EP3532051A4 - Kleinmolekülige protein-arginin-methyltransferase 5 (prmt5)-inhibitoren und verfahren zur behandlung - Google Patents
Kleinmolekülige protein-arginin-methyltransferase 5 (prmt5)-inhibitoren und verfahren zur behandlung Download PDFInfo
- Publication number
- EP3532051A4 EP3532051A4 EP17863518.1A EP17863518A EP3532051A4 EP 3532051 A4 EP3532051 A4 EP 3532051A4 EP 17863518 A EP17863518 A EP 17863518A EP 3532051 A4 EP3532051 A4 EP 3532051A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- prmt5
- inhibitors
- treatment
- methods
- small molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662413341P | 2016-10-26 | 2016-10-26 | |
US201762534969P | 2017-07-20 | 2017-07-20 | |
PCT/US2017/058572 WO2018081451A1 (en) | 2016-10-26 | 2017-10-26 | Small molecule protein arginine methyltransferase 5 (prmt5) inhibitors and methods of treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3532051A1 EP3532051A1 (de) | 2019-09-04 |
EP3532051A4 true EP3532051A4 (de) | 2020-08-12 |
Family
ID=62025487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17863518.1A Pending EP3532051A4 (de) | 2016-10-26 | 2017-10-26 | Kleinmolekülige protein-arginin-methyltransferase 5 (prmt5)-inhibitoren und verfahren zur behandlung |
Country Status (4)
Country | Link |
---|---|
US (3) | US11034689B2 (de) |
EP (1) | EP3532051A4 (de) |
CN (1) | CN110325188A (de) |
WO (1) | WO2018081451A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108689960B (zh) * | 2018-06-07 | 2022-03-04 | 济南大学 | 5-苯亚甲基-2-苯基噻唑酮类化合物及其制备和应用 |
CN111686113B (zh) * | 2019-03-15 | 2022-12-30 | 北京大学 | Sonic Hedgehog抑制剂及应用 |
WO2020206289A1 (en) * | 2019-04-05 | 2020-10-08 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 |
WO2020206299A1 (en) * | 2019-04-05 | 2020-10-08 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 |
GB201908885D0 (en) * | 2019-06-20 | 2019-08-07 | Storm Therapeutics Ltd | Therapeutic compounds |
EP4084871A4 (de) * | 2019-12-31 | 2024-01-24 | Univ Indiana Trustees | Wiederverwendung von fda-zugelassenen medikamenten als neue krebstherapie durch hemmung von prmt5 |
US20230025976A1 (en) * | 2020-01-07 | 2023-01-26 | Pfizer Inc. | PRMT5 Inhibitor for Use In A Method of Treating Psoriasis and Other Autoimmune Conditions |
WO2022002142A1 (zh) * | 2020-06-30 | 2022-01-06 | 江苏先声药业有限公司 | 四氢异喹啉类化合物及其用途 |
CN112831521B (zh) * | 2021-02-02 | 2022-07-05 | 中国人民解放军军事科学院军事医学研究院 | 一种扩张型心肌病小鼠模型的构建方法及其应用 |
CN115124534B (zh) * | 2021-11-23 | 2023-09-15 | 中山大学 | 非核苷酸类prmt5小分子抑制剂、制备方法及用途 |
US20230181589A1 (en) * | 2021-12-03 | 2023-06-15 | The Trustees Of Indiana University | Prmt5 inhibitors for ocular therapy |
WO2023125947A1 (zh) * | 2021-12-30 | 2023-07-06 | 江苏先声药业有限公司 | 四氢异喹啉类化合物的可药用盐、晶型及其用途 |
CN114366813A (zh) * | 2022-01-21 | 2022-04-19 | 中南大学 | 一种治疗肿瘤的靶点及其应用、肿瘤治疗制剂 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016145150A2 (en) * | 2015-03-11 | 2016-09-15 | The Broad Institute Inc. | Selective treatment of prmt5 dependent cancer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5064947A (en) * | 1989-03-29 | 1991-11-12 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine reseptor compounds |
TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
US6403599B1 (en) * | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
US6218387B1 (en) | 1996-12-20 | 2001-04-17 | Hoechst Aktiengesellschaft | Vitronectin receptor anatagonists, their preparation and their use |
EP1149583A3 (de) | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Kombinationen bestehend aus Antagonisten des Corticotropin freisetzenden Faktors und Stoffen, die die Wachstumshormonsekretion fördern |
TW200400034A (en) * | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
CA2619365A1 (en) | 2005-08-22 | 2007-03-01 | Amgen Inc. | Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators |
GB0522880D0 (en) | 2005-11-09 | 2005-12-21 | Glaxo Group Ltd | Novel compounds |
JP2012503613A (ja) * | 2008-09-25 | 2012-02-09 | ラシオファルム ゲーエムベーハー | コンパクト化シナカルセット |
WO2012009258A2 (en) * | 2010-07-13 | 2012-01-19 | Edward Roberts | Peptidomimetic galanin receptor modulators |
-
2017
- 2017-10-26 US US16/344,644 patent/US11034689B2/en active Active
- 2017-10-26 WO PCT/US2017/058572 patent/WO2018081451A1/en unknown
- 2017-10-26 EP EP17863518.1A patent/EP3532051A4/de active Pending
- 2017-10-26 CN CN201780080769.0A patent/CN110325188A/zh active Pending
-
2021
- 2021-05-14 US US17/320,381 patent/US20210269431A1/en not_active Abandoned
-
2023
- 2023-11-02 US US18/500,786 patent/US20240083894A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016145150A2 (en) * | 2015-03-11 | 2016-09-15 | The Broad Institute Inc. | Selective treatment of prmt5 dependent cancer |
Non-Patent Citations (6)
Title |
---|
CHENG C C ET AL: "Potential Purine Antagonists. XII. Synthesis of 1-Alkyl(aryl)-4,6-disubstituted Pyrazolo[3,4-d]pyrimidines", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 23, 1 June 1958 (1958-06-01), pages 852 - 861, XP002385022, ISSN: 0022-3263, DOI: 10.1021/JO01100A025 * |
ELAYNE CHAN-PENEBRE ET AL: "A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models", NATURE CHEMICAL BIOLOGY, vol. 11, no. 6, 27 April 2015 (2015-04-27), Basingstoke, pages 432 - 437, XP055297240, ISSN: 1552-4450, DOI: 10.1038/nchembio.1810 * |
GUI-MEI KONG ET AL: "Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity", PLOS ONE, vol. 12, no. 8, 14 August 2017 (2017-08-14), pages 1 - 23, XP055673216, DOI: 10.1371/journal.pone.0181601 * |
KEITARO SENGA ET AL: "Synthesis and xanthine oxidase inhibitory activity of 4,6-disubstituted 1- p -chlorophenylpyrazolo[3,4- d ]pyrimidines", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 19, no. 6, 1 November 1982 (1982-11-01), pages 1565 - 1567, XP055117070, ISSN: 0022-152X, DOI: 10.1002/jhet.5570190666 * |
MURTY DEVARAKONDA ET AL: "Synthesis of novel 2-alkyl-4-substituted-amino-pyrazolo[3,4-d]pyrimidines as new leads for anti-bacterial and anti-cancer activity", MEDICINAL CHEMISTRY RESEARCH., vol. 22, no. 3, 4 June 2012 (2012-06-04), US, pages 1090 - 1101, XP055673495, ISSN: 1054-2523, DOI: 10.1007/s00044-012-0084-0 * |
See also references of WO2018081451A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018081451A1 (en) | 2018-05-03 |
EP3532051A1 (de) | 2019-09-04 |
US20200062745A1 (en) | 2020-02-27 |
US20210269431A1 (en) | 2021-09-02 |
CN110325188A (zh) | 2019-10-11 |
US11034689B2 (en) | 2021-06-15 |
US20240083894A1 (en) | 2024-03-14 |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THE TRUSTEES OF INDIANA UNIVERSITY |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 43/23 20060101ALI20200401BHEP Ipc: A61P 35/00 20060101ALI20200401BHEP Ipc: A61K 31/4439 20060101ALI20200401BHEP Ipc: C07D 453/02 20060101ALI20200401BHEP Ipc: A61K 31/416 20060101ALI20200401BHEP Ipc: C07D 487/04 20060101AFI20200401BHEP |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20200710 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 43/23 20060101ALI20200706BHEP Ipc: C07D 453/02 20060101ALI20200706BHEP Ipc: A61P 35/00 20060101ALI20200706BHEP Ipc: C07D 487/04 20060101AFI20200706BHEP Ipc: A61K 31/416 20060101ALI20200706BHEP Ipc: A61K 31/4439 20060101ALI20200706BHEP |
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