CA3178223A1 - Arnm modifie pour transformation multicellulaire - Google Patents
Arnm modifie pour transformation multicellulaire Download PDFInfo
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- CA3178223A1 CA3178223A1 CA3178223A CA3178223A CA3178223A1 CA 3178223 A1 CA3178223 A1 CA 3178223A1 CA 3178223 A CA3178223 A CA 3178223A CA 3178223 A CA3178223 A CA 3178223A CA 3178223 A1 CA3178223 A1 CA 3178223A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Abstract
Un ARN messager bactérien synthétique peut être utilisé pour préparer des vaccins contre le cancer autologues, allogéniques ou directs. Les cellules cancéreuses sont transfectées in vitro ou in vivo avec l'ARNm obtenu à partir d'ADN qui code pour une protéine bactérienne immunogène. Une réponse immunitaire au cancer est générée à partir de l'administration directe de l'ARNm in vivo ou l'administration de vaccins préparés à partir de cellules cancéreuses in vitro. La modification de codon de l'ARNm peut optimiser l'expression d'un polypeptide immunogène dans des cellules cancéreuses.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/869,642 US20200317764A1 (en) | 2015-05-19 | 2020-05-08 | Modified mrna for multicell transformation |
| US16/869,642 | 2020-05-08 | ||
| PCT/US2021/031204 WO2021226413A2 (fr) | 2020-05-08 | 2021-05-07 | Arnm modifié pour transformation multicellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3178223A1 true CA3178223A1 (fr) | 2021-11-11 |
Family
ID=78468490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3178223A Pending CA3178223A1 (fr) | 2020-05-08 | 2021-05-07 | Arnm modifie pour transformation multicellulaire |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4146260A2 (fr) |
| JP (1) | JP2023524818A (fr) |
| KR (1) | KR20230009462A (fr) |
| CN (1) | CN115052621A (fr) |
| AU (1) | AU2021269036A1 (fr) |
| CA (1) | CA3178223A1 (fr) |
| WO (1) | WO2021226413A2 (fr) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10682401B2 (en) * | 2015-05-19 | 2020-06-16 | Morphogenesis, Inc. | Multi-indication mRNA cancer immunotherapy |
| WO2018151816A1 (fr) * | 2017-02-16 | 2018-08-23 | Modernatx, Inc. | Compositions immunogènes très puissantes |
-
2021
- 2021-05-07 AU AU2021269036A patent/AU2021269036A1/en active Pending
- 2021-05-07 EP EP21800236.8A patent/EP4146260A2/fr active Pending
- 2021-05-07 JP JP2022567590A patent/JP2023524818A/ja active Pending
- 2021-05-07 CA CA3178223A patent/CA3178223A1/fr active Pending
- 2021-05-07 KR KR1020227043200A patent/KR20230009462A/ko active Search and Examination
- 2021-05-07 WO PCT/US2021/031204 patent/WO2021226413A2/fr unknown
- 2021-05-07 CN CN202180007853.6A patent/CN115052621A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115052621A (zh) | 2022-09-13 |
| WO2021226413A2 (fr) | 2021-11-11 |
| WO2021226413A3 (fr) | 2021-12-30 |
| JP2023524818A (ja) | 2023-06-13 |
| AU2021269036A1 (en) | 2022-12-15 |
| EP4146260A2 (fr) | 2023-03-15 |
| KR20230009462A (ko) | 2023-01-17 |
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