EP3669163A4 - Dispositifs et procédés pour séparer des cellules tumorales circulantes d'échantillons biologiques - Google Patents
Dispositifs et procédés pour séparer des cellules tumorales circulantes d'échantillons biologiques Download PDFInfo
- Publication number
- EP3669163A4 EP3669163A4 EP18841411.4A EP18841411A EP3669163A4 EP 3669163 A4 EP3669163 A4 EP 3669163A4 EP 18841411 A EP18841411 A EP 18841411A EP 3669163 A4 EP3669163 A4 EP 3669163A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- devices
- tumor cells
- biological samples
- circulating tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762541552P | 2017-08-04 | 2017-08-04 | |
PCT/US2018/045294 WO2019028445A1 (fr) | 2017-08-04 | 2018-08-04 | Dispositifs et procédés pour séparer des cellules tumorales circulantes d'échantillons biologiques |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3669163A1 EP3669163A1 (fr) | 2020-06-24 |
EP3669163A4 true EP3669163A4 (fr) | 2021-08-11 |
Family
ID=65233143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18841411.4A Pending EP3669163A4 (fr) | 2017-08-04 | 2018-08-04 | Dispositifs et procédés pour séparer des cellules tumorales circulantes d'échantillons biologiques |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3669163A4 (fr) |
CA (1) | CA3071593A1 (fr) |
WO (1) | WO2019028445A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110093246B (zh) * | 2019-05-05 | 2022-05-24 | 温州医科大学 | 一种多极磁场连续磁珠细胞分离装置及其方法 |
WO2022170340A1 (fr) * | 2021-02-03 | 2022-08-11 | University Of Georgia Research Foundation, Inc. | Dispositifs, kits et procédés de séparation cellulaire inertielle ferrohydrodynamique sans étiquette, à rendement et résolution élevés |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432630B1 (en) * | 1996-09-04 | 2002-08-13 | Scandinanian Micro Biodevices A/S | Micro-flow system for particle separation and analysis |
DE102009005925A1 (de) * | 2009-01-23 | 2010-07-29 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und Verfahren zur Handhabung von Biomolekülen |
US20100297733A1 (en) * | 2009-04-21 | 2010-11-25 | Qiao Lin | Systems And Methods For The Capture And Separation Of Microparticles |
US20130306566A1 (en) * | 2012-05-18 | 2013-11-21 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating particles |
US9278353B2 (en) * | 2012-06-25 | 2016-03-08 | The General Hospital Corporation | Sorting particles using high gradient magnetic fields |
US20160244714A1 (en) * | 2013-10-18 | 2016-08-25 | The General Hosptial Corporation | Microfluidic sorting using high gradient magnetic fields |
US20170029782A1 (en) * | 2015-07-31 | 2017-02-02 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating particles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8689981B2 (en) * | 2009-04-10 | 2014-04-08 | President And Fellows Of Harvard College | Manipulation of particles in channels |
JP6744302B2 (ja) * | 2014-11-03 | 2020-08-19 | ザ ジェネラル ホスピタル コーポレイション | ミクロ流体装置における粒子の分類 |
-
2018
- 2018-08-04 CA CA3071593A patent/CA3071593A1/fr active Pending
- 2018-08-04 EP EP18841411.4A patent/EP3669163A4/fr active Pending
- 2018-08-04 WO PCT/US2018/045294 patent/WO2019028445A1/fr unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432630B1 (en) * | 1996-09-04 | 2002-08-13 | Scandinanian Micro Biodevices A/S | Micro-flow system for particle separation and analysis |
DE102009005925A1 (de) * | 2009-01-23 | 2010-07-29 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und Verfahren zur Handhabung von Biomolekülen |
US20100297733A1 (en) * | 2009-04-21 | 2010-11-25 | Qiao Lin | Systems And Methods For The Capture And Separation Of Microparticles |
US20130306566A1 (en) * | 2012-05-18 | 2013-11-21 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating particles |
US9278353B2 (en) * | 2012-06-25 | 2016-03-08 | The General Hospital Corporation | Sorting particles using high gradient magnetic fields |
US20160244714A1 (en) * | 2013-10-18 | 2016-08-25 | The General Hosptial Corporation | Microfluidic sorting using high gradient magnetic fields |
US20170029782A1 (en) * | 2015-07-31 | 2017-02-02 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating particles |
Non-Patent Citations (1)
Title |
---|
See also references of WO2019028445A1 * |
Also Published As
Publication number | Publication date |
---|---|
CA3071593A1 (fr) | 2019-02-07 |
WO2019028445A1 (fr) | 2019-02-07 |
EP3669163A1 (fr) | 2020-06-24 |
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Legal Events
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
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17P | Request for examination filed |
Effective date: 20200424 |
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AK | Designated contracting states |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20210708 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 3/00 20060101AFI20210702BHEP Ipc: G01N 15/10 20060101ALI20210702BHEP Ipc: G01N 33/574 20060101ALI20210702BHEP Ipc: B01L 3/00 20060101ALI20210702BHEP |