EP3595511A1 - Procédé et dispositif pour déterminer un niveau de contamination de la peau par des bactéries d'acnéiques - Google Patents

Procédé et dispositif pour déterminer un niveau de contamination de la peau par des bactéries d'acnéiques

Info

Publication number
EP3595511A1
EP3595511A1 EP18708658.2A EP18708658A EP3595511A1 EP 3595511 A1 EP3595511 A1 EP 3595511A1 EP 18708658 A EP18708658 A EP 18708658A EP 3595511 A1 EP3595511 A1 EP 3595511A1
Authority
EP
European Patent Office
Prior art keywords
skin
light
colonization
degree
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP18708658.2A
Other languages
German (de)
English (en)
Inventor
Andreas Bock
Thomas Welss
Claudia Hundeiker
Marianne Waldmann-Laue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of EP3595511A1 publication Critical patent/EP3595511A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0013—Medical image data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/486—Bio-feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Definitions

  • Various embodiments generally relate to a method and apparatus for determining a degree of colonization of skin with acne bacteria (also abbreviated to "colonization level,” “degree of colonization of the skin” or “degree of colonization with bacteria”) and a method of determining a cosmetic skin treatment recommendation.
  • Bacteria that colonize the skin can be the cause of redness and inflammation in the skin. You may be responsible for the development of blackheads (comedones) and pimples to acne.
  • various special facial and / or body cosmetic products may be available, for example, hiding makeup and masking care products, anti-inflammatory and / or breathable decorative cosmetics, etc.
  • the effectiveness of the cosmetic products may be greatly enhanced an individual physiology of the skin, for example, a degree of colonization of the skin with acne bacteria, which can correlate with a degree in which acne can manifest.
  • a device for determining a degree of colonization of skin with acne bacteria may be provided.
  • the determination of the degree of colonization of the skin and a continuous checking of changes can offer the user, in various embodiments, an added benefit of an individualizable cosmetic treatment.
  • a sensor can be used which can quantify the content of bacteria on the skin.
  • the quantification of the bacteria can be determined indirectly via a content of endogenous porphyrin.
  • the quantification can be done via the orange-red fluorescence of the endogenous porphyrin.
  • excitation of porphyrin contained in the bacteria may be necessary by means of a light emitting device which emits light in a long wavelength UV-A and / or blue light (e.g., a so-called Wood lamp).
  • the senor may include a camera that may be configured to detect fluorescent light that may be emitted by the excited porphyrin.
  • the apparatus for determining the degree of colonization of skin may include an electronic circuit device that may be configured to determine the detected amount of light emitted from the fluorescent agent as fluorescence due to the exposure in the photograph, and to assign a degree of colonization the skin to the detected detected amount of light by means of a database.
  • a device may be provided which may be connected to or integrated with a smartphone, tablet, laptop, or other computing device.
  • the device may communicate via a data link with a processor cloud architecture (also referred to as "cloud” for brevity).
  • a processor cloud architecture also referred to as "cloud” for brevity.
  • a database may be provided which allocates a respective amount of light of one of the acne bacteria produced fluorescence agent is provided to provide bacterial colonization of the skin, wherein the database may have been determined as a reference database, eg in laboratory experiments, and possibly can be updated by means of measurement data of other users
  • a degree of colonization of the skin with acne bacteria may be determined by means of an app or other software and provided in the form of a value (e.g., with arbitrary units), a graphical representation, and / or an acoustic message.
  • a degree of colonization of the skin with acne bacteria may be recorded over an extended period of time, and control / tracking of the degree of colonization of the skin may be enabled by (e.g., plotting) the measurement results over time.
  • the device can be designed in various embodiments low and small (eg portable).
  • the device may be applied to a (live) user, for example, the user at home, at a point of sale of cosmetics, and / or in a beauty salon.
  • the device may comprise a smartphone, a tablet, an iPad or similar electronic circuit device (eg, a data processing device and / or a data transfer device), and an integrated device or attachment attachable to and / or with the electronic circuit device, for example connectable (eg connectable by means of a data connection) can be.
  • the integrated device or attachment (or even the entire device as the case may be) may be of a size which allows it to be easily accommodated in a hand or trouser pocket, for example less than 36 cm 2 in area and less thick than 2 cm.
  • the fluorescence signal detected using the camera and the light emitting device may be compared to reference fluorescence signals for known bacterial colonization levels, and from which a bacterial colonization level of the user's skin may be determined (which comparison may also be made such that the signal is by means of a converted from reference signals and reference data to bacterial colonization level of the user).
  • the reference data may have been previously determined in various embodiments, for example in laboratory experiments, and may be continuously updated by including data from other users, wherein the reference data may be provided in the form of a database.
  • comparing the signal to the reference signal and / or determining the bacterial colonization level therefrom may be accomplished by electronic means Circuit device (eg directly), for example by means of an app or other software program, which is operated by the electronic circuit device (eg a smartphone, a tablet, an iPad or the like).
  • electronic means Circuit device eg directly
  • an app or other software program which is operated by the electronic circuit device (eg a smartphone, a tablet, an iPad or the like).
  • the database may be provided by means of a processor cloud architecture, for which the electronic circuit device may provide a (e.g., contactless) data communication connection.
  • a processor cloud architecture for which the electronic circuit device may provide a (e.g., contactless) data communication connection.
  • the database may be stored in the electronic circuit device.
  • comparing the fluorescence signal with the reference fluorescence signal to determine the bacterial colonization level may be done directly by the electronic circuit device.
  • the comparison of the fluorescence signal with the reference fluorescence signal to determine the degree of bacterial colonization can be done indirectly by means of the electronic circuit device, for example by the electronic circuit device providing a (eg contactless) data communication connection and by means of the data communication connection the fluorescence signal of an external data processing device (eg a processor). Cloud architecture) and receives from the external data processing device determined by the fluorescence signal bacterial colonization of the skin.
  • the electronic circuit device providing a (eg contactless) data communication connection and by means of the data communication connection the fluorescence signal of an external data processing device (eg a processor). Cloud architecture) and receives from the external data processing device determined by the fluorescence signal bacterial colonization of the skin.
  • a (physical) size of a skin area for which fluorescence is detected by means of the camera can be determined.
  • the size of the skin area e.g. as described below, on the basis of the image (for example, of structures in the image which have a defined typical size (in a unit of area)).
  • the size of the skin area may be determined using a distance between the camera and the skin area using camera characteristics (e.g., a magnification and a physical detector size), e.g. as described below. In this case, the distance between the camera and the skin area may be predetermined and / or measured by means of a distance measuring device, e.g. as described below.
  • the determined bacterial colonization rate of the skin can be provided to the user in any manner, eg selectable by the user, eg as a numerical value, a graphical representation (for example a representation of the determined value in relation to a total range from sparsely populated to moderately populated to heavily populated), an acoustic message, or the like.
  • providing the bacterial colonization degree of the skin to the user may include a graphical representation, for example, a display, e.g. by means of a display device.
  • the determined bacterial colonization degree of the skin of the plurality of regions may be displayed with a coding based on the bacterial cell colonization degree in a representation of the user (e.g., a schematic or a photograph of the user).
  • the user's image captured by the camera may be used to superimpose bacterial colonization sites, such as false color representation or superimposed contours of the fluorescence intensity image.
  • different representations of bacterial colonization may be used for different times, e.g. different colors in the false color representation, a false color representation for a time and a different colored contour for another time, etc.
  • the display device may be part of the device, e.g. a display of a smartphone, tablet or iPad.
  • the display device may be coupled to the device, for example by means of a (e.g., wireless) data connection.
  • the electronic circuit device may be configured, itself, i. directly to determine the degree of colonization, for example by means of software, e.g. an app that may be installed on the electronic circuit device, wherein the software (e.g., the app) may be configured to use a database for determining the degree of colonization that may or may not be provided by a processor cloud architecture.
  • software e.g. an app that may be installed on the electronic circuit device
  • the software e.g., the app
  • the software may be configured to use a database for determining the degree of colonization that may or may not be provided by a processor cloud architecture.
  • a method and apparatus for determining a degree of colonization of skin with acne bacteria may be provided.
  • the device, the method, and / or the degree of colonization determined by means of the device or method can be used to determine the needs of the skin of the user.
  • it is intended to enable a user to specifically find cosmetic products and / or to obtain grooming suggestions that can be tailored to the individual needs of the user's skin.
  • various embodiments may utilize software, for example an app, which may be installed, for example, on a portable data processing device (for example a smartphone, a tablet, an iPad or the like).
  • a camera that may be configured to detect a fluorescence signal of a fluorescer generated by acne bacteria may be connected to or integrated with the data processing device.
  • an ultraviolet and / or blue light emitting device may be provided by which the skin of the user may be illuminated to generate the fluorescent signal.
  • An evaluation of the detected fluorescence signal can enable a quantification of the degree of colonization of the skin with acne bacteria, by means of a database, which can be provided by means of a cloud, the fluorescence signal, a colonization of the skin with acne bacteria can be assigned.
  • the use of the database provided by the cloud can make it possible, even after the device has been provided to the user, to improve the statistical reliability of data in the database and, if necessary, to expand a range covered by the data with regard to the degree of colonization.
  • the determined colonization degree as a value (e.g., with arbitrary units), as a verbal message, as a graphic representation (e.g., as a schematic pictorial representation indicating skin areas with acne bacterial colonization), or the like. be presented or communicated.
  • the user can be recommended at least one cosmetic product that meets his individual needs.
  • the cosmetic product may be capable of maintaining or improving the skin condition of the user (e.g., reducing or at least not increasing a degree of colonization with acne bacteria).
  • the cosmetic product may comprise a cream, a lotion, an ointment, an oil, an emulsion, a gel, a soap or the like, for example a make-up, a powder, a concealer, a concealer or a covering care product such as Example a tinted day cream.
  • the product recommendations and / or care instructions can be provided, for example, by means of software, for example an app.
  • the user may be advised to apply a cosmetic care product which has a relatively high coverage to a skin area which is relatively heavily populated by acne bacteria. Apply and a cosmetic care product, which has a relatively low coverage, to apply to a skin area that is not or only slightly colonized by acne bacteria, to apply.
  • the user may be advised to use or avoid products with certain ingredients.
  • the user may be advised to apply a cosmetic care product containing benzoyl peroxide to a skin area that is relatively heavily populated by acne bacteria.
  • a cosmetic care product containing benzoyl peroxide to a skin area that is relatively heavily populated by acne bacteria.
  • users may be advised to use antiseptic care products such as a combination of ammonium dodecylsulfate and dodecylbenzenesulfonic acid, sodium bituminosulfonate (shale oil), salicylic acid, retinoids or antibiotics.
  • antiseptic care products such as a combination of ammonium dodecylsulfate and dodecylbenzenesulfonic acid, sodium bituminosulfonate (shale oil), salicylic acid, retinoids or antibiotics.
  • the user can be advised against the use of care products with a high content of comedogenic ingredients.
  • the software / app that determines the bacterial colonization rate of the skin may be the same that determines the product recommendation and / or the care instructions.
  • different software programs / apps may be used for a portion of the various operations or all of the various operations (determining the bacterial cell colonization rate, determining a product recommendation, determining a care indication).
  • a treatment success in a cosmetic treatment which may be aimed at reducing the determined bacterial colonization level of the skin with anchoring bacteria, may be monitored.
  • the software / app may enable control and / or tracking of the results by means of a representation (e.g., a graphical representation, such as shown above) of the measurement results over time.
  • information may also be used regarding general health, skin condition, dietary habits, and other user behaviors (e.g., daily outdoor / sun / water dwell, smoking habits, etc.), e.g. by means of the software / app.
  • This information can be requested by the user in various embodiments by means of the software / app.
  • literature data may be used to assess suitability of a care product and / or a care indication for maintaining a skin having a given skin condition.
  • a care product and / or a care indication for a skin condition may be considered appropriate, for example, based on literature data, test results, or empirical values (eg, ongoing, eg, during use of the software / app by the user , can be updated with new experiences of other users, see below), that with a (eg regular) application of the care product and / or the care instructions, the bacterial colonization of the user's skin is reduced, or at least not increased.
  • an assessment of a suitability of a care product to improve a skin condition can be confirmed or modified by including experience values of other users with the same or a similar degree of colonization, for example, empirical values with regard to a treatment success. This can make it possible for the user to always receive an optimal recommendation. It is advantageous if the other users whose empirical values are recorded also have a similar profile with regard to age, gender, weight, general health and / or living habits in addition to the same or a similar degree of colonization.
  • the cosmetic treatment may, in various embodiments, aim to reduce the degree of bacterial colonization of the skin, and / or to achieve a different cosmetic effect, e.g. a decorative effect without increasing the bacterial colonization of the skin.
  • efficacy of (e.g., cosmetic) treatment may be better understood, thereby facilitating or facilitating selection of an individually suitable product.
  • a user's motivation may be increased to perform a cosmetic treatment in the longer term, for example, by comparison with other users, e.g. by information about treatment success provided by the other users.
  • a method for determining a degree of colonization of skin with acne bacteria may include: for at least one skin area of a user during exposing the skin area to ultraviolet and / or blue light; capturing the area of the skin by means of a camera, the camera being configured to at least generate light in a fluorescence wavelength range of one of the acne bacteria Detecting fluorescence means, determining a detected amount of light, which of the fluorescent agent is emitted as fluorescence due to the exposure, by means of the recording, and assigning a degree of colonization of the skin to the determined detected amount of light, wherein the assignment of the degree of colonization of the skin to the detected detected amount of light by means of a database stored in a processor cloud architecture ,
  • the method may further comprise updating the database based on new allocations of the degree of colonization of the skin to the determined detected amount of light from a plurality of other users.
  • the method may further include capturing a background light image of the skin area by the camera while the skin area is not exposed to the ultraviolet and / or blue light, wherein determining the detected amount of light emitted from the fluorescence medium as fluorescence due to the exposure was, a determination of a difference of the recording and the difference recording can have.
  • the fluorescer may comprise a porphyrin, preferably coprophorphyrin III.
  • the fluorescence wavelength range may range from 560 nm to 780 nm.
  • the at least one skin area has a plurality of skin areas of the user.
  • the camera and a lighting device for generating the ultraviolet and / or blue light may be parts of at least one portable device.
  • the portable device may include a smartphone, a tablet, or an iPad, or may be attachable to a smartphone, a tablet, or an iPad.
  • the determination of the detected amount of light and / or the assignment of the degree of colonization of the skin to the determined detected amount of light can be carried out by means of an app.
  • a method for determining a cosmetic skin treatment recommendation may include determining a skin condition according to various embodiments, and determining the cosmetic product and / or a care instruction based on the determined degree of colonization of the skin and a further database stored in the processor cloud architecture having a plurality of colonization levels and a plurality of associated cosmetic products and / or grooming instructions, wherein each skin condition of the plurality of skin conditions is at least a suitable cosmetic product and / or at least one care instruction can be assigned.
  • the cosmetic product and / or the care instruction may be suitable for the degree of colonization of the skin if a reduction in the degree of colonization of the skin is to be expected based on empirical values of a plurality of further users with the cosmetic product stored in the further database.
  • determining the degree of colonization of the skin and / or determining the cosmetic skin treatment recommendation may include transferring the uptake and / or colonization level of the skin to an external data processing device and receiving the degree of colonization of the skin and / or the cosmetic skin treatment recommendation.
  • an apparatus for determining a degree of colonization of skin with acne bacteria may include a light emitting device for exposing at least one skin area of a user to ultraviolet and / or blue light, a camera for picking up the skin area during exposure of the skin area by means of the light emitting device, the camera being configured to at least light in a fluorescence wavelength range of detecting fluorescence generated by the acne bacteria, an electronic circuit device which may be configured to detect a detected amount of light emitted from the fluorescence as fluorescence due to the exposure by means of the photograph, and to assign a degree of colonization of the skin to the detected one detected amount of light by means of a database; and a data exchange device for exchanging data between the electronic circuit device and a processor cloud architecture, wherein by means of the data exchange device, the database stored in the processor cloud architecture for allocating the degree of colonization to the amount of light can be provided.
  • the fluorescence wavelength range may range from 590 nm to 760 nm.
  • the ultraviolet and / or blue light may be in a wavelength range between 380 nm and 500 nm. In various embodiments, the ultraviolet and / or blue light may be in a wavelength range between 315 nm and 380 nm.
  • the device may further comprise a filter whose permeability may be arranged and arranged such that the ultraviolet and / or blue light of the lighting device is prevented from being detected by the camera, whereas the filter may be permeable to the light in the fluorescence wavelength range.
  • the lighting device, the camera, and the electronic circuit device may be parts of at least one portable device.
  • the camera and the electronic circuit device may be parts of an integrated handheld device.
  • the integrated portable device may include a smartphone, a tablet, or an iPad.
  • the data exchange device may comprise a data exchange device for contactless data exchange.
  • an apparatus for determining a degree of colonization of skin with acne bacteria may include a light emitting device for exposing at least a skin area of a user to ultraviolet and / or blue light, a camera for picking up the skin area during exposure of the skin area by means of the light emitting device, the camera being adapted to at least light in a fluorescence wavelength range detecting a fluorescence generated by the acne bacteria, a distance measuring device for measuring a distance between the distance measuring device and the skin area, and an electronic circuit device which may be configured to detect a detected amount of light emitted from the fluorescence as fluorescence due to the exposure; by recording, determining a size of the skin area taking into account camera characteristics, the measured distance between the distance measuring device and the skin area, and a distance between the distance ndsmessvorraumcardi and the camera, and to assign a degree of colonization of the skin to the determined detected amount of light by means of a database, taking into account the size of the skin area.
  • the apparatus may further comprise a distance measuring device for measuring a distance between the distance measuring device and the skin area, wherein determining the size of the skin area may be based on Distance Device Skin Area Distance, Camera Distance Device Distance and Camera Features.
  • the camera properties may include, for example, a magnification and a physical size of a camera detector.
  • a method for determining a degree of colonization of skin with acne bacteria may include, for at least one skin area of a user, capturing the skin area by means of a camera during exposure of the skin area to ultraviolet and / or blue light, wherein the camera may be configured to at least light in a fluorescence wavelength range of a fluorescer generated by the acne bacteria detecting, in the taking, a detection, a detected amount of light emitted from the fluorescent agent as fluorescence due to the exposure and a size of the skin area, and assigning a colonization degree of the skin to the detected detected amount of light taking into consideration the size of the skin area by means of a database.
  • FIG. 1A and FIG. 1 B each show an apparatus for determining a degree of colonization of skin with acne bacteria according to various embodiments and illustrating use of the apparatus;
  • FIG. Figure 2 shows an apparatus for determining a degree of colonization of skin with acne bacteria according to various embodiments
  • FIG. 3A and 3B each show an apparatus for determining a degree of colonization of skin with acne bacteria according to various embodiments, wherein FIG. 3A further illustrates using the device;
  • FIG. Figure 4 illustrates a representation of a degree of colonization of skin with acne bacteria determined according to various embodiments
  • FIG. 5 is a flow chart illustrating a method of determining a skin care cosmetic product according to various embodiments
  • FIG. 6 shows a flow chart of a method for determining a degree of colonization of skin with acne bacteria according to various embodiments
  • FIG. 7 shows a flowchart of a method for determining a degree of colonization of skin with acne bacteria according to various embodiments
  • FIG. 8 shows a flow chart of a method for determining a cosmetic skin treatment recommendation according to various embodiments.
  • FIG. 1A, FIG. 1B, FIG. 2, FIG. 3A and FIG. 3B each depict an apparatus 100 (100a, 100b, 100c, 100d, and 100e, respectively) for determining a bacterial colonization level of skin of a user 102 according to various embodiments.
  • the skin of a user 102 may be populated by bacteria.
  • the bacteria may also contain acne bacteria, e.g. Propionibacterium acne.
  • Propionibacterium acne e.g. Propionibacterium acne.
  • Porphyrin eg coproporphyrin III and / or protoporphyrin IX
  • terms such as "bacterial colonization level of skin” and the like herein refer to only the described (acne) bacteria, and not colonization with any kind of bacteria.
  • the device 100 for determining a bacterial colonization level of a user's skin 102 may include a camera 108 that may be configured to receive the skin area 102H, thereby capturing a photograph of the user Skin area 102H can be generated.
  • the camera 108 may be a digital camera that images the skin area 102H that it detects.
  • another light measuring device instead of the camera 108, another light measuring device may be used, which only provides a signal integrated with respect to the surface, for example a photometer, for the skin area 102H detected by it.
  • the camera 108 may be configured to detect at least light in a fluorescence wavelength region of a fluorescence generated by the acne bacteria.
  • the camera 108 may include a detector which may be susceptible to at least the fluorescence wavelength range of the fluorescer produced by the acne bacteria.
  • the fluorescer may be or may be a porphyrin, e.g. Coproporphyrin III and / or protoporphyrin IX.
  • the fluorescence wavelength range, i. the wavelength range in which the fluorescent agent emits fluorescent light may range from about 590 nm to about 760 nm, e.g. between about 600 nm and about 740 nm, i. in a yellow-red to red or red wavelength range of visible light.
  • the device 100 for determining a bacterial colonization level of skin of a user 102 may include a lighting device 106.
  • the lighting device 106 may be configured to expose the at least one skin area 102H of the user 102 to ultraviolet and / or blue light 110.
  • One wavelength or wavelength range of the ultraviolet and / or blue light 110 may be selected to be at least one overlap results in fluorescence with an excitation wavelength of the fluorescer (eg, porphyrin).
  • the wavelength of the ultraviolet and / or blue light 110 emitted by the light emitting device may be in a wavelength range between about 315 nm and about 450 nm, e.g. between about 315 nm and 380 nm, e.g. between about 340 nm and 380 nm or e.g. between about 355 nm and about 380 nm.
  • the light emitting device 106 and the camera 108 may be disposed relative to each other and to the skin area 102H such that the light emitting device 106 may illuminate the skin area 102H with the ultraviolet and / or blue light 110 which may be present therein Acne bacteria) possibly present porphyrin for the emission of fluorescent light 1 12 can excite, and that fluorescent light 1 12 can be at least partially detected by the camera 108, ie, that at least a portion of the fluorescent light 1 12 reach the detector of the camera 108 and can be detected there.
  • the device 100 for determining a bacterial colonization level of skin of a user 102 may further include an electronic circuit device 16.
  • the electronic circuit device 1 16 may be configured in various embodiments to determine a detected amount of light emitted from the fluorescent agent as fluorescent light 1 12 due to the exposure (this amount of light may also be referred to herein as a fluorescence signal), by the acquisition, and to a Assigning a degree of colonization of the skin to the determined detected amount of light by means of a database, wherein the database an assignment of reference light levels and known bacterial colonization levels of the skin, eg for comparison with the fluorescent signal.
  • FIG. 1 B and FIG. 3A is depicted as a skin area 102H
  • the skin area 102H may be part of a facial skin of the user 102, which typically may be most frequently affected by impurities, redness, inflammation, etc.
  • another or further skin region 102 for example on a user's back, can be used to determine the degree of colonization with bacteria.
  • the lighting device 106 and the camera 108 may be coupled to the electronic circuit device 16, e.g. by means of a (wired or wireless) data connection 1 14 or 1 18.
  • the detection of a detected amount of light emitted from the fluorescence means as fluorescent light 1 12 as a result of the exposure may, in various embodiments, have a benefit of a measurement value provided by the camera 108 as the amount of light quantity (fluorescence signal) representing the amount of light, for example in one case in which the camera 108 is an integrating light measuring device which is so arranged, for example by means of a filter 104 arranged between the skin area 102H and the camera (see FIGS.
  • the determination of a detected amount of light which was emitted by the fluorescence means as fluorescent light 12 as a result of the exposure can, in various embodiments, integrate measured intensity values over a surface area in an image provided by the camera 108 (eg, over the entire image ), eg summing up pixel values, and utilizing the integrated value as the amount of light amount (fluorescence signal) representing the amount of light, for example, in a case where the camera 108 is an imaging (digital) camera thus arranged, for example, by means of one between the two Skin portion 102H and the camera 108 arranged filter 104 (see FIG 2 and FIG 3B), which is permeable only to light from a wavelength range in which the fluorescence is typically significantly outweighs other light entries from the skin area 102H, eg has a proportion of at least 75% (eg in a range from about 640 nm to about 650 nm), and / or in a case in which other light entries from the skin area 102H are minimized or
  • the acne bacteria typically colonize skin pores of the skin, so that the fluorescence emission of the porphyrin seems to originate from the colonized skin pores, so that in an imaging uptake of colonized skin, the colonized skin pores can represent point or substantially circular areas of increased emission. Accordingly, in various embodiments, the area over which the measured intensity values are integrated (e.g., summed up) may be composed of the point or substantially circular areas with the increased emission.
  • the determination of the detected amount of light emitted by the fluorescence means as fluorescent light 12 as a result of the exposure may further comprise determining the other light entries from the skin area 102H, and subtracting the other light entries from the integrated intensity values.
  • Determining the other light inputs from the skin region 102H may include taking a backlight image in various embodiments as shown in FIG. 1 B (top) is shown.
  • the lighting device 106 may be switched off.
  • the background light recording can be integrated over the same area as the recording, for example over the entire picture or, for example, over the point or point essentially circular areas in which the skin pores with the acne bacteria are imaged.
  • Determining the other light entries from the skin area 102H may, in various embodiments (not shown), comprise determining the other light entries from the receptacle, e.g. For example, in integrating only the point or substantially circular areas in which the pores of the skin with the acne bacteria are imaged, areas in which no skin pores are imaged with the acne bacteria (eg, annular outside the point or substantially circular areas) may be determined which no fluorescence emission is present), and one of these areas (which may have a total of another area, eg a different number of picture elements than the accumulated point or substantially circular areas) by integrating (eg summing) obtained intensity value can be normalized in that it corresponds to the area of the point or substantially circular areas, and the normalized intensity value is subtracted from the integrated value for the point or substantially circular areas. In various embodiments, this method can also be performed individually for each point or substantially circular area, and the difference values for the point or substantially circular areas are added up to the determined amount of light.
  • only a red portion of the intensity value may be used to determine the amount of light emitted from the fluorescer as fluorescent light 12 as a result of the exposure become.
  • an evaluation of the intensity values may be restricted to an R channel (the red color channel).
  • the fluorescence wavelength range ie the range between about 560 nm and about 780 nm ) predominantly falls.
  • the electronic circuit device 1 16 may be arranged in various embodiments, on the basis of the determined amount of light, for example by comparing with a database, which may have an assignment of reference amounts of light to known Baktenenbesiedelungsdenden the skin, a bacterial colonization of the skin of the skin of the user 102 to determine, eg a very high, moderately high, normal, moderately low or very low bacterial colonization rate of the skin.
  • the bacterial colonization level of the skin may be otherwise described or quantified, eg, as a numerical bacterial colonization level (eg, with any unit) or the like.
  • the electronic circuit device 16 may further be configured to determine a size (ie, a physical size, eg, a length and width, a diameter, or the like in a unit length, eg, centimeter) of the detected skin area 102H.
  • a size ie, a physical size, eg, a length and width, a diameter, or the like in a unit length, eg, centimeter
  • the electronic circuit device 16 may be configured to determine the size of the detected skin area 102H based on the shot, for example, based on a size of the substantially circular areas that the bacteria-colonized skin pores may be imaged (if displayed in a spatially resolved manner). in comparison to typical sizes of skin pores, based on an average distance between several (eg adjacent) of the punctiform or substantially circular areas where the bacteria-colonized skin pores can be imaged compared to typical pore spacings and / or other face structures eg can be recognized by conventional methods in the image, compared with typical values for the structures, e.g. an iris diameter (which may be relatively constant from human to human, about 12 mm), a distance between the pupil and / or nostrils of the user 102, a nasal tip chin distance, or similar structures.
  • an iris diameter which may be relatively constant from human to human, about 12 mm
  • a distance between the pupil and / or nostrils of the user 102 a nasal tip chin distance, or similar structures.
  • the apparatus 100 may be used to determine a bacterial colonization level of a user's skin 102, such as e.g. in FIG. 3A and FIG. 3B for the devices 100d and 100e, respectively, have a distance measuring device 332 for measuring a distance d between the distance measuring device 332 and the skin region 102H.
  • the electronic circuit device 1 16 may be configured to detect the detected amount of light emitted from the fluorescent agent as fluorescence due to the exposure by taking the image, determining the (physical) size of the skin area 102H taking into account camera characteristics, measured distance d between the distance measuring device 332 and the skin area 102H and a distance (parallel to a direction camera - skin area) between the distance measuring device 332 and the camera 332, and assigning a degree of colonization of the skin to the determined detected amount of light by means of a database under consideration the size of the skin area 102H.
  • the camera characteristics may include a magnification and physical dimensions of the detector (eg, length and width in millimeters), or other suitable combinations of camera characteristics that allow for calculating the size of the skin area 102H, including the distance between the camera 108 and the skin area 102H.
  • a distance measuring device 332 may be used in various embodiments, a conventional triangulation device, for example using a light emitting diode and a detector, or other suitable distance measuring device.
  • the integrated camera can be used both as the camera 108, and possibly also provided by an autofocus system of the camera 108 information for determining the distance between the camera 108 and the skin area 102H.
  • the distance between the camera 108 and the skin area 102H may be determined only when there is a photograph (to be evaluated). In various embodiments, the distance between the camera 108 and the skin area 102H may be continuously determined while the device 100 is used to determine a bacterial colonization level of a user's skin 102. In this case, the distance determination can be used, for example, to allow the user 102 to set a preferred distance, for example by means of an optical signal, e.g.
  • the lighting device 106 may be operated at intervals, with a frequency that changes with approaching the preferred distance, and operated constantly when the preferred distance (e.g., approximately) is reached, or for example by means of an acoustic signal, e.g. when approaching the preferred distance, it sounds less frequently and stops when the (for example, approximate) preferred distance is reached.
  • the device 100 may be provided with a spacer (not shown).
  • a spacer By means of the spacer, a preferred distance between the camera 108 and the skin area 102H can be adjustable so that the camera physical properties can be used to determine the (physical) size of the skin area 102H without the distance between the camera 108 and the skin area 102H or the sizes mapped structures.
  • knowledge of the (physical) size of the skin area 102H may allow for improved quantification of the bacterial colonization level, for example, by correlating the detected detected amount of light to the size of the skin area 102H, e.g. as amount of light per square centimeter, and / or by taking into account the physical size of the skin area when comparing the amount of light with the plurality of reference light quantities.
  • the database can have a plurality of reference light quantities and a respectively associated bacterial colonization level, which can be determined at least partially by means of laboratory measurements, and in each case under Regarding the physical size of the reference skin area can be normalized to a unit area (eg as amount of light per square centimeter or similar), with values for comparable degrees of colonization can be averaged, regardless of how large the reference skin area.
  • degrees of colonization qualitative descriptions can be used in various embodiments, e.g. "Heavily populated”, “sparsely populated”, etc.
  • alternative or additional quantitative degrees of colonization can be used, which can be determined for example by means of laboratory measurements, e.g. an average number of bacteria per square centimeter or similar.
  • the database may also specify a respective (physical) size (eg in square centimeters or square millimeters) of the reference skin area for which the reference light amount has been detected, and for comparing the amount of light with the reference light amount to determine the associated bacterial colonization degree, the physical size of the skin area 102H may be taken into account, eg by only comparing those entries of the database (i.e., light quantity / bacterial colonization assignments) that were based on mappings due to similarly sized skin areas 102H.
  • a respective (physical) size eg in square centimeters or square millimeters
  • a range of commonly measurable amounts of light at a given bacterial colonization level may depend on the (physical) size of the skin area 102H. For example, even with a very high degree of colonization, it may not be possible to determine values as high as determining the amount of light per unit area for, for example, an entire face, such as the amount of light per unit area for only one e.g. one square centimeter skin area 102H on the chin (because some areas of the skin are typically typically bacteria-free or poor even with heavy bacterial colonization, e.g., areas under the eyes), and vice versa.
  • the device 100 for determining a bacterial colonization level of skin of a user 102 may be a portable device 100, as illustrated by way of example in FIG. 2 and FIG. 3B, wherein the portable device 100 is not limited to a smartphone.
  • the electronic circuit device 16 may comprise a processor and a memory in various embodiments.
  • the electronic circuit device 16 may in various embodiments be coupled to the camera 108 and the lighting device 106, for example such that a transmission of a signal detected by the camera (eg a recording, for example, a digital image or a value of a photometer) is possible, for example by means of a data connection 1 18.
  • the data link 1 18, for example, a data cable, an internal conductive connection and / or a wireless transmission, eg by means of WLAN, thread, ZigBee or Bluetooth.
  • the electronic circuit device 16 may, for example, be a smartphone, an iPad, a tablet, a laptop or the like.
  • the camera 108 and the electronic circuit device 16 may form a portable integrated unit.
  • the lighting device 106 and the camera 108 may form a portable integrated unit.
  • the device 100 may have a size that allows it to be accommodated in a hand or trouser pocket.
  • the device 100 may have an area of less than 36 cm 2 and a thickness of less than 2 cm.
  • the electronic circuit device 16 may be configured in various embodiments to determine a degree of bacterial colonization of the skin as described above. In various embodiments, the electronic circuit device 16 may be configured itself, i. directly to determine the degree of bacterial colonization of the skin.
  • various embodiments may utilize software, such as an app, which may be installed on a portable data processing device, for example, the portable data processing device may be the electronic circuit device 16, e.g. in FIG. 2 and in FIG. 3B, or an additional, e.g.
  • the camera 108 and lighting device 106 may form an integrated unit that may be coupled to the external computing device, such as a smartphone, a tablet, an iPad, or the like).
  • the degree of bacterial colonization of the skin may be dependent on time (eg, several times a day, daily, weekly, monthly, or any other temporal dependency) and / or under various environmental conditions (eg, in a high or low humidity environment, in cold or hot weather) or low sunshine, etc.).
  • the reference measurements which may be provided, for example, in the form of a database, may be used as part of the software / app to associate the determined detected amount of light with a bacterial colonization level of the skin.
  • the database may be stored in the memory of the electronic circuit device 16.
  • the database may be stored in an external data processing device, e.g. a processor cloud architecture 222 may be stored.
  • the database may be provided to the electronic circuit device 16 for comparison with the detected detected amount of light, and / or the comparison may be after providing the detected amount of light or at least the recording and possibly further data (eg the data described above for determining the distance between the camera and the skin area 102H), by means of the processor cloud architecture.
  • This may be referred to as indirectly determining the bacterial colonization level by means of the electronic circuit device 16.
  • the bacterial colonization degree determined by the comparison performed by the external data processing device 222 may be provided to the electronic circuit device 16, for example, to be provided to the user 102.
  • a data link 224 may be utilized, such as a wireless data link 224, e.g. via WLAN or Bluetooth or a comparable wireless data transmission device.
  • the apparatus 100 may include, for providing and receiving data to / from the external data processing device 222, a data exchange device 120 (see FIG. 1B) that may be part of or associated with the electronic circuit device 16, for example.
  • the database may be updated using data from other users 1020, such as a user.
  • FIG. 1A and FIG. 1 B shown schematically.
  • the electronic circuit device 16 may, in various embodiments, comprise a relatively simple electronic circuit device, which, for example, may be configured to detect substantially only the camera signal and transmit it to the external data processing device 222.
  • the electronic circuit device 16 may include a more powerful, versatile circuit device (eg, a smartphone, a tablet, or an iPad) that not only may be configured to detect the camera signal (and possibly to determine the detected amount of light and compare with the reference amounts of light in the database and / or the external data processing device 222), but may additionally be configured to perform various other functions, such as inputs request and store by the user 102, present results, provide values (eg, autofocus values) for determining the distance camera skin area, etc.
  • a more powerful, versatile circuit device eg, a smartphone, a tablet, or an iPad
  • the bacterial colonization rate of the skin is provided to the user.
  • the degree of bacterial colonization of the skin may be described, for example, as a value (e.g., as described above), as a verbal message, as a graphical representation, or the like. communicated, e.g. are represented, e.g. by means of displays, e.g. on a screen of the portable electronic circuit device 1 16.
  • providing the skin condition to the user by means of the graphical representation may include the shot, which may be overlaid with an illustration of the bacterial colonization level of the skin, e.g. by means of different symbols / markings / hatching for areas different bacterial colonization of the skin.
  • the receptacle which can be used, for example, by means of the electronic circuit device 16 and / or the external data processing device 222, e.g. to produce a two-dimensional intensity distribution of the detected detected fluorescence light in the skin area 102H, e.g. a two-dimensional digital image, which has the dimensions of the recording, but only at locations for which a fluorescent light contribution was determined at the determined intensity values, the fluorescent light contribution as an intensity value.
  • the intensity distribution of the detected fluorescence light can be represented superimposed, for example, as a contour representation 550 (as shown by way of example in FIG. 4) and / or as a false color representation of the image, e.g. on a screen of the electronic circuit device 1 16.
  • intensity distributions obtained at different times may be represented in different ways, e.g. with different colors.
  • the device 100 may further be configured to determine a cosmetic skin treatment recommendation based on the ascertained bacterial colonization level of the skin and to provide it to the user 102.
  • at least one suitable cosmetic product and / or at least one care indication may be assigned to each of the plurality of bacterial colonization levels of the skin. The assignment may, for example, be determined experimentally, eg in laboratory experiments.
  • the cosmetic product and / or the care instructions for the skin with the predetermined bacterial colonization degree may be suitable if it is either suitable to reduce the degree of bacterial colonization, or at least not reaching a different destination, eg in a predominantly decorative application, the degree of bacterial colonization to increase.
  • literature data may be used to assess suitability of a care product and / or a care label to maintain a skin having a given bacterial colonization level of the skin.
  • an assessment of a suitability of a personal care product to reduce a degree of bacterial colonization of the skin may be confirmed or modified by including experience of other users 1020 having the same or a similar bacterial colonization level of the skin, for example, experience of treatment success.
  • the empirical values can be provided by the other users, for example, the external data processing device 222, for example by means of a wireless data transmission 226. Alternatively, a transmission of the data by means of cable can be used.
  • the database may be updated in the external data processing device 222 and / or in the portable electronic circuit device 16. This can make it possible for the user 102 to always receive an optimal recommendation.
  • the product and / or care recommendations when determining the product and / or care recommendations, further information regarding general health, skin condition, eating habits, and other user behaviors (eg, daily outdoor / sun / water intake (eg, trace water), smoking habits etc.), for example by means of the software / app installed on the portable electronic circuit device 16 and / or on the external data processing device 222.
  • the information may, in various embodiments, be retrieved by the user 102 via the portable electronic circuit device 116, which may input it to the electronic circuit device 16, for example by means of a keyboard, as a voice message, as a selection from one of the portable electronic circuit device 16 Menu, or similar.
  • the user 102 provides as additional information that he spends a lot of time in the water or outdoors, in the product and / or care recommendation recommendation based on the Baktenbesiedelungsgrad the skin of the user 102, for example, those associated care products recommended to the user 102 which are not only suitable for its Baktenenbesiedelungsgrad, but also, for example, waterproof and / or provided with a UV filter.
  • the product recommendation and / or the care indication may be provided to the user 102, for example by means of the electronic circuit device 16, e.g. by way of the screen of the electronic circuit device 16.
  • the graph of FIG. 4 are supplemented by (e.g., text) messages (not shown), e.g. the identified product recommendations and / or care instructions, such as "apply cream A in the area marked with the contours 550" or the like.
  • FIG. 5 shows a diagram 500 illustrating a method of determining a skin care cosmetic product according to various embodiments.
  • FIG. 5 may substantially illustrate those processes described elsewhere in the context of the method of determining a skin care cosmetic product according to various embodiments.
  • the method may include, according to various embodiments, determining a bacterial colonization rate (at 510), for example, as described above.
  • a product or care recommendation can be found (at 560).
  • a product or care recommendation can be found (at 560).
  • literature data labeled 530
  • personal data e.g., 540 as described above
  • / or other users' data e.g. their empirical values (indicated as 550) are consulted.
  • a determination of a treatment outcome may be monitored (at 510) by determining the bacterial cell colonization level (at 510) (at 590). This may be useful, for example, during and after a cosmetic treatment based on the product recommendation (at 560). A successful treatment by means of the method for determining the skin condition based on objective values can increase a motivation for the user (at 599).
  • product recommendations can be derived for cosmetic products that are individually suitable for the user 102 and / or individual care instructions. The product recommendations and / or care instructions can be provided, for example, by means of software, for example an app.
  • the user can be offered a recommended product directly for sale and the user can initiate the purchase by entering the purchase.
  • the user can also be offered further information on the purchase.
  • This further information may refer to more detailed treatment and application instructions.
  • a software / app receives the request that the user wants to purchase the product, stores the request, and / or submits the request to a trading company that distributes the product.
  • the user may be prompted by the software / app to enter his personal data (address, bank information, delivery preference, etc.) via the input unit.
  • the user can be indicated where (for example, drugstore, beauty salon, pharmacy, etc.) he can purchase the recommended product.
  • the software / app may be the same software or app that performs the procedure for determining a cosmetic skin treatment recommendation.
  • the user can be introduced to the use of cosmetic products that are produced individually for the individual, and an order process, preferably by calling a website of a manufacturer of individual cosmetic products, initiated.
  • a product that is individually tailored to their needs.
  • This can be a product manufactured specifically for the customer or a so-called "mass customized” product, whereby a variation of a few, but from the customer's point of view decisive characteristics of a product can be achieved in a "mass customized” product.
  • these "mass customized” products are based on the concept of modularization, that is, the product can be assembled individually from various modules / building blocks.
  • the selection of chemically and / or physically incompatible ingredients or the selection of the determined degree of colonization of unsuitable ingredients can be avoided.
  • the selection for the determined degree of colonization of suitable ingredients can be specified or proposed by the product configurator.
  • the software / app that determines the bacterial colonization level of the skin may be the same that determines the product recommendation and / or the care instructions.
  • different software programs / apps can be used for the various processes (determination of the degree of bacterial colonization of the skin, determination of a product recommendation, determination of a care indication).
  • visiting a dermatologist or a cosmetician may be recommended.
  • a booking process can be initiated directly via the software / app, which determines the degree of colonization.
  • the contact details of dermatologists and / or cosmeticians can be stored in the software / app and these are displayed to the user.
  • the selection can be restricted via filters, such as the postal code.
  • an appointment booking can be made directly via the software / app.
  • the booking of a dermatologist appointment and / or a cosmetic appointment may be made via a separate software / app, such as Treatwell.
  • a treatment success in a cosmetic treatment which may have a positive effect on the determined bacterial colonization of the skin to be targeted, can be monitored.
  • the software / app may enable control and / or tracking of the results by presenting (e.g., plotting) the measurement results over time.
  • FIG. FIG. 6 shows a flowchart 600 of a method for determining a bacterial colonization level of a user's skin according to various embodiments.
  • a method for determining a bacterial colonization level of a user's skin may include, for at least one skin area of a user during exposure of the skin area to ultraviolet and / or blue light, taking a picture of the area of the skin by means of a Camera, wherein the camera is adapted to detect (at 610) at least light in a fluorescence wavelength range of an acne bacteria-generated fluorescence, determining a detected amount of light emitted from the fluorescence as fluorescence due to the exposure in the captured image (at 620), and assigning a degree of colonization of the skin to the determined detected amount of light, wherein the mapping of the degree of colonization of the skin to the detected detected amount of light is performed by a database stored in a processor cloud architecture (at 630).
  • FIG. 7 shows a flowchart 700 of a method for determining a bacterial colonization level of a user's skin according to various embodiments.
  • a method for determining a bacterial colonization level of a user's skin may include, for at least one user's skin area, capturing an image of the skin area by a camera during exposure of the skin area to ultraviolet and / or blue light, the camera being configured to at least light in a fluorescence wavelength range of an acne bacteria-produced fluorescer detecting (at 710), detecting a detected amount of light emitted from the fluorescent agent as fluorescence due to the exposure in the captured image, and determining a size of the skin area (at 720), and assigning a degree of colonization of the skin the determined detected amount of light taking into account the size of the skin area by means of a database (at 730).
  • FIG. 8 shows a flowchart 800 of a method for determining a cosmetic skin treatment recommendation according to various embodiments.
  • a method for determining a cosmetic skin treatment recommendation may include: determining a bacterial colonization level of a user's skin according to various embodiments (at 810) and determining the cosmetic product and / or the care instruction based on the determined skin condition and a database having a plurality of skin conditions and a plurality of associated cosmetic products and / or care instructions, wherein each bacterial colonization level of the plurality of bacterial colonization levels may be associated with at least one suitable cosmetic product and / or at least one suitable care instruction (at 820).
  • a first preferred embodiment of the invention comprises a method for determining a degree of colonization of skin with acne bacteria, comprising:
  • the camera being adapted to detect at least light in a fluorescence wavelength range of a fluorescence agent generated by the acne bacteria
  • a second preferred embodiment comprises that the method according to embodiment 1, further comprising updating the database based on new allocations of the degree of colonization of the skin to the detected detected amount of light from a plurality of other users.
  • a third preferred embodiment comprises that the method according to embodiment 1 or 2 further comprises taking a background light image of the skin area by means of the camera while the skin area is not exposed to the ultraviolet and / or blue light, wherein determining the detected amount of light from which fluorescence has been emitted as fluorescence as a result of the exposure, has a determination of a difference of the recording and the background light recording,
  • a fourth preferred embodiment comprises the method according to any one of embodiments 1 to 3, wherein the fluorescer comprises a porphyrin, preferably coprophorphyrin III.
  • a fifth preferred embodiment comprises the method according to any of embodiments 1 to 4, wherein the fluorescence wavelength range is from 590 nm to 760 nm.
  • a sixth preferred embodiment comprises the method according to one of embodiments 1 to 5, wherein the at least one skin area comprises a plurality of skin areas of the user.
  • a seventh preferred embodiment comprises the method according to one of the embodiments 1 to 6, wherein the camera and a lighting device for generating the ultraviolet and / or blue light are parts of at least one portable device.
  • An eighth preferred embodiment comprises the method according to one of the embodiments 1 to 7, wherein the portable device has a smartphone, a tablet or an iPad or is attachable to a smartphone, a tablet or an iPad.
  • a ninth preferred embodiment comprises the method according to one of the embodiments 1 to 8, wherein the determination of the detected amount of light and / or the allocation of the degree of colonization of the skin to the determined detected amount of light is carried out by means of an app.
  • a tenth preferred embodiment comprises a method for determining a cosmetic skin treatment recommendation, comprising:
  • An eleventh preferred embodiment comprises the method according to embodiment 10, wherein the cosmetic product and / or the care instruction for the degree of colonization of the skin is suitable, if based on stored in the further database experience of a plurality of other users with the cosmetic product, a reduction in the degree of colonization of the skin is to be expected.
  • a twelfth preferred embodiment comprises the method according to one of embodiments 10 or 11, wherein determining the degree of colonization of the skin and / or determining the cosmetic skin treatment recommendation comprises transferring the uptake and / or colonization level of the skin to an external data processing device and receiving the degree of colonization of the skin and / or the cosmetic skin treatment recommendation.
  • a thirteenth preferred embodiment comprises an apparatus for determining a degree of colonization of skin with acne bacteria, comprising:
  • a lighting device for exposing at least one skin area of a user to ultraviolet and / or blue light; a camera for picking up the skin area during the exposure of the skin area by means of the lighting device, the camera being arranged to detect at least light in a fluorescence wavelength range of a fluorescence medium generated by the acne bacteria;
  • An electronic circuit device which is adapted to determine a detected amount of light which has been emitted by the fluorescence means as fluorescence due to the exposure, in the recording, and to assign a degree of colonization of the skin to the determined detected amount of light by means of a database;
  • a data exchange device for exchanging data between the electronic circuit device and a processor cloud architecture, the data exchange device providing the database stored in the processor cloud architecture for allocating the degree of colonization to the amount of light.
  • a fourteenth preferred embodiment comprises a device according to embodiment 13, wherein the fluorescence wavelength range is from 560 nm to 780 nm.
  • a fifteenth preferred embodiment comprises the device according to one of the embodiments 13 or 14, wherein the ultraviolet and / or blue light is in a wavelength range between 380 nm and 500 nm.
  • a sixteenth preferred embodiment comprises the device according to one of the embodiments 13 or 14,
  • ultraviolet and / or blue light is in a wavelength range between 315 nm and 380 nm.
  • a seventeenth preferred embodiment includes the device according to any of embodiments 13 to 16, further comprising:
  • a filter whose transmissivity is arranged and arranged so that the ultraviolet and / or blue light of the lighting device is prevented from being detected by the camera, whereas the filter is transparent to the light in the fluorescence wavelength region.
  • An eighteenth preferred embodiment includes the device according to any of embodiments 13 to 17, wherein the lighting device, the camera and the electronic circuit device are parts of at least one portable device.
  • a nineteenth preferred embodiment includes the device according to any one of Embodiments 13 to 18, wherein the camera and the electronic circuit device are parts of an integrated portable device.
  • a twentieth preferred embodiment includes a device according to embodiment 19, wherein the integrated portable device comprises a smartphone, a tablet or an iPad.
  • a twenty-first preferred embodiment comprises the device according to any one of Embodiments 13 to 20, wherein the data exchange device comprises a data exchange device for contactless data exchange.
  • a twenty-second preferred embodiment comprises an apparatus for determining a degree of colonization of skin with acne bacteria, comprising:
  • a lighting device for exposing at least one skin area of a user to ultraviolet and / or blue light
  • a camera for picking up the skin area during the exposure of the skin area by means of the lighting device, the camera being arranged to detect at least light in a fluorescence wavelength range of a fluorescence medium generated by the acne bacteria;
  • An electronic circuit device which is adapted to determine a detected amount of light which has been emitted by the fluorescence as fluorescence due to the exposure, by the recording, a determination of a size of the skin area, and to assign a degree of colonization of the skin to the determined detected Amount of light by means of a database taking into account the size of the skin area.
  • a twenty-third preferred embodiment comprises a device according to embodiment 22, further comprising:
  • a distance measuring device for measuring a distance between the distance measuring device and the skin area, wherein determining the size of the skin area is based on the distance device skin area distance, a camera pitch distance and camera characteristics.
  • a twenty-fourth preferred embodiment comprises a method for determining a degree of colonization of skin with acne bacteria, comprising:

Abstract

Selon divers exemples de réalisation, l'invention concerne un procédé permettant de déterminer un degré de contamination de la peau par des bactéries acnéiques. Le procédé peut comprendre : pour au moins une zone cutanée d'un utilisateur lors de l'exposition de la zone cutanée à une lumière ultraviolette et/ou bleue, un enregistrement de la zone cutanée au moyen d'une caméra, la caméra étant prévue pour détecter au moins de la lumière dans une gamme de longueurs d'onde de fluorescence d'un agent de fluorescence généré par les bactéries acnéiques, la détermination d'une quantité de lumière détectée, qui est rayonnée par l'agent de fluorescence sous la forme de fluorescence due à l'exposition, au moyen de l'enregistrement, et l'association d'un niveau de contamination de la peau à la quantité de lumière détectée déterminée. L'association du niveau de contamination de la peau à la quantité de lumière détectée déterminée est effectuée au moyen d'une base de données en mémoire dans une architecture cloud-processeur.
EP18708658.2A 2017-03-16 2018-03-01 Procédé et dispositif pour déterminer un niveau de contamination de la peau par des bactéries d'acnéiques Ceased EP3595511A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017204365.2A DE102017204365A1 (de) 2017-03-16 2017-03-16 Verfahren und Vorrichtung zum Ermitteln eines Besiedelungsgrads von Haut mit Aknebakterien
PCT/EP2018/055024 WO2018166804A1 (fr) 2017-03-16 2018-03-01 Procédé et dispositif pour déterminer un niveau de contamination de la peau par des bactéries d'acnéiques

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EP3595511A1 true EP3595511A1 (fr) 2020-01-22

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BRPI0806109A2 (pt) 2007-01-05 2011-08-30 Myskin Inc sistema, dispositivo e método para imagem dérmica
US8849380B2 (en) * 2007-11-26 2014-09-30 Canfield Scientific Inc. Multi-spectral tissue imaging
ES2715633T3 (es) * 2008-05-20 2019-06-05 Univ Health Network Dispositivo y método para formación de imágenes y supervisión por fluorescencia
US9549703B2 (en) * 2013-11-27 2017-01-24 Elwha Llc Devices and methods for sampling and profiling microbiota of skin
JP6323227B2 (ja) 2013-12-16 2018-05-16 ソニー株式会社 画像解析装置、画像解析方法、およびプログラム、並びに照明装置

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US20200000397A1 (en) 2020-01-02
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