EP3484417A1 - Système mélangeur et distributeur pour substitut osseux - Google Patents

Système mélangeur et distributeur pour substitut osseux

Info

Publication number
EP3484417A1
EP3484417A1 EP17733767.2A EP17733767A EP3484417A1 EP 3484417 A1 EP3484417 A1 EP 3484417A1 EP 17733767 A EP17733767 A EP 17733767A EP 3484417 A1 EP3484417 A1 EP 3484417A1
Authority
EP
European Patent Office
Prior art keywords
container
separating element
mixing
closure
distal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17733767.2A
Other languages
German (de)
English (en)
Inventor
Benjamin NIEBER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Switzerland AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Publication of EP3484417A1 publication Critical patent/EP3484417A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8825—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by syringe details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
    • A61B2017/8838—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means for mixing bone cement or fluid fillers

Definitions

  • the present invention relates to a mixing and dispensing system and a corresponding method for impregnating granules with a liquid and for discharging the mixture.
  • bone replacement materials bone graft materials
  • the bone substitute material usually consists of a granular (particulate) phase of natural or synthetic origin (eg a biphasic calcium phosphate / hydroxylapatite material) and a liquid phase (eg endogenous blood or a physiological sodium chloride solution).
  • the bone substitute material usually has a pasty consistency.
  • the granular material hereinafter referred to as granules, is provided in a dish and the liquid phase is added, whereby the granules are wetted.
  • the finished bone graft material thus prepared to the patient, it is brought to the destination with a spatula.
  • EP 0 470 393 B1 discloses a granular syringe in which a cap with a disk of porous material is plugged or screwed onto the outlet end of the syringe housing. To discharge the mixture, the cap is removed and a plunger is pushed forward.
  • EP 1 093 767 B1 discloses a syringe with a syringe barrel which is filled with granules.
  • a cannula tip is attached by means of a friction fit, which has a sieve in a recess. Through an opening, blood is sucked into the syringe barrel. If the blood is sufficiently mixed with the granules, the cannula tip is manually pushed down from the syringe barrel.
  • a syringe for the application of bone substitute material is known, which has a cylinder, is received in the granules.
  • the cylinder has at its distal end an external thread on which a removable attachment is held with an internal thread.
  • the attachment has an injection opening and drainage openings, through which liquid can be injected or sucked into the cylinder. If the bone substitute material is sufficiently saturated with liquid, the attachment is unscrewed and replaced by a curved discharge nozzle.
  • the mixing and discharge system should also be easy and inexpensive to manufacture.
  • a mixing and dispensing system for impregnating granules with a liquid and for discharging a mixture resulting therefrom, which has a syringe-like container for receiving the granules, with a peripheral container wall, a proximal container end and a distal container end.
  • the container may form an elongated cavity of substantially constant cross-section.
  • the distal end of the container forms a container opening for introducing the liquid into the container.
  • a feed element arranged displaceably in the container serves for discharging the mixture along a distal discharge direction.
  • a separator Disposed in a distal end portion of the container is a separator which is adapted to retain granules but to allow the passage of liquid.
  • the container has a predetermined breaking point proximal to the separating element, so that the distal end region located between the predetermined breaking point and the distal container end can be broken off from the container together with the separating element and thereby a discharge opening for discharging the mixture is created on the container.
  • the granules can on the one hand be retained in the container and effectively impregnated with liquid.
  • a sieve with a plurality of defined sieve openings or a filter can serve as separating element.
  • the separating element may be formed as a flat plastic disc manufactured by injection molding with a plurality of defined passage openings.
  • the separation element can be removed after impregnation of the granules with liquid due to the predetermined breaking point in a very simple manner. The resulting mixture can be discharged directly through the thus created discharge opening, without the need for an essay or the like to be attached to the mixing and dispensing system. The handling is thereby facilitated and is very intuitive.
  • the Trermelement may be formed integrally with the container wall according to a first embodiment.
  • An integrally formed respectively integrally with the container wall separating element has the advantage that a production of the container together with the separating element can be carried out in the same manufacturing step. This can be done in particular by injection molding. According to further embodiments, however, the separating element may also be formed separately from the container.
  • the separating element is at least fixed against displacement along the distal discharge direction, preferably also in the opposite (proximal) direction in the container.
  • the container wall may have at least one corresponding retaining means (eg in the form of at least one inwardly projecting projection in the form of a nose or a circumferential bead, or in the form of an inside groove), which supports the separating element against displacement at least in the distal, preferably also in the proximal direction is fixed in the container.
  • the release agent may be secured against rotation about the longitudinal axis of the container by the same or other retention means engaging the release means along the circumference. This is particularly advantageous when the release agent is initially connected to a closure, as will be described in more detail below.
  • the mixing and dispensing system further preferably comprises a removable closure on to close the container opening.
  • a closure prevents contamination of the container opening and of the container contents from occurring prior to use of the mixing and dispensing system due to environmental influences.
  • the closure is removed from the container so that the liquid can be received in the container through the container opening. After impregnation of the granules with the liquid, the closure can be re-attached to the container if necessary to re-close the container opening.
  • the closure can serve as a break-off aid for easier termination of the distal end region.
  • the closure has a stopper which extends counter to the discharge direction through the container opening to the separating element into the distal end region of the container.
  • a stopper which extends counter to the discharge direction through the container opening to the separating element into the distal end region of the container.
  • the closure may e.g. be fixable by a pure plug connection on the container. Alternatively, it can be fixed by means of a threaded connection to the container.
  • a threaded connection different embodiments of a threaded connection are conceivable.
  • the closure may have an internal thread which engages with a corresponding external thread on a distal outer side of the container when the closure is screwed or axially pressed onto the container.
  • an external thread on the stopper is conceivable, which engages with a corresponding internal thread on a distal inner side of the container wall when the stopper is screwed into the container opening or pressed in axially.
  • the closure is initially with the separating element connected, wherein the separating element is fixed to the container such that the separating element remains in the container when the closure is removed from the container.
  • the closure is preferably formed in one piece with the separating element and in particular connected to the separating element via a predetermined breaking point.
  • the unit of closure and separating element can in turn be produced by injection molding.
  • the closure is fixed to the container via a threaded connection, in particular with round or saw thread, as described above.
  • the closure together with the separating element can be connected to the container during assembly of the mixing and discharge system by axial pressing or pressing.
  • the separating element engages in the retaining means of the container wall and is thereby fixed in the container.
  • the closure can be solved without aids only by a screw again from the container.
  • the connection between the closure and the separating element ruptures without the user having to use excessive forces.
  • the separation of the closure from the separating element succeeds particularly easily when the separating element is fixed not only axially, but also with respect to rotations in the container. In this case, act on the connection between the closure and separating element when unscrewing the closure not only tensile forces, but also torsional forces, which facilitates the separation of the compound.
  • the container has a curvature and forms, distally of the curvature, an angled portion which extends outwardly from the central longitudinal axis with respect to a central longitudinal axis of the container, the angled portion preferably being at a bend angle between 20 ° and 50 ° extends outwardly away from the central longitudinal axis, and wherein the distal end portion is disposed in the angled portion.
  • the separating element and the predetermined breaking point in the angled portion of the container so that the discharge opening after the distal end portion has been broken off, is also located in the angled portion of the container.
  • Such an angled design of the container allows the user a targeted discharge of the mixture at the site.
  • break-off aids can be provided at the distal end region.
  • the feed element preferably has a piston which is connected to a piston rod.
  • the piston rod has an outer diameter which is smaller than the inner diameter of the container.
  • annular guide beads can be formed on the peripheral surface of the piston rod.
  • the piston rod has a region of reduced outer diameter in a distal region, the reduced diameter being smaller than the outer diameter in the proximal region. In this way, the piston rod becomes more flexible and can follow the curvature more easily. Even in the area of reduced outside diameter, ring-shaped guide beads can be attached to the piston rod so that good guidance of the piston rod in the container is nevertheless ensured.
  • the container may be prefilled with granules having an average granule diameter.
  • the separating element then preferably has passage openings whose diameter is smaller than the average granule diameter.
  • the mixing and discharging system described above can be used as follows. First, the mixing and discharge system is provided with granules, and the granules is soaked in a liquid. In order to create the discharge opening for discharging the mixture to the container, the distal end region is broken off together with the separating element at the predetermined breaking point. To discharge the mixture from the discharge port, the piston rod is displaced along the distal discharge direction.
  • the impregnation of the granules is carried out by absorbing the liquid by the feed element is moved counter to the discharge.
  • the discharge opening can be immersed in a reservoir with liquid.
  • the impregnation of the granules can be effected by injecting the liquid through the container opening and the separating element.
  • a moistening syringe can be filled with liquid for this purpose, wherein the syringe cannula is guided through the separating element and thus supplies the liquid to the granules. It is advantageous if the cannula is inserted through an already prefabricated opening of the separating element into the container.
  • FIG. 1 shows a perspective view of a mixing and discharge device with a closure according to a first embodiment
  • Fig. 2 shows a central longitudinal section through the mixing and discharge of the
  • FIG. 1 A first figure.
  • FIG. 3 shows a detailed view of the region A of FIG. 2 with a separating element according to a first embodiment
  • FIG. 4 shows a detailed view of the region A of FIG. 2 with a separating element according to a second embodiment
  • Fig. 5 is a detail view of the area A of Figure 2 with the separator of the first embodiment, but a closure according to a second
  • FIG. 6 shows a perspective view of the mixing and discharging device of FIG. 1 with a closure according to a third embodiment
  • Fig. 7 shows a central longitudinal section through the mixing and discharge of the
  • Fig. 8 is a detail view of area B of Fig. 7;
  • FIG. 9 shows a central longitudinal section through a mixing and discharging device with a closure according to a fourth embodiment, wherein the closure forms a unit with a separating element according to a third embodiment
  • Fig. 10 is a detail view of the area C of Fig. 9;
  • FIG. 1 1 shows a detailed view of the region C of FIG. 9 with a closure according to a fifth embodiment, wherein the closure forms a unit with a separating element according to a fourth embodiment;
  • FIG. 12 shows a detailed view of the region C of FIG. 9 with a closure according to the fifth embodiment and a separating element according to a fifth embodiment
  • FIG. 13 shows a detailed view of the region C of FIG. 9 with a closure according to a sixth embodiment and a separating element according to the fourth embodiment;
  • FIG. 14 shows a detail view of the region C of FIG. 9 with a closure according to the sixth embodiment and a separating element according to the fifth embodiment
  • Fig. 15 is a detail view of the area D of Fig. 13;
  • Fig. 16 is a detail view of the area E of Fig. 14;
  • Fig. 17 is a central longitudinal section through the mixing and discharge of the
  • Fig. 18 is a detail view of the area H of Fig. 17;
  • Fig. 21 is a detail view of the area G of Fig. 20;
  • FIG. 22 shows a central longitudinal section through a mixing and discharging device with broken end region
  • Fig. 23 is a detail view of the area H of Fig. 22; a perspective view of a container of the mixing and discharge device with break-off aid according to a first embodiment; a perspective view of a container of the mixing and discharge device with break-off aid according to a second embodiment;
  • FIG. 1 a perspective view of a container of the mixing and discharge device with break-off aid according to a third embodiment
  • FIGS. 1 to 3 a first embodiment of a mixing and discharging device 1 according to the invention is illustrated in various views.
  • the mixing and discharging device 1 comprises a container 2 with a separating element 4 and a feed element 3 displaceably arranged in the container 2 for discharging a mixture along a distal discharge direction L.
  • the container 2 is closed by a closure 5.
  • the distal discharge direction L is defined as the direction along which the feed element 3 moves into the container 2 to discharge the mixture from the container 2.
  • the opposite direction is called the proximal direction.
  • the container 2 has a peripheral container wall 21, which delimits a cylindrical container interior 215 for receiving a granulate G, as well as a proximal container end 22 and a distal container end 23.
  • the proximal end of the container 22 forms an insertion opening 216, which opens into the container interior 215.
  • the feed element 3 is also introduced through the insertion opening 216 into the container 2.
  • the container 2 has a holding plate 212 which revolves around the central longitudinal axis Z. Alternatively, of course, holding wings may be provided, as is common practice in syringes.
  • the distal container end 23 forms a container opening 24 for receiving a liquid F into the container interior 215.
  • the separator 4 is arranged in the form of a filter or sieve in a distal end region 25 of the container 2. It serves to retain the granules G in the container interior 215, but to allow the passage of liquids F into the container interior 215.
  • the advancing element 3 has a piston rod 37, at the distal end 33 of which a piston 39 is formed.
  • the piston rod 37 has a pressure plate 31 designed as a thumb rest, which is designed to advance the piston rod 37 along the distal discharge direction L in order to discharge the mixture or withdraw it against this discharge direction in order to receive liquid into the container 2.
  • the container 2 has a predetermined breaking point 27 proximal to the separating element 4, so that the distal end region 25 of the container 2 lying between the predetermined breaking point 27 and the distal container end 23 together with the separating element 4 is breakable from the container 2, whereby a discharge opening 28 for discharging the mixture is formed on the container 2.
  • the container 2 has a curvature region 29 and forms an angled portion 213 distally of the curvature.
  • the angled portion 213 extends with respect to a central one Longitudinal axis Z of the container 2 in a curvature angle ⁇ of about 30 ° from the central longitudinal axis Z to the outside.
  • Proximal of the curvature of the container 2 has a straight portion 214, which extends parallel to the central longitudinal axis Z of the container 2.
  • the separating element 4 is arranged distally from the straight region 214 in the angled section 213 of the container 2.
  • the separating element 4 completely fills the clear cross-section of the container interior 215 and is manufactured in one piece with the container wall 21.
  • the separating element 4 has passage openings 41, which extend completely along the discharge direction L through the separating element 4.
  • the passage openings 41 have a diameter which is smaller than the average granule diameter.
  • the separating element 4 may be a sieve having a multiplicity of round openings with a diameter of 0.6 mm, so that granulate G with an average granule diameter of approximately 1 mm is retained in the container interior 215.
  • the mean granule diameter here means the average particle size, determined by a sieve analysis according to DIN EN 933-1: 2012-03.
  • Distal from the separating element 4 is the container opening 24, through which the liquid F can be received in the container 2 and which is closed before use of the mixing and dispensing system 1 with the removable closure 5.
  • a separating element 4 ' is shown according to a second embodiment, which, in contrast to the integrally formed separating element of Figures 1 to 3, is formed separately from the container 2 and can be subsequently inserted into the container interior 215.
  • the closure 5 has a plug 57 and is inserted with the latter into the container opening 24.
  • the closure 5 projects beyond the distal container end 23 and is provided with a handle 53 provided, which can be taken by a user for the removal of the shutter 5 well.
  • closure 5 in this case only partially projects into the container opening 24 and is arranged at a distance from the separating element 4 in the container 2, the closure may however also have a stopper which extends through the distal end region 25 all the way to the separating element 4.
  • a closure 5 ' is shown in Figure 5 and has the additional advantage that it prevents fine granules whose diameter is smaller than the diameter of the passage openings 41 of the separating element 4, in the distal end region 25 between the separating element 4 and the sealing plug accumulate.
  • the mixing and discharging device 1 of Figures 6 to 8 has a closure according to a second embodiment, wherein the closure as a closure cap 5 "is formed and here has an internal thread 52.
  • the container 2 has the outside in the region of the container opening 24 has a corresponding external thread 21 1, so that the closure cap 5 "can be screwed onto the distal container end 23.
  • the closure cap 5 is formed without an internal thread and that the container 2 has no external thread, so that the closure cap 5" is attached solely to the distal container end 23.
  • the closure cap 5 " also has a stopper 57 which extends through the distal end region 25 as far as the separating element 4.
  • the closure cap 5" here is provided with holding wings 55, 55 'for easier handling.
  • 9 to 16 show various combinations of closures 5 “', 5"",5""', each having a separating element 4", 4 “', 4"", in all these embodiments, the closure 5"', 5 “", 5 “”'are each initially connected to the separating element 4 ", 4"', 4 "", wherein the separating element 4 ", 4"', 4 “” is fixed to the container 2 such that the separating element 4 " 4 "', 4""remains in the container 2 when the closure 5"', 5 "", 5 “”'is removed from the container 2.
  • the projections 210, 210 ', 210 ", 210”' are formed integrally with the container wall 21 and extend from the container wall 21 in Direction of the container interior 215 at least partially along the proximal side 42 and the distal side 43 of the separating element 4 ", wherein the projections 210, 210 ', 210", 210 "' directly adjacent to the proximal and distal sides 42, 43 of the separating element 4" Alternatively or additionally, however, the separating element 4 "', 4""may have lateral recesses 44, 44', 44" into which the projections 210, 210 'engage n and the separating element 4 "', 4""thus fix with respect to a rotation in the container 2. As can be seen in particular from FIGS.
  • the separating element 4 "' can project, for example, on both sides with two projections 210, 210' which project into corresponding lateral recesses 44, 44 'in a separating element edge ( see FIG. 15) or on both sides, each with a projection 210 which projects into a laterally centrally formed recess 44 "in the separating element 4""(see FIG. 16), being fixed in the container 2.
  • 11 to 16 of the closure 5 "", 5 “'” fixed in each case via a threaded connection to the container 2. As shown in FIGS.
  • the container wall 21 can have a round thread 211 'or a saw thread 211 "on the inside in the distal end region 25, which has a corresponding external thread 52', 52" on the sealing plug 5 "". , 5 ""'engages.
  • the provision of such a threaded connection has the advantage that the closure 5 "", 5 “"'together with the separating element 4'",4""can be pushed into the container 2 during assembly in the proximal direction through the container opening 24.
  • the granulate G in the container interior 215 is now soaked with liquid F.
  • One possibility for impregnating the granulate G consists, as shown in FIG. 19, in that the liquid F is absorbed into the container interior 215.
  • the mixing and dispensing system 1 is immersed with its released container opening 24 in a reservoir with liquid F, and a suction of the liquid takes place in that the feed element 3 is withdrawn against the discharge L in the container 2.
  • the impregnating liquid passes through the passage openings 41, 4, 41 ", 4", 41 "” of the separating element 4, 4 ', 4 ", 4"', 4 "” into the container interior 215.
  • FIG. 20 Another possibility for impregnation of the granules G is shown in Figure 20, wherein Liquid F is injected through the container opening 24 and through the passage openings 41, 4, 41 ", 41 '", 41 “” of the separating element 4, 4', 4 ', 4 “, 4"', 4 "” into the container interior 215 becomes.
  • a moistening syringe 6 can be used, the syringe cannula 61 of which has an outer diameter which is equal to or smaller than the diameter of the passage openings 41, 41 ', 41 ", 41"', 41 “” of the separating element 4, 4 ', 4 ", 4 '", 4""is.
  • the syringe cannula 61 can be inserted directly through the passage openings 41, 41 ', 41 "without firstly piercing the separating element under the force of the force.
  • the finished bone substitute material can be discharged from the mixing and discharging device 1
  • the separating element 4, 4 ', 4 ", 4"', 4 "" must be removed from the mixing and discharging device 1.
  • the container 2 has proximally from the separating element 4, 4 ', 4 ".
  • the distal end region 25 of the container 2 may have an external snap-off aid, for example in the form of longitudinally extending ribs 217, retaining wings 217 'or transverse grooves 217 ", which give the user better grip and As a result, it is also possible for the closure cap to serve as a break-off aid If, for example, the closure cap 5 "of FIG. 6 is again placed on the distal container end 23 after impregnation of the granulate G, these holding wings 55, 55 Of course, all the closures disclosed herein may be re-applied to the distal container end 23 after impregnation of the granules applied and taken for breaking the distal end portion 25.
  • an external snap-off aid for example in the form of longitudinally extending ribs 217, retaining wings 217 'or transverse grooves 217 ", which give the user better grip and
  • the closure cap it is also possible for the closure cap to serve as a break-off aid If, for example, the closure cap 5 "of FIG.
  • the container 2 is formed in the present embodiments as a cylindrical tube which defines a constant inner diameter DB.
  • the piston rod 37 of the advancing element 3 has an outer diameter in a proximal region 34, which is a little smaller than the inner diameter DB of the container 2.
  • the piston rod 37 radially outwardly projecting, circumferential, annular effetswülste 38, 38 ', 38 ", 38"', which bear against the container wall 21.
  • the piston rod 37 has a region of further reduced diameter 36 in a distal region 35.
  • the reduced diameter DK of the piston rod 37 is smaller than the diameter in the proximal region 34 of the piston rod 37, which gives the piston rod 37 in the distal region of the container 2 a good flexibility.
  • FIG. 27 shows the mixing and discharging device 1 in the initial state, at the beginning of the discharge of the mixture.
  • the distal end region 25 of the container 2 was broken off together with the separating element 4, 4 ', 4 ", 4"', 4 “” and the piston rod 37 was retracted in the proximal direction and extends parallel to the central longitudinal axis Z.
  • the mixing and discharging device 1 is shown in an intermediate state, wherein the piston 39 has been partially advanced into the container 2 along the distal discharge direction L and has discharged part of the mixture. If now the piston 39 is advanced further in the distal direction, then both the piston 39 and the distal region 35 of the piston rod 37 follow the angled portion 213 of the container 2, whereby this flexibility of the piston rod 37 in particular by the reduced diameter portion 36 of the piston rod 37th is guaranteed.
  • Figure 29 shows the final state in which the piston 39 has been advanced to the outlet opening 28 of the container 2 in the distal direction and the piston rod 37 completely received in the container interior 215.
  • the length dimension of the piston 39 and the area of tapered diameter 36 corresponds to the length dimension of the angled portion 213 of the container 2.
  • the piston 39 and the guide bead 38 seal against the container wall 21 of the container 2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

L'invention concerne un système mélangeur et distributeur (1) ainsi qu'un procédé pour imprégner des granulés (G) avec un liquide et pour distribuer un mélange produit selon celui-ci. Le système mélangeur et distributeur (1) présente un récipient (2) destiné à recevoir les granulés. Un élément de séparation (4) est agencé dans une zone d'extrémité distale (25) du récipient, ledit élément étant conçu pour retenir les granulés tout en permettant l'entrée du liquide. Le récipient présente un point de rupture (27) proximal par rapport à l'élément de séparation (4) de manière à ce que la zone d'extrémité distale située entre le point de rupture et l'extrémité distale du récipient (23) puisse être détachée du récipient par cassure conjointement avec l'élément de séparation (4) et ainsi créer un orifice de distribution dans le récipient afin de distribuer le mélange.
EP17733767.2A 2016-07-12 2017-06-19 Système mélangeur et distributeur pour substitut osseux Withdrawn EP3484417A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH8892016 2016-07-12
PCT/EP2017/064947 WO2018010914A1 (fr) 2016-07-12 2017-06-19 Système mélangeur et distributeur pour substitut osseux

Publications (1)

Publication Number Publication Date
EP3484417A1 true EP3484417A1 (fr) 2019-05-22

Family

ID=56413442

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17733767.2A Withdrawn EP3484417A1 (fr) 2016-07-12 2017-06-19 Système mélangeur et distributeur pour substitut osseux

Country Status (4)

Country Link
US (1) US20190223931A1 (fr)
EP (1) EP3484417A1 (fr)
CN (1) CN109475416A (fr)
WO (1) WO2018010914A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11083569B1 (en) 2020-05-16 2021-08-10 Khalid Al-Sebeih Semisolid graft applicator

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH622752A5 (en) * 1978-01-10 1981-04-30 Sulzer Ag Container for the storage of the powder component of a bone cement
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
DE9011685U1 (fr) 1990-08-10 1991-12-12 Thera Patent Gmbh & Co. Kg Gesellschaft Fuer Industrielle Schutzrechte, 8031 Seefeld, De
EP1093767B1 (fr) 1999-10-21 2005-03-23 Arthur Ashman Conbination d'une syringe et d'un aspirateur pour substance de régénération d'os.
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
DK2436342T3 (da) 2010-10-01 2013-05-27 Geistlich Pharma Ag Indretning til påføring af knoglesubstitutionsmateriale

Also Published As

Publication number Publication date
CN109475416A (zh) 2019-03-15
WO2018010914A1 (fr) 2018-01-18
US20190223931A1 (en) 2019-07-25

Similar Documents

Publication Publication Date Title
EP2723482B1 (fr) Dispositif destiné à mélanger et appliquer un produit ayant peu de bulles
EP1138396B1 (fr) Dispositif pour ouvrir un sachet tubulaire contenant une matière pâteuse
DE2948653C2 (de) Blutentnahmevorrichtung
DE102005058133A1 (de) Spritze mit Verschluss
EP2384820A1 (fr) Système de cartouche et tuyau de sortie pour un tel système de cartouche
EP0470393A1 (fr) Séringue pour granulés
DE60319368T2 (de) Vorfüllbare einweg-injektionsvorrichtung
WO2011100852A1 (fr) Dispositif de mélange de type seringue à élément de mélange actionnable distalement
EP2730332A2 (fr) Dispositif de mélange et d'extraction d'une masse pâteuse
EP1520562B1 (fr) Dispositif pour mélanger et distribuer des substances liquides et pulvérulentes pour l'utilisation médicale.
WO2013041573A1 (fr) Crayon d'application et son procédé de fabrication
WO2016095989A1 (fr) Dispositif distributeur pour matériaux de remplacement osseux
EP3584004A1 (fr) Applicateur de ciment osseux pourvu de bâton mélangeur pouvant être abaissé et procédé de fabrication d'un ciment osseux
EP1797920B1 (fr) Dispositif apte à recevoir et à délivrer une substance fluide
DE3217044A1 (de) Behaelter fuer plastische massen
DE102004044288A1 (de) Vorrichtung zur Verbindung eines rohrförmigen Teils, insbesondere einer Kanüle, mit dem Inneren einer Flasche oder dergleichen
DE102008024440A1 (de) Implantat und Implantationssystem
WO2018010914A1 (fr) Système mélangeur et distributeur pour substitut osseux
DE102011013791A1 (de) Verschluss und Verfahren zur Herstellung eines Verschlusses
EP3528728B1 (fr) Dispositif de distribution modulaire avec élément de séparation
EP2762103B1 (fr) Système et procédé de distribution d'une masse dentaire
WO2015132034A1 (fr) Dispositif et procédé de préparation d'une matière pâteuse
WO2008154912A1 (fr) Dispositif de déversement d'une substance apte à l'écoulement
DE19647977A1 (de) Blutentnahmevorrichtung
CH708198A1 (de) System zur Herstellung eines Knochenersatzmaterials, umfassend einen Behälter und ein Rückhalteelement.

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20181127

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SULZER MIXPAC AG

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20210112