EP3615108A1 - Automatic injection device provided with a device for generating sound signals - Google Patents

Automatic injection device provided with a device for generating sound signals

Info

Publication number
EP3615108A1
EP3615108A1 EP18724945.3A EP18724945A EP3615108A1 EP 3615108 A1 EP3615108 A1 EP 3615108A1 EP 18724945 A EP18724945 A EP 18724945A EP 3615108 A1 EP3615108 A1 EP 3615108A1
Authority
EP
European Patent Office
Prior art keywords
control member
automatic injection
injection
injection device
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18724945.3A
Other languages
German (de)
French (fr)
Inventor
Pascal Dugand
Kevin Stamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nemera la Verpilliere SAS
Original Assignee
Nemera la Verpilliere SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nemera la Verpilliere SAS filed Critical Nemera la Verpilliere SAS
Publication of EP3615108A1 publication Critical patent/EP3615108A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback

Definitions

  • the present invention relates to the field of automatic injection devices for liquid products, in particular pharmaceuticals.
  • Such automatic injection devices are particularly used in the medical field for the automatic administration of a liquid medicine requiring injection.
  • a device of this type makes it possible in particular for a person, for example suffering from rheumatoid arthritis, multiple sclerosis, diabetes or suffering anaphylactic shock in the event of allergy, to inject himself a dose of independently.
  • an automatic injection device comprising a syringe for injecting liquid provided with a syringe body carrying an injection needle and a displaceable mounted piston rod. in this syringe body to travel a liquid injection stroke.
  • the automatic injection device comprises an outer casing and a positioning control member which are telescopic and whose relative movement controls the operation of this automatic injection device.
  • control members are arranged to selectively control the movement of the syringe body and the movement of the piston within the positioning control member to automatically inject the liquid in the syringe.
  • This automatic injection device advantageously allows the dosing of the injection not to be dependent on the force applied to the outer casing but only of the positioning control member and control members which avoids a wrong dosage.
  • the invention aims to overcome these disadvantages by providing an automatic injection device to indicate when to remove the automatic injection device of the skin of the person into which the liquid is injected.
  • the invention relates to an automatic injection device comprising a liquid injection syringe provided with a syringe body carrying an injection needle and a piston rod movably mounted in this body. syringe for traversing a liquid injection stroke, an outer casing and a telescopic positioning control member whose relative movement controls the operation of the automatic injection device, and control members arranged to selectively control the movement of the syringe body and moving the piston inside the positioning control member to automatically inject the liquid present in the syringe, characterized in that the automatic injection device further comprises a device for generating sound signals activated during the automatic injection of the liquid present in the syringe.
  • the automatic injection device generates a succession of sound signals from the beginning to the end of the injection in order to indicate when to withdraw the automatic injection device from the skin of the person in which the liquid is injected. Indeed, the user no longer hears sound signals, it deduces that the injection is complete and that the automatic injection device can be removed from the skin of the person in which the liquid has been injected.
  • the device for generating sound signals is mounted between the positioning control member and one of the control members in order to generate sound signals during the relative movement between the syringe body and the piston;
  • the device for generating sound signals is mounted between the positioning control member and the control member of the syringe body;
  • the device for generating sound signals is mounted between the positioning control member and the piston control member;
  • the device for generating sound signals comprises at least one elastic-toothed hook assembly intended to generate a sound signal at each tooth pass of the elastic hook against the toothing;
  • the device for generating sound signals comprises two sets elastic hook - toothing
  • the two elastic hook sets - toothing are offset to generate two alternating sound signals
  • each set of teeth is arranged on the positioning control member
  • the automatic injection device further comprises a visual indication element of the injection stroke
  • the visual indication element comprises at least one visual indicator being positioned in line with a window fitted on the outer casing at the end of the injection stroke.
  • FIG. 1 is a perspective view of an automatic injection device according to the invention
  • FIG. 2 is a perspective view of the automatic injection device of FIG. 1, the outer casing of which has been masked;
  • FIG. 3 is a perspective view of the automatic injection device of FIG. 1, the outer casing, part of the positioning control member and the protective cap having been masked;
  • FIG. 4 is a sectional view of the automatic injection device according to the plane IV-IV of Figure 1;
  • FIG. 5 is a perspective view of the automatic injection device of FIG. 1 after removal of the protective cap;
  • FIG. 6 is a perspective view of the automatic injection device of FIG. 5, the outer casing and part of the positioning control member being masked;
  • FIG. 7 is a sectional view of the automatic injection device along the plane VII-VII of FIG. 5;
  • FIG. 8 is a perspective view of the automatic injection device of FIG. 5 showing the positioning of a part of a device for generating sound signals according to the invention
  • FIG. 9 is a perspective view of the automatic injection device of FIG. 1 after insertion of the needle into the skin of the patient;
  • FIG. 10 is a perspective view of the automatic injection device of Figure 9, the outer housing and a portion of the positioning control member have been masked;
  • FIG. 11 is a sectional view of the automatic injection device according to the plane XI-XI of Figure 9;
  • FIG. 12 is a perspective view of the automatic injection device of FIG. 9 showing the positioning of a part of a device for generating sound signals according to the invention
  • FIG. 13 is a perspective view of the automatic injection device of FIG. 1 after injection of the liquid into the skin of the patient;
  • FIG. 14 is a perspective view of the automatic injection device of FIG. 13, including the outer casing and a part of the control device of FIG. positioning were masked;
  • FIG. 15 is a sectional view of the automatic injection device according to plane XV-XV of FIG. 13;
  • FIG. 16 is a perspective view of the automatic injection device of FIG. 13 showing the positioning of a part of a device for generating sound signals according to the invention
  • FIG. 17 is a perspective view of the automatic injection device of FIG. 1 after retraction of the needle;
  • FIG. 18 is a perspective view of the automatic injection device of FIG. 17 whose outer casing and part of the positioning control member have been masked;
  • FIG. 19 is a sectional view of the automatic injection device according to plane XIX-XIX of FIG. 17.
  • the orientations are the orientations with respect to the user.
  • distal and proximal generally refer to the distance of the hand of the user holding the automatic injection device. More specifically, with reference to FIG. 1, the user applies his hand to the distal end of the automatic injection device, on the right in FIG.
  • the invention relates to an automatic injection device 1 intended to preferentially receive an injection syringe 3.
  • the injection syringe 3 can be, for example, a pre-filled syringe made of glass, with a needle stuck, having a capacity of 1 milliliter.
  • the injection syringe 3 could be replaced, for example, by a cartridge provided with an injection needle.
  • the automatic injection device 1 may thus comprise an injection syringe 3 comprising a liquid 4, for example of the pharmaceutical type as explained in the technical background of the invention.
  • the injection syringe 3 is preferably provided with a syringe body 5 carrying an injection needle 6 and a piston rod 7a 7 mounted movably in this syringe body 5 to travel a stroke of injection of the liquid 4 carried out by the automatic injection device 1.
  • the automatic injection device 1 comprises an outer casing 9 forming a gripping element for a user and a positioning control member 11, the outer casing 9 and the positioning control member 11. being telescopic so that their relative movement controls the operation of the automatic injection device 1 as explained below.
  • the automatic injection device 1 comprises control members 13, 15 arranged to selectively control the movement of the syringe body 5 and the displacement of the piston 7 inside the positioning control member 11 in order to inject automatically the liquid 4 present in the injection syringe 3.
  • the automatic injection device 1 further comprises a device for generating sound signals 17 for indicating when to remove the automatic injection device 1 from the skin of the person in which the liquid 4 is injected.
  • the sound signal generation device 17 is advantageously activated during the automatic injection of the liquid 4 present in the injection syringe 3 to generate a succession of sound signals continuously substantially between the beginning and the end of the 'injection.
  • the user when the user no longer hears sound signals, he deduces that the injection is complete and that the automatic injection device 1 can be removed from the skin of the person into whom the liquid 4 has been injected, the user may or may not be said person.
  • the device for generating sound signals 17 is preferably mounted between the positioning control member 11 and one of the Actually, as explained below, once the control member 13 of the syringe body 5 has been disengaged, the liquid 4 will be injected with a combined displacement of the control member 13 of the body of the syringe 5 and the control member 15 of the piston 7 with respect to the positioning control member 11. It is thus clear that the device for generating sound signals 17 can be indifferently mounted between the positioning control member 11 and one or both of the two control members 13, 15.
  • the device for generating sound signals 17 comprises at least one assembly 19 of the elastic hook type 21 - toothing 23.
  • Each assembly 19 is preferably intended to generate a sound signal at each tooth passage 24 of an elastic hook 21 against a toothing 23 It will therefore be understood that each toothing 23 of an assembly may be indifferently mounted on the positioning control member 11 or on one or both of the two control members 13, 15 and, conversely, for each elastic hook 21.
  • each assembly 19 may comprise one (or more) toothing (s) 23 cooperating with one (or more) hook (s) elastic (s) 21.
  • a set 19 could thus comprise a single elastic hook 21 mounted on the positioning control member 11 cooperating consecutively, following the advance of the injection, with a first toothing 23 mounted on the control member 13 of the syringe body 5 and a second toothing 23 mounted on the control member 15 of the piston 7.
  • a device for generating sound signals 17 comprising two sets 19 each with an elastic hook 21 mounted on the control member 13 of the body syringe 5 and a toothing 23 mounted on the positioning control member 11.
  • the control member 13 of the syringe body 5 thus comprises two resilient hooks 21 mounted symmetrically at one of its ends to cooperate each with a toothing 23 mounted on one of the shells 12a, 12b of the control member of positioning 11.
  • the use of several sets 19 thus makes it possible to generate more intense sound signals, or even detectable by the gripping of the outer casing 9. This also makes it possible to shift each set 19 in order to generate two alternating sound signals . It is then understood that, for the same injection stroke and the same number of sound signals, the distance between the teeth 24 of each toothing 23 may be twice as large, the teeth 23 being thus easier to manufacture.
  • the automatic injection device 1 may also include a visual indication element 25 of the injection stroke.
  • a visual indication element 25 may thus comprise at least one visual indicator 26, 27, such as a pictogram, carried by one of the control members 13, 15 or by the positioning control member 11.
  • a visual indicator of the end of injection stroke 27 can therefore be positioned at right windows 28, 29 respectively provided on the outer casing 9 and, optionally, the positioning control member. 11, to be visible to the user.
  • the automatic injection device 1 is in a configuration shown in FIGS. 1 to 4, which will be described as a configuration before use in which the visual indication element 25 of the injection stroke shows the visual indicator 26 of FIG. ready to use.
  • This ready-to-use visual indicator 26 is carried by the syringe holder 10 and is made visible by its positioning to the right of the windows 28 and 29 arranged respectively on the outer casing 9 and the positioning control member 11 in order to show that the automatic injection device 1 is ready for use.
  • the automatic injection device 1 is in a configuration shown in Figures 5 to 8, which will be called initial configuration. Then, the user grasps the automatic injection device 1 through the outer housing 9 and applies the distal surface of the end sleeve 12c against the skin where the injection of the liquid 4 contained in the syringe body 5 is desired. As can be seen in FIG. 8, it can be seen that the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 are angularly offset with respect to the teeth 23. control 13 of the syringe body 5 is positioned upstream of the windows 29 of the shells 12a, 12b of the positioning control member 11. It will therefore be understood that the visual indication element element 25 of the injection stroke always shows the ready-to-use visual indicator 26.
  • the user applies an axial force towards the distal portion of the automatic injection device 1, on the outer casing 9.
  • the outer casing 9 moves, telescopically, axially to the distal portion of the positioning control member 11.
  • This displacement causes the release of the retaining ring 12d of the positioning control member 11 which, incidentally, no longer axially immobilizes the piston control member 7 with the positioning control member 11.
  • the unlocking step may be accompanied by an audible signal generated by the release of the control member 15 relative to the retaining ring 12d.
  • the automatic injection device 1 thus reaches the configuration in which the piston control member 7 is free to move axially toward the distal portion of the positioning control member 11.
  • an insertion step takes place.
  • the injection spring 16 axially pushes the control members 13, 15 of the syringe body 5 and the piston 7 towards the distal portion of the positioning control member 11. Since the control member 13 of the syringe body 5 is in configuration in engagement with the syringe holder 10, it cooperates axially with the syringe holder 10 and moves the syringe so that the injection needle 6 protrudes from the distal surface of the end sleeve 12c as shown in Fig. 9 and is inserted into the skin of the patient.
  • the locking elements 14 being in their immobilization configuration, the injection syringe 3 is held axially when the injection needle 6 is inserted into the patient's skin to limit its penetration.
  • the cam 30a of the control member 13 of the syringe body 5 cooperates with a first cam path 31a of the positioning control member 11 so that the control member 13 of the body of the syringe 5 rotates relative to the syringe holder 10 to its disengaging configuration of the syringe holder 10.
  • the cam 30b of the piston control member 15 cooperates with a second cam path 31b of the positioning control member 11 so that the piston control member 7 rotates relative to the piston rod 7a 7.
  • the piston control member 7 does not reach its configuration. 7 at the end of this step, the automatic injection device 1 is in the configuration shown in Figures 9 to 12, wherein the piston control member 7 is in its configuration. in engagement with the piston rod 7a 7 and the control member 13 of the syringe body 5 is in its disengaged configuration.
  • the injection needle 28 is inserted into the skin of the patient.
  • the visual indication element 25 of the injection stroke almost no longer shows the ready-to-use visual indicator 26 and presents the external surface of the control member 13 of the syringe body 5.
  • the control member 13 of the syringe body 5 may comprise a particular color and / or a scale used (s) to indicate the advance of the injection. Indeed, as can be seen in FIG. 12, it can be seen that the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 are now aligned with the teeth 23 and whose external surface is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9. However, the elastic hooks 21 have not begun to cooperate with the teeth 23.
  • an injection step takes place.
  • the injection spring 16 continues to axially push the control members 13, 15 of the syringe body 5 and the piston 7 towards the distal portion of the positioning control member 11, however, the control member 13 of the body of the syringe 5 does not cooperate axially with the syringe holder 10.
  • the piston control member 7 being in configuration engaged with the piston rod 7a 7, it pushes this last so that it goes through its injection stroke.
  • the liquid 4, for example pharmaceutical, is then injected into the body of the patient.
  • the visual indication element 25 of the injection stroke then consecutively shows the outer surface of the control member 13 of the syringe body 5 and the outer surface of the control member 15 of the piston 7.
  • the sound signal generating device 17 being advantageously activated, the elastic hooks 21, now aligned with the teeth 23, cooperate with their respective teeth 24 to generate a succession of sound signals continuously substantially between the beginning and the end of the automatic injection of the liquid 4 present in the injection syringe 3.
  • the automatic injection device 1 is in the configuration shown in FIGS. 13 to 16, in which the piston 7 and the piston rod 7a 7 abut against the bottom wall of the syringe body 5 and the piston control member 7 is in configuration engaged with the piston rod 7a 7.
  • the visual indication element 25 of the injection stroke now shows the pictogram 27i of the visual end-of-stroke injection indicator 27 present on the external surface of the control member 15 of the piston 7 indicating that the injection is complete.
  • the pictogram 27i of the control member 15 of the piston 7 is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9.
  • the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 have reached the end of the teeth 23 and can therefore no longer generate sound signals.
  • the arrangement of the device for generating sound signals 17 thus offers a longitudinal displacement which makes it possible to generate a single sound pattern evolving throughout the injection stroke. Indeed, for comparison, a circumferential movement requires the use of a sound pattern that needs to be repeated to cover the entire injection and therefore generates uncertainty about the progress of the injection. Consequently, the longitudinal displacement advantageously allows, according to the invention, to create a single evolutionary and customizable pattern according to the desired sound signals on a stroke greater than that possible with a device for generating circumferentially arranged sound signals. In addition, the longitudinal arrangement is simpler to implement than a circumferential arrangement. Following this injection step, a step of triggering the retraction takes place.
  • the user no longer hearing sound signals and can see the pictogram 27i, he deduced that the injection is complete.
  • the user therefore releases the axial force that he exerts on the outer casing 9 so that the return spring 18 moves the outer casing 9 in the direction of the telescopic extension of the automatic injection device 1.
  • This action of the user thus triggers the retraction of the injection needle 6.
  • the first cam path 31 co-operates with the cam 30a of the piston control member 7, which causes a rotation of the piston control member 7 relative to the piston rod 7a 7 to its disengaged configuration.
  • the automatic injection device 1 is in the configuration, in which the piston control member 7 is in its disengaged configuration of the piston rod 7a and the radial projections of the piston ring. retain 12d cooperate with the edges of the lights in the outer housing 9.
  • a retraction step takes place.
  • the piston control member 7 is in the disengaged configuration of the piston rod 7a 7, the latter 7 is free to move axially toward the proximal portion of the automatic injection device 1.
  • the retraction springs 20 are then free to push the syringe holder 10 towards the proximal portion of the positioning control member 11.
  • the injection needle 6 retracts into the positioning control member 11 so that it is no longer projecting from the distal surface of the end sleeve 12c.
  • the retraction is accompanied by a sound signal that can be generated by the movement of the control member 15 relative to the head of the piston rod 7a 7.
  • the automatic injection device 1 is in the configuration shown in Figures 17 to 19, in which the operation of the automatic injection device 1 is completed.
  • the visual indication element 25 of the injection stroke then shows the pictogram 27 2 of the visual end-of-stroke injection indicator 27 present on the external surface of the control member 15 of the piston 7 indicating that the automatic injection device 1 has already been used. Indeed, it can be seen that the pictogram 27 2 of the control member 15 of the piston 7 is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9 .
  • the device for generating sound signals 17 be active before the start of the injection, for example from when the user presses on the outer housing 9 to generate sound signals before the start of the injection.
  • each set 19 of the sound signal generation device 17 can be adapted according to the desired implementations in order to regulate the beginning, the intensity, the frequency and the end of the sound signals.
  • a first toothing 23 could thus cooperate with a first elastic hook 21 during the entire operation of the automatic injection device 1 while a second toothing 23 could cooperate with a second elastic hook 21 only during the first operation.
  • injection step so as to vary the intensity and / or the frequency of the sound signals during the duration of the injection step relative to the rest of the operating steps of the automatic injection device 1.
  • the distance between the teeth of one or other of the teeth can be variable so, for example, that the frequency of the audible signals accelerates or slows down at the end of the injection.
  • the height of the teeth of one or other of the teeth can be variable so, for example, that the sound level of the audible signals increases or decreases depending on the injection progress.
  • each visual indication element 25 may be adapted according to the desired implementations to adjust the start, the information and the end of the displayed displays.
  • it can provide a toothing whose spacing between the teeth is different from one area of the toothing to another. This spacing may vary regularly or not.
  • This spacing may vary regularly or not.
  • one or more intermediate tooth portions, each provided with an intermediate tooth spacing at the initial and final spacings, may be provided between the initial and final tooth portions. It is also possible to provide a progressively evolving spacing, for example more and more reduced so that the frequency of the sound signals is higher end than at the beginning of injection.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention concerns an automatic injection device (1) comprising an injection syringe (3) for injecting liquid (4) provided with a syringe body (5) carrying an injection needle (6) and a piston (7) rod (7a) mounted so as to be able to move inside this syringe body (5) in order to cover an injection stroke during which the liquid (4) is injected, an external casing (9) and a positioning control member (11) that are telescopic, the relative movement of which controls the operation of the automatic injection device (1), and control members (13, 15) arranged to selectively control the movement of the syringe body (5) and the movement of the piston (7) inside the positioning control member (11) in order to automatically inject the liquid (4) present in the injection syringe (3), the automatic injection device (1) further comprising a device (17) for generating sound signals activated during the automatic injection of the liquid (4) present in the injection syringe (3) so as to generate a series of sounds signals from the start to the end of the injection.

Description

DISPOSITIF D'INJECTION AUTOMATIQUE MUNI D'UN DISPOSITIF DE  AUTOMATIC INJECTION DEVICE WITH A DEVICE
GENERATION DE SIGNAUX SONORES  GENERATION OF SOUND SIGNALS
DOMAINE TECHNIQUE DE L'INVENTION TECHNICAL FIELD OF THE INVENTION
La présente invention se rapporte au domaine des dispositifs d'injection automatique de produits liquides, notamment pharmaceutiques.  The present invention relates to the field of automatic injection devices for liquid products, in particular pharmaceuticals.
ARRIERE-PLAN TECHNIQUE DE L'INVENTION  TECHNICAL BACKGROUND OF THE INVENTION
De tels dispositifs d'injection automatique sont notamment utilisés dans le domaine médical pour l'administration automatique d'un médicament liquide nécessitant une injection. Un dispositif de ce type permet en particulier à une personne, par exemple atteinte d'arthrite rhumatoïde, de sclérose en plaque, de diabète ou subissant un choc anaphylactique en cas d'allergie, de s'injecter elle-même une dose de médicament de manière autonome.  Such automatic injection devices are particularly used in the medical field for the automatic administration of a liquid medicine requiring injection. A device of this type makes it possible in particular for a person, for example suffering from rheumatoid arthritis, multiple sclerosis, diabetes or suffering anaphylactic shock in the event of allergy, to inject himself a dose of independently.
Il a ainsi déjà été proposé, notamment dans le document US 8,734,402, un dispositif d'injection automatique comprenant une seringue d'injection de liquide munie d'un corps de seringue portant une aiguille d'injection et d'une tige de piston montée déplaçable dans ce corps de seringue pour parcourir une course d'injection du liquide. Le dispositif d'injection automatique comprend un boîtier extérieur et un organe de contrôle de positionnement qui sont télescopiques et dont le déplacement relatif commande le fonctionnement de ce dispositif d'injection automatique. De plus, des organes de commande sont agencés pour sélectivement contrôler le déplacement du corps de seringue et le déplacement du piston à l'intérieur de l'organe de contrôle de positionnement afin d'injecter automatiquement le liquide présent dans la seringue. It has already been proposed, in particular in document US Pat. No. 8,734,402, an automatic injection device comprising a syringe for injecting liquid provided with a syringe body carrying an injection needle and a displaceable mounted piston rod. in this syringe body to travel a liquid injection stroke. The automatic injection device comprises an outer casing and a positioning control member which are telescopic and whose relative movement controls the operation of this automatic injection device. In addition, control members are arranged to selectively control the movement of the syringe body and the movement of the piston within the positioning control member to automatically inject the liquid in the syringe.
Ce dispositif d'injection automatique permet avantageusement au dosage de l'injection de ne pas être dépendant de la force appliquée sur le boîtier extérieur mais uniquement de l'organe de contrôle de positionnement et des organes de commande ce qui évite un mauvais dosage. This automatic injection device advantageously allows the dosing of the injection not to be dependent on the force applied to the outer casing but only of the positioning control member and control members which avoids a wrong dosage.
Toutefois, l'injection étant automatique, il n'est pas aisé pour l'utilisateur de savoir quand la totalité du médicament liquide a été administrée.  However, since the injection is automatic, it is not easy for the user to know when all the liquid medication has been administered.
RESUME DE L'INVENTION  SUMMARY OF THE INVENTION
L'invention a pour but de remédier à ces inconvénients en fournissant un dispositif d'injection automatique permettant d'indiquer quand retirer le dispositif d'injection automatique de la peau de la personne dans laquelle le liquide est injecté.  The invention aims to overcome these disadvantages by providing an automatic injection device to indicate when to remove the automatic injection device of the skin of the person into which the liquid is injected.
À cet effet, l'invention se rapporte à un dispositif d'injection automatique comprenant une seringue d'injection de liquide munie d'un corps de seringue portant une aiguille d'injection et d'une tige de piston montée déplaçable dans ce corps de seringue pour parcourir une course d'injection du liquide, un boîtier extérieur et un organe de contrôle de positionnement télescopiques dont le déplacement relatif commande le fonctionnement du dispositif d'injection automatique, et des organes de commande agencés pour sélectivement contrôler le déplacement du corps de seringue et le déplacement du piston à l'intérieur de l'organe de contrôle de positionnement afin d'injecter automatiquement le liquide présent dans la seringue, caractérisé en ce que le dispositif d'injection automatique comporte en outre un dispositif de génération de signaux sonores activé pendant l'injection automatique du liquide présent dans la seringue. To this end, the invention relates to an automatic injection device comprising a liquid injection syringe provided with a syringe body carrying an injection needle and a piston rod movably mounted in this body. syringe for traversing a liquid injection stroke, an outer casing and a telescopic positioning control member whose relative movement controls the operation of the automatic injection device, and control members arranged to selectively control the movement of the syringe body and moving the piston inside the positioning control member to automatically inject the liquid present in the syringe, characterized in that the automatic injection device further comprises a device for generating sound signals activated during the automatic injection of the liquid present in the syringe.
Avantageusement selon l'invention, le dispositif d'injection automatique génère une succession de signaux sonores du début à la fin de l'injection afin d'indiquer quand retirer le dispositif d'injection automatique de la peau de la personne dans laquelle le liquide est injecté. En effet, l'utilisateur n'entendant plus de signaux sonores, il en déduit que l'injection est terminée et que le dispositif d'injection automatique peut être retiré de la peau de la personne dans laquelle le liquide a été injecté.  Advantageously according to the invention, the automatic injection device generates a succession of sound signals from the beginning to the end of the injection in order to indicate when to withdraw the automatic injection device from the skin of the person in which the liquid is injected. Indeed, the user no longer hears sound signals, it deduces that the injection is complete and that the automatic injection device can be removed from the skin of the person in which the liquid has been injected.
Selon d'autres caractéristiques optionnelles de réalisation de l'invention :  According to other optional features of embodiment of the invention:
- le dispositif de génération de signaux sonores est monté entre l'organe de contrôle de positionnement et l'un des organes de commande afin de générer des signaux sonores lors du déplacement relatif entre le corps de seringue et le piston ;  the device for generating sound signals is mounted between the positioning control member and one of the control members in order to generate sound signals during the relative movement between the syringe body and the piston;
- le dispositif de génération de signaux sonores est monté entre l'organe de contrôle de positionnement et l'organe de commande du corps de seringue ; the device for generating sound signals is mounted between the positioning control member and the control member of the syringe body;
- le dispositif de génération de signaux sonores est monté entre l'organe de contrôle de positionnement et l'organe de commande du piston ; the device for generating sound signals is mounted between the positioning control member and the piston control member;
- le dispositif de génération de signaux sonores comporte au moins un ensemble crochet élastique- denture destiné à générer un signal sonore à chaque passage de dent du crochet élastique contre la denture ;  the device for generating sound signals comprises at least one elastic-toothed hook assembly intended to generate a sound signal at each tooth pass of the elastic hook against the toothing;
- le dispositif de génération de signaux sonores comporte deux ensembles crochet élastique - denture ;  the device for generating sound signals comprises two sets elastic hook - toothing;
- les deux ensembles crochet élastique - denture sont décalés afin de générer deux signaux sonores alternés ;  - The two elastic hook sets - toothing are offset to generate two alternating sound signals;
- chaque denture est aménagée sur l'organe de contrôle de positionnement ;  each set of teeth is arranged on the positioning control member;
- le dispositif d'injection automatique comporte en outre un élément d'indication visuelle de la course d'injection ;  the automatic injection device further comprises a visual indication element of the injection stroke;
- l'élément d'indication visuelle comprend au moins un indicateur visuel se positionnant au droit d'une fenêtre aménagée sur le boîtier extérieur à la fin de la course d'injection. BREVE DESCRI PTION DES DESSINS - The visual indication element comprises at least one visual indicator being positioned in line with a window fitted on the outer casing at the end of the injection stroke. BRIEF DESCRIPTION OF THE DRAWINGS
D'autres particularités et avantages ressortiront clairement de la description qui en est faite ci-après, à titre indicatif et nullement limitatif, en référence aux dessins annexés, dans lesquels :  Other particularities and advantages will emerge clearly from the description which is given hereinafter, by way of indication and in no way limiting, with reference to the appended drawings, in which:
- La figure 1 est une vue en perspective d'un dispositif d'injection automatique selon l'invention ;  FIG. 1 is a perspective view of an automatic injection device according to the invention;
- La figure 2 est une vue en perspective du dispositif d'injection automatique de la figure 1 dont le boîtier extérieur a été masqué ;  FIG. 2 is a perspective view of the automatic injection device of FIG. 1, the outer casing of which has been masked;
- La figure 3 est une vue en perspective du dispositif d'injection automatique de la figure 1 dont le boîtier extérieur, une partie de l'organe de contrôle de positionnement et le capuchon de protection ont été masqués ;  FIG. 3 is a perspective view of the automatic injection device of FIG. 1, the outer casing, part of the positioning control member and the protective cap having been masked;
- La figure 4 est une vue en coupe du dispositif d'injection automatique selon le plan IV-IV de la figure 1 ;  - Figure 4 is a sectional view of the automatic injection device according to the plane IV-IV of Figure 1;
- La figure 5 est une vue en perspective du dispositif d'injection automatique de la figure 1 après retrait du capuchon de protection ;  FIG. 5 is a perspective view of the automatic injection device of FIG. 1 after removal of the protective cap;
- La figure 6 est une vue en perspective du dispositif d'injection automatique de la figure 5 dont le boîtier extérieur et une partie de l'organe de contrôle de positionnement ont été masqués ;  FIG. 6 is a perspective view of the automatic injection device of FIG. 5, the outer casing and part of the positioning control member being masked;
- La figure 7 est une vue en coupe du dispositif d'injection automatique selon le plan VII-VII de la figure 5 ;  FIG. 7 is a sectional view of the automatic injection device along the plane VII-VII of FIG. 5;
- La figure 8 une vue en perspective du dispositif d'injection automatique de la figure 5 montrant le positionnement d'une partie d'un dispositif de génération de signaux sonores selon l'invention ;  FIG. 8 is a perspective view of the automatic injection device of FIG. 5 showing the positioning of a part of a device for generating sound signals according to the invention;
- La figure 9 est une vue en perspective du dispositif d'injection automatique de la figure 1 après insertion de l'aiguille dans la peau du patient ;  FIG. 9 is a perspective view of the automatic injection device of FIG. 1 after insertion of the needle into the skin of the patient;
- La figure 10 est une vue en perspective du dispositif d'injection automatique de la figure 9 dont le boîtier extérieur et une partie de l'organe de contrôle de positionnement ont été masqués ;  - Figure 10 is a perspective view of the automatic injection device of Figure 9, the outer housing and a portion of the positioning control member have been masked;
- La figure 11 est une vue en coupe du dispositif d'injection automatique selon le plan XI-XI de la figure 9 ;  - Figure 11 is a sectional view of the automatic injection device according to the plane XI-XI of Figure 9;
- La figure 12 est une vue en perspective du dispositif d'injection automatique de la figure 9 montrant le positionnement d'une partie d'un dispositif de génération de signaux sonores selon l'invention ;  FIG. 12 is a perspective view of the automatic injection device of FIG. 9 showing the positioning of a part of a device for generating sound signals according to the invention;
- La figure 13 est une vue en perspective du dispositif d'injection automatique de la figure 1 après injection du liquide dans la peau du patient ;  FIG. 13 is a perspective view of the automatic injection device of FIG. 1 after injection of the liquid into the skin of the patient;
- La figure 14 est une vue en perspective du dispositif d'injection automatique de la figure 13 dont le boîtier extérieur et une partie de l'organe de contrôle de positionnement ont été masqués ; FIG. 14 is a perspective view of the automatic injection device of FIG. 13, including the outer casing and a part of the control device of FIG. positioning were masked;
- La figure 15 est une vue en coupe du dispositif d'injection automatique selon le plan XV-XV de la figure 13 ;  FIG. 15 is a sectional view of the automatic injection device according to plane XV-XV of FIG. 13;
- La figure 16 est une vue en perspective du dispositif d'injection automatique de la figure 13 montrant le positionnement d'une partie d'un dispositif de génération de signaux sonores selon l'invention ;  FIG. 16 is a perspective view of the automatic injection device of FIG. 13 showing the positioning of a part of a device for generating sound signals according to the invention;
- La figure 17 est une vue en perspective du dispositif d'injection automatique de la figure 1 après rétraction de l'aiguille ;  FIG. 17 is a perspective view of the automatic injection device of FIG. 1 after retraction of the needle;
- La figure 18 est une vue en perspective du dispositif d'injection automatique de la figure 17 dont le boîtier extérieur et une partie de l'organe de contrôle de positionnement ont été masqués ;  FIG. 18 is a perspective view of the automatic injection device of FIG. 17 whose outer casing and part of the positioning control member have been masked;
- La figure 19 est une vue en coupe du dispositif d'injection automatique selon le plan XIX-XIX de la figure 17.  FIG. 19 is a sectional view of the automatic injection device according to plane XIX-XIX of FIG. 17.
DESCRI PTION DÉTAILLÉE D'AU MOINS UN MODE DE RÉALISATION DE L'INVENTION  DETAILED DESCRIPTION OF AT LEAST ONE MODE OF CARRYING OUT THE INVENTION
Sur les différentes figures, les éléments identiques ou similaires portent les mêmes références, éventuellement additionnées d'un indice. La description de leur structure et de leur fonction n'est donc pas systématiquement reprise.  In the different figures, identical or similar elements bear the same references, possibly added with an index. The description of their structure and function is therefore not systematically repeated.
Dans tout ce qui suit, les orientations sont les orientations par rapport à l'utilisateur. En particulier, les termes « distal » et « proximal » s'entendent généralement par rapport à la distance de la main de l'utilisateur qui tient le dispositif d'injection automatique. Plus précisément, en référence à la figure 1 , l'utilisateur applique sa main sur l'extrémité distale du dispositif d'injection automatique, à droite sur la figure 1 .  In all that follows, the orientations are the orientations with respect to the user. In particular, the terms "distal" and "proximal" generally refer to the distance of the hand of the user holding the automatic injection device. More specifically, with reference to FIG. 1, the user applies his hand to the distal end of the automatic injection device, on the right in FIG.
Comme illustré aux figures 1 à 4, l'invention se rapporte à un dispositif d'injection automatique 1 destiné à préférentiellement recevoir une seringue d'injection 3. La seringue d'injection 3 peut être par exemple une seringue préremplie en verre, à aiguille collée, ayant une contenance de 1 millilitre. Toutefois, la seringue d'injection 3 pourrait être remplacée, par exemple, par une cartouche munie d'une aiguille d'injection.  As illustrated in FIGS. 1 to 4, the invention relates to an automatic injection device 1 intended to preferentially receive an injection syringe 3. The injection syringe 3 can be, for example, a pre-filled syringe made of glass, with a needle stuck, having a capacity of 1 milliliter. However, the injection syringe 3 could be replaced, for example, by a cartridge provided with an injection needle.
Le dispositif d'injection automatique 1 peut ainsi comprendre une seringue d'injection 3 comportant un liquide 4, par exemple, du type pharmaceutique comme expliqué dans l'arrière-plan technique de l'invention. La seringue d'injection 3 est, de manière préférée, munie d'un corps de seringue 5 portant une aiguille d'injection 6 et d'une tige 7a de piston 7 montée déplaçable dans ce corps de seringue 5 pour parcourir une course d'injection du liquide 4 réalisée par le dispositif d'injection automatique 1 .  The automatic injection device 1 may thus comprise an injection syringe 3 comprising a liquid 4, for example of the pharmaceutical type as explained in the technical background of the invention. The injection syringe 3 is preferably provided with a syringe body 5 carrying an injection needle 6 and a piston rod 7a 7 mounted movably in this syringe body 5 to travel a stroke of injection of the liquid 4 carried out by the automatic injection device 1.
Plus précisément, le dispositif d'injection automatique 1 comporte un boîtier extérieur 9 formant un élément de préhension pour un utilisateur et un organe de contrôle de positionnement 11 , le boîtier extérieur 9 et l'organe de contrôle de positionnement 11 étant télescopiques afin que leur déplacement relatif commande le fonctionnement du dispositif d'injection automatique 1 comme expliqué ci-dessous. More specifically, the automatic injection device 1 comprises an outer casing 9 forming a gripping element for a user and a positioning control member 11, the outer casing 9 and the positioning control member 11. being telescopic so that their relative movement controls the operation of the automatic injection device 1 as explained below.
En outre, le dispositif d'injection automatique 1 comporte des organes de commande 13, 15 agencés pour sélectivement contrôler le déplacement du corps de seringue 5 et le déplacement du piston 7 à l'intérieur de l'organe de contrôle de positionnement 11 afin d'injecter automatiquement le liquide 4 présent dans la seringue d'injection 3.  In addition, the automatic injection device 1 comprises control members 13, 15 arranged to selectively control the movement of the syringe body 5 and the displacement of the piston 7 inside the positioning control member 11 in order to inject automatically the liquid 4 present in the injection syringe 3.
Avantageusement, le dispositif d'injection automatique 1 selon l'invention comporte en outre un dispositif de génération de signaux sonores 17 destiné à indiquer quand retirer le dispositif d'injection automatique 1 de la peau de la personne dans laquelle le liquide 4 est injecté. Le dispositif de génération de signaux sonores 17 est, de manière avantageuse, activé pendant l'injection automatique du liquide 4 présent dans la seringue d'injection 3 pour générer une succession de signaux sonores de manière continue sensiblement entre le début et la fin de l'injection.  Advantageously, the automatic injection device 1 according to the invention further comprises a device for generating sound signals 17 for indicating when to remove the automatic injection device 1 from the skin of the person in which the liquid 4 is injected. The sound signal generation device 17 is advantageously activated during the automatic injection of the liquid 4 present in the injection syringe 3 to generate a succession of sound signals continuously substantially between the beginning and the end of the 'injection.
Ainsi, quand l'utilisateur n'entend plus de signaux sonores, il en déduit que l'injection est terminée et que le dispositif d'injection automatique 1 peut être retiré de la peau de la personne dans laquelle le liquide 4 a été injecté, l'utilisateur pouvant ou non être ladite personne.  Thus, when the user no longer hears sound signals, he deduces that the injection is complete and that the automatic injection device 1 can be removed from the skin of the person into whom the liquid 4 has been injected, the user may or may not be said person.
Dans le but de générer des signaux sonores lors du déplacement relatif entre le corps de seringue 5 et le piston 7, le dispositif de génération de signaux sonores 17 est, préférentiellement, monté entre l'organe de contrôle de positionnement 11 et l'un des organes de commande 13, 15. En effet, comme expliqué ci-dessous, une fois l'organe de commande 13 du corps de seringue 5 débrayé, le liquide 4 sera injecté avec un déplacement conjugué de l'organe de commande 13 du corps de seringue 5 et de l'organe de commande 15 du piston 7 par rapport à l'organe de contrôle de positionnement 11 . On comprend donc que le dispositif de génération de signaux sonores 17 peut être indifféremment monté entre l'organe de contrôle de positionnement 11 et un des deux ou les deux organes de commande 13, 15.  In order to generate sound signals during the relative movement between the syringe body 5 and the piston 7, the device for generating sound signals 17 is preferably mounted between the positioning control member 11 and one of the Actually, as explained below, once the control member 13 of the syringe body 5 has been disengaged, the liquid 4 will be injected with a combined displacement of the control member 13 of the body of the syringe 5 and the control member 15 of the piston 7 with respect to the positioning control member 11. It is thus clear that the device for generating sound signals 17 can be indifferently mounted between the positioning control member 11 and one or both of the two control members 13, 15.
Le dispositif de génération de signaux sonores 17 comporte au moins un ensemble 19 du type crochet élastique 21 - denture 23. Chaque ensemble 19 est préférentiellement destiné à générer un signal sonore à chaque passage de dent 24 d'un crochet élastique 21 contre une denture 23. On comprend donc que chaque denture 23 d'un ensemble peut être indifféremment montée sur l'organe de contrôle de positionnement 11 ou sur un des deux ou les deux organes de commande 13, 15 et, inversement, pour chaque crochet élastique 21 .  The device for generating sound signals 17 comprises at least one assembly 19 of the elastic hook type 21 - toothing 23. Each assembly 19 is preferably intended to generate a sound signal at each tooth passage 24 of an elastic hook 21 against a toothing 23 It will therefore be understood that each toothing 23 of an assembly may be indifferently mounted on the positioning control member 11 or on one or both of the two control members 13, 15 and, conversely, for each elastic hook 21.
Bien entendu, suivant les mises en œuvre souhaitées, chaque ensemble 19 peut comporter une (ou plusieurs) denture(s) 23 coopérant avec un (ou plusieurs) crochet(s) élastique(s) 21 . À titre d'exemple, un ensemble 19 pourrait ainsi comprendre un unique crochet élastique 21 monté sur l'organe de contrôle de positionnement 11 coopérant consécutivement, suivant l'avancée de l'injection, avec une première denture 23 montée sur l'organe de commande 13 du corps de seringue 5 et une deuxième denture 23 montée sur l'organe de commande 15 du piston 7. Of course, according to the desired implementations, each assembly 19 may comprise one (or more) toothing (s) 23 cooperating with one (or more) hook (s) elastic (s) 21. By way of example, a set 19 could thus comprise a single elastic hook 21 mounted on the positioning control member 11 cooperating consecutively, following the advance of the injection, with a first toothing 23 mounted on the control member 13 of the syringe body 5 and a second toothing 23 mounted on the control member 15 of the piston 7.
Comme visible notamment à la figure 8 et de manière non limitative, l'explication ci- dessous sera donnée pour un dispositif de génération de signaux sonores 17 comportant deux ensembles 19 avec chacun un crochet élastique 21 monté sur l'organe de commande 13 du corps de seringue 5 et une denture 23 montée sur l'organe de contrôle de positionnement 11 . Plus précisément, l'organe de commande 13 du corps de seringue 5 comporte ainsi deux crochets élastiques 21 monté symétriquement à une de ses extrémités afin de coopérer chacun avec une denture 23 montée sur une des coques 12a, 12b de l'organe de contrôle de positionnement 11 . As can be seen in particular in FIG. 8 and in a nonlimiting manner, the explanation below will be given for a device for generating sound signals 17 comprising two sets 19 each with an elastic hook 21 mounted on the control member 13 of the body syringe 5 and a toothing 23 mounted on the positioning control member 11. More specifically, the control member 13 of the syringe body 5 thus comprises two resilient hooks 21 mounted symmetrically at one of its ends to cooperate each with a toothing 23 mounted on one of the shells 12a, 12b of the control member of positioning 11.
Avantageusement selon l'invention, l'utilisation de plusieurs ensembles 19 permet ainsi de générer des signaux sonores plus intenses, voire détectables tactilement par la préhension du boîtier extérieur 9. Cela permet également de pouvoir décaler chaque ensemble 19 afin de générer deux signaux sonores alternés. On comprend alors que, pour une même course d'injection et un même nombre de signaux sonores, la distance entre les dents 24 de chaque denture 23 peut être deux fois plus grande, les dentures 23 étant ainsi plus faciles à fabriquer. Advantageously according to the invention, the use of several sets 19 thus makes it possible to generate more intense sound signals, or even detectable by the gripping of the outer casing 9. This also makes it possible to shift each set 19 in order to generate two alternating sound signals . It is then understood that, for the same injection stroke and the same number of sound signals, the distance between the teeth 24 of each toothing 23 may be twice as large, the teeth 23 being thus easier to manufacture.
De plus, le dispositif d'injection automatique 1 peut également comporter un élément d'indication visuelle 25 de la course d'injection. Un tel élément d'indication visuelle 25 peut ainsi comprendre au moins un indicateur visuel 26, 27, tel qu'un pictogramme, porté par l'un des organes de commande 13, 15 ou par l'organe de contrôle de positionnement 11 . À la fin de la course d'injection, un indicateur visuel de fin de course d'injection 27 peut donc se positionner au droit de fenêtres 28, 29 aménagées respectivement sur le boîtier extérieur 9 et, éventuellement, l'organe de contrôle de positionnement 11 , pour être visible par l'utilisateur.  In addition, the automatic injection device 1 may also include a visual indication element 25 of the injection stroke. Such a visual indication element 25 may thus comprise at least one visual indicator 26, 27, such as a pictogram, carried by one of the control members 13, 15 or by the positioning control member 11. At the end of the injection stroke, a visual indicator of the end of injection stroke 27 can therefore be positioned at right windows 28, 29 respectively provided on the outer casing 9 and, optionally, the positioning control member. 11, to be visible to the user.
Le dispositif d'injection automatique 1 est dans une configuration représentée aux figures 1 à 4, que l'on qualifiera de configuration avant utilisation dans laquelle l'élément d'indication visuelle 25 de la course d'injection montre l'indicateur visuel 26 de prêt à l'emploi. Cet indicateur visuel 26 de prêt à l'emploi est porté par le support de seringue 10 et est rendu visible par son positionnement au droit des fenêtres 28 et 29 aménagées respectivement sur le boîtier extérieur 9 et l'organe de contrôle de positionnement 11 afin de montrer que le dispositif d'injection automatique 1 est prêt à l'emploi.  The automatic injection device 1 is in a configuration shown in FIGS. 1 to 4, which will be described as a configuration before use in which the visual indication element 25 of the injection stroke shows the visual indicator 26 of FIG. ready to use. This ready-to-use visual indicator 26 is carried by the syringe holder 10 and is made visible by its positioning to the right of the windows 28 and 29 arranged respectively on the outer casing 9 and the positioning control member 11 in order to show that the automatic injection device 1 is ready for use.
Pour faire fonctionner le dispositif d'injection automatique 1 , il est nécessaire, dans un premier temps, de retirer le capuchon de protection 8 de la partie distale du dispositif d'injection automatique 1 afin d'enlever le bouchon de seringue 2 entourant l'aiguille d'injection 6. To operate the automatic injection device 1, it is necessary, in a first step, to remove the protective cap 8 from the distal part of the device automatic injection 1 to remove the syringe cap 2 surrounding the injection needle 6.
Le dispositif d'injection automatique 1 est dans une configuration représentée aux figures 5 à 8, que l'on qualifiera de configuration initiale. Ensuite, l'utilisateur saisi le dispositif d'injection automatique 1 par le boîtier extérieur 9 et applique la surface distale du manchon d'extrémité 12c contre la peau à l'endroit où l'injection du liquide 4 contenu dans le corps de seringue 5 est souhaitée. Comme visible à la figure 8, on s'aperçoit que l'organe de commande 13 du corps de seringue 5 est dans une position dans laquelle, les crochets élastiques 21 sont décalés angulairement par rapport aux dentures 23. De plus, l'organe de commande 13 du corps de seringue 5 est positionné en amont des fenêtres 29 des coques 12a, 12b de l'organe de contrôle de positionnement 11 . On comprend donc que l'élément élément d'indication visuelle 25 de la course d'injection montre toujours l'indicateur visuel 26 de prêt à l'emploi.  The automatic injection device 1 is in a configuration shown in Figures 5 to 8, which will be called initial configuration. Then, the user grasps the automatic injection device 1 through the outer housing 9 and applies the distal surface of the end sleeve 12c against the skin where the injection of the liquid 4 contained in the syringe body 5 is desired. As can be seen in FIG. 8, it can be seen that the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 are angularly offset with respect to the teeth 23. control 13 of the syringe body 5 is positioned upstream of the windows 29 of the shells 12a, 12b of the positioning control member 11. It will therefore be understood that the visual indication element element 25 of the injection stroke always shows the ready-to-use visual indicator 26.
Ensuite, lors d'une étape de déverrouillage, l'utilisateur applique un effort axial, vers la partie distale du dispositif d'injection automatique 1 , sur le boîtier extérieur 9. Ainsi, le boîtier extérieur 9 se déplace, de manière télescopique, axialement vers la partie distale de l'organe de contrôle de positionnement 11 . Ce déplacement entraîne la libération de la bague de retenue 12d de l'organe de contrôle de positionnement 11 qui, incidemment, n'immobilise plus axialement l'organe de commande 15 de piston 7 avec l'organe de contrôle de positionnement 11 . L'étape de déverrouillage peut être accompagnée d'un signal sonore généré par la libération de l'organe de commande 15 par rapport à la bague de retenue 12d. Le dispositif d'injection automatique 1 atteint donc la configuration dans laquelle l'organe de commande 15 de piston 7 est libre de se déplacer axialement vers la partie distale de l'organe de contrôle de positionnement 11 .  Then, during an unlocking step, the user applies an axial force towards the distal portion of the automatic injection device 1, on the outer casing 9. Thus, the outer casing 9 moves, telescopically, axially to the distal portion of the positioning control member 11. This displacement causes the release of the retaining ring 12d of the positioning control member 11 which, incidentally, no longer axially immobilizes the piston control member 7 with the positioning control member 11. The unlocking step may be accompanied by an audible signal generated by the release of the control member 15 relative to the retaining ring 12d. The automatic injection device 1 thus reaches the configuration in which the piston control member 7 is free to move axially toward the distal portion of the positioning control member 11.
Durant cette étape, les deux éléments de blocage 14, montés coulissant sensiblement radialement dans deux fentes ménagées dans le manchon d'extrémité 12c, coulissent sensiblement radialement afin d'être dans une configuration permettant l'immobilisation de la seringue d'injection 3, dans laquelle les éléments de blocage 14 sont rapprochées entre eux de manière à ce que l'espace entre les éléments de blocage 14 soit suffisamment faible pour retenir axialement la seringue d'injection 3 par son épaulement distal.  During this step, the two locking elements 14, mounted sliding substantially radially in two slots in the end sleeve 12c, slide substantially radially to be in a configuration allowing the immobilization of the injection syringe 3, in the locking elements 14 are brought together so that the space between the locking elements 14 is sufficiently small to axially retain the injection syringe 3 by its distal shoulder.
À la suite de cette étape de déverrouillage, une étape d'insertion a lieu. Le ressort d'injection 16 pousse axialement les organes de commande 13, 15 du corps de seringue 5 et de piston 7 vers la partie distale de l'organe de contrôle de positionnement 11 . Comme l'organe de commande 13 du corps de seringue 5 est en configuration en prise avec le support de seringue 10, il coopère axialement avec le support de seringue 10 et déplace ce dernier de telle sorte que l'aiguille d'injection 6 devient saillante par rapport à la surface distale du manchon d'extrémité 12c comme visible à la figure 9 et est insérée dans la peau du patient. Avantageusement, comme visible aux figures 10 et 11 , les éléments de blocage 14 étant dans leur configuration d'immobilisation, la seringue d'injection 3 est retenue axialement lorsque l'aiguille d'injection 6 est insérée dans la peau du patient pour limiter sa pénétration. Following this unlocking step, an insertion step takes place. The injection spring 16 axially pushes the control members 13, 15 of the syringe body 5 and the piston 7 towards the distal portion of the positioning control member 11. Since the control member 13 of the syringe body 5 is in configuration in engagement with the syringe holder 10, it cooperates axially with the syringe holder 10 and moves the syringe so that the injection needle 6 protrudes from the distal surface of the end sleeve 12c as shown in Fig. 9 and is inserted into the skin of the patient. Advantageously, as shown in Figures 10 and 11, the locking elements 14 being in their immobilization configuration, the injection syringe 3 is held axially when the injection needle 6 is inserted into the patient's skin to limit its penetration.
Durant cette étape, la came 30a de l'organe de commande 13 du corps de seringue 5 coopère avec un premier chemin de came 31 a de l'organe de contrôle de positionnement 11 de telle sorte que l'organe de commande 13 du corps de seringue 5 tourne par rapport au support de seringue 10 jusqu'à sa configuration de débrayage du support de seringue 10. De la même manière, la came 30b de l'organe de commande 15 de piston 7 coopère avec un deuxième chemin de came 31 b de l'organe de contrôle de positionnement 11 de telle sorte que l'organe de commande 15 de piston 7 tourne par rapport à la tige 7a de piston 7. Cependant, l'organe de commande 15 de piston 7 n'atteint pas sa configuration de débrayage de la tige 7a de piston 7. À la fin de cette étape, le dispositif d'injection automatique 1 est dans la configuration représentée aux figures 9 à 12, dans laquelle l'organe de commande 15 de piston 7 est dans sa configuration en prise avec la tige 7a de piston 7 et l'organe de commande 13 du corps de seringue 5 est dans sa configuration débrayée.  During this step, the cam 30a of the control member 13 of the syringe body 5 cooperates with a first cam path 31a of the positioning control member 11 so that the control member 13 of the body of the syringe 5 rotates relative to the syringe holder 10 to its disengaging configuration of the syringe holder 10. In the same way, the cam 30b of the piston control member 15 cooperates with a second cam path 31b of the positioning control member 11 so that the piston control member 7 rotates relative to the piston rod 7a 7. However, the piston control member 7 does not reach its configuration. 7 at the end of this step, the automatic injection device 1 is in the configuration shown in Figures 9 to 12, wherein the piston control member 7 is in its configuration. in engagement with the piston rod 7a 7 and the control member 13 of the syringe body 5 is in its disengaged configuration.
Dans cette configuration, l'aiguille d'injection 28 est insérée dans la peau du patient. L'élément d'indication visuelle 25 de la course d'injection ne montre quasiment plus l'indicateur visuel 26 de prêt à l'emploi et présente la surface externe de l'organe de commande 13 du corps de seringue 5. On comprend donc que l'organe de commande 13 du corps de seringue 5 peut comprendre une couleur particulière et/ou une graduation utilisée(s) pour indiquer l'avancée de l'injection. En effet, comme visible à la figure 12, on s'aperçoit que l'organe de commande 13 du corps de seringue 5 est dans une position dans laquelle, les crochets élastiques 21 sont désormais alignés avec les dentures 23 et dont sa surface externe est positionnée devant les fenêtres 29 des coques 12a, 12b de l'organe de contrôle de positionnement 11 et des fenêtres 28 du boîtier extérieur 9. Toutefois, les crochets élastiques 21 n'ont pas commencé à coopérer avec les dentures 23.  In this configuration, the injection needle 28 is inserted into the skin of the patient. The visual indication element 25 of the injection stroke almost no longer shows the ready-to-use visual indicator 26 and presents the external surface of the control member 13 of the syringe body 5. It is therefore clear that that the control member 13 of the syringe body 5 may comprise a particular color and / or a scale used (s) to indicate the advance of the injection. Indeed, as can be seen in FIG. 12, it can be seen that the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 are now aligned with the teeth 23 and whose external surface is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9. However, the elastic hooks 21 have not begun to cooperate with the teeth 23.
À la suite de cette étape d'insertion, une étape d'injection a lieu. Le ressort d'injection 16 continue de pousser axialement les organes de commande 13, 15 du corps de seringue 5 et de piston 7 vers la partie distale de l'organe de contrôle de positionnement 11 , cependant, l'organe de commande 13 du corps de seringue 5 ne coopère plus axialement avec le support de seringue 10. L'organe de commande 15 de piston 7 étant en configuration en prise avec la tige 7a de piston 7, il pousse cette dernière de telle sorte qu'elle parcourt sa course d'injection. Le liquide 4, par exemple pharmaceutique, est alors injecté dans le corps du patient. Following this insertion step, an injection step takes place. The injection spring 16 continues to axially push the control members 13, 15 of the syringe body 5 and the piston 7 towards the distal portion of the positioning control member 11, however, the control member 13 of the body of the syringe 5 does not cooperate axially with the syringe holder 10. The piston control member 7 being in configuration engaged with the piston rod 7a 7, it pushes this last so that it goes through its injection stroke. The liquid 4, for example pharmaceutical, is then injected into the body of the patient.
L'élément d'indication visuelle 25 de la course d'injection montre alors consécutivement la surface externe de l'organe de commande 13 du corps de seringue 5 puis la surface externe de l'organe de commande 15 du piston 7. De plus, le dispositif de génération de signaux sonores 17 étant, de manière avantageuse, activé, les crochets élastiques 21 , désormais alignés avec les dentures 23, coopèrent avec leurs dents 24 respectives afin de générer une succession de signaux sonores de manière continue sensiblement entre le début et la fin de l'injection automatique du liquide 4 présent dans la seringue d'injection 3.  The visual indication element 25 of the injection stroke then consecutively shows the outer surface of the control member 13 of the syringe body 5 and the outer surface of the control member 15 of the piston 7. In addition, the sound signal generating device 17 being advantageously activated, the elastic hooks 21, now aligned with the teeth 23, cooperate with their respective teeth 24 to generate a succession of sound signals continuously substantially between the beginning and the end of the automatic injection of the liquid 4 present in the injection syringe 3.
Durant cette étape, la came 30b de l'organe de commande 15 de piston 7 continue à coopérer avec le deuxième chemin de came 31 b, par mouvement relatif, mais n'atteint pas sa configuration de débrayage de la tige 7a de piston 7. À la fin de cette étape, le dispositif d'injection automatique 1 est dans la configuration représentée des figures 13 à 16, dans laquelle le piston 7 et la tige 7a de piston 7 sont en butée contre la paroi de fond du corps de seringue 5 et l'organe de commande 15 de piston 7 est en configuration en prise avec la tige 7a de piston 7.  During this step, the cam 30b of the piston control member 7 continues to cooperate with the second cam path 31b, by relative movement, but does not reach its disengagement configuration of the piston rod 7a 7. At the end of this step, the automatic injection device 1 is in the configuration shown in FIGS. 13 to 16, in which the piston 7 and the piston rod 7a 7 abut against the bottom wall of the syringe body 5 and the piston control member 7 is in configuration engaged with the piston rod 7a 7.
L'élément d'indication visuelle 25 de la course d'injection montre désormais le pictogramme 27i de l'indicateur visuel de fin de course d'injection 27 présent sur la surface externe de l'organe de commande 15 du piston 7 indiquant que l'injection est terminée. En effet, on s'aperçoit que le pictogramme 27i de l'organe de commande 15 du piston 7 est positionné devant les fenêtres 29 des coques 12a, 12b de l'organe de contrôle de positionnement 11 et des fenêtres 28 du boîtier extérieur 9. De plus, comme visible à la figure 16, l'organe de commande 13 du corps de seringue 5 est dans une position dans laquelle, les crochets élastiques 21 sont arrivés à la fin des dentures 23 et ne peuvent donc plus générer de signaux sonores.  The visual indication element 25 of the injection stroke now shows the pictogram 27i of the visual end-of-stroke injection indicator 27 present on the external surface of the control member 15 of the piston 7 indicating that the injection is complete. Indeed, it can be seen that the pictogram 27i of the control member 15 of the piston 7 is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9. Moreover, as shown in FIG. 16, the control member 13 of the syringe body 5 is in a position in which the elastic hooks 21 have reached the end of the teeth 23 and can therefore no longer generate sound signals.
Avantageusement selon l'invention, l'agencement du dispositif de génération de signaux sonores 17 offre donc un déplacement longitudinal qui permet de générer un unique motif sonore évoluant pendant toute la course d'injection. En effet, à titre de comparaison, un déplacement circonférentiel oblige à utiliser un motif sonore nécessitant d'être répété pour couvrir toute l'injection et donc générant une incertitude sur la progression de l'injection. Par conséquent, le déplacement longitudinal permet, avantageusement selon l'invention, de créer un unique motif évolutif et personnalisable suivant les signaux sonores souhaités sur une course supérieure à celle possible avec un dispositif de génération de signaux sonores agencés circonférentiellement. De plus l'agencement longitudinal est plus simple à mettre en œuvre qu'un agencement circonférentiel. À la suite de cette étape d'injection, une étape de déclenchement de la rétraction a lieu. En effet, l'utilisateur n'entendant plus de signaux sonores et pouvant voir le pictogramme 27i , il en déduit que l'injection est terminée. L'utilisateur relâche donc l'effort axial qu'il exerce sur le boîtier extérieur 9 de manière à ce que le ressort de rappel 18 déplace le boîtier extérieur 9 dans le sens de l'allongement télescopique du dispositif d'injection automatique 1 . Cette action de l'utilisateur déclenche donc la rétraction de l'aiguille d'injection 6. Lors de ce déplacement, le premier chemin de came 31 a coopère avec la came 30a de l'organe de commande 15 de piston 7 ce qui entraîne une rotation de l'organe de commande 15 de piston 7 par rapport à la tige 7a de piston 7 jusqu'à sa configuration débrayée. À la fin de cette étape, le dispositif d'injection automatique 1 est dans la configuration, dans laquelle l'organe de commande 15 de piston 7 est dans sa configuration débrayée de la tige 7a de piston 7 et les saillies radiales de la bague de retenue 12d coopèrent avec les bords des lumières ménagées dans le boîtier extérieur 9. Advantageously according to the invention, the arrangement of the device for generating sound signals 17 thus offers a longitudinal displacement which makes it possible to generate a single sound pattern evolving throughout the injection stroke. Indeed, for comparison, a circumferential movement requires the use of a sound pattern that needs to be repeated to cover the entire injection and therefore generates uncertainty about the progress of the injection. Consequently, the longitudinal displacement advantageously allows, according to the invention, to create a single evolutionary and customizable pattern according to the desired sound signals on a stroke greater than that possible with a device for generating circumferentially arranged sound signals. In addition, the longitudinal arrangement is simpler to implement than a circumferential arrangement. Following this injection step, a step of triggering the retraction takes place. Indeed, the user no longer hearing sound signals and can see the pictogram 27i, he deduced that the injection is complete. The user therefore releases the axial force that he exerts on the outer casing 9 so that the return spring 18 moves the outer casing 9 in the direction of the telescopic extension of the automatic injection device 1. This action of the user thus triggers the retraction of the injection needle 6. During this movement, the first cam path 31 co-operates with the cam 30a of the piston control member 7, which causes a rotation of the piston control member 7 relative to the piston rod 7a 7 to its disengaged configuration. At the end of this step, the automatic injection device 1 is in the configuration, in which the piston control member 7 is in its disengaged configuration of the piston rod 7a and the radial projections of the piston ring. retain 12d cooperate with the edges of the lights in the outer housing 9.
À la suite de cette étape de déclenchement de la rétraction, une étape de rétraction à lieu. Comme l'organe de commande 15 de piston 7 est en configuration débrayée de la tige 7a de piston 7, cette dernière est libre de se déplacer axialement vers la partie proximale du dispositif d'injection automatique 1 . Les ressorts de rétraction 20 sont alors libres de pousser le support de seringue 10 vers la partie proximale de l'organe de contrôle de positionnement 11 . Ainsi, l'aiguille d'injection 6 se rétracte dans l'organe de contrôle de positionnement 11 de telle sorte qu'elle n'est plus saillante de la surface distale du manchon d'extrémité 12c. Avantageusement, la rétraction s'accompagne d'un signal sonore qui peut être généré par le mouvement de l'organe de commande 15 par rapport à la tête de la tige 7a de piston 7.  Following this step of triggering the retraction, a retraction step takes place. As the piston control member 7 is in the disengaged configuration of the piston rod 7a 7, the latter 7 is free to move axially toward the proximal portion of the automatic injection device 1. The retraction springs 20 are then free to push the syringe holder 10 towards the proximal portion of the positioning control member 11. Thus, the injection needle 6 retracts into the positioning control member 11 so that it is no longer projecting from the distal surface of the end sleeve 12c. Advantageously, the retraction is accompanied by a sound signal that can be generated by the movement of the control member 15 relative to the head of the piston rod 7a 7.
À la fin de cette étape, le dispositif d'injection automatique 1 est dans la configuration représentée aux figures 17 à 19, dans laquelle le fonctionnement du dispositif d'injection automatique 1 est terminé. L'élément d'indication visuelle 25 de la course d'injection montre alors le pictogramme 272 de l'indicateur visuel de fin de course d'injection 27 présent sur la surface externe de l'organe de commande 15 du piston 7 indiquant que le dispositif d'injection automatique 1 a déjà été utilisé. En effet, on s'aperçoit que le pictogramme 272 de l'organe de commande 15 du piston 7 est positionnée devant les fenêtres 29 des coques 12a, 12b de l'organe de contrôle de positionnement 11 et des fenêtres 28 du boîtier extérieur 9. At the end of this step, the automatic injection device 1 is in the configuration shown in Figures 17 to 19, in which the operation of the automatic injection device 1 is completed. The visual indication element 25 of the injection stroke then shows the pictogram 27 2 of the visual end-of-stroke injection indicator 27 present on the external surface of the control member 15 of the piston 7 indicating that the automatic injection device 1 has already been used. Indeed, it can be seen that the pictogram 27 2 of the control member 15 of the piston 7 is positioned in front of the windows 29 of the shells 12a, 12b of the positioning control member 11 and the windows 28 of the outer casing 9 .
L'invention n'est pas limitée au mode de réalisation présenté et aux variantes proposées et d'autres modes de réalisation et variantes apparaîtront clairement à l'homme du métier. Il est notamment possible que le dispositif de génération de signaux sonores 17 soit actif avant le début de l'injection comme par exemple à partir du moment où l'utilisateur appui sur le boîtier extérieur 9 afin de générer des signaux sonores avant le début de l'injection. The invention is not limited to the embodiment shown and to the proposed variants and other embodiments and variants will become apparent to those skilled in the art. It is possible in particular that the device for generating sound signals 17 be active before the start of the injection, for example from when the user presses on the outer housing 9 to generate sound signals before the start of the injection.
Ainsi, chaque ensemble 19 du dispositif de génération de signaux sonores 17 peut être adapté suivant les mises en œuvre souhaitées afin de régler le début, l'intensité, la fréquence et la fin des signaux sonores. À titre d'exemple, une première denture 23 pourrait ainsi coopérer avec un premier crochet élastique 21 pendant toute la durée du fonctionnement du dispositif d'injection automatique 1 alors qu'une deuxième denture 23 pourrait coopérer avec un deuxième crochet élastique 21 uniquement pendant l'étape d'injection de sorte à faire varier l'intensité et/ou la fréquence des signaux sonores pendant la durée de l'étape d'injection par rapport au reste des étapes de fonctionnement du dispositif d'injection automatique 1 . À titre d'exemple complémentaire, la distance entre les dents de l'une ou l'autre des dentures peut être variable de sorte, par exemple, à ce que la fréquence des signaux sonores s'accélère ou ralentisse en fin d'injection. De même, la hauteur des dents de l'une ou l'autre des dentures peut être variable de sorte, par exemple, à ce que le niveau sonore des signaux sonores augmente ou diminue en fonction de la progression de d'injection.  Thus, each set 19 of the sound signal generation device 17 can be adapted according to the desired implementations in order to regulate the beginning, the intensity, the frequency and the end of the sound signals. By way of example, a first toothing 23 could thus cooperate with a first elastic hook 21 during the entire operation of the automatic injection device 1 while a second toothing 23 could cooperate with a second elastic hook 21 only during the first operation. injection step so as to vary the intensity and / or the frequency of the sound signals during the duration of the injection step relative to the rest of the operating steps of the automatic injection device 1. As a complementary example, the distance between the teeth of one or other of the teeth can be variable so, for example, that the frequency of the audible signals accelerates or slows down at the end of the injection. Similarly, the height of the teeth of one or other of the teeth can be variable so, for example, that the sound level of the audible signals increases or decreases depending on the injection progress.
De plus, chaque élément d'indication visuelle 25 peut être adapté suivant les mises en œuvre souhaitées afin de régler le début, l'information et la fin des affichages présentés.  In addition, each visual indication element 25 may be adapted according to the desired implementations to adjust the start, the information and the end of the displayed displays.
Selon un mode de réalisation non représentée, on peut prévoir une denture dont l'espacement entre les dents est différent d'une zone de la denture à une autre. Cet espacement peut varier régulièrement ou non. Ainsi, on peut prévoir une portion initiale de denture avec un espacement initial et une portion finale de denture (en fin d'injection) avec un espacement final inférieur à l'espacement initial. De manière optionnelle, une ou plusieurs portions de dentures intermédiaires, chacune pourvue d'un espacement entre dents intermédiaire aux espacements initial et final, peuvent être prévues entre les portions initiale et finale de denture. On peut également prévoir un espacement évoluant progressivement, par exemple de plus en plus réduit de sorte que la fréquence des signaux sonores soit plus élevée en fin qu'en début d'injection.  According to an embodiment not shown, it can provide a toothing whose spacing between the teeth is different from one area of the toothing to another. This spacing may vary regularly or not. Thus, it is possible to provide an initial portion of toothing with initial spacing and a final portion of toothing (at the end of injection) with a final spacing less than the initial spacing. Optionally, one or more intermediate tooth portions, each provided with an intermediate tooth spacing at the initial and final spacings, may be provided between the initial and final tooth portions. It is also possible to provide a progressively evolving spacing, for example more and more reduced so that the frequency of the sound signals is higher end than at the beginning of injection.

Claims

REVENDICATIONS
1 . Dispositif d'injection automatique (1 ) comprenant une seringue d'injection (3) de liquide (4) munie d'un corps de seringue (5) portant une aiguille d'injection (6) et d'une tige (7a) de piston (7) montée déplaçable dans ce corps de seringue (5) pour parcourir une course d'injection du liquide (4), un boîtier extérieur (9) et un organe de contrôle de positionnement (11 ) télescopiques dont le déplacement relatif commande le fonctionnement du dispositif d'injection automatique (1 ), et des organes de commande (13, 15) agencés pour sélectivement contrôler le déplacement du corps de seringue (5) et le déplacement du piston (7) à l'intérieur de l'organe de contrôle de positionnement (11 ) afin d'injecter automatiquement le liquide (4) présent dans la seringue d'injection (3), caractérisé en ce que le dispositif d'injection automatique (1 ) comporte en outre un dispositif de génération de signaux sonores (17) activé pendant l'injection automatique du liquide (4) présent dans la seringue d'injection (3) pour générer une succession de signaux sonores du début à la fin de l'injection. 1. Automatic injection device (1) comprising an injection syringe (3) of liquid (4) provided with a syringe body (5) carrying an injection needle (6) and a rod (7a) of piston (7) displaceably mounted in this syringe body (5) for traversing a liquid injection stroke (4), an outer casing (9) and a telescopic positioning control member (11) whose relative displacement controls the operation of the automatic injection device (1), and control members (13, 15) arranged to selectively control the movement of the syringe body (5) and the movement of the piston (7) within the organ positioning control device (11) for automatically injecting the liquid (4) present in the injection syringe (3), characterized in that the automatic injection device (1) further comprises a signal generating device sound (17) activated during automatic liquid injection (4) nt in the injection syringe (3) to generate a succession of sound signals from the beginning to the end of the injection.
2. Dispositif d'injection automatique (1 ) selon la revendication précédente, dans lequel le dispositif de génération de signaux sonores (17) est monté entre l'organe de contrôle de positionnement (11 ) et l'un des organes de commande (13, 15) afin de générer des signaux sonores lors du déplacement relatif entre le corps de seringue (5) et le piston (7).  2. Automatic injection device (1) according to the preceding claim, wherein the device for generating sound signals (17) is mounted between the positioning control member (11) and one of the control members (13). , 15) for generating sound signals during relative movement between the syringe body (5) and the piston (7).
3. Dispositif d'injection automatique (1 ) selon la revendication précédente, dans lequel le dispositif de génération de signaux sonores (17) est monté entre l'organe de contrôle de positionnement (11 ) et l'organe de commande (13) du corps de seringue (5).  3. Automatic injection device (1) according to the preceding claim, wherein the device for generating sound signals (17) is mounted between the positioning control member (11) and the control member (13). syringe body (5).
4. Dispositif d'injection automatique (1 ) selon la revendication 2, dans lequel le dispositif de génération de signaux sonores (17) est monté entre l'organe de contrôle de positionnement (11 ) et l'organe de commande (15) du piston (7).  An automatic injection device (1) according to claim 2, wherein the sound signal generation device (17) is mounted between the positioning control member (11) and the control member (15) of the piston (7).
5. Dispositif d'injection automatique (1 ) selon l'une quelconque des revendications précédentes, dans lequel le dispositif de génération de signaux sonores (17) comporte au moins un ensemble (19) crochet élastique (21 ) - denture (23) destiné à générer un signal sonore à chaque passage de dent (24) du crochet élastique (21 ) contre la denture (23).  Automatic injection device (1) according to any one of the preceding claims, wherein the sound signal generating device (17) comprises at least one assembly (19) elastic hook (21) - toothing (23) for generating a sound signal at each tooth passage (24) of the elastic hook (21) against the toothing (23).
6. Dispositif d'injection automatique (1 ) selon la revendication précédente, dans lequel le dispositif de génération de signaux sonores (17) comporte deux ensembles (19) crochet élastique (21 ) - denture (23).  6. Automatic injection device (1) according to the preceding claim, wherein the device for generating sound signals (17) comprises two sets (19) elastic hook (21) - toothing (23).
7. Dispositif d'injection automatique (1 ) selon la revendication précédente, dans lequel les deux ensembles (19) crochet élastique (21 ) - denture (23) sont décalés afin de générer deux signaux sonores alternés. 7. Automatic injection device (1) according to the preceding claim, wherein the two sets (19) elastic hook (21) - toothing (23) are offset in order to generate two alternating sound signals.
8. Dispositif d'injection automatique (1 ) selon l'une quelconque des revendications 5 à 7, dans lequel chaque denture (23) est aménagée sur l'organe de contrôle de positionnement (11 ).  8. Automatic injection device (1) according to any one of claims 5 to 7, wherein each toothing (23) is arranged on the positioning control member (11).
9. Dispositif d'injection automatique (1 ) selon l'une quelconque des revendications précédentes, comportant en outre un élément d'indication visuelle (25) de la course d'injection.  9. Automatic injection device (1) according to any one of the preceding claims, further comprising a visual indication element (25) of the injection stroke.
10. Dispositif d'injection automatique (1 ) selon la revendication précédente, dans lequel l'élément d'indication visuelle (25) comprend au moins un indicateur visuel (26, 27) se positionnant au droit d'une fenêtre (28) aménagée sur le boîtier extérieur (9) à la fin de la course d'injection.  10. Automatic injection device (1) according to the preceding claim, wherein the visual indication element (25) comprises at least one visual indicator (26, 27) positioned at the right of a window (28) arranged on the outer casing (9) at the end of the injection stroke.
EP18724945.3A 2017-04-28 2018-04-10 Automatic injection device provided with a device for generating sound signals Pending EP3615108A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1753772A FR3065647B1 (en) 2017-04-28 2017-04-28 AUTOMATIC INJECTION DEVICE HAVING A DEVICE FOR GENERATING SOUND SIGNALS
PCT/FR2018/050892 WO2018197774A1 (en) 2017-04-28 2018-04-10 Automatic injection device provided with a device for generating sound signals

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EP3615108A1 true EP3615108A1 (en) 2020-03-04

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US (1) US11357925B2 (en)
EP (1) EP3615108A1 (en)
FR (1) FR3065647B1 (en)
WO (1) WO2018197774A1 (en)

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Publication number Priority date Publication date Assignee Title
BR112017011213A2 (en) 2014-12-23 2018-02-14 Automed Pty Ltd delivery apparatus, system and associated methods
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900930D0 (en) * 2009-01-20 2009-03-04 Future Injection Technologies Ltd Injection device
JP5778143B2 (en) * 2009-07-08 2015-09-16 ノボ・ノルデイスク・エー／エス Automatic priming injection device
CA3081934C (en) * 2009-10-16 2023-12-12 Janssen Biotech, Inc. Palm activated drug delivery device
JP6433484B2 (en) * 2013-04-10 2018-12-05 サノフイＳａｎｏｆｉ Drive mechanism of drug delivery device
TWI616218B (en) * 2014-03-06 2018-03-01 卡貝歐洲有限公司 Device for delivering a medicament
TW201603849A (en) * 2014-07-01 2016-02-01 賽諾菲公司 Clicker arrangement and drug delivery herewith
CN107206166B (en) * 2014-11-12 2020-12-04 诺和诺德股份有限公司 Method of manufacturing one of a series of auto-injectors

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Publication number Publication date
WO2018197774A1 (en) 2018-11-01
US11357925B2 (en) 2022-06-14
US20200147311A1 (en) 2020-05-14
FR3065647B1 (en) 2019-07-19
FR3065647A1 (en) 2018-11-02

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