2)

Publication Number Publication Date
EP3700936A1 EP3700936A1 (en) 2020-09-02
EP3700936A4 true EP3700936A4 (en) 2021-05-26

Family

ID=66247577

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17929557.1A Pending EP3700936A4 (en) 2017-10-24 2017-10-24 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES

Country Status (10)

Country Link
EP (1) EP3700936A4 (enrdf_load_html_response)
JP (2) JP7358367B2 (enrdf_load_html_response)
KR (2) KR102608763B1 (enrdf_load_html_response)
CN (1) CN111479828B (enrdf_load_html_response)
AU (1) AU2017436815B2 (enrdf_load_html_response)
BR (1) BR112020008001A2 (enrdf_load_html_response)
CA (1) CA3078812A1 (enrdf_load_html_response)
IL (1) IL274202A (enrdf_load_html_response)
MX (1) MX2020004220A (enrdf_load_html_response)
WO (1) WO2019083506A1 (enrdf_load_html_response)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7358367B2 (ja) * 2017-10-24 2023-10-10 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｍｕｃ１抗体およびその使用
AU2021316098A1 (en) * 2020-07-31 2023-03-16 R.P. Scherer Technologies, Llc Antibody specific for Mucin-1 and methods of use thereof
WO2023027534A1 (ko) * 2021-08-27 2023-03-02 주식회사 펩트론 신규 항 muc1항체 및 이의 용도
AU2022420709A1 (en) * 2021-12-21 2024-08-01 Merus N.V. Binding domains against cancer-associated muc1
CN114099685B (zh) * 2022-01-27 2022-06-21 中国农业大学 抑制muc1表达和糖基化修饰的物质在降低抗乳腺癌药物耐药性中的应用
TW202444432A (zh) * 2023-04-13 2024-11-16 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｅｇｆｒ和ｍｕｃ１的抗原結合分子、其藥物偶聯物及其醫藥用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150005474A1 (en) * 2003-01-23 2015-01-01 Glycotope Gmbh Recognition molecules for the treatment and detection of tumors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001249760B2 (en) * 2000-03-30 2005-04-21 Dyax Corp. Mucin-1 specific binding members and methods of use thereof
US8440798B2 (en) * 2006-10-04 2013-05-14 Københavns Universitet Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies
EP2014302A1 (en) * 2007-07-12 2009-01-14 Institut Curie An antibody specific for the Tn antigen for the treatment of cancer
EP2221374A4 (en) * 2007-12-05 2011-01-19 Kyowa Hakko Kirin Co Ltd MONOCLONAL ANTIBODY CAPABLE OF BINDING TO A GROWTH FACTOR OF HB-EGF (HEPARIN-BINDING EPIDERMAL GROWTH FACTOR)
US8722856B2 (en) * 2008-10-28 2014-05-13 National University Corporation Hokkaido University Anti-MUC1 antibody
EP2281844A1 (en) * 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
US10208125B2 (en) * 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
WO2015120180A1 (en) * 2014-02-05 2015-08-13 The University Of Chicago Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants
KR102262720B1 (ko) * 2014-04-28 2021-06-08 이카가쿠 소우야쿠 가부시키가이샤 항muc1 항체 또는 그의 항원 결합성 단편 및 그 용도
JP7358367B2 (ja) * 2017-10-24 2023-10-10 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｍｕｃ１抗体およびその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150005474A1 (en) * 2003-01-23 2015-01-01 Glycotope Gmbh Recognition molecules for the treatment and detection of tumors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, FONTENOT: "Synthesis of large multideterminant peptide immunogens using a poly-proline beta-turn helix motif", XP055796187, Database accession no. PREV199497079884 *

Also Published As

Publication number Publication date
JP2024001073A (ja) 2024-01-09
AU2017436815B2 (en) 2025-05-29
KR102608763B1 (ko) 2023-11-30
KR20200067885A (ko) 2020-06-12
CN111479828B (zh) 2024-07-05
KR102832078B1 (ko) 2025-07-08
JP7358367B2 (ja) 2023-10-10
IL274202A (en) 2020-06-30
WO2019083506A1 (en) 2019-05-02
JP2021510307A (ja) 2021-04-22
AU2017436815A1 (en) 2020-04-23
MX2020004220A (es) 2020-10-05
KR20230165874A (ko) 2023-12-05
BR112020008001A2 (pt) 2020-10-20
CA3078812A1 (en) 2019-05-02
CN111479828A (zh) 2020-07-31
EP3700936A1 (en) 2020-09-02

Similar Documents

Publication Publication Date Title
EP3625263B8 (en) Anti-galectin-9 antibodies and uses thereof
EP3596119A4 (en) ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
EP3572427A4 (en) BCMA TARGETING ANTIBODIES AND USES
EP3891183A4 (en) ANTI-CLAUDINE ANTIBODIES AND THEIR USES
EP3658185A4 (en) ANTI-TIM-3 ANTIBODIES AND USES THEREOF
EP3675898A4 (en) ANTI-LAG-3 ANTIBODIES AND THEIR USES
EP3850012A4 (en) ANTI-TNFRSF9 ANTIBODIES AND THEIR USES
EP3567054A4 (en) ANTI-ALPHA SYN ANTIBODIES AND USES THEREOF
EP3774888A4 (en) Anti-phf-tau antibodies and uses thereof
EP3529273A4 (en) ANTI-O1 ANTIBODIES AND USES THEREOF
EP3700936A4 (en) ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES
EP3699193A4 (en) ANTI-VISTA ANTIBODIES AND USE THEREOF
EP3894439A4 (en) ANTI-PERIOSTIN ANTIBODIES AND THEIR USES
EP3841124A4 (en) ANTI-L1CAM ANTIBODIES AND THEIR USES
EP3724657A4 (en) Anti-cannabidiol antibody and uses thereof
EP3762028A4 (en) ANTI-TIP 1 ANTIBODIES AND USES THEREOF
EP3604336A4 (en) ANTI-EMAP II ANTIBODIES AND THEIR USES
HK40097160A (en) Anti-tim-3 antibodies and use thereof
HK40088438A (en) Anti-tim-3 antibodies and use thereof
HK40027176A (en) Anti-galectin-9 antibodies and uses thereof
HK40034341A (en) Axl-specific antibodies and uses thereof
HK40019122B (en) Anti-apelin antibodies and uses thereof
HK40115176A (en) Bispecific antibodies and uses thereof
HK40031036A (en) Anti-cd166 antibodies and uses thereof
HK40030314A (en) Anti-fam19a5 antibodies and uses thereof

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200521

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40025649

Country of ref document: HK

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210429

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/30 20060101AFI20210422BHEP

Ipc: G01N 33/574 20060101ALI20210422BHEP