EP3474762A1 - Selective skin treatments utilizing laser-equivalent intense pulsed light devices - Google Patents

Selective skin treatments utilizing laser-equivalent intense pulsed light devices

Info

Publication number
EP3474762A1
EP3474762A1 EP17816217.8A EP17816217A EP3474762A1 EP 3474762 A1 EP3474762 A1 EP 3474762A1 EP 17816217 A EP17816217 A EP 17816217A EP 3474762 A1 EP3474762 A1 EP 3474762A1
Authority
EP
European Patent Office
Prior art keywords
ipl
band pass
pass filter
source
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17816217.8A
Other languages
German (de)
French (fr)
Other versions
EP3474762A4 (en
Inventor
Yacov Domankevitz
Israel Schuster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumenis BE Ltd
Original Assignee
Lumenis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumenis Ltd filed Critical Lumenis Ltd
Publication of EP3474762A1 publication Critical patent/EP3474762A1/en
Publication of EP3474762A4 publication Critical patent/EP3474762A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/26—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0654—Lamps

Definitions

  • the present invention relates to light treatments applied to human skin tissue and in particular to light treatments utilizing selective band pass filters in Intense Pulsed Light devices.
  • Optical energy radiation is a known modality for the treatment of skin disorders.
  • the irradiated optical energy will preferably be absorbed in the skin.
  • Light absorbance in the skin is dominated by three endogenous chromophores: water, melanin and hemoglobin.
  • a correct matching between a light wavelength or a spectrum of wavelengths, with a targeted chromophore, may lead to an optical energy absorbance which may be followed by a clinical effect due to one or more of
  • selective laser treatment may be achieved by selecting the right wavelength to the right chromophore as mentioned above, by applying an energy pulse which is shorter or equal to the thermal relaxation time of the target chromophore and by delivering above-threshold energy to the target tissue.
  • IPL devices emit polychromatic, non-coherent and non-collimated light in a spectrum range from about 400nm to about 1 ,400nm, and are normally delivered in a variety of pulse durations. As such, IPL is less selective since different chromophores may be targeted in this range.
  • One option to improve selectivity of IPL-generated light energy is by using filters. Cut off filters are used on the lower end of the emission spectrum of IPL devices and cut on filters are used on the upper end of the emission spectrum. Such filters may improve treatment selectivity or reduce parasitic wavelengths which may put the patient at risk, such as ultra-violet or increased bulk heating such as is possible with the presence of an infrared component in the light emitted. Common medical IPL cut off filters include 550, 560, 570, 590, 615, 645, 695, 755 and 780 nm filters. Cut off and cut on filters may be used together to create what is termed a band pass filter.
  • Band pass filters provided by some providers, such as Alma Lasers, for example, provide a narrow spectrum IPL based treatment within the range of 500nm-600nm for the treatment of vascular lesions which are targeted at larger blood vessels.
  • An alternative narrow band pass filter is provided in the range of 550nm-600nm for skin rejuvenation.
  • One of the problems with such filters is that, in the filtering process, they also remove part of the total optical energy produced by the light source, which is an IPL light source. Therefore, in order to produce a clinical effect by meeting the threshold-energy requirement mentioned above, only a limited amount of the spectrum can be removed.
  • vascular lesions are treated by targeting intravascular chromophore of oxyhemoglobin which has light absorption peaks at 418nm, 542nm and 577nm.
  • the most common vascular lasers are KTP, 532nm, pulsed dye laser (PDL) 585nm-595nm, Alexandrite 755nm, diode laser 940-980 nm and Nd:YAG 532 or l,064nm.
  • PDL pulsed dye laser
  • An IPL light source may also be used for the treatment of vascular lesions, as mentioned above, using filters which include at least one of these absorption peaks and remove damaging UV wavelengths and/or infrared wavelengths which may cause collateral thermal damage.
  • filters which include at least one of these absorption peaks and remove damaging UV wavelengths and/or infrared wavelengths which may cause collateral thermal damage.
  • Two companies, Lumenis and Palomar provide such dual band filters. For example, in the vascular dual band filter, the shorter wavelengths are used for smaller superficial vessels and the longer wavelengths are used for larger deeper vessels.
  • Pigmented lesions are also treated by lasers by targeting melanin in melanosomes as the target chromophore with lasers such as KTP (532 nm), Ruby (694 nm), alexandrite (755 nm), etc. using a variety of pulse durations ranging from milliseconds down to picoseconds.
  • IPL may also be used for some pigmented lesions such as dyschromia or solar lentigines.
  • filters which generate the appropriate spectrum of optical energy provided that the spectrum is wide enough such that a sufficient amount of fluence reaches the target tissue, an IPL-powered device may be used to treat at least some pigmented lesions.
  • different chromophores may be targeted and selectivity may be decreased.
  • short pulses may be required to confine the area or volume of any thermal effects in the target tissue. These short pulses may be in the range of nanoseconds or less while IPL offers pulses in the range of milliseconds only.
  • IPL single light source
  • a device for the cosmetic treatment of vascular lesions on skin tissue which is an equivalent of a laser with an operating wavelength of 532nm, includes: an intense pulsed light (IPL) source, the IPL source being activatable; it further includes a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 525nm to about 585nm; the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 532nm.
  • IPL intense pulsed light
  • a method of providing cosmetic treatment equivalent to a 532nm laser on a body vascular region includes: providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the body vascular region; the band pass filter is of a type that substantially passes light in the range of about 525nm to about 585nm; the method further includes activating the IPL source; the filtered light impinging on the vascular body portion provides cosmetic treatment equivalent to that of the 532nm laser.
  • IPL intense pulsed light
  • a cosmetic method of providing light treatment to skin tissue includes providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the body vascular region; the band pass filter passes light in the range of about 525nm to about 585nm; the method further includes activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of a 532nm laser.
  • IPL intense pulsed light
  • a band pass filter is the equivalent to a 532nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter
  • a cosmetic method of providing light treatment to skin tissue includes the steps of providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the skin tissue; the band pass filter passes light in a selected range of wavelengths with an average absorption coefficient equivalent to that of a selected laser light source; the method further includes activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of the selected laser light source.
  • IPL intense pulsed light
  • a cosmetic method of providing an intense pulsed light (IPL) source equivalent in treatment effect to a selected laser light source includes for the selected laser light source of a specific wavelength, determining the average absorption coefficient of the specific wavelength in skin tissue; and, selecting a band pass filter with a substantially equivalent average absorption coefficient in skin tissue.
  • the skin tissue may be one or more of: absorption in blood and absorption in melanin.
  • the IPL source further includes a body portion which includes the IPL source and an opening in the body portion to accept one or more band pass filters and wherein the one or more band pass filters are filters which pass different ranges of light from the IPL source to the skin tissue.
  • the one or more band pass filters may be in one or more of the following ranges: 560-690nm; 675 - 900nm; 700 - 800nm; 725 - 775nm; 940 - 980nm.
  • a method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue includes the steps of: selecting a laser light source of a specified
  • the target may be skin tissue.
  • a method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue includes the steps of: selecting a laser light source of a specified
  • activating the laser light source directing the laser light source at a target; measuring the average depth of penetration of the selected laser in the target; storing the depth of penetration; selecting a band pass filter; activating the IPL light source;
  • a band pass filter is an equivalent to a 595nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter substantially in the 560nm to 690nm range.
  • the light may be an IPL light source.
  • a band pass filter is an equivalent to a 755nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter substantially in the 700nm to 800nm range.
  • the light may be an IPL light source.
  • a device for the cosmetic treatment of vascular lesions on skin tissue wherein the device is an equivalent of a laser having an operating wavelength of 595nm, includes an intense pulsed light (IPL) source, the IPL source being activatable; a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 560nm to about 690nm; and, the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 595nm.
  • IPL intense pulsed light
  • a device for the cosmetic treatment of vascular lesions on skin tissue wherein the device is an equivalent of a laser having an operating wavelength of 755nm includes an intense pulsed light (IPL) source, the IPL source being activatable; a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 700nm to about 800nm; and, the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 755nm.
  • IPL intense pulsed light
  • Fig. 1 graphically illustrates absorption of blood by light of various wavelengths.
  • Fig. 2 illustrates by a table the absorbent coefficients shown in Fig. 1
  • Fig. 3 graphically illustrates absorption of melanin by light in various
  • Fig. 4 illustrates in a table the absorbent coefficients shown in Fig. 3.
  • Fig. 5 illustrates graphically the ratio of the absorption coefficient of light in melanin over blood as a function of wavelength.
  • Fig. 6 illustrates graphically penetration depths of light into tissue at various wavelengths.
  • Fig. 7 illustrates graphically at different wavelengths the relative efficiency of IPL light sources.
  • Figs. 8 and 9 illustrate in tabular form typical numerical values of optical absorption at different wavelengths for different chromophores.
  • the absorption coefficient of light in tissue or chromophore is a function of wavelength.
  • Fig. 1 shown is a graph of light absorption values in whole blood as a function of wavelength for a "532 laser filter” in “solid lines” and a “Dye laser filter” in “dashed lines”.
  • the blood is assumed to consist of about 70% oxyhemoglobin and 30% deoxyhemoglobin on the average. It can be seen that the absorption level varies with the wavelength.
  • Fig. 2 shows a table containing selected numerical values derived from the graph of Fig. 1.
  • Fig. 3 shows a graph of the absorption values of light in melanin as a function of wavelength
  • Fig. 4 provides selected numerical values derived from the graph of Fig.3.
  • Figs 8 and 9 list typical numerical values of optical absorption at different wavelengths for different chromophores. Average absorption calculations which will be given as examples below are based on these numerical values.
  • a band pass filter for an IPL system may be provided in the range of 525 to 585 nm, as indicated in Fig. 1 as "532 laser filter" for vascular lesion treatment and as indicated in Fig. 9 which shows an example of a range of wavelengths which can be chosen to provide an equivalent averaged absorption coefficient as provided by the laser.
  • the average absorption coefficient referring to all wavelengths in this range in blood, is equal to the 232 1/cm which characterizes the 532 KTP laser absorbance in blood.
  • an IPL system having such a band pass filter would be expected to have a similar tissue interaction on skin as would the 532nm laser and may be as effective in the treatment of vascular lesions as a 532nm laser.
  • a dye laser which has a wavelength of about 595 nm has an absorption coefficient in the blood of about 60 1/cm.
  • the average absorption coefficient value of the band pass filter between 560nm and 690 nm will have the same average absorption coefficient in blood as a dye laser and therefore, according to this aspect of the invention, an IPL system with a band pass filter of 560nm to 690nm, "dye laser filter" as may be seen marked in Fig. 2 as such, may be provided for the treatment of vascular lesions.
  • an alexandrine laser (755nm) has an absorption coefficient of about 172 1/cm in melanin, as may be seen in Fig. 3.
  • a band pass filter from, for example, 700nm to 800nm passes a light spectrum which has, on the average, an absorption coefficient in melanin of 173 1/cm and therefore, according to this aspect of the present invention, an IPL system having a band pass filter between 700 nm to 800 nm is provided as an equivalent to an Alexandrite laser and called herein an "Alexandrite laser filter".
  • a band pass filter which passes a light spectrum from 675nm to 900nm may provide similar results.
  • Fig. 8 is a table with examples of ranges of wavelengths which can be chosen to provide, in an IPL device, an equivalent averaged absorption coefficient as the laser Alexandrite.
  • Such an IPL system may be deemed to be characterized with the same or very similar clinical effects as an Alexandrite laser for the treatment of pigmented lesions.
  • an IPL system having an IPL handpiece which has a permanent embedded filter which is configured to hold a band pass filter which delivers a spectrum of light which has an average absorption coefficient which is about similar to the absorption coefficient of one of the known laser wavelengths, such as for example KTP, 532nm, pulsed dye laser (PDL) 585nm-595nm, Alexandrite 755nm, diode laser 800-8 lOnm and Nd:YAG 532, Ruby 694nm or l,064nm and more.
  • PDL pulsed dye laser
  • an IPL system with an IPL handpiece may be configured to accept different filters, each in accordance with the present invention, so that a single handpiece may interchangeably deliver light spectrums which have average absorption coefficients on a target tissue or chromophore similar to those of equivalent known lasers.
  • the average calculation of a series of absorption values associated with a certain light spectrum which is passed through a band pass filter as described above, can be made in different ways.
  • the calculation of the average was a basic arithmetic average calculation in which the "weight" of each wavelength is similar.
  • the penetration depth of light into a tissue varies and is also a function of wavelength. Therefore, according to another aspect of the invention, the average absorption coefficient of a spectrum of light passed through a band pass filter in accordance with the present invention may be calculated based on a weighted average calculation.
  • an IPL system having an IPL band pass filter which is configured to deliver a spectrum of light which has an average absorption coefficient of a target tissue or chromophore which is similar to the absorption coefficient of a known laser at a predefined depth in the skin.
  • an Alexandrite laser of 755nm has an absorption value of an about 172 1/cm in melanin, as can be seen in Fig. 4.
  • a spectrum of light which on the average will have a similar absorption in melanin as the Alexandrite laser may be a band pass filter of 700nm to 800nm.
  • different band pass filters may also, on the average, produce a spectrum with an averaged absorption coefficient similar to an Alexandrite laser, for example, a band pass filter of 725 nm to 775 nm.
  • a critical energy threshold also preferably is reached in order to achieve a required clinical effect. Therefore, a band pass filter should be chosen, based on the lamp performances and intensity, to not only deliver a spectrum having an average light absorption in a target tissue or chromophore similar to that of a known laser but also to deliver at least the threshold energy to achieve a clinical effect.
  • an Alexandrite laser filter for pigmented lesion which aims to target melanin deeper in the skin due to the shift toward mid-infrared, may need to deliver a slightly different light spectrum shifted toward blue, in order to keep the average absorption value of the delivered spectrum around the 172 1/cm + at this deeper location.
  • the energy emitted from a lamp is also a function of wavelength.
  • the efficiency of the lamp is different and therefore a different amount of energy is irradiated and delivered Therefore, as mentioned above, a weighted average calculation may be performed in order to compensate for uneven energy distribution of the lamp.
  • An IPL system and an appropriate band pass filter which is configured to deliver a light spectrum which on a weighted average basis has an absorption coefficient value in the skin or anywhere inside the skin which is similar to the absorption coefficient value of a known laser in a target tissue or chromophore is also an aspect of the present invention.
  • FIG. 5 shows the ratio of the absorption coefficient of light in melanin over blood as a function of the wavelength.
  • the band pass filter of the present invention may be configured to pass a spectrum of wavelengths in which the ratio of the absorption of light in melanin over the absorption of light in blood is at least above 10 1/cm. A ratio higher than 10 1/cm will be expected to produce good selectivity for the treatment of pigmented lesion.
  • an IPL system may be configured to deliver a light spectrum having a ratio larger than 20 1/cm, larger than 30 1/cm, larger than 40 1/cm or larger than 50 1/cm to further enhance selectivity.
  • a lamp having a high degree of brightness is configured to deliver high energy fluences and therefore, even with the use of a relatively narrow band pass filters, a threshold energy sufficient to produce a clinical effect will be achieved.
  • One example of a suitable flash lamp for practicing the present invention may be that flashlamp structure as described in US Provisional Application Serial No.

Abstract

A cosmetic method of providing light treatment to skin tissue includes: providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the skin tissue; the band pass filter passes light in a selected range of wavelengths with an average absorption coefficient equivalent to that of a selected laser light source; the method includes activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of the selected laser light source.

Description

SELECTIVE SKIN TREATMENTS UTILIZING LASER-EQUIVALENT
INTENSE PULSED LIGHT DEVICES
Field of the Invention
The present invention relates to light treatments applied to human skin tissue and in particular to light treatments utilizing selective band pass filters in Intense Pulsed Light devices.
Background
Optical energy radiation is a known modality for the treatment of skin disorders. In order to obtain a clinical effect in the skin, the irradiated optical energy will preferably be absorbed in the skin.
Light absorbance in the skin is dominated by three endogenous chromophores: water, melanin and hemoglobin. A correct matching between a light wavelength or a spectrum of wavelengths, with a targeted chromophore, may lead to an optical energy absorbance which may be followed by a clinical effect due to one or more of
photothermal, photochemical or photomechanical effects. Light scattering effects, when light energy impinges on the skin, may affect the depth of light penetration into the tissue. Such effects, if any, are more dominant in the dermis than in the epidermis due to a higher concentration of collagen fibers in the dermis. In general, up to the mid-infrared region of light energy, the amount of scattering is inversely proportional to the
wavelength of light. As mentioned by Anderson and Parrish, "Selective
photo thermolysis: precise microsurgery by selective absorption of pulsed radiation", Science, 1983 Apr 29; 220(4596):524-7, selective laser treatment may be achieved by selecting the right wavelength to the right chromophore as mentioned above, by applying an energy pulse which is shorter or equal to the thermal relaxation time of the target chromophore and by delivering above-threshold energy to the target tissue. Different
l varieties of lasers and intense pulsed light (IPL) devices use these principles to deliver a wide range of optical treatments for skin disorders.
IPL devices emit polychromatic, non-coherent and non-collimated light in a spectrum range from about 400nm to about 1 ,400nm, and are normally delivered in a variety of pulse durations. As such, IPL is less selective since different chromophores may be targeted in this range. One option to improve selectivity of IPL-generated light energy is by using filters. Cut off filters are used on the lower end of the emission spectrum of IPL devices and cut on filters are used on the upper end of the emission spectrum. Such filters may improve treatment selectivity or reduce parasitic wavelengths which may put the patient at risk, such as ultra-violet or increased bulk heating such as is possible with the presence of an infrared component in the light emitted. Common medical IPL cut off filters include 550, 560, 570, 590, 615, 645, 695, 755 and 780 nm filters. Cut off and cut on filters may be used together to create what is termed a band pass filter.
Band pass filters provided by some providers, such as Alma Lasers, for example, provide a narrow spectrum IPL based treatment within the range of 500nm-600nm for the treatment of vascular lesions which are targeted at larger blood vessels. An alternative narrow band pass filter is provided in the range of 550nm-600nm for skin rejuvenation. One of the problems with such filters is that, in the filtering process, they also remove part of the total optical energy produced by the light source, which is an IPL light source. Therefore, in order to produce a clinical effect by meeting the threshold-energy requirement mentioned above, only a limited amount of the spectrum can be removed.
In the laser domain, vascular lesions are treated by targeting intravascular chromophore of oxyhemoglobin which has light absorption peaks at 418nm, 542nm and 577nm. The most common vascular lasers are KTP, 532nm, pulsed dye laser (PDL) 585nm-595nm, Alexandrite 755nm, diode laser 940-980 nm and Nd:YAG 532 or l,064nm. The PDL is considered the "workhorse" vascular laser. An IPL light source may also be used for the treatment of vascular lesions, as mentioned above, using filters which include at least one of these absorption peaks and remove damaging UV wavelengths and/or infrared wavelengths which may cause collateral thermal damage. Two companies, Lumenis and Palomar, provide such dual band filters. For example, in the vascular dual band filter, the shorter wavelengths are used for smaller superficial vessels and the longer wavelengths are used for larger deeper vessels.
Pigmented lesions are also treated by lasers by targeting melanin in melanosomes as the target chromophore with lasers such as KTP (532 nm), Ruby (694 nm), alexandrite (755 nm), etc. using a variety of pulse durations ranging from milliseconds down to picoseconds. IPL may also be used for some pigmented lesions such as dyschromia or solar lentigines. Again, by selecting filters which generate the appropriate spectrum of optical energy provided that the spectrum is wide enough such that a sufficient amount of fluence reaches the target tissue, an IPL-powered device may be used to treat at least some pigmented lesions. However, the wider the spectrum, different chromophores may be targeted and selectivity may be decreased. Moreover, in order to avoid side effects of scarring or depigmentation, short pulses may be required to confine the area or volume of any thermal effects in the target tissue. These short pulses may be in the range of nanoseconds or less while IPL offers pulses in the range of milliseconds only.
The flexibility of using a single light source, IPL, in a device to treat various types of skin disorders at various types of skin remains very attractive. Therefore, there is a need for a more advanced system to provide an IPL-based treatment with a higher effective selectivity or a higher absorbance that is similar to the equivalent known laser wavelengths it is designed to mimic.
Summary of the Present Invention
In an aspect, a device for the cosmetic treatment of vascular lesions on skin tissue which is an equivalent of a laser with an operating wavelength of 532nm, includes: an intense pulsed light (IPL) source, the IPL source being activatable; it further includes a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 525nm to about 585nm; the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 532nm.
In another aspect, a method of providing cosmetic treatment equivalent to a 532nm laser on a body vascular region includes: providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the body vascular region; the band pass filter is of a type that substantially passes light in the range of about 525nm to about 585nm; the method further includes activating the IPL source; the filtered light impinging on the vascular body portion provides cosmetic treatment equivalent to that of the 532nm laser.
In yet another aspect, a cosmetic method of providing light treatment to skin tissue includes providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the body vascular region; the band pass filter passes light in the range of about 525nm to about 585nm; the method further includes activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of a 532nm laser.
In a further aspect, a band pass filter is the equivalent to a 532nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter
substantially in the 525nm to 585nm range.
In yet a further aspect, a cosmetic method of providing light treatment to skin tissue includes the steps of providing an intense pulsed light (IPL) source; interposing a band pass filter between the IPL source and the skin tissue; the band pass filter passes light in a selected range of wavelengths with an average absorption coefficient equivalent to that of a selected laser light source; the method further includes activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of the selected laser light source.
In another aspect, a cosmetic method of providing an intense pulsed light (IPL) source equivalent in treatment effect to a selected laser light source includes for the selected laser light source of a specific wavelength, determining the average absorption coefficient of the specific wavelength in skin tissue; and, selecting a band pass filter with a substantially equivalent average absorption coefficient in skin tissue. The skin tissue may be one or more of: absorption in blood and absorption in melanin.
In a further aspect, the IPL source further includes a body portion which includes the IPL source and an opening in the body portion to accept one or more band pass filters and wherein the one or more band pass filters are filters which pass different ranges of light from the IPL source to the skin tissue. The one or more band pass filters may be in one or more of the following ranges: 560-690nm; 675 - 900nm; 700 - 800nm; 725 - 775nm; 940 - 980nm.
In an aspect, a method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue includes the steps of: selecting a laser light source of a specified
wavelength; activating the laser light source; directing the laser light source at a target; measuring the average absorption coefficient of the selected laser in the target; storing the measured coefficient; selecting a band pass filter; activating the IPL light source;
measuring the average absorption coefficient of the selected band pass filter in the target; comparing the measured coefficient of the band pass filter with the stored measured coefficient of the selected laser light source; if the measured coefficients substantially match, determining that the selected laser light source and the IPL light source with the selected band pass filter are equivalent. The target may be skin tissue.
In an aspect, a method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue, includes the steps of: selecting a laser light source of a specified
wavelength; activating the laser light source; directing the laser light source at a target; measuring the average depth of penetration of the selected laser in the target; storing the depth of penetration; selecting a band pass filter; activating the IPL light source;
measuring the average depth of penetration of the selected band pass filter in the target; comparing the measured average penetration of the band pass filter with the stored measured average penetration of the selected laser light source; if the measured average depths of penetration substantially match, determining that the selected laser light source and the IPL light source with the selected band pass filter are equivalent.
In an aspect, a band pass filter is an equivalent to a 595nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter substantially in the 560nm to 690nm range. The light may be an IPL light source.
In an aspect, a band pass filter is an equivalent to a 755nm laser impinging on skin tissue; the band pass filter is constructed to pass light through the filter substantially in the 700nm to 800nm range. The light may be an IPL light source.
In another aspect, a device for the cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 595nm, includes an intense pulsed light (IPL) source, the IPL source being activatable; a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 560nm to about 690nm; and, the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 595nm.
In yet a further aspect, a device for the cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 755nm includes an intense pulsed light (IPL) source, the IPL source being activatable; a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated; the band pass filter permits transmission of light from the IPL source when activated in the range of about 700nm to about 800nm; and, the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 755nm. Brief Description of the Drawings
Fig. 1 graphically illustrates absorption of blood by light of various wavelengths.
Fig. 2 illustrates by a table the absorbent coefficients shown in Fig. 1
Fig. 3 graphically illustrates absorption of melanin by light in various
wavelengths.
Fig. 4 illustrates in a table the absorbent coefficients shown in Fig. 3.
Fig. 5 illustrates graphically the ratio of the absorption coefficient of light in melanin over blood as a function of wavelength.
Fig. 6 illustrates graphically penetration depths of light into tissue at various wavelengths.
Fig. 7 illustrates graphically at different wavelengths the relative efficiency of IPL light sources.
Figs. 8 and 9 illustrate in tabular form typical numerical values of optical absorption at different wavelengths for different chromophores.
Detailed Description of the Present Invention
The absorption coefficient of light in tissue or chromophore is a function of wavelength. Referring now to Fig. 1, shown is a graph of light absorption values in whole blood as a function of wavelength for a "532 laser filter" in "solid lines" and a "Dye laser filter" in "dashed lines". In this non-limiting example, the blood is assumed to consist of about 70% oxyhemoglobin and 30% deoxyhemoglobin on the average. It can be seen that the absorption level varies with the wavelength.
Fig. 2 shows a table containing selected numerical values derived from the graph of Fig. 1. Alternatively, Fig. 3 shows a graph of the absorption values of light in melanin as a function of wavelength while Fig. 4 provides selected numerical values derived from the graph of Fig.3. Figs 8 and 9 list typical numerical values of optical absorption at different wavelengths for different chromophores. Average absorption calculations which will be given as examples below are based on these numerical values.
As can be seen, for example, from Fig. 2, the absorption coefficient of blood at a wavelength of 532 nm is about 232 1/cm. Therefore, according to this aspect of the invention, a band pass filter for an IPL system may be provided in the range of 525 to 585 nm, as indicated in Fig. 1 as "532 laser filter" for vascular lesion treatment and as indicated in Fig. 9 which shows an example of a range of wavelengths which can be chosen to provide an equivalent averaged absorption coefficient as provided by the laser. The average absorption coefficient referring to all wavelengths in this range in blood, is equal to the 232 1/cm which characterizes the 532 KTP laser absorbance in blood.
Therefore, an IPL system having such a band pass filter would be expected to have a similar tissue interaction on skin as would the 532nm laser and may be as effective in the treatment of vascular lesions as a 532nm laser.
As another example illustrated in Fig. 2, a dye laser which has a wavelength of about 595 nm has an absorption coefficient in the blood of about 60 1/cm. The average absorption coefficient value of the band pass filter between 560nm and 690 nm will have the same average absorption coefficient in blood as a dye laser and therefore, according to this aspect of the invention, an IPL system with a band pass filter of 560nm to 690nm, "dye laser filter" as may be seen marked in Fig. 2 as such, may be provided for the treatment of vascular lesions.
As another example, and referring now to Fig. 3, an alexandrine laser (755nm) has an absorption coefficient of about 172 1/cm in melanin, as may be seen in Fig. 3. A band pass filter from, for example, 700nm to 800nm passes a light spectrum which has, on the average, an absorption coefficient in melanin of 173 1/cm and therefore, according to this aspect of the present invention, an IPL system having a band pass filter between 700 nm to 800 nm is provided as an equivalent to an Alexandrite laser and called herein an "Alexandrite laser filter". A band pass filter which passes a light spectrum from 675nm to 900nm may provide similar results.
Fig. 8 is a table with examples of ranges of wavelengths which can be chosen to provide, in an IPL device, an equivalent averaged absorption coefficient as the laser Alexandrite. Such an IPL system may be deemed to be characterized with the same or very similar clinical effects as an Alexandrite laser for the treatment of pigmented lesions.
According to another aspect of the present invention, an IPL system may be provided having an IPL handpiece which has a permanent embedded filter which is configured to hold a band pass filter which delivers a spectrum of light which has an average absorption coefficient which is about similar to the absorption coefficient of one of the known laser wavelengths, such as for example KTP, 532nm, pulsed dye laser (PDL) 585nm-595nm, Alexandrite 755nm, diode laser 800-8 lOnm and Nd:YAG 532, Ruby 694nm or l,064nm and more.
According to yet another aspect of the present invention, an IPL system with an IPL handpiece may be configured to accept different filters, each in accordance with the present invention, so that a single handpiece may interchangeably deliver light spectrums which have average absorption coefficients on a target tissue or chromophore similar to those of equivalent known lasers. A device manufactured and sold by the assignee of the present invention, Lumenis LTD of Israel, named the M22 Universal IPL, is an example of such a device that accepts different filters.
The average calculation of a series of absorption values associated with a certain light spectrum which is passed through a band pass filter as described above, can be made in different ways. In the above examples, the calculation of the average was a basic arithmetic average calculation in which the "weight" of each wavelength is similar.
However, as can be seen in Fig. 6, the penetration depth of light into a tissue, such as skin, varies and is also a function of wavelength. Therefore, according to another aspect of the invention, the average absorption coefficient of a spectrum of light passed through a band pass filter in accordance with the present invention may be calculated based on a weighted average calculation.
Moreover, due to the dependency of the depth of penetration on the wavelength, spots in different depths in the skin will experience different effective wavelength intensity distribution. In general, there is a shift towards red and mid-infrared of the spectrum as depth increases. Therefore, according to this aspect of the present invention, an IPL system is provided having an IPL band pass filter which is configured to deliver a spectrum of light which has an average absorption coefficient of a target tissue or chromophore which is similar to the absorption coefficient of a known laser at a predefined depth in the skin.
For example, on the skin surface, an Alexandrite laser of 755nm has an absorption value of an about 172 1/cm in melanin, as can be seen in Fig. 4. As can be seen in Fig. 3, a spectrum of light which on the average will have a similar absorption in melanin as the Alexandrite laser may be a band pass filter of 700nm to 800nm. It should be mentioned that different band pass filters may also, on the average, produce a spectrum with an averaged absorption coefficient similar to an Alexandrite laser, for example, a band pass filter of 725 nm to 775 nm.
As mentioned above, a critical energy threshold also preferably is reached in order to achieve a required clinical effect. Therefore, a band pass filter should be chosen, based on the lamp performances and intensity, to not only deliver a spectrum having an average light absorption in a target tissue or chromophore similar to that of a known laser but also to deliver at least the threshold energy to achieve a clinical effect. Turning attention now back to the example concerning the depth of a target tissue in the skin, an Alexandrite laser filter for pigmented lesion, which aims to target melanin deeper in the skin due to the shift toward mid-infrared, may need to deliver a slightly different light spectrum shifted toward blue, in order to keep the average absorption value of the delivered spectrum around the 172 1/cm + at this deeper location. According to another aspect of the present invention, as can be seen in Fig.7, the energy emitted from a lamp is also a function of wavelength. At different wavelengths, the efficiency of the lamp is different and therefore a different amount of energy is irradiated and delivered Therefore, as mentioned above, a weighted average calculation may be performed in order to compensate for uneven energy distribution of the lamp. An IPL system and an appropriate band pass filter which is configured to deliver a light spectrum which on a weighted average basis has an absorption coefficient value in the skin or anywhere inside the skin which is similar to the absorption coefficient value of a known laser in a target tissue or chromophore is also an aspect of the present invention.
FIG. 5 shows the ratio of the absorption coefficient of light in melanin over blood as a function of the wavelength. As can be seen, in a wavelength range of 600 nm to 900 nm, the ratio is higher than 10. Therefore, according to this aspect of the present invention, the band pass filter of the present invention may be configured to pass a spectrum of wavelengths in which the ratio of the absorption of light in melanin over the absorption of light in blood is at least above 10 1/cm. A ratio higher than 10 1/cm will be expected to produce good selectivity for the treatment of pigmented lesion. According to another embodiment, an IPL system may be configured to deliver a light spectrum having a ratio larger than 20 1/cm, larger than 30 1/cm, larger than 40 1/cm or larger than 50 1/cm to further enhance selectivity. According to this aspect of the invention, and to other aspects of the present invention, a lamp having a high degree of brightness is configured to deliver high energy fluences and therefore, even with the use of a relatively narrow band pass filters, a threshold energy sufficient to produce a clinical effect will be achieved.
One example of a suitable flash lamp for practicing the present invention may be that flashlamp structure as described in US Provisional Application Serial No.
62/465,210, filed March 1, 2017.

Claims

What is claimed is:
1. A device for the cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 532nm, the device comprising:
an intense pulsed light (IPL) source, the IPL source being activatable;
further comprising a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated;
wherein the band pass filter permits transmission of light from the IPL source when activated in the range of about 525nm to about 585nm; and,
wherein the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 532nm.
2. A method of providing cosmetic treatment equivalent to a 532nm laser on a body vascular region comprising:
providing an intense pulsed light (IPL) source;
interposing a band pass filter between the IPL source and the body vascular region;
wherein the band pass filter is of a type that substantially passes light in the range of about 525nm to about 585nm;
activating the IPL source;
wherein the filtered light impinging on the vascular body portion provides cosmetic treatment equivalent to that of the 532nm laser.
3. A cosmetic method of providing light treatment to skin tissue, the method comprising:
providing an intense pulsed light (IPL) source;
interposing a band pass filter between the IPL source and the body vascular region; wherein the band pass filter passes light in the range of about 525nm to about 585nm;
activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of a 532nm laser.
4. A band pass filter equivalent to a 532nm laser impinging on skin tissue, the band pass filter being constructed to pass light through the filter substantially in the 525nm to 585nm range.
5. A cosmetic method of providing light treatment to skin tissue, the method comprising:
providing an intense pulsed light (IPL) source;
interposing a band pass filter between the IPL source and the skin tissue;
wherein the band pass filter passes light in a selected range of wavelengths with an average absorption coefficient equivalent to that of a selected laser light source;
activating the IPL source and applying it to the skin tissue, wherein the filtered light impinging on the skin tissue provides equivalent treatment to that of the selected laser light source.
6. A cosmetic method of providing an intense pulsed light (IPL) source equivalent in treatment effect to a selected laser light source, comprising:
for the selected laser light source of a specific wavelength, determining the average absorption coefficient of the specific wavelength in skin tissue; and,
selecting a band pass filter with a substantially equivalent average absorption coefficient in skin tissue.
7. The cosmetic method of claim 6, wherein the skin tissue is one or more of: absorption in blood and absorption in melanin.
8. The device of claim 1, wherein the IPL source further comprises a body portion which includes the IPL source and an opening in the body portion to accept one or more band pass filters and wherein the one or more band pass filters are filters which pass different ranges of light from the IPL source to the skin tissue.
9. The device of claim 8, wherein the one or more band pass filters are in one or more of the following ranges: 560-690nm; 675 - 900nm; 700 - 800nm; 725 - 775nm; 940 - 980nm.
10. A method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue, the steps comprising:
selecting a laser light source of a specified wavelength;
activating the laser light source;
directing the laser light source at a target;
measuring the average absorption coefficient of the selected laser in the target; storing the measured coefficient;
selecting a band pass filter;
activating the IPL light source;
measuring the average absorption coefficient of the selected band pass filter in the target;
comparing the measured coefficient of the band pass filter with the stored measured coefficient of the selected laser light source; and,
if the measured coefficients substantially match, determining that the selected laser light source and the IPL light source with the selected band pass filter are equivalent.
11. The method of claim 10, wherein the target is skin tissue.
12. A method of selecting an IPL light source having a band pass filter equivalent to a specified wavelength laser light source for providing cosmetic treatment of skin tissue, the steps comprising:
selecting a laser light source of a specified wavelength;
activating the laser light source;
directing the laser light source at a target;
measuring the average depth of penetration of the selected laser in the target; storing the depth of penetration;
selecting a band pass filter;
activating the IPL light source;
measuring the average depth of penetration of the selected band pass filter in the target;
comparing the measured average penetration of the band pass filter with the stored measured average penetration of the selected laser light source; and,
if the measured average depths of penetration substantially match, determining that the selected laser light source and the IPL light source with the selected band pass filter are equivalent.
13. A band pass filter equivalent to a 595nm laser impinging on skin tissue, the band pass filter being constructed to pass light through the filter substantially in the 560nm to 690nm range.
14. A band pass filter equivalent to a 755nm laser impinging on skin tissue, the band pass filter being constructed to pass light through the filter substantially in the 700nm to 800nm range.
15. The band pass filter of claim 13, wherein the light is an IPL light source.
16. The band pass filter of claim 14, wherein the light is an IPL light source.
17. A device for the cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 595nm, the device comprising:
an intense pulsed light (IPL) source, the IPL source being activatable;
further comprising a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated;
wherein the band pass filter permits transmission of light from the IPL source when activated in the range of about 560nm to about 690nm; and,
wherein the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 595nm.
18. A device for the cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 755nm, the device comprising:
an intense pulsed light (IPL) source, the IPL source being activatable;
further comprising a band pass filter which blocks substantially all but one range of wavelengths of light emanating from the IPL source when activated;
wherein the band pass filter permits transmission of light from the IPL source when activated in the range of about 700nm to about 800nm; and,
wherein the IPL with the band pass filter provides equivalent cosmetic treatment as a laser with an operating wavelength of 755nm.
EP17816217.8A 2016-06-24 2017-06-22 Selective skin treatments utilizing laser-equivalent intense pulsed light devices Pending EP3474762A4 (en)

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