EP3618856A1 - Immunothérapie anticancéreuse à base d'arnm à indications multiples - Google Patents
Immunothérapie anticancéreuse à base d'arnm à indications multiplesInfo
- Publication number
- EP3618856A1 EP3618856A1 EP18795120.7A EP18795120A EP3618856A1 EP 3618856 A1 EP3618856 A1 EP 3618856A1 EP 18795120 A EP18795120 A EP 18795120A EP 3618856 A1 EP3618856 A1 EP 3618856A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mrna
- seq
- dna
- emml
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
Abstract
L'invention concerne un ARN messager bactérien, synthétique, qui peut être utilisé pour préparer des vaccins contre le cancer autoplastiques, allogènes ou utilisant directement l'acide nucléique. Les cellules cancéreuses sont transfectées in vitro ou in vivo avec un ARNm obtenu de l'ADN qui code pour une protéine bactérienne immunogène. Une réponse immunitaire contre le cancer est générée par l'administration directe de l'ARNm in vivo ou par l'administration de vaccins préparés in vitro à partir de cellules cancéreuses.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/583,599 US10682401B2 (en) | 2015-05-19 | 2017-05-01 | Multi-indication mRNA cancer immunotherapy |
| PCT/US2018/030142 WO2018204234A1 (fr) | 2017-05-01 | 2018-04-30 | Immunothérapie anticancéreuse à base d'arnm à indications multiples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3618856A1 true EP3618856A1 (fr) | 2020-03-11 |
| EP3618856A4 EP3618856A4 (fr) | 2021-02-24 |
Family
ID=64016702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18795120.7A Withdrawn EP3618856A4 (fr) | 2017-05-01 | 2018-04-30 | Immunothérapie anticancéreuse à base d'arnm à indications multiples |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP3618856A4 (fr) |
| WO (1) | WO2018204234A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3125532A1 (fr) * | 2019-01-04 | 2020-07-09 | Etherna Immunotherapies Nv | Vaccins a arnm |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795020B2 (en) * | 1998-01-14 | 2010-09-14 | Morphogenesis, Inc. | Tumor cell vaccines |
| US7348015B2 (en) * | 1998-01-14 | 2008-03-25 | Morphogenesis, Inc. | Antigen modified cancer cell vaccines for cancer therapy |
| WO2015134577A1 (fr) * | 2014-03-06 | 2015-09-11 | Morphogenesis, Inc. | Vecteur adn et vaccins à cellules tumorales transformées |
| ES2875589T3 (es) * | 2015-05-15 | 2021-11-10 | Curevac Ag | Regímenes de sensibilización-refuerzo que implican la administración de al menos un constructo de ARNm |
| DK3297664T3 (da) * | 2015-05-19 | 2020-12-07 | Morphogenesis Inc | Cancervaccine omfattende mrna, der koder for et m-lignende protein |
-
2018
- 2018-04-30 WO PCT/US2018/030142 patent/WO2018204234A1/fr unknown
- 2018-04-30 EP EP18795120.7A patent/EP3618856A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP3618856A4 (fr) | 2021-02-24 |
| WO2018204234A1 (fr) | 2018-11-08 |
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