EP3645105A1 - Système de dialyse péritonéale - Google Patents

Système de dialyse péritonéale

Info

Publication number
EP3645105A1
EP3645105A1 EP18746100.9A EP18746100A EP3645105A1 EP 3645105 A1 EP3645105 A1 EP 3645105A1 EP 18746100 A EP18746100 A EP 18746100A EP 3645105 A1 EP3645105 A1 EP 3645105A1
Authority
EP
European Patent Office
Prior art keywords
peritoneal dialysis
concentrate
water
concentrate container
information
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18746100.9A
Other languages
German (de)
English (en)
Inventor
Peter Wabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Publication of EP3645105A1 publication Critical patent/EP3645105A1/fr
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654Dialysates therefor
    • A61M1/1656Apparatus for preparing dialysates
    • A61M1/1668Details of containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287Dialysates therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1044Verifying the connection, e.g. audible feedback, tactile feedback, visual feedback, using external light sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/584Means for facilitating use, e.g. by people with impaired vision by visual feedback having a color code
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6018General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6063Optical identification systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6063Optical identification systems
    • A61M2205/6072Bar codes

Definitions

  • the present invention relates to a peritoneal dialysis system comprising at least one peritoneal dialysis machine.
  • Peritoneal dialysis is performed by patients at a typical treatment site.
  • peritoneal dialysis takes place at home or in the home bedroom.
  • bags are used with fresh dialysis solution, which is introduced via a tube system and a patient catheter into the abdominal cavity of the patient and there for a certain period of time remains.
  • the peritoneum acts as a dialysis membrane which allows an exchange between the dialysis solution and the patient's blood in the form that contaminants from the patient's blood are transferred via the membrane into the dialysis solution.
  • the dialysis solution is removed again from the abdominal cavity.
  • the peritoneal dialysis system further comprises at least one water unit for treatment and / or dosage of water and at least one concentrate container, wherein the concentrate container has at least one connector or is in communication therewith and wherein the water unit and / or the Peritonealdialyse réelle at least a connector for the connector, wherein the connector has at least one piece of information, preferably in the form of at least one bar code, which represents the amount of water to be filled into the concentrate container or conclusions on it, and wherein the water unit or the Peritonealdialyse réelle is formed, this information read out and cause the addition of water according to the information read or cause.
  • the solution containers suitable for the treatment are obtained and the ready-to-use dialysis solution or a part thereof is produced.
  • PoC point of care
  • container in the context of the present invention includes all conceivable containers, such as for example those with solid walls, such as boxes or even those with flexible walls, such as bags.
  • the information as to how much water has to be poured into the concentrate containers is located on the connector (s), which may be located directly on the concentrate container, but preferably on the end of a hose connected to the interior of the concentrate container.
  • the information can concretely contain the amount (mass, volume, etc.) of the water to be filled in, or else permit conclusions to be drawn indirectly. This may be done, for example, such that the information contains only the type of concentrate and is made therefrom e.g. from a storage medium, the amount of water to be added to the concentrate to obtain the finished dialysis solution or a part thereof is read out.
  • Electrolyte solutions used for the production of the finished dialysis solution.
  • finished dialysis solution is understood to mean that the finished dialysis solution is mixed, for example in the peritoneal dialysis machine, from two or more parts, ie In this case, the finished dialysis solution is produced only in the peritoneal dialysis machine from the parts of the finished dialysis solution.
  • the water unit is preferably designed to be connected to a conventional domestic water system or to a conventional faucet.
  • the water unit may e.g. have at least one RO unit and / or one or more filters.
  • purified water is produced by reverse osmosis from tap water. Further purification is possible by further treatment of water in one or more filters. These can be upstream and / or downstream of the RO unit.
  • another unit for producing pure water may also be present, such as e.g. a unit for deionization, for distillation or else a combination of one or more of the abovementioned units.
  • the concentrate container is a concentrate bag and / or that at least one tube is located on the concentrate container, at the end of which the connector is arranged.
  • the one or more hoses are in fluid communication with the interior of the concentrate container (s) so that water may be introduced through the hose into the concentrate container and the finished dialysis solution or a portion thereof removed from the concentrate container to the peritoneal dialysis machine via the same or a different hose can.
  • the concentrate container has at least two connectors or is in communication therewith, at least one of the connectors containing said information and the other connector containing the same or different information, and wherein both the peritoneal dialysis apparatus and Also, the water unit has at least one receptacle for each one of these connectors.
  • a preferred embodiment of the invention thus consists in that the concentrate container is designed with at least two hoses, each of which is provided with a connector.
  • a connector connects to the water unit and a connector connects to the peritoneal dialysis machine.
  • At least one of these connectors contains the o.g. Information that represents or allows conclusions to be drawn about the amount of water to be added to the concentrate container.
  • This information may e.g. be arranged in the form of a barcode on the connector or in the form of another code that is readable.
  • the water unit and / or the Peritonealdialyse réelle contain at least one receptacle for receiving this connector and reading means which are adapted to read the information located on the connector.
  • the water unit can immediately supply the desired amount of water and dose it into the concentrate container.
  • the peritoneal dialysis device If the peritoneal dialysis device contains this receptacle and the connector is inserted there, the peritoneal dialysis device transmits the information to the water unit so that it can provide the desired amount of water and dose it into the concentrate container.
  • the dosage of the amount of water is carried out by the peritoneal dialysis machine.
  • the other connector may also be such a connector provided with an information or even a standard connector that contains no information.
  • the other connector may also be a connector that contains information, eg in form a barcode or in the form of another code. Both connectors can contain the same or different information.
  • the concentrate container (s) has all the substances required for peritoneal dialysis which, after dilution with water, are present in the desired concentration, the substances comprising the following group: electrolyte ions and at least one osmoticum, in particular glucose and optionally one or more buffers.
  • the concentrate or concentrates may be concentrated solutions as well as dry concentrates.
  • the peritoneal dialysis machine and / or the water unit can have a plurality of receptacles for connectors of different concentrate containers and / or the peritoneal dialysis machine can have at least one receptacle for a connector for a prefilled solution container.
  • concentrate containers can be connected and filled one after the other or simultaneously with water.
  • the concentrate containers may contain identical or different concentrates.
  • the concentrate container or containers may have a first tube, by means of which water can be fed into the concentrate container from the water unit and have a second tube, by means of which the concentrate produced in the concentrate container can be fed to the peritoneal dialysis machine.
  • the first tube can be provided with a code containing the information about the amount of water to be added, in particular a barcode, and introduced into the water unit, the other tube can be made with a standard connector which is connected to the peritoneal dialysis machine.
  • hose can be provided with a connector with information, eg about the type and amount of the solution.
  • the concentrate container (s) have only a single tube, by means of which water can be admitted into the concentrate container by the water unit and by means of which the concentrate produced in the concentrate container can be fed to the peritoneal dialysis machine.
  • the concentrate container (s) have at least one hose by means of which water can be admitted into the concentrate container by the water unit, wherein at least one filter and / or at least one one-way valve is located in this hose.
  • the filter causes further purification of the water by which the concentrate is diluted, the one-way valve ensures that no fluid from the Konzentratbehalter flows back to the water unit, but only in the opposite direction.
  • the filter and / or the one-way valve may be considered disposable, i. be designed as disposable article.
  • the peritoneal dialysis machine may comprise at least one receptacle for the connector having the information, and the peritoneal dialysis apparatus may further comprise transmission means for transmitting this information to the water unit. This is necessary when the connector is inserted into the peritoneal dialysis machine but not into the water unit. In this case, it is possible to dispense with receptacles for connectors and a readout unit of the connector information in the water unit.
  • the connector or connectors may have one or more information about the type of concentrate, in particular about the ingredients and / or their concentrations.
  • the concentrate (s) may be in liquid or solid form in the concentrate container (s).
  • the water unit may have at least one pump to be balanced. This introduces water in the desired amount into the concentrate container (s).
  • any other dosage unit may be provided which doses water preferably with an accuracy of 1%.
  • the water unit and / or the Peritonealdialyse réelle can be arranged on a movable frame or trolley or in a container that also serves as a base for the peritoneal dialysis machine.
  • the peritoneal dialysis machine is an APD device, but any other peritoneal dialysis devices are also usable within the scope of the invention.
  • the volume of the concentrate container represents information which is likewise contained in the code, in particular the bar code of the connector.
  • Exemplary volumes are 2 I, 5 I or 15 I if only one bag is to be used for the entire therapy.
  • the water unit may be connected to a platform and / or the peritoneal dialysis machine wirelessly, via WIFI, Bluetooth, or other techniques. It is also possible that at least one balance is provided for detecting the weight of the concentrate container and that communication means for communication between the balance and the water unit are present, via which the information about the current weight of the concentrate container can be transmitted to the water unit. So it is possible to use a non-balancing pump. In this case, the filling volume in the concentrate container is defined by a balance. It is conceivable that the balance or another unit connected to it controls a valve which blocks or releases the flow path into the concentrate container, depending on whether the desired volume or weight has already been reached in the concentrate container. Thus, it is also possible to make or verify several concentrate containers in succession.
  • the peritoneal dialysis machine has at least one memory in which the prescription to be made is stored for the treatment. Based on the prescription, the peritoneal dialysis machine determines which concentrate containers to attach to the water unit. The water unit reads from the bar codes or other codes the information on the amount of volume to be used for diluting the concentrates and makes the appropriate filling of the concentrate container (s).
  • the water unit may include means configured to give a timestamp indicating when the solution has been completely diluted. This timestamp is communicated via a connection (eg WLAN or LAN) to the peritoneal dialysis machine.
  • the peritoneal dialysis machine verifies that the timestamp is still valid, ie, that it has not been too long since the solution was prepared, and only allows the solution to be treated if the time has not yet passed. Typical values are in the range of 6 and 24 h.
  • at least one movement element such as eg a shaker, can be provided in order to move the concentrate container or containers.
  • the present invention further relates to a concentrate container containing a concentrate which is used after dilution for use as a solution for peritoneal dialysis, wherein the concentrate container has at least one connector having one or more information, preferably in the form of at least one barcode, which Represents the amount of water to be filled into the concentrate container or allows conclusions to be drawn.
  • the concentrate container may for example have one or two tubes. In the case of two hoses, each hose may be provided with a connector having information, or only one of the connectors, as detailed above.
  • the present invention further relates to a process for the preparation of a peritoneal dialysis solution, which preparation is carried out using a peritone aldialysis system according to one of claims 1 to 12.
  • the method is carried out such that it comprises the step of inserting the at least one connector into the water unit and / or into the peritoneal dialysis apparatus, that the information located on the connector is read out, and that the addition of water into the concentrate container (s) corresponding to read information takes place.
  • FIG. 1 a schematic view of the peritoneal dialysis system with two each
  • FIG. 2 shows a schematic view of the peritoneal dialysis system with one each
  • FIG. 3 is a schematic view of the peritoneal dialysis system with trolley
  • FIG. 1 shows a peritoneal dialysis system according to the invention in a first embodiment.
  • the reference numeral 10 denotes the water unit, which has means for dosing and means for treating or purifying the water.
  • the water unit 10 is connected to the faucet 1 of a household or clinic, etc.
  • the reference numeral 20 denotes a peritoneal dialysis apparatus
  • the reference character P denotes a patient whose prescription is stored in the peritoneal dialysis apparatus 20.
  • Reference numerals 30 and 31 designate two concentrate containers of different sizes with the concentrates K30 and K31, the concentrate container 30 having a volume of 15 l and the concentrate container 31 having a volume of 5 l.
  • each of these concentrate containers 30, 31 has a first tube S1 with a first connector K1 and a second tube S2 with a second connector K2, the tubes S1 for supplying water from the unit 10 into the bags 30, 31 and the tubes S2 serve to remove the diluted concentrate or the finished dialysis solution from the bags 30, 31 to the peritoneal dialysis machine 20.
  • the tubes S1 is in each case a disposable ultrapure filter 1 1.
  • the connectors K1 and K2 each contain bar codes B1 and B2.
  • the barcodes B1 contain information that allows conclusions about what volume or mass of water is to be filled in the bags 30, 31.
  • the water unit 10 reads this information and doses a corresponding amount of water into the bags, so that the desired concentration of the individual substances is present in the bags.
  • the solution can be used for use in the peritoneal dialysis machine 20.
  • the solution is read by the peritoneal dialysis machine 20 from the barcode B2 of the connector K2.
  • the peritoneal dialysis machine 20 also has one or more receptacles for standard connectors, so that a ready-filled standard solution bag 33 can be connected and used, as shown in FIG.
  • FIG. 2 shows an exemplary embodiment in which the concentrate containers have only one tube S3 which is designed with a connector K3 with barcode B3 is.
  • the same or functionally identical parts are denoted by the same reference numerals as in FIG. 1.
  • the connector K3 is inserted into a receptacle of the peritoneal dialysis machine 20 and thus does not communicate directly with the water unit 10.
  • the water unit 10 comprises a pre-filter and RO unit 1 1, a pump, such as a pump. an impeller pump 12 and this downstream filter 13.
  • the water unit 10 is connected via a hose 40 or other line with the peritoneal dialysis machine 20 in connection.
  • this tube 40 is another filter 41, e.g. a 0.2 ⁇ filter.
  • the peritoneal dialysis machine 20 reads out the bar codes B3 and reports to the water unit 10 which amount of water is to be metered.
  • the water unit 10 delivers this amount of water to the peritoneal dialysis machine 20 and this or into the concentrate containers 30, 31. After dilution and dissolution in the concentrate containers 30, 31, the solution is delivered to or from the peritoneal dialysis machine, for example. promoted by one or more pumps to the patient.
  • Reference numeral 60 denotes a safety chamber in the concentrate container 30.
  • the barcodes B1 and B3 have information indicating the type of solution or concentrate to be prepared and the amount of water to be added. Despite the same reference numbers B1, the barcode B1 of the bag 30 may have information different from the barcode B1 of the bag 31 , This applies to the bar codes B2 and B3 accordingly.
  • the peritoneal dialysis system can be used as a batch-type system, which produces the solutions batch-wise for the respective treatment.
  • the peritoneal dialysis machine can be moved on a trolley T from a filling station or from the water unit to the patient.
  • FIG. 3 a shows the peritoneal dialysis machine 20 and the water unit as a movable peritoneal dialysis system, with the peritoneal dialysis machine 20 standing on top of the water unit 10.
  • FIG. 3 b shows the peritoneal dialysis machine 20 on a trolley T and independent of the water unit 10, which in this case is designed as a separate unit separate from the peritoneal dialysis machine 20.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un système de dialyse péritonéale comprenant au moins un appareil de dialyse péritonéale, le système de dialyse péritonéale présentant en outre au moins une unité pour l'eau destinée à la préparation et/ou au dosage de l'eau et au moins un récipient pour concentré, le récipient pour concentré présentant au moins un raccord ou étant en liaison avec celui-ci et l'unité pour l'eau et/ou l'appareil de dialyse péritonéale présentant au moins un logement pour le raccord et le raccord présentant au moins une information, de préférence sous forme de code à barres, qui représente la quantité d'eau à verser dans le récipient pour concentré ou qui en donne une indication, et l'unité pour l'eau ou l'appareil de dialyse péritonéale étant conçu(e) pour lire cette information et pour effectuer ou provoquer l'ajout d'eau en fonction de l'information lue.
EP18746100.9A 2017-06-28 2018-06-28 Système de dialyse péritonéale Pending EP3645105A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017114401.3A DE102017114401A1 (de) 2017-06-28 2017-06-28 Peritonealdialysesystem
PCT/EP2018/067436 WO2019002477A1 (fr) 2017-06-28 2018-06-28 Système de dialyse péritonéale

Publications (1)

Publication Number Publication Date
EP3645105A1 true EP3645105A1 (fr) 2020-05-06

Family

ID=63036008

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18746100.9A Pending EP3645105A1 (fr) 2017-06-28 2018-06-28 Système de dialyse péritonéale

Country Status (8)

Country Link
US (1) US20200121843A1 (fr)
EP (1) EP3645105A1 (fr)
JP (1) JP7245181B2 (fr)
KR (1) KR102661124B1 (fr)
CN (1) CN110799240A (fr)
AU (1) AU2018293333B2 (fr)
DE (1) DE102017114401A1 (fr)
WO (1) WO2019002477A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4035705A1 (fr) * 2021-01-29 2022-08-03 Bellco S.r.l. Système et procédé de dialyse

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Also Published As

Publication number Publication date
AU2018293333A1 (en) 2020-02-13
WO2019002477A1 (fr) 2019-01-03
DE102017114401A1 (de) 2019-01-03
JP2020525236A (ja) 2020-08-27
KR20200023429A (ko) 2020-03-04
CN110799240A (zh) 2020-02-14
KR102661124B1 (ko) 2024-04-29
JP7245181B2 (ja) 2023-03-23
US20200121843A1 (en) 2020-04-23
AU2018293333B2 (en) 2023-12-07

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