EP3609495A4 - Association comprenant un antagoniste de nk1 et méthode de traitement de synucléinopathies - Google Patents

Association comprenant un antagoniste de nk1 et méthode de traitement de synucléinopathies Download PDF

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Publication number
EP3609495A4
EP3609495A4 EP18785191.0A EP18785191A EP3609495A4 EP 3609495 A4 EP3609495 A4 EP 3609495A4 EP 18785191 A EP18785191 A EP 18785191A EP 3609495 A4 EP3609495 A4 EP 3609495A4
Authority
EP
European Patent Office
Prior art keywords
antagonist combination
treating synucleinopathies
synucleinopathies
treating
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18785191.0A
Other languages
German (de)
English (en)
Other versions
EP3609495A1 (fr
Inventor
Thomas N. Chase
Kathleen E. Clarence-Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chase Therapeutics Corp
Original Assignee
Chase Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chase Therapeutics Corp filed Critical Chase Therapeutics Corp
Publication of EP3609495A1 publication Critical patent/EP3609495A1/fr
Publication of EP3609495A4 publication Critical patent/EP3609495A4/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
EP18785191.0A 2017-04-10 2018-04-09 Association comprenant un antagoniste de nk1 et méthode de traitement de synucléinopathies Pending EP3609495A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762483555P 2017-04-10 2017-04-10
PCT/US2018/026699 WO2018191160A1 (fr) 2017-04-10 2018-04-09 Association comprenant un antagoniste de nk1 et méthode de traitement de synucléinopathies

Publications (2)

Publication Number Publication Date
EP3609495A1 EP3609495A1 (fr) 2020-02-19
EP3609495A4 true EP3609495A4 (fr) 2020-12-02

Family

ID=63792736

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18785191.0A Pending EP3609495A4 (fr) 2017-04-10 2018-04-09 Association comprenant un antagoniste de nk1 et méthode de traitement de synucléinopathies

Country Status (14)

Country Link
US (1) US11160809B2 (fr)
EP (1) EP3609495A4 (fr)
JP (1) JP7271437B2 (fr)
KR (1) KR20200002899A (fr)
CN (1) CN110730662A (fr)
AU (1) AU2018251604B2 (fr)
BR (1) BR112019021125A2 (fr)
CA (1) CA3059418A1 (fr)
EA (1) EA201992414A1 (fr)
IL (2) IL309770A (fr)
MA (1) MA51658A (fr)
MX (1) MX2019012088A (fr)
TW (1) TWI803488B (fr)
WO (1) WO2018191160A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111032158A (zh) 2017-06-30 2020-04-17 才思治疗公司 用于治疗抑郁的nk-1拮抗剂组合物和方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1998024446A1 (fr) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Utilisation d'antagonistes du recepteur nk-1 dans le traitement des diskynesies
WO2019006050A1 (fr) * 2017-06-30 2019-01-03 Chase Therapeutics Corporation Compositions d'antagoniste de nk-1 et méthodes destinées à être utilisées dans le traitement de la dépression

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DE9290063U1 (de) 1991-05-31 1994-02-24 Pfizer Chinuclidin-Derivate
US5719147A (en) 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
DE4241013A1 (de) * 1992-12-05 1994-06-09 Boehringer Ingelheim Kg Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
TW385308B (en) 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
WO2000006162A1 (fr) * 1998-07-27 2000-02-10 Boehringer Ingelheim Pharma Kg Agents a effet antidepresseur, comprenant du pramipexol et un autre antidepresseur
EP1394150B1 (fr) 1999-02-24 2011-01-19 F. Hoffmann-La Roche AG Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
SI1303490T1 (sl) 2000-07-14 2008-10-31 Hoffmann La Roche N-oksidi kot predzdravila NK 1 receptorskega antagonista 4-fenil-piridin derivatov
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
DK1349541T3 (da) 2000-12-14 2007-01-08 Hoffmann La Roche Selvemulgerende lipidmatrix (SELM)
PE20030762A1 (es) * 2001-12-18 2003-09-05 Schering Corp Compuestos heterociclicos como antagonistas nk1
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0310881D0 (en) * 2003-05-12 2003-06-18 Merck Sharp & Dohme Pharmaceutical formulation
TWI341198B (en) 2004-01-27 2011-05-01 Merck Sharp & Dohme Hydroisoindoline tachykinin receptor antagonists
HUE034099T2 (en) 2004-01-30 2018-01-29 Zoetis Services Llc Antimicrobial preservatives for the delivery of multidose formulations using beta-cyclodextrins for liquid dosage forms
US20120253047A1 (en) 2004-03-19 2012-10-04 Dipharma S.P.A. Process for the preparation of (r)-pramipexole
BRPI0608847A2 (pt) * 2005-03-08 2010-02-02 Janssen Pharmaceutica Nv derivados de diaza-espiro-[4,4]-nonano substituìdos e seu uso como antagonistas de neurocinina
EP1904445B1 (fr) 2005-07-11 2011-03-02 Merck Sharp & Dohme Corp. Procede de fabrication d'antagonistes des recepteurs de l'hydroisoindoline tachykinine
AU2006279643B2 (en) 2005-08-15 2010-06-17 University Of Virginia Patent Foundation Neurorestoration with R(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CN102160865A (zh) 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
CN101641096A (zh) * 2006-12-14 2010-02-03 诺普神经科学股份有限公司 (r)-普拉克索的组合物以及使用该组合物的方法
WO2008113003A1 (fr) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Formulations à libération modifiée de (6r)-4,5,6,7-tétrahydro-n6-propyl-2,6-benzothiazole-diamine et procédés d'utilisation de celles-ci
US20080254117A1 (en) 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
GB0806652D0 (en) 2008-04-11 2008-05-14 Glaxo Group Ltd Anhydrous crystal form of orvepitant maleate
AU2010282483B2 (en) 2009-08-14 2014-09-04 Opko Health, Inc. Intravenous formulations of neurokinin-1 antagonists
EP2722045B1 (fr) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions pour traiter les nausées et vomissements à médiation centrale
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Publication number Priority date Publication date Assignee Title
WO1998024446A1 (fr) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Utilisation d'antagonistes du recepteur nk-1 dans le traitement des diskynesies
WO2019006050A1 (fr) * 2017-06-30 2019-01-03 Chase Therapeutics Corporation Compositions d'antagoniste de nk-1 et méthodes destinées à être utilisées dans le traitement de la dépression

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Also Published As

Publication number Publication date
IL309770A (en) 2024-02-01
JP2020516625A (ja) 2020-06-11
US11160809B2 (en) 2021-11-02
TWI803488B (zh) 2023-06-01
KR20200002899A (ko) 2020-01-08
EA201992414A1 (ru) 2020-03-16
US20200147097A1 (en) 2020-05-14
IL269875B1 (en) 2024-02-01
MA51658A (fr) 2020-12-02
CA3059418A1 (fr) 2018-10-18
BR112019021125A2 (pt) 2020-05-12
MX2019012088A (es) 2020-02-07
WO2018191160A1 (fr) 2018-10-18
IL269875A (fr) 2019-12-31
AU2018251604B2 (en) 2022-04-14
AU2018251604A1 (en) 2019-11-21
CN110730662A (zh) 2020-01-24
EP3609495A1 (fr) 2020-02-19
JP7271437B2 (ja) 2023-05-11
TW201841634A (zh) 2018-12-01

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