CN101553279B - Method and apparatus for light-based hair removal - Google Patents

Method and apparatus for light-based hair removal Download PDF

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Publication number
CN101553279B
CN101553279B CN200780010851.2A CN200780010851A CN101553279B CN 101553279 B CN101553279 B CN 101553279B CN 200780010851 A CN200780010851 A CN 200780010851A CN 101553279 B CN101553279 B CN 101553279B
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pulse
light
average
power
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CN101553279A (en
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Z·卡尔尼
J·莱普塞尔特尔
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Alma Lasers Ltd
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Alma Lasers Ltd
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Abstract

Methods and apparatus for damaging hair follicles using a series of rapidly-delivered low-fluence pulses of coherent or incoherent light are disclosed herein. In some embodiments, the pulses of coherent or incoherent light have a wavelength or wavelengths primarily in the range between 750 nm and 1500 nm. In some embodiments, applied electromagnetic radiation comprising the rapidly-delivered low-fluence pulses is effective for concomitantly heating both the sub-dermal layer (i.e. the dermis) of the tissue and the hair follicles. In some embodiments, the thermal damaging of the hair follicles is useful for facilitating hair-removal.

Description

The method and apparatus of light depilation
Technical field
The present invention relates to and use the light of such as laser and/or flash lamp to carry out the method and apparatus lost hair or feathers.
Background technology
The disclosure relates to the method and apparatus using laser and/or pulse incoherent light to improve to (such as, for alopecia) of destroying hair follicle.
Selective light pyrolysis effect (selective photothermolysis) is a kind of surgical method, in nineteen eighty-three, (" Selective Photothermolysis:PreciseMicrosurgery by Selective Absorption of Pulsed Radiation " is proposed by Anderson and Parrish, Science, Vol.220, pp.524-527), for destroying on skin or specific pathological changes or ugly tissue near skin, and minimum injury is caused to the health tissues of surrounding.Tissue to be destroyed must have the electromagnetic radiation of some wavelength organizes much bigger light absorption than surrounding.The method comprises use pulsed electromagnetic radiation to irradiate target and surrounding tissue, and this pulsed electromagnetic radiation can be absorbed by this target priority.Because the incident radiation of target absorption is far above surrounding tissue, so the heating of surrounding tissue can be ignored usually.
In the past decade, manyly remove the laser instrument of undesired hair based on selective light pyrolysis effect principle and flash type equipment puts goods on the market, and up to the present, this technology is extensive use clinically.During processing, by the skin in light beam treatment with irradiation region, absorb the electromagnetic radiation transmitted containing melanic hair follicle, cause temperature to rise and hair follicle destruction.
Regrettably, according to this processing procedure, the light being transferred to processing region also heated patient simultaneously and contains the abundant epidermis of neural melanin, and therefore in many clinical settings, the depilation thinking based on light is a painful process.
Recognize the method and apparatus needing a kind of improvement for hair treatment at large at present, its hair follicle is heated to a sufficiently high temperature with destroy hair follicle and facilitate alopecia simultaneously by minimum heat transfer to comprising neural epidermis, this method and apparatus will be highly beneficial.This can be used for meeting the long market demand to comfortable depilation.
The patent documentation of following discloses provides the background technology that may be correlated with, and its full content is introduced in this is for reference: US application 2005/0215988; US6,485,484; WO2005/079687; US6,544,259; US5,632,741; US5,752,948; US6,214,034; US6,273,884; US5,683,380; US6,514,243; US application 2005/0143792; US5,735,844; US5,595,568; US application 2002/0019624; US application 2005/0143792.
Summary of the invention
Embodiments of the invention part is based on following wonderful discovery, namely pass through by the light pulse of a series of low energy densities (fluence) (such as, coherent optical pulse from laser instrument or the incoherent light pulses from flash lamp) fast transport to the skin of processing region, while removing hair from this processing region, minimally can heat epidermis.
Make public for the first time now a kind of method that the hair follicle had in the tissue regions of multiple hair follicle is destroyed, described method comprises: a) electromagnetic energy comprising multiple coherent optical pulse is applied to described tissue regions (such as, tissue surface), the wavelength of wherein said coherent light is at least the minimum wavelength value being at least 750nm, the maximum wavelength value being at most 1500nm at the most, wherein:
I) average energy density of pulse of described multiple pulse is at least be at least 3J/cm 2minimum average B configuration energy density values, be at most 20J/cm at the most 2maximum average fluence value;
Ii) average repetition rate of described multiple pulse is at least the minimum repetition values being at least 5HZ; And
Iii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described minimum wavelength value is at least 780nm, and described maximum wavelength value is 1000nm at the most.
According to some embodiments, the average pulse duration of described pulse is at least 4 milliseconds.
According to some embodiments, the average pulse duration of described pulse is at least 10 milliseconds.
According to some embodiments, the average pulse duration of described pulse is 25 milliseconds at the most.
According to some embodiments, apply at least 5 pulses with described average repetition rate.
According to some embodiments, apply at least 15 pulses with described average repetition rate.
According to some embodiments, apply at least 30 pulses with described average repetition rate.
According to some embodiments, the average power density of every square centimeter of the electromagnetic energy applied is at least be at least 50 watts/cm 2minimum average B configuration power density values.
According to some embodiments, described minimum average B configuration power density values is at least 75 watts/cm 2.
According to some embodiments, described minimum average B configuration power density values is at least 100 watts/cm 2.
According to some embodiments, described average power density is at least the minimum average B configuration power density values during the time period when applying at least 5 pulses with described average repetition rate.
According to some embodiments, described average power density is at least the minimum power density value during the time period when applying at least 15 pulses with described average repetition rate.
According to some embodiments, described average power density is at least the minimum power density value during the time period when applying at least 30 pulses with described average repetition rate.
According to some embodiments, described average power density is at least the minimum power density value during the time period being at least 1 second.
According to some embodiments, described average power density is at least the minimum power density value during the time period being at least 2 seconds.
According to some embodiments, described average power density is at least the minimum power density value during the time period being at least 3 seconds.
According to some embodiments, the average power density of the electromagnetic energy applied is be at most 250 watts/cm at the most 2maximum power density value.
According to some embodiments, described maximum power density value is 150 watts/cm at the most 2.
According to some embodiments, the maximum power density value during the time period that described average power density is at least 1 second at the most.
According to some embodiments, the maximum power density value during the time period that described average power density is at least 2 seconds at the most.
According to some embodiments, the maximum power density value during the time period that described average power density is at least 3 seconds at the most.
According to some embodiments, the mean power of the electromagnetic energy applied is at least be at least the minimum average B configuration performance number of 50 watts.
According to some embodiments, described minimum average B configuration performance number is at least 75 watts.
According to some embodiments, described minimum average B configuration performance number is at least 100 watts.
According to some embodiments, described mean power is at least the minimum average B configuration performance number during the time period when applying at least 5 pulses with described average repetition rate.
According to some embodiments, described mean power is at least the minimal power values during the time period when applying at least 15 pulses with described average repetition rate.
According to some embodiments, described mean power is at least the minimal power values during the time period when applying at least 30 pulses with described average repetition rate.
According to some embodiments, described mean power is at least the minimal power values during the time period being at least 1 second.
According to some embodiments, described mean power is at least the minimal power values during the time period being at least 2 seconds.
According to some embodiments, described mean power is at least the minimal power values during the time period being at least 3 seconds.
According to some embodiments, the mean power of the electromagnetic energy applied is be at most the maximum power value of 250 watts at the most.
According to some embodiments, described maximum power density value is 150 watts at the most.
According to some embodiments, the maximum power value during the time period that described mean power is at least 1 second at the most.
According to some embodiments, the maximum power value during the time period that described mean power is at least 2 seconds at the most.
According to some embodiments, the maximum power value during the time period that described mean power is at least 3 seconds at the most.
According to some embodiments, described minimum repetition values is at least 7.5HZ.
According to some embodiments, the average repetition rate of described multiple pulse is the maximum repetition values being at most 20HZ at the most.
According to some embodiments, described maximum repetition values is 15HZ at the most.
According to some embodiments, described maximum average fluence value is 15J/cm at the most 2.
According to some embodiments, described maximum average fluence value is 12.5J/cm at the most 2.
According to some embodiments, described maximum average fluence value is 10J/cm at the most 2.
According to some embodiments, described minimum average B configuration energy density values is at least 5J/cm 2.
According to some embodiments, described minimum average B configuration energy density values is 7.5J/cm at the most 2.
According to some embodiments, pulse fluence standard deviation and the ratio of the average energy density of pulse of described multiple pulse of described multiple pulse be at the most be at most 0.5 standard deviation value.
According to some embodiments, described standard deviation is 0.2 than at the most.
According to some embodiments, the electromagnetic energy applied is for being heated to the minimum temperature of at least 42 degree by the subcutis of skin area.
According to some embodiments, described minimum temperature is at least 45 degree.
According to some embodiments, the maximum temperature of the electromagnetic energy applied for the subcutis of skin area being heated to 50 degree at the most.
According to some embodiments, the peak power of described coherent optical pulse and the ratio of mean power be at least be at least 1.5 minimum power ratio.
According to some embodiments, described minimum power is 2 than at least.
According to some embodiments, described minimum power is 5 than at least.
According to some embodiments, the peak power of described coherent optical pulse and the ratio of mean power be at the most be at most 20 maximum power ratio.
According to some embodiments, described maximum power ratio is 15 at the most.
According to some embodiments, described maximum power ratio is 10 at the most.
According to some embodiments, the peak power of the electromagnetic energy applied is be at most the maximum peak power value of 1500 watts at the most.
According to some embodiments, described maximum peak power value is 1000 watts at the most.
According to some embodiments, the facula area of described coherent light is at 0.5cm 2and 2cm 2between.
According to some embodiments, described facula area is more than 1.2cm 2.
According to some embodiments, the average energy density of pulse of described multiple pulse and the ratio of average repetition rate are be at most 3 (J × s)/cm at the most 2maximum ratio.
According to some embodiments, described maximum ratio is 2.5 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 2 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 1.5 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 1 (J × s)/cm at the most 2.
According to some embodiments, described average energy density of pulse is be at most 1.5J/ (cm with the ratio of described average pulse duration at the most 2× ms) maximum ratio.
According to some embodiments, described maximum ratio is 1J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 0.75J/ (cm at the most 2× ms).
According to some embodiments, the size of described tissue regions is at least 2cm 2, be 1000cm at the most 2.
According to some embodiments, the step applying described coherent optical pulse comprises use diode laser and produces described coherent light.
According to some embodiments, described electromagnetic energy transmits from applicator, and described applicator is positioned at above described tissue regions, and has gap between the surface of the lower surface of described applicator and described tissue regions.
According to some embodiments, described electromagnetic energy transmits from applicator, and described applicator comprises: i) transparent transfer surface; And ii) spacer shell, described applicator is configured to when applicator engages with the surface of tissue regions, and described transparent transfer surface is in the surface of described tissue regions.
According to some embodiments, use applicator be at least be at least 1cm/sec minimum applicator velocity value and be the maximum applicator velocity value being at most 20cm/sec at the most, the minimum applicator distance that at least movement is at least 2cm on the surface of described tissue regions performs the applying of the electromagnetic energy comprising described multiple pulse.
According to some embodiments, described minimum applicator distance is at least 3cm.
According to some embodiments, described minimum applicator velocity is at least 3.5cm/sec.
According to some embodiments, described maximum applicator velocity is 10cm/sec at the most.
According to some embodiments, described maximum applicator velocity is 6.5cm/sec at the most.
According to some embodiments, described method also comprises: b) cool described tissue at least partially.
According to some embodiments, apply described electromagnetic energy and do not cool described tissue regions.
According to some embodiments, described applying comprises: i) set up energized state, and wherein surface area is 2cm 2given area stand the electromagnetic energy comprising described multiple pulse that applies with described average repetition rate; And ii) after described energized state, Remaining Stages is set up immediately for described given area, the persistent period of described Remaining Stages is at least 2 seconds is maximum residual phase duration at the most, described maximum residual phase duration is 60 minutes at the most, thus during described Remaining Stages, the wavelength being applied to described tissue regions is at least 750nm, is that the mean power of the electromagnetic energy applied of 1500nm is 30 watts at the most at the most; Iii) after described Remaining Stages, repeat step (a) and (b) at least M time to described given tissue regions immediately, M is the integer that value is at least 1.
According to some embodiments, the described Remaining Stages persistent period is at least 10 seconds.
According to some embodiments, the described Remaining Stages persistent period is at least 30 seconds.
According to some embodiments, the described Remaining Stages persistent period is at least 90 seconds.
According to some embodiments, the described Remaining Stages persistent period is 10 minutes at the most.
According to some embodiments, the described Remaining Stages persistent period is 5 minutes at the most.
According to some embodiments, M is at least 2.
According to some embodiments, M is at least 3.
According to some embodiments, for each energized state of multiple Remaining Stages, the energy density applied for the accumulation of the electromagnetic energy applied of each energized state is at least 20 joules/cm within time period of 20 minutes at the most 2, be 200 joules/cm at the most 2.
According to some embodiments, the electromagnetic energy comprising described pulse is applied on light skin.
According to some embodiments, the electromagnetic energy comprising described pulse is applied to the tissue comprising low melanin hair, to destroy described low melanin hair.
According to some embodiments, the electromagnetic energy comprising described pulse is applied on the skin of Fitzpatrick Class1-3, to destroy the hair be associated with Fitzpatrick Class1-3.
According to some embodiments, the electromagnetic energy comprising described pulse is applied on the skin of Fitzpatrick type 4-6, to destroy the hair be associated with Fitzpatrick type 4-6.
According to some embodiments, described electromagnetic energy is applied to described tissue to destroy the low melanin hair be associated with this tissue.
Make public for the first time now a kind of method destroyed the hair follicle had in the tissue regions of multiple hair follicle, described method comprises:
A) electromagnetic energy comprising multiple light pulse is applied to described tissue regions, wherein each described light pulse mainly comprises one or more wavelength of wave-length coverage between the minimum wavelength value of at least 750nm and the maximum wavelength value of 1500nm at the most, wherein:
I) average energy density of pulse of described multiple light pulse is be at most 3 (J × s)/cm with the ratio of the repetitive rate of described multiple light pulse at the most 2maximum ratio; And
Ii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described multiple light pulse comprises the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiments, described multiple light pulse comprises the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiments, described incoherent light pulses at least 75% the wavelength of incoherent light in described scope.
According to some embodiments, described incoherent light pulses at least 95% the wavelength of incoherent light in described scope.
According to some embodiments, described maximum ratio is 2J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 1.5J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 1J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 0.75J/ (cm at the most 2× ms).
Make public for the first time now a kind of method that the hair follicle had in the tissue regions of multiple hair follicle is destroyed, described method comprises: a) electromagnetic energy comprising multiple light pulse is applied to described tissue regions, wherein each described light pulse mainly comprises wave-length coverage is at least one or more wavelength between the minimum wavelength value of 750nm and the maximum wavelength value being 1500nm at the most, wherein: i) average energy density of pulse of described multiple pulse is be at most 1.5J/ (cm with the ratio of the average pulse duration of described pulse at the most 2× ms) maximum; And ii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described multiple light pulse comprises the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiments, described multiple light pulse comprises the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiments, described incoherent light pulses at least 75% the wavelength of incoherent light in described scope.
According to some embodiments, described incoherent light pulses at least 95% the wavelength of incoherent light in described scope.
According to some embodiments, described maximum ratio is 1J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 0.75J/ (cm at the most 2× ms).
Make public for the first time now a kind of method that the hair follicle had in the tissue regions of multiple hair follicle is destroyed, described method comprises: a) electromagnetic energy comprising multiple coherent optical pulse is applied to described tissue regions, the wavelength of wherein said coherent light is at least the minimum wavelength value being at least 750nm, the maximum wavelength value being at most 1500nm at the most, wherein: i) average energy density of pulse of described multiple pulse is at least be at least 5J/cm 2minimum average B configuration energy density values, be at most 20J/cm at the most 2maximum average fluence value; Ii) average repetition rate of described multiple pulse is at least the minimum repetition values being at least 7.5HZ; And iii) average pulse duration of described light pulse is at least 7.5 milliseconds, be 25 milliseconds at the most; And iv) apply at least 15 described pulses with described average repetition rate.
Make public for the first time now a kind of method that the hair follicle had in the tissue regions of multiple hair follicle is destroyed, described method comprises: a) electromagnetic energy comprising multiple coherent optical pulse is applied to described tissue regions, the wavelength of wherein said coherent light is at least the minimum wavelength value being at least 750nm, the maximum wavelength value being at most 1500nm at the most, wherein: i) average energy density of pulse of described multiple pulse is at least be at least 5J/cm 2minimum average B configuration energy density values, be at most 20J/cm at the most 2maximum average fluence value; Ii) average repetition rate of described multiple pulse is at least the minimum repetition values being at least 7.5HZ; And iii) average pulse duration of described light pulse is at least 7.5 milliseconds, be 25 milliseconds at the most; Iv) mean power of described multiple pulse is at least 60 watts; And v) apply at least 15 described pulses with described average repetition rate.
Make public for the first time now a kind of device that the hair follicle had in the tissue regions of multiple hair follicle is destroyed, described device comprises: a) coherent source, for generation of the coherent light comprising multiple coherent optical pulse, the wavelength of wherein said coherent optical pulse is at least the minimum wavelength value being at least 750nm, is the maximum wavelength value being at most 1500nm at the most; And b) controller, for controlling the pulse characteristic of described light pulse at least in part, described source and described controller are configured so that: i) average energy density of pulse of described multiple pulse is at least be at least 3J/cm 2minimum average B configuration energy density values, be at most 20J/cm at the most 2maximum average fluence value; Ii) average repetition rate of described multiple pulse is at least the minimum repetition values being at least 5HZ; And iii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described minimum wavelength value is at least 780nm, and described maximum wavelength value is 1000nm at the most.
According to some embodiments, described source and described controller are configured so that the average pulse duration of described pulse is at least 4 milliseconds.
According to some embodiments, described source and described controller are configured so that the average pulse duration of described pulse is at least 10 milliseconds.
According to some embodiments, described source and described controller are configured so that the average pulse duration of described pulse is 25 milliseconds at the most.
According to some embodiments, described source and described controller are configured to provide at least 5 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to provide at least 15 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to provide at least 30 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to carry out the described coherent light of providing package containing described multiple pulse with every square centimeter of average power density, and described every square centimeter of average power density is at least be at least 50 watts/cm 2minimum average B configuration power density values.
According to some embodiments, described minimum average B configuration power density values is at least 75 watts/cm 2.
According to some embodiments, described minimum average B configuration power density values is at least 100 watts/cm 2.
According to some embodiments, it is at least described every square centimeter of average power density of minimum average B configuration power density values that described source and described controller are configured to provide when producing at least 5 pulses with described average repetition rate.
According to some embodiments, it is at least described every square centimeter of average power density of minimum average B configuration power density values that described source and described controller are configured to provide when producing at least 15 pulses with described average repetition rate.
According to some embodiments, it is at least described every square centimeter of average power density of minimum average B configuration power density values that described source and described controller are configured to provide when producing at least 30 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to provided every square centimeter average power density to maintain at least 1 second, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to provided every square centimeter average power density to maintain at least 2 seconds, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to provided every square centimeter average power density to maintain at least 3 seconds, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to carry out the described coherent light of providing package containing described multiple pulse with every square centimeter of average power density, and described every square centimeter of average power density is be at most 250 watts/cm at the most 2maximum average power density value.
According to some embodiments, described maximum power density value is 150 watts/cm at the most 2.
According to some embodiments, described source and described controller are configured to the transmission of described every square centimeter of average power density to maintain at least 1 second, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to the transmission of described every square centimeter of average power density to maintain at least 2 seconds, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to the transmission of described every square centimeter of average power density to maintain at least 3 seconds, and described every square centimeter of average power density is at least described minimum average B configuration power density values.
According to some embodiments, described source and described controller are configured to be at least that the mean power of the minimum average B configuration performance number being at least 50 watts operates.
According to some embodiments, described minimum average B configuration performance number is at least 75 watts.
According to some embodiments, described minimum average B configuration performance number is at least 100 watts.
According to some embodiments, described source and described controller are configured to operate with described mean power, and described mean power is at least the minimum average B configuration performance number during the time period when applying at least 5 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to operate with described mean power, and described mean power is at least the minimum average B configuration performance number during the time period when applying at least 15 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to operate with described mean power, and described mean power is at least the minimum average B configuration performance number during the time period when applying at least 30 pulses with described average repetition rate.
According to some embodiments, described source and described controller are configured to the described mean power being at least described minimum average B configuration performance number to maintain at least 1 second.
According to some embodiments, described source and described controller are configured to the described mean power being at least described minimum average B configuration performance number to maintain at least 2 seconds.
According to some embodiments, described source and described controller are configured to the described mean power being at least described minimum average B configuration performance number to maintain at least 3 seconds.
According to some embodiments, described source and described controller are configured to be that the mean power of the maximum average power value being at least 250 watts operates at the most.
According to some embodiments, described maximum power density value is 150 watts at the most.
According to some embodiments, described source and described controller are configured to the described mean power being at most described maximum average power value to maintain at least 1 second.
According to some embodiments, described source and described controller are configured to the described mean power being at most described maximum average power value to maintain at least 2 seconds.
According to some embodiments, described source and described controller are configured to the described mean power being at most described maximum average power value to maintain at least 3 seconds.
According to some embodiments, described source and described controller are configured so that described minimum repetition values is at least 7.5HZ.
According to some embodiments, described source and described controller are configured so that the average repetition rate of described multiple pulse is the maximum repetition values being at most 20HZ at the most.
According to some embodiments, described source and described controller are configured so that described maximum repetition values is 15HZ at the most.
According to some embodiments, described source and described controller are configured so that described maximum average fluence value is 15J/cm at the most 2.
According to some embodiments, described source and described controller are configured so that described maximum average fluence value is 12.5J/cm at the most 2.
According to some embodiments, described source and described controller are configured so that described maximum average fluence value is 10J/cm at the most 2.
According to some embodiments, described source and described controller are configured so that described minimum average B configuration energy density values is at least 5J/cm 2.
According to some embodiments, described source and described controller are configured so that described minimum average B configuration energy density values is 7.5J/cm at the most 2.
According to some embodiments, described source and described controller be configured so that the pulse fluence standard deviation of described multiple pulse and the ratio of the described average energy density of pulse of described multiple pulse be at the most be at most 0.5 standard deviation ratio.
According to some embodiments, described standard deviation is 0.2 than at the most.
According to some embodiments, described source and described controller are configured to provide described coherent light to make provided coherent light for the subcutis of skin area being heated to the minimum temperature of at least 42 degree.
According to some embodiments, described minimum temperature is at least 45 degree.
According to some embodiments, described source and described controller are configured to provide described coherent light to make the maximum temperature of provided coherent light for the subcutis of skin area being heated to 50 degree at the most.
According to some embodiments, described source and described controller be configured so that the peak power of the described coherent light comprising described coherent optical pulse and the ratio of mean power be at least be at least 1.5 minimum power ratio.
According to some embodiments, described minimum power is 2 than at least.
According to some embodiments, described minimum power is 5 than at least.
According to some embodiments, described source and described controller be configured so that the peak power of the described coherent light comprising described coherent optical pulse and the ratio of mean power be at the most be at most 20 maximum power ratio.
According to some embodiments, described maximum power ratio is 15 at the most.
According to some embodiments, described maximum power ratio is 10 at the most.
According to some embodiments, described source and described controller are configured to the peak power providing described coherent optical pulse, and described peak power is be at most the maximum peak power value of 1500 watts at the most.
According to some embodiments, described maximum peak power value is 1000 watts at the most.
According to some embodiments, described device is used for providing facula area at 0.5cm 2and 2cm 2between coherent light.
According to some embodiments, described facula area is more than 1.2cm 2.
According to some embodiments, described source and described controller are configured so that the average energy density of pulse of described multiple pulse and the ratio of average repetition rate are be at most 3 (J × s)/cm at the most 2maximum ratio.
According to some embodiments, described maximum ratio is 2.5 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 2 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 1.5 (J × s)/cm at the most 2.
According to some embodiments, described maximum ratio is 1 (J × s)/cm at the most 2.
According to some embodiments, described source and described controller are configured so that described average energy density of pulse is be at most 1.5J/ (cm with the ratio of described average pulse duration at the most 2× ms) maximum ratio.
According to some embodiments, described maximum ratio is 1J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 0.75J/ (cm at the most 2× ms).
According to some embodiments, described maximum ratio is 0.6J/ (cm at the most 2× ms).
According to some embodiments, the step applying described coherent optical pulse comprises use diode laser and produces described coherent optical pulse.
According to some embodiments, described coherent source comprises diode laser.
According to some embodiments, described device also comprises: d) cooling package, for cools tissue at least partially
According to some embodiments, described cooling package is selected from the group be made up of contact cooling package and spray cooling assembly.
According to some embodiments, described device also comprises: c) optical module, for the described coherent light comprising described coherent optical pulse is pointed to tissue regions.
According to some embodiments, described optical module comprises light transmitting surface, the surface area with substantially flat and is at least 0.8cm 2the light transmission component of substantially transparent.
According to some embodiments, described device also comprises d) applicator shell, for holding the light transmitting surface of described substantially flat, described applicator is configured so that, when applicator engages with the surface of tissue regions, described transparent transfer surface is in the surface of tissue regions.
Make public for the first time now a kind of device for removing hair from the tissue regions with multiple hair follicle, described device comprises:
A) coherent source, for generation of the coherent light comprising multiple coherent optical pulse, the wavelength of wherein said coherent optical pulse is at least the minimum wavelength value being at least 750nm, is the maximum wavelength value being at most 1500nm at the most; And
B) controller, for controlling the pulse characteristic of described light pulse at least in part, described source and described controller are configured so that:
I) average energy density of pulse of described multiple pulse is at least be at least 0.5J/cm 2minimum average B configuration energy density values, be at most 20J/cm at the most 2maximum average fluence value;
Ii) average repetition rate of described multiple pulse is at least the minimum repetition values being at least 5HZ; And
Iii) average pulse duration of described light pulse is at least 1 millisecond.
Make public for the first time now a kind of device for removing hair from the tissue regions with multiple hair follicle, described device comprises:
A) light source, for generation of the light comprising multiple light pulse, each described light pulse mainly comprises wave-length coverage and is being at least one or more wavelength between the minimum wavelength value of 750nm and the maximum wavelength value being 1500nm at the most; And
B) controller, for controlling the pulse characteristic of described light pulse at least in part, wherein said source and described controller are configured so that:
I) average energy density of pulse of described multiple light pulse is be at most 3 (J × s)/cm with the ratio of the repetitive rate of described multiple light pulse at the most 2maximum ratio; And
Ii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described light source comprises and is configured so that described multiple light pulse comprises the coherent source of the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiments, described light source comprises and is configured so that described multiple light pulse comprises the incoherent light source of the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiments, described incoherent light source is configured so that the wavelength of the coherent light of at least 75% of described incoherent light pulses is in described scope.
According to some embodiments, described incoherent light source is configured so that the wavelength of the coherent light of at least 95% of described incoherent light pulses is in described scope.
According to some embodiments, described maximum ratio is 2J/ (cm at the most 2× ms).
According to some embodiments, described controller and described light source are configured so that described maximum ratio is 1.5J/ (cm at the most 2× ms).
According to some embodiments, described controller and described light source are configured so that described maximum ratio is 1J/ (cm at the most 2× ms).
According to some embodiments, described controller and described light source are configured so that described maximum ratio is 0.75J/ (cm at the most 2× ms).
Make public for the first time now a kind of device for removing hair from the tissue regions with multiple hair follicle, described device comprises: a) light source, for generation of the light comprising multiple coherent optical pulse, the wavelength of described coherent optical pulse is at least the minimum wavelength value being at least 750nm, is the maximum wavelength value being at most 1500nm at the most; And b) controller, for controlling the pulse characteristic of described light pulse at least in part, wherein said source and described controller are configured so that: i) average energy density of pulse of described multiple pulse is be at most 1.5J/ (cm with the ratio of the average pulse duration of described pulse at the most 2× ms) maximum; And ii) average pulse duration of described light radiation pulse is at least 1 millisecond.
Make public for the first time now a kind of method for destroying the hair follicle had in the tissue regions of multiple hair follicle, described method comprises: a) electromagnetic energy comprising multiple light pulse is applied to skin area, not being heated to above by the epidermis of skin area so that the subcutis of skin area is heated to the first temperature is second temperature of 42 degrees Celsius at the most, described first temperature is at least 42 degrees Celsius and lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and heat hair is removed to hair follicle, ii) average repetition rate of pulse is at least 5 pulse/sec.
According to some embodiments, average repetition rate is at least 7.5 pulse/sec.
According to some embodiments, light pulse is coherent optical pulse.
According to some embodiments, the first temperature is at least 45 degree.
Make public for the first time now a kind of method for destroying the hair follicle had in the tissue regions of multiple hair follicle, described method comprises: a) electromagnetic energy comprising multiple light pulse is applied to skin area, not being heated to above by the epidermis of skin area so that the subcutis of skin area is heated to the first temperature is second temperature of 42 degrees Celsius at the most, described first temperature is at least 42 degrees Celsius and lower than 50 degrees Celsius, wherein: i) apply light pulse and heat hair is removed to hair follicle, ii) average repetition rate of pulse is at least 5 pulse/sec.
According to some embodiments, the first temperature is at least 45 degree.
Make public for the first time now a kind of method for destroying the hair follicle had in the tissue regions of multiple hair follicle, described method comprises: a) apply to comprise the electromagnetic energy at least 0.5 second of multiple light pulse and time period of 20 seconds at the most to skin area, so that the subcutis of skin area is heated to the first temperature, and not to be heated to above by the epidermis of skin area be second temperature of 42 degrees Celsius at the most, described first temperature is at least 42 degrees Celsius and lower than 50 degrees Celsius, the mean power of the electromagnetic radiation wherein during this time period equals the maximum average power value being at most 250 watts at the most.
According to some embodiments, the first temperature is at least 45 degree.
According to some embodiments, the persistent period of described time period is at least 1.5 seconds.
According to some embodiments, the persistent period of described time period is at least 3 seconds.
According to some embodiments, the persistent period of described time period is at least 5 seconds.
According to some embodiments, the persistent period of described time period is at least 10 seconds.
Make public for the first time now a kind of method for destroying the hair follicle had in the tissue regions of multiple hair follicle, described method comprises: a) apply to comprise the electromagnetic energy at least 0.5 second of multiple light pulse and time period of 20 seconds at the most to skin area, so that the subcutis of skin area is heated to the first temperature, and not to be heated to above by the epidermis of skin area be second temperature of 42 degrees Celsius at the most, described first temperature is at least 42 degrees Celsius and lower than 50 degrees Celsius, the peak power of the electromagnetic energy wherein during this time period and the ratio of mean power be at least be at least 1.5 power ratio.
According to some embodiments, the first temperature is at least 45 degree.
According to some embodiments, power ratio is at least 2.
Make public for the first time now a kind of method for removing low melanin hair from the skin area with multiple hair follicle, each hair follicle extends in skin, described method comprises: a) apply multiple light pulse to skin area, so that the subcutis of skin area is heated to the first temperature, and not to be heated to above by the epidermis of skin area be second temperature of 42 degrees Celsius at the most, described first temperature is at least 45 degrees Celsius and lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and heat to make low melanin (namely to hair follicle, golden and/or red and/or Lycoperdon polymorphum Vitt) hair is removed, ii) mean energy density of pulse is 20J/cm at the most 2.
In the exemplary embodiment, pulse is coherent optical pulse, and the mean energy density of coherent optical pulse is 20J/cm at the most 2.Make public for the first time now a kind of method removing hair from the skin area with multiple hair follicle, each hair follicle extends in skin.Current disclosed method comprises: a) apply multiple light pulse to skin area, so that the subcutis of skin area is heated to the first temperature, and not to be heated to above by the epidermis of skin area be second temperature of 42 degrees Celsius at the most, described first temperature is at least 45 degrees Celsius and lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and heat hair is removed to hair follicle, ii) average repetition rate of pulse is at least 5 pulse/sec.
In the exemplary embodiment, average repetition rate is at least 7.5 pulse/sec.
In the exemplary embodiment, light pulse is coherent optical pulse.
Make public for the first time now a kind of method removing hair from the skin area with multiple hair follicle, each hair follicle extends in skin.Current disclosed method comprises: a) apply multiple light pulse to skin area, so that the subcutis of skin area is heated to the first temperature, and not to be heated to above by the epidermis of skin area be second temperature of 42 degrees Celsius at the most, described first temperature is at least 45 degrees Celsius and lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and heat hair is removed to hair follicle, ii) peak power of light pulse is at least 1.5 with the ratio of mean power.
Make public for the first time now a kind of device removing hair from the skin area with multiple hair follicle.Described device comprises: a) impulse radiation source, for generation of multiple coherent optical pulse; B) optical module (such as, comprise waveguide), it is such as embedded in applicator or bonder, for (namely produced light pulse is pointed to tissue regions, via tissue surface), and c) controller, for determining the pulse characteristic of light pulse, be at least be at least 0.5J/cm to make the average energy density of pulse of i) described multiple pulse 2minimum energy density value, be at most 20J/cm at the most 2maximum energy-density value; Ii) average repetition rate of described multiple pulse is at least the repetition values of 5HZ; And iii) average pulse duration of described light pulse is at least 1 millisecond.
According to some embodiments, described device also comprises: d) cooling package, for cooling at least tissue surface.
Note, the device some embodiments provided for performing any current described depilating method (such as, comprises laser instrument and/or flash lamp; Such as, the computer control with electronic circuit and/or software is comprised).In the exemplary embodiment, device is programmed in advance performs any processing scheme as described herein (that is, describing the energy density of repetitive rate and/or light pulse and/or pulse duration and/or power parameter).
Note, there has been described multiple processing scheme.Be appreciated that configuration performs the arbitrary equipment of current disclosed processing scheme or device all within the scope of the invention.
From detailed description below and example, these and further embodiment will clearly.
Accompanying drawing explanation
Figure 1A to Fig. 1 C illustrates the block diagram of the exemplary means of use electromagnetic radiation destruction hair follicle according to some embodiments of the invention;
Fig. 2 illustrates the block diagram of Exemplary control unit;
Fig. 3 illustrates the block diagram of exemplary pulse light source;
Fig. 4 illustrates the block diagram of the energy intensity of the function as the time for exemplary process scheme;
Fig. 5 A illustrates the block diagram in exemplary process region;
Fig. 5 B illustrates the block diagram of the example technique of each sub regions for the treatment of a processing region;
Fig. 6 illustrates the flow chart for the treatment of the given position of the tissue of such as skin or the example process in region.
Although describe the present invention by some embodiments and illustrative embodiments at this, it will be recognized by those skilled in the art, the present invention is not limited to described embodiment or accompanying drawing.Be construed as, accompanying drawing and detailed description are not intended to limit the invention as particular forms disclosed, but on the contrary, this invention is intended to cover all modifications in the principle of the invention and scope, equivalent and replacement.As in the application in the whole text use, word " can " have and allow connotation (that is, meaning " likely "), and optional connotation (that is, meaning " necessary ").
Detailed description of the invention
Now for concrete exemplary embodiment, present invention is described.Be appreciated that the present invention is not limited to disclosed exemplary embodiment.Be also to be understood that in the current disclosed apparatus and method for heat damage hair follicle, not all feature is all necessary for the invention required by any specific claim implementing claims.The various element and the feature that have described device realize the present invention fully.Be also to be understood that process that is described or that illustrate or method whole open in, the step of method can perform with random order or perform, unless clearly illustrated that a step depends on another step formerly performed from the context simultaneously.
general introduction and theoretic discussion
Embodiments of the invention part is based on following wonderful discovery, namely pass through by the light pulse of a series of or multiple low energy densities (such as, coherent optical pulse from laser instrument or the incoherent light pulses from flash lamp) fast transport is to the skin of processing region, and the hair follicle that can effectively destroy in this processing region minimally heats epidermis simultaneously.Note that foreshortened follicle destroy technology can be used for removing hair easily from the skin safe of processing region.
Specifically, and not bound by theory ground, please note, even if each independent low energy densities pulse only provides the peak power of " low " relatively, but multiple low energy densities pulse collections of fast transport get up and also can transmit the mean power of " height " relatively on time enough, thus heat conducting subcutis or corium are heated to enough temperature (such as, at least 42 degree or at least 45 degree), thus hair follicle is corrupted to the degree facilitating alopecia.
Again do not want bound by theory ground, suppose: because corium is good heat conductor, so when pulse is with " high-repetition-rate " fast transport, i (namely the temperature of () hair follicle can not be reduced to the temperature of the corium heated within the time period that one is enough destroyed hair follicle, the dermal temperature heated) under, (ii) hair follicle this adds heat damage and can be used for facilitating alopecia.
Note, the light of particular range of wavelengths can be used heat and destroy hair follicle (that is, can be used for the mode of hair).Therefore, in certain embodiments, the low energy densities pulsed-light radiation of fast transport comprise wavelength between 750nm and 1500nm (or between 780nm and 1000nm) " optical window " in light, it is penetrated under epidermis, and to subepidermal tissue layer (that is, the corium) transmission of power under epidermis.
Not bound by theory ground, note, the light in this " optical window " will lack the heating of epidermis compared to the light in the scope such as between 650nm to 700nm or within the scope of other.Therefore, chromophore (chromophore) in surrounding tissue can be used as " reservoir (reservoir) " effectively heat and destroy hair follicle, instead of dependence selective light pyrolysis effect heats the abundant hair follicle of melanin completely.
In certain embodiments, for the coherent light of concrete condition, one or more following characteristics can be provided:
Total average power density of the light radiation (such as, coherent light) i) transmitted is at least 35 watts/cm 2, or at least 50 watts/cm 2, or at least 75 watts/cm 2." high-average power " should can continue sufficiently long " exposure " time (such as, at least 0.5 second, or longer, such as at least 1 second or at least 2 seconds or longer) the subepidermal tissue (or corium) in given hair follicle region to be heated at least 42 or at least 45 degree;
Ii) ratio between the peak power of coherent light and aforementioned mean power is at most 20 or is at most 10 (situations for using the coherent light of such as laser to process).This can be avoided hair carbonization and/or the superheated situation of epidermis;
Iii) " fast-pulse ", the repetitive rate of wherein light pulse (such as, coherent optical pulse) is at least 3.5 pulse/sec, or at least 5 pulse/sec, or at least and at the most 7.5 pulse/sec;
Iv) mean energy density (that is, average in each pulse) of multiple light pulses (such as, relevant or incoherent light pulses) of fast transport is at least 3J/cm 2(or at least 5J/cm 2) and 20J/cm at the most 2(or 15J/cm at the most 2); And
V) multiple light pulse (namely, " short pulse ") in each pulse (such as, relevant or noncoherent) average pulse duration or " pulse width " situation of coherent light is at least 3 milliseconds and 25 milliseconds at the most, such as, between 10 milliseconds and 20 milliseconds.For the situation of incoherent light, different pulse widths (such as, shorter pulse width) can be provided.
For the situation of incoherent light, different characteristic sum values can be provided, although in the exemplary embodiment, incoherent light pulses can be obtained with the repetitive rate of relative " fast " transmission a series of " low energy densities " relatively.
The instruction that the embodiment of the present invention provides can be applied to coherent light equipment and scheme (such as, using the laser instrument including but not limited to diode laser) and incoherent light equipment and scheme (such as, using the broadband light of filtering).
Note, instruction of the present invention may be used for removing hair from any region of health, includes but not limited to back, face, head, eyebrow, eyelashes, chest, abdominal part, genital area, lower limb and axillary fossa.
In addition, note, apply or transmission light to organizing the given area of (such as skin) or subregion or region, such as one or more light pulse, refer to light (such as, one or more light pulse) is applied or is transferred to tissue this region or subregion in optional position.
light radiation and pulse characteristic
Various embodiment of the present invention provides the combination in any of following marked feature.Be appreciated that not to be that each in these features following must comprise in each example.
a) wavelength characteristic.The invention discloses the processing method to the skin transport light radiation of patient and device, described light radiation comprises " degree of depth penetrates " light radiation, and it passes the abundant epidermis of melanin and is absorbed by subepidermal tissue (that is, corium).In certain embodiments, the light radiation that this degree of depth penetrates comprises wavelength such as, at minimum wavelength value (such as 750nm, 780nm or 800nm) and maximum wavelength value (such as 950nm, or 980nm, or 1000nm, or 1200nm, or 1500nm) between light.Not bound by theory ground, disclose: select the light in " optical window " to may be used for providing the unlikely processing scheme (or treatment facility) of heating containing neural epidermis, thus get rid of (but nonessential elimination) loaded down with trivial details cooling (with what apply, or using " pre-cooled scheme " to apply) needs and/or safer processing scheme is provided.
In the exemplary embodiment relevant with utilizing the organized processing of laser, such as, semiconductor diode laser by using wavelength to be approximately 810nm provides above-mentioned wavelength characteristic, and other laser equipment also within the scope of the invention certainly.
In the exemplary embodiment relevant with incoherent light, by providing light (such as with multiple frequency, light from utilizing the IPL equipment of band-pass filter) above-mentioned wavelength characteristic is provided, make the most wavelength of applied light radiation at minimum wavelength value (such as 750nm, such as 780nm or 800nm) and maximum wavelength value (such as 950nm, or 980nm, or 1000nm, or 1200nm, or 1500nm) within the scope of the setted wavelength that defines.
In certain embodiments, the incoherent light applied and/or its each pulse " mainly " comprise in the scope that defined by minimum wavelength value and maximum wavelength value wavelength---namely, the wavelength of the incoherent light of at least 70% or its each pulse is within the scope of this.
In certain embodiments, at least 75% incoherent light or the wavelength of its each pulse within the scope of this.
In certain embodiments, at least 90% incoherent light or the wavelength of its each pulse within the scope of this.
In certain embodiments, at least 95% incoherent light or the wavelength of its each pulse within the scope of this.
b) energy density feature.The present invention makes public for the first time: can remove hair by applying low energy densities pulse to the skin of patient.Particular energy density value can destroy hair follicle according to laser or incoherent light being applied to tissue and different.
In applied light radiation from the exemplary embodiment of laser instrument, " low energy densities " average pulse is 20J/cm at the most 2every pulse, or 15J/cm at the most 2every pulse, or 12.5J/cm at the most 2every pulse, or 10J/cm at the most 2every pulse.In applied light radiation from the exemplary embodiment of laser instrument, " low energy densities " pulse is at least 0.5J/cm 2, or at least 3J/cm 2, or at least 5J/cm 2.
Be appreciated that when being applied with multiple series of pulses, be not that each independent pulse must have just in time identical energy density, the energy density between different pulse can change.
But, in certain embodiments, given multiple (such as, at least 3 or at least 5 or at least 15 or at least 30) each pulse in pulse has energy density in disclosed " average energy density of pulse " scope, such as, for the situation of coherent light or laser, the energy density of each pulse in given multiple pulse is less than 20J/cm 2, or be less than 15J/cm 2, or be less than 12.5J/cm 2.In the example relevant with incoherent light (such as, from flash lamp), the energy density of each pulse in this series or multiple pulse is less than 10J/cm 2or 8J/cm 2deng.
Note, the concrete energy density (and other features of such as pulse width, repetitive rate, power etc.) provided can be depending on multiple physiologic factor, includes but not limited to skin color and hair color.Such as, for the hair (not too the hair of " black ") of light color, need to select larger energy density.Similar, for darker skin, need to select less energy density.
Note, these low energy densities pulses are very effective for depilation.
c) repetitive rate featurethe present invention makes public for the first time and light is applied to depilation scheme on skin and equipment with certain " height " repetitive rate.
As used herein, " repetitive rate " represent the independent pulse transmitted in section in preset time ratio (that is, per second by pulse or HZ in units of)--the pulse number transmitting or provide is divided by the length of " given " time period.In different embodiments, preset time, section can be such as at least 0.5 second, at least 1 second, at least 1.5 seconds, at least 2 seconds, at least 3 seconds, at least 5 seconds or at least 10 seconds.
In applied light radiation from the exemplary embodiment of laser instrument, repetitive rate is at least 5 pulse/sec, and/or at least 7.5 pulse/sec, and/or at least 10 pulse/sec.In applied light radiation from the exemplary embodiment of laser instrument, repetitive rate is 25 pulse/sec at the most, and/or 20 pulse/sec at the most, and/or 15 pulse/sec at the most.
d) pulse duration/pulse width feature.Applied light radiation be coherent light (such as, laser instrument from such as diode laser) exemplary embodiment in, pulse duration (that is, the persistent period of individual pulse) is at least 3 milliseconds and/or at least 5 milliseconds and/or at least 10 milliseconds and/or at least 15 milliseconds.In applied light radiation from the exemplary embodiment of laser instrument, the pulse duration is 30 milliseconds and/or 25 milliseconds and/or 20 milliseconds at the most at the most at the most.
Note, the concrete energy density provided and concrete pulse duration or pulse width can be depending on multiple physiologic factor, include but not limited to skin color and hair color.Such as, for the hair (not too the hair of " black ") of light color, need the longer pulse selecting to have compared with macro-energy density.Similar, for darker skin, need the shorter pulse selecting there is less energy density.
e) relation between energy density and pulse duration and/or peak powerin the exemplary embodiment, the pulse of low energy densities can be with the pulse of relative " wide, flat " of maximum peak power applying in minimum time section.In the example that relevant with laser pulse, within the time period of at least 22 milliseconds, transmission of power density is at least 10J/cm 2pulse.Therefore, in the exemplary embodiment relevant with laser pulse, the ratio in energy density and pulse duration is 1.5J/ (cm at the most 2× ms), and/or 1J/ (cm at the most 2× ms), and/or 0.7J/ (cm at the most 2× ms) M, and/or 0.5J/ (cm at the most 2× ms).
F) relation between energy density and repetitive rate in the exemplary embodiment, is applied with " the serial low energy densities pulse applied fast " light.Therefore, in the exemplary embodiment, the ratio between the average energy density of pulse of multiple light pulse and the repetitive rate of multiple light pulse is be 3 (J × s)/cm at the most 2, or 2 (J × s)/cm at the most 2, or 1.5 (J × s)/cm at the most 2maximum rate.
g) mean power feature.
In certain embodiments, in order to ensure by subcutis (namely, corium) (or its part) be heated to above minimum corium heating-up temperature and provide minimum average B configuration power (that is, with minimum average B configuration power delivery incoherent light and/or coherent light).Such as, 35 watts/cm is provided in section preset time (that is, corium being heated to the enough time needed at least 42 or 45 degrees Celsius) 2or 50 watts/cm 2minimum average B configuration power density.
Not bound by theory ground, note, by operate with relative " high " mean power one preset time section (such as, at least 0.5 second, or at least 1 second, or at least 2 seconds etc.-or transmit certain minimal amount pulse time period-such as, at least 3,5,10,15 or 30 pulses), enough power can be provided to heat subcutis or corium.
In certain embodiments, such as, in order to provide safer process and/or not too need to cool the process of corium, maximum average power (and/or maximum average power of some wavelength light) is provided.Therefore, in the exemplary embodiment, mean power is less than 400 watts or be less than 300 watts or be less than 200 watts or be less than 150 watts.
h) the ratio feature of peak power and mean powerthe invention discloses the time dependent light radiation of intensity transmission to heat process and the equipment of the subepidermal tissue (that is, corium) of patient.In certain embodiments, apply the light radiation with the suitable wavelength of the intensity of change profile in time, ratio between the peak power of wherein applied radiation and the mean power of radiation applied is maximum is the first ratio, and alternatively, is at least the second ratio.The example of the first ratio and the second ratio provided by different embodiment is below provided.
Not bound by theory ground, note, ratio is greater than to the situation of the second ratio, the light radiation applied is characterized in that the short strong impulses with low frequency transmission, even if for the wavelength in " optical window ", epidermis heating (especially, but being not limited to the darker patient of skin) also unnecessarily (the strong energy burst suffered by skin) may be exceeded required degree by this, thus needs stronger cooling to provide safe epilation process.Therefore, by avoiding these strong impulses (namely, the strong impulses of specifying ratio is exceeded by avoiding causing the ratio between peak power and mean power), in the exemplary embodiment, a kind of unlikely removal can be provided or burn the process of epidermis and/or hair shaft.
Therefore, in certain embodiments (such as, the light radiation applied is from the coherent source of diode laser including but not limited to wavelength 810nm), this second proportionality in this way at the most 20 or at the most 15 or at the most 12 or at the most 10.
In addition, note, the ratio between peak power and mean power close to 1 time, this equipment becomes the equipment of CW equipment instead of transmission pulse radiation.In the exemplary embodiment, in fact current disclosed equipment provide that the time dependent radiation of intensity-this is conducive to being positioned hair follicle at least partially such as by transmitted energy.
Therefore, in certain embodiments (such as, the light radiation applied is from the coherent source of diode laser including but not limited to wavelength 810nm), this first proportionality in this way at least 1.2, at least 1.5, at least 2 and/or at least 3.Note, make the first ratio be the marked feature of pulse energy equipment more than 1, this is contrary with special CW equipment, and in special CW equipment, this ratio is 1.
In different embodiments, at least 30% or at least 50% or at least 70% or at least 90% of the electromagnetic energy (or the electromagnetic energy in one or more designated wavelength range described herein transmitted) transmitted provides as relevant and/or incoherent light pulses.
According to some embodiments, the peak power of the coherent optical pulse applied and the ratio of mean power are at least the power ratios (such as, at least 1.5, at least 2.5, at least 5) of 1.5.
According to some embodiments, the peak power of the coherent optical pulse applied and the ratio of mean power are the power ratio (such as, at the most 15 or at the most 12) of 20 at the most.
exemplary processing devices
Figure 1A to Fig. 1 C illustrates the block diagram of the example devices according to exemplary embodiment of the present invention.These figure (and all figure) are illustrative and nonrestrictive.
This equipment comprises light-pulse generator 110 (incoherent light source of such as flash lamp and/or the coherent source of such as laser instrument), controller 215 (in the instantiation of this figure, being provided as a part for control unit 116) and applicator 114.
Applicator 114 is suitable for the processing region transmission light to patient.In certain embodiments, applicator 114 comprises the shell that has aperture, and this aperture is used for transmission light pulse.In certain embodiments, control can be provided determine or control applicator size.
Note, for being known in the field to skin transport light radiation to remove the applicator 114 of hair, and any known applicator 114 and any known applicator feature may be used to current disclosed in in the device that loses hair or feathers.
In certain embodiments, applicator can comprise the embedded Control of some types and/or can combine with the embedded Control of some types, and these control such as for controlling transmitted radiation-such as, the button that " ON/OFF " controls.
Although applicator 114 is shown as and contact skin (that is, contacting with epidermis 52) in figure ia, can not thinks that this is a restriction, not contact skin and the embodiment be applied on skin falls within the scope of the present invention by light.
In fig. ib, applicator 114 skin surface " on " (that is, not contacting skin), make between the bottom of applicator 114 and skin surface, to there is the gap that length is d1.
In fig. 1 c, applicator 114 comprises transparent energy transmission 45, and relevant and/or incoherent light (and alternatively other electromagnetic energy) is applied to skin surface 49 by this element.Energy transmission 45 is configured in applicator 114, to make there is " interval " or " gap " that length is d2 between the lower surface (or energy transfer surface 43) and skin surface of transparent energy transmission 45.
As shown in Figure 1A to Fig. 1 C, control unit 116 comprises controller 215 (such as, the automatic electronic controller of i code that () such as comprises microprocessor and/or use the combination in any of software and hardware to provide, and/or manual controller), for the various parameters of the electromagnetic radiation that control impuls light source 110 is launched.
Therefore, note, in the instantiation of Figure 1A to Fig. 1 C and Fig. 2, controller 215 is arranged separately (and being arranged in independent unit) with light source 110 and applicator 114.This can not think a restriction.In certain embodiments, " controller " 215 can be configured to the integration section of light source 110, or as the integration section-namely of laser instrument or flash unit (that is, comprising light source 110), itself be configured to the light source producing required pulse sequence.In addition, do not need independent " control unit 116 ".
In the example of Figure 1A to Fig. 1 C, light-pulse generator 110 is embedded in applicator 114.Alternatively or extraly, in certain embodiments, light-pulse generator 110 is positioned at outside applicator 114, and light such as via the waveguide of some type or pipeline from " outside " light sources transmit to applicator 114.
In the exemplary embodiment, applicator 114 is cooled to provide the cooling of the contact cooling (such as, such as sapphire contact formula cooling) such as using applicator to provide.Cooling in relevant embodiment with contact, preferably provide good thermal contact.
Although be appreciated that and do not need cooling, the cooling technology of combination in any can be used, comprise pre-cooled, synchronous cooling, spray cooling, gel cooling, air cooling etc.
In the exemplary embodiment, before using light pulse process and/or period and/or apply cooling afterwards.In the exemplary embodiment, cool (such as, contact cooling and/or spray cooling or any other cooling) amount such as determined according to one or more parameters of pulsed light by control unit 116 (such as, controller 215).
In the exemplary embodiment, light penetrates corium 54 and corium is such as heated at least 42 degrees Celsius or at least 45 degrees Celsius.In the exemplary embodiment, hair follicle 50 is heated to the temperature higher than dermal temperature, such as, is heated to thermal denaturation temperature.But this is not required, and can destroy hair follicle and need not be heated denaturation temperature.
Not bound by theory ground, note, in the exemplary embodiment, due to the dermal temperature of heat, hair follicle can not be cooled to the temperature lower than corium in special time period.When this happens, such as can by waiting for alopecia and/or using tweezers etc. to remove hair.
In certain embodiments, the heating region of corium (or subcutis) is at least 20% or at least 50% or at least 80% of any hot spot (spot) area disclosed herein, and by heating minimum time section-such as, at least 0.5 second, at least 1 second, at least 2 seconds, or any section At All Other Times that can be used for hair follicle heating (and heat damage of hair follicle) needed for realization.
Fig. 2 illustrates the block diagram of Exemplary control unit 116.As noted earlier, various parameter manually can be determined by operator, and/or can use electronic circuit to calculate.But, provide specific " pre-programmed option " by more convenient.
The control unit 116 of the example of Fig. 2 comprises controller 215.Controller 215 is for controlling one or more pulse characteristic at least in part, include but not limited to the persistent period of pulse energy density, individual pulse (namely, pulse width), persistent period of power parameter (such as, average and/or peak power), pulse train, umber of pulse in pulse train and pulsation rate.
Therefore, in the example of figure 2, controller 215 comprises following one or more: the selector 213 of the umber of pulse in repetitive rate selector 210, energy density selector 212, individual pulse persistent period (or pulse width) selector 217, power selector 214 (for the parameter determining such as peak power and/or mean power and/or released by both) and pulse train duration selector and/or pulse train.
Therefore, in different embodiments, controller 215 can operate or programme and provide specific pulse train with given repetitive rate, this pulse train comprises the pulse (such as, at least 3 pulses, at least 5 pulses, at least 10 pulses, at least 15 pulses or at least 30 pulses) of at least minimal amount.
In certain embodiments, by control unit 116 " pre-configured " for providing selected processing scheme as described herein (such as, describing any processing scheme of repetitive rate and/or the pulse width in optical pulse energy density and/or pulse duration and/or power parameter) for alopecia.In an example, user can use the user interface (not shown) that make use of display 216 of certain type from multiple scheme, select given processing scheme (such as, the scheme of current description).
In certain embodiments, provide multiple " programs " that are associated with given pulse train, and provide the mechanism for selecting specific program.In an instantiation, provide the user interface for selecting specific procedure according to skin and/or hair color.
Such as, " light skin " program can provide higher energy density pulse, and but " comparatively descending skin " program can provide lower energy density pulse such as higher repetitive rate.
In the exemplary embodiment, control unit comprises such as the user display of option program.
Note, in certain embodiments, user can specify the first parameter or parameter set (such as, energy density), and controller 215 can be determined according to specified parameter or parameter set or calculate another parameter (such as, repetitive rate).
Note, as shown in the figure, light source 110 " embedding " is (such as at head place) in applicator.Some embodiment provides this marked feature, but this can not think a kind of restriction.
In the exemplary embodiment, one or more user's input control device (such as, keyboard, foot switch etc.) (not shown) can be provided.
Fig. 3 illustrates exemplary light source 110 (that is, pulse and/or CW light source).In the example of fig. 3, it comprises pulse generator 310 (such as, being controlled by device control cell), light source 312 (such as, the incoherent light source of laser instrument and/or such as flash lamp), and optical module 314.
Optical module 314 is configured to such as to change the propagation of the electromagnetic radiation of relevant and/or incoherent light so that light is pointed to predetermined direction and/or precalculated position.Optical module can comprise the optics suitable arbitrarily that well known to a person skilled in the art for performing this function, includes but not limited to waveguide, lens (that is, including but not limited to refraction and diffraction lens) and mirror.Alternatively, with incoherent light loses hair or feathers some embodiments relevant, optical module 314 can comprise band filter, such as, for carrying out the low pass filter of filtering to the incoherent light from flash lamp.
The light that different wavelength range is provided can be programmed to flash lamp or other incoherent light source.
Note, the shape of light pulse is not limited.In the exemplary embodiment, the shape of pulse is square, but this is of course not restrictive, and the pulse of arbitrary shape (such as, sinusoidal, zigzag etc.) all within the scope of the invention.
Note, coherent light (that is, from laser instrument) and incoherent light (that is, from flash lamp) are all within the scope of the invention.Typically, the facula area of incoherent light is larger.Therefore, in the exemplary embodiment relating to laser instrument, facula area is such as at 0.5cm 2and 2cm 2between.In the exemplary embodiment relating to incoherent light, facula area is such as at 3cm 2and 10cm 2between, such as, at 3cm 2and 7cm 2between.
In certain embodiments, the interpulse time keeps constant.Or this parameter can change, to provide the repetitive rate of change.
In certain embodiments, the marked feature provided by control unit is that light pulse can have different predetermined light radiation and/or pulse parameter, such as, and predetermined wavelength, energy density, repetitive rate, pulse shape etc.
Note, in certain embodiments, the electromagnetic radiation (such as, RF radiation) except light radiation can apply with light pulse simultaneously.But this is not restrictive, the overall strength of this non-optical energy accounts for the embodiment of total electromagnetic radiation intensity 10% also within the scope of the invention at the most.Usually, do not apply RF radiation, and only apply light (relevant and/or incoherent), certainly this and nonrestrictive.
As mentioned above, various parameter can change alternatively in time, such as repetitive rate, pulse shape, pulse width etc.
Note, in various embodiments, be applied with the electromagnetic radiation that comprises light pulse and do not burn to remove hair (temporary transient and/or permanent hair loss) surrounding tissue/skin and/or surrounding tissue/skin is preserved from.
about the extra discussion of processing scheme
In certain embodiments, the process of patient comprises step: (i) identifies that patient exists the region (or needing to destroy the region of hair follicle) of hair follicle; (ii) electromagnetic radiation comprising multiple incoherent and/or coherent optical pulse is applied; (iii) hair follicle is made to be destroyed by applied electromagnetic radiation.
impulse radiation and the adjoint of continuous-wave radiation (CW) apply
Fig. 4 shows and can realize in a number of different ways with " high-average power " (that is, enough heat corium and remove hair) transmission light radiation.In the example A of Fig. 4, by a series of low energy densities pulse (such as, 20J/cm at the most 2every pulse, such as, at the most 15 or 10J/cm 2every pulse) (such as, at least 1J/cm 2every pulse) fast (such as at least 3HZ, such as at least 4HZ, such as at least 5HZ, such as at least 8HZ, such as at least 10HZ) be transferred to the skin of patient.By fast transport " low energy densities pulse ", a certain amount of energy can be navigated to hair follicle while heating patient corium and be beneficial to remove hair.In the example B of Fig. 4, CW energy (or alternatively, a series of " long pulse ") transmit with " short pulse " is adjoint.According to example B, the energy density of each single short pulse can be less than the energy density in example A, and/or the repetitive rate of the transmission of single short pulse can be less than in example A.But as mentioned above, overall " average energy " still enough heats the corium of patient.Be appreciated that for some example, if the average energy of CW raises, the energy transmitted by " short pulse " can reduce, and the total amount of the average energy simultaneously transmitted remains " height ".
head or applicator velocity
Bound by theory ground, does not note, use relative to the burst transmissions speed of " height " or frequency achieve via on a skin surface with the head of the speed movement relative to " height " to apply light pulse.This is because when burst transmissions speed is higher, the individual pulse transmitted in section in preset time is more, though therefore handpiece speed relatively " height ", given hair follicle still can receive the pulse of minimal amount.
In the exemplary embodiment, on average, given processing region (such as, at least 1cm 2, or at least 5cm 2, or at least 10cm 2, or at least 50cm 2given processing region) in each hair follicle receive 10 to 15 pulses.Be appreciated that and depend on embody rule, under some clinical settings, such as given hair follicle will be subject at least 5 pulses, at the most the pulse of 20 pulses or other number arbitrarily.
In certain embodiments, by during transmitting the time period of multiple light pulse with given minimum average B configuration repetitive rate (such as, during the time period of transmission at least 10 pulses, or during the time period of transmission at least 20 pulses, or during the time period of transmission at least 50 pulses, or during the time period of transmission at least 75 pulses, or during the time period of transmission at least 100 pulses), with (or at least 4cm/ second average at least 3cm/ second, or about 5cm/ second) speed on the surface for the treatment of surface (namely, on a skin surface) the mobile or applicator of " slip " or head are (such as, the applicator including but not limited to that contact cools is provided simultaneously) apply multiple light pulse.
As used herein, " speed " of applicator or head represents when applicator or head move (such as on the surface of processing region or skin, be parallel to the part plan of processing region) time, fixing point (such as barycenter on applicator or head, or in another example, the fixing point on energy process surface) relative to the speed of processing region or skin.
Be appreciated that in different application, applying or the minimum or average speed of head required for transmission light impulse duration can be depending on application-namely the depend on intrusion degree such as needed for repetitive rate, facula area, process etc. and different.
Therefore, in an example, if repetitive rate is higher, then the light pulse from the head or applicator with fair speed can be transmitted during pulse transit time.In another example, larger facula area is also by the higher head of permission or applicator velocity.
In certain embodiments, the average handpiece speed (for laser or incoherent light) during burst transmissions is at least 3cm/ second, at least 4cm/ second, or at least 5cm/ second.In certain embodiments, average head or applicator velocity ν are defined as at the multiple light of transmission (namely, relevant or incoherent light) pulse time period during, (ν ^2)/[(freq) ^2* (spot)] (wherein ν is the speed of head or applicator, in units of cm/ second, spot is facula area, in units of cm^2) be at least 0.1 or at least 0.3 or at least 0.5 or at least 0.7 or at least 1.
Not bound by theory ground, note, in certain embodiments, in order to provide process of losing hair or feathers faster, to patient carry out lose hair or feathers process practitioner can select employing " faster " or " higher " speed.
the subsequent treatment of the subregion of processing region
Fig. 5 A illustrates exemplary process region 500.Note, every sub regions is Mathematics structural.In the example of Fig. 5 A, every sub regions is rectangular shape (total processing region 500 is also rectangular shape), but this can not think a kind of restriction.According to the example of Fig. 5 A to Fig. 5 B, the practitioner of depilation process is provided such as by the head for transmission light pulse mobile on processing region, light pulse to be applied to zones of different or the subregion of processing region 500 to patient.
Therefore, can process successively.In an instantiation, during the processing procedure of processing region 500, multiple light pulse is used to carry out process 511 to the first subregion " A " 502; Then multiple light pulse is used to carry out process 513 to the first subregion " B " 504; Then multiple light pulse is used to carry out process 515 to the first subregion " C " 506; Then multiple light pulse is used to carry out process 517 to the first subregion " D " 508; Then multiple light pulse is used to carry out process 519 to the first subregion " E " 510.
This process can repeat secondary arbitrarily.As shown in Figure 5 A, subscript i represents that execution is to i-th of stator region process.
In the example of Fig. 5 A to Fig. 5 B, when to when processing to stator region, other subregion is not in trial (that is, because head or applicator are in other position).Therefore, during interval t11, subregion " A " quilt is first processed.Then, interval is being comprised , , , with " residue " interval during, other subregion of applicator process (that is, subregion " B " arrives " F ").Therefore, in this interim remaining time, subregion " A " 502 does not receive light pulse.Subsequently, at interval period, subregion " A " 502 is subject to multiple light pulse 511 again.
Therefore, the process described in Fig. 5 B is the instantiation (that is, every sub regions is subject to multiple light pulse off and on) that light pulse " intermittently " applies, and will be described in the following.
light pulse applies to be beneficial to depilation to the interval of the given position on patient skin
In certain embodiments, not all pulse is transferred to given position on skin or given hair follicle all continuously or simultaneously.
Therefore, described by with reference to figure 5A to Fig. 5 B, multiple pulse can be used to process the first given subregion, then the second subregion is processed (such as, by applicator or head are moved to the second subregion from the first subregion, such as, by applicator being slided on the skin of processing region arrive the second subregion), then the first subregion will receive extra light pulse.
Alternatively or extraly, in another example that light pulse " intermittently " applies, the pulse of some can be transferred to specific region, a period of time afterwards, burst transmissions is not had to arrive processing region (such as, operator such as can use foot switch temporarily stop pulse transmission), again transmit the pulse of some afterwards.
In addition, be appreciated that in certain embodiments, the speed of applicator can be the function of processing region size.
Fig. 6 illustrates that the given position of tissue or area are subject to the flow chart of the example process of applied light pulse-namely off and on, light pulse (step 401) is applied in first time period, then, during the second time period (step 403), given position or the area of tissue do not receive light pulse, subsequently, during the 3rd time period (namely, the repetition of step 401), the given position of tissue or area are subject to applied light pulse again.Step 401 and 403 can repeat arbitrary number of times and remove hair to facilitate from given position or area.
Therefore, in step 401, apply with given repetitive rate or transmit a series of light pulse (that is, comprising the pulse P of minimal amount).In an example, light pulse is mean energy density is 20J/cm at the most 2every pulse, be at least 0.5J/cm 2the coherent optical pulse of every pulse.In another example, light pulse is that mean energy density is less than 8J/cm 2every pulse and be at least 0.5J/cm 2the incoherent light pulses (such as, from flash lamp) of every pulse.
As used herein, to certain area or area transmissions or apply one or more (incoherent or relevant) light pulse and can comprise burst transmissions to the one or more positions in this area or region.
Note, in certain embodiments, this area or region is transferred to (namely in step 401, one or more positions in this area or region) the number P of pulse depend on the size of this area, wherein such as carry out the more multiposition received pulse in this larger area, so larger area can receive more pulse because larger area has larger " ability ".
Therefore, in an example, if the area of tissue is N cm 2(that is, surface area is N cm 2), then the pulse number transmitted in step 401 is at least the smallest positive integral being greater than 1.5N.
According to this example, the value of N can in the scope of 1 to 20, in the scope of 1.5 to 15, in the scope of 2 to 15, and in other subrange.
In an instantiation, size is 1cm 2organize area at given head " process " in the time (that is, during an example in step 401) 2 pulses can be received.Similar, in this example, size is 4cm 2area of organizing in this instantiation, 8 pulses can be received in the time at given head " process ".
With reference now to step 403, note, after being applied with at least P light pulse, this region or area (it can be or not be the subregion of larger processing region) can be subject to remaining pulse, wherein can not transmission light pulse (that is, not being transferred to the optional position in this region or area) or can only to the light that this region or area apply or transmission mean power reduces.
During the time period of step 403, given area or area can allow to cool before repetition step 401.This is useful for providing safe process.
In an example, applicator applies energy elsewhere during the time period of step 403, does not need to apply any energy at Remaining Stages.This is described in Fig. 4 A to Fig. 4 B.Therefore, for subregion " A " 502, the execution first of step 401 is at interval period.The execution first of step 403 is comprising interval with interval during.It is at interval that the second time of step 401 performs period.
For subregion " B " 502, the execution first of step 401 is at interval period.The execution first of step 403 is comprising interval with interval during.It is at interval that the second time of step 401 performs period.
Note, in various embodiments, this Remaining Stages can be " noenergy applies the stage " or " relatively low-yield applying stage ".
In an example, in " Remaining Stages " period of step 403, institute transmits and (such as, is transmitted by the head for transmitting or applicator, namely, in step 401, described multiple light pulse) the mean power of light (or amount of light in spectral regions between the total amount of light or 750nm and 1500nm) be no more than certain " low-power " number-such as, be no more than 30 watts, or be no more than 20 watts, or be no more than 10 watts, or be no more than 5 watts.
In different embodiments, persistent period in " residue " stage such as invades degree and/or all size in " process " region and/or the physiological parameter (such as, hair or skin color) of patient and/or one or more various factors and change according to required process.
The skilled practitioner carrying out processing determines the length in " residue " stage according to Multi-instance.Therefore, in different instances, the duration lasts of " Remaining Stages " of step 403 depends on a minimum time of one or more factor.Therefore, such as, given hair follicle can stand a certain amount of time of " Remaining Stages ", this time is at least several seconds, be at the most depilation process persistent period magnitude on time period-namely, be at the most a few minutes (such as, 20 minutes at the most, or 30 minutes, or 60 minutes).
In an example, such as with the example class of Fig. 5 A seemingly, remaining time, the length of section can by the impact of the size of stator region relative to the size of whole processing region.Therefore, if give stator region size relative to whole processing region size less, then this can increase the time span of " section remaining time " of step 403.If give the size of stator region relative to whole processing region size comparatively large, then this can reduce the time span of " section remaining time " of step 403.
Note, the sum of the pulse transmitted can be depending on the size of processing region 500.In an example, this equipment can be preconfigured to the pulse (or being programmed for the pulse of transmission arbitrary number) of transmission at least certain number, such as, at least 15, at least 30, at least 50, at least 100, and at least 500.In addition, in different instances, the user of depilation process or practitioner is provided can to carry out controlling stopping transmission pulse (temporarily or fully).
Example below is only thought illustrative and nonrestrictive in itself.For obviously can carrying out many amendments, displacement and distortion those skilled in the art in the invention and not departing from the scope of the present invention.
Example
Inventors performed various experiment to prove and carry out human hair depilation by applying light radiation according to one or more instruction disclosed herein.In example 1-2, describe some experiments carried out.In example 3, describe other exemplary arrangement and the equipment configuration parameter relevant with incoherent light.
example 1: the depilation using diode laser
Inventor has constructed exemplary diode laser Depilatory device, and some instruction according to the present invention is configured with this equipment.Inventor has carried out some experiments and the depilation using aforementioned device has been described.
Table 1 below lists the configuration parameter of the various optical fields used during a specific experiment.At this experimental session, a series of square pulse is applied to skin, wherein for all pulses concerning, pulse between time equal.
After being applied with multiple light pulse, observing hair and be removed.For this group specific experiment, observe after 3 months: after applying light pulse, in the region processed, have at least 3 months hairs there is no significant regrowth (that is, regrowth rate is less than 30%).Be appreciated that hair does not have the time of remarkable regrowth to be not limited to current 3 months of observing, it also will continue.
example 2: the depilation using incoherent intense pulsed light
Inventor has constructed exemplary flash lamp Depilatory device, and some instruction according to the present invention is configured with this equipment.Inventor has carried out some experiments and the depilation using aforementioned device has been described.
In this example devices, use low pass filter to be less than 780nm to wavelength and carry out filtering with the light being greater than 1300nm.
Table 2 below lists the various optical field configuration parameters used during a specific experiment.At this experimental session, a series of square pulse is applied to skin, wherein for all pulses concerning, pulse between time equal.
example 3: the depilation using incoherent intense pulsed light
Example 3 describes the another kind of equipment relevant with incoherent light (such as, IPL or flash of light) or processes non-limiting parameter.
In the description and claim of the application, each verb " comprises ", " comprising ", " having " and change thereof object not necessarily the enumerating completely of the element of the subject of this verb, parts, element or part for representing this verb.
Here quoted all lists of references are introduced all completely.Quoting of list of references is not admitted that this list of references is prior art.
Here used article " ", " one " refer to the phraseological object of one or more than one (that is, at least one) this article.Such as, " element " represents an element or more than one element.
Here used term " comprise " represent phrase " including, but not limited to ", and interchangeable with it.
Here used term "or" represents term "and/or", and interchangeable with it, unless context has clearly illustrated that other implication.
Here used term " such as " represents phrase " such as but be not limited to ", and interchangeable with it.
Used provided by example but not the detailed description of the embodiment limited the scope of the invention invention has been described.Described embodiment comprises different characteristic, and these features not all are all required in all embodiments of the invention.Some embodiments of the present invention only make use of may combining of some features or feature.The embodiments of the invention of the distortion of described embodiments of the invention and the various combination that includes the feature indicated in the embodiments described it will be apparent to those skilled in the art that.

Claims (6)

1., to the device that the hair follicle had in the skin area of multiple hair follicle destroys, described device comprises:
A) coherent source, for generation of the coherent light comprising multiple coherent optical pulse, the wavelength of wherein said multiple coherent optical pulse is at least the minimum wavelength value of 750nm, is the maximum wavelength value being at most 1500nm; And
B) controller, for controlling the pulse characteristic of described multiple coherent optical pulse at least in part, described light source and described controller are configured so that:
I) average energy density of pulse of described multiple coherent optical pulse is at least 3J/cm 2minimum average B configuration energy density values, be at most 20J/cm 2maximum average fluence value;
Ii) average repetition rate of described multiple coherent optical pulse is at least the minimum repetition values of 7.5HZ; And
Iii) average pulse duration of described multiple coherent optical pulse is at least 10 milliseconds, is 30 milliseconds at the most;
Wherein, described light source and described controller are for generation of described multiple coherent optical pulse, wherein produced multiple coherent optical pulses are transferred to described skin area, and the corium of described skin area is heated to 42 degree at least Celsius, but be no more than 50 degree Celsius, and the temperature that the subcutis of described skin area is heated is lower than the heat damage temperature of hair follicle.
2. device according to claim 1, wherein said light source and described controller are configured to provide described coherent light, when making to work as transmitted optical pulse propagation to described skin area, the corium of described skin area are heated to 45 degree at least Celsius.
3. device according to claim 1 and 2, wherein said light source and described controller are configured to carry out the described coherent light of providing package containing described multiple coherent optical pulse with the average power density of every square centimeter, and the average power density of described every square centimeter is at least 75W/cm 2minimum average B configuration power density values.
4. device according to claim 1 and 2, wherein said light source and described controller are configured so that the peak power of the described coherent light comprising described multiple coherent optical pulse and the ratio of mean power are at least the minimum power ratios of 2.
5. device according to claim 1 and 2, wherein said light source and described controller be configured so that the peak power of the described coherent light comprising described multiple coherent optical pulse and the ratio of mean power be at most 10 maximum power ratio.
6. device according to claim 1 and 2, wherein said maximum average fluence value is at most 12.5J/cm 2.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168590B1 (en) * 1997-08-12 2001-01-02 Y-Beam Technologies, Inc. Method for permanent hair removal
US6235015B1 (en) * 1997-05-14 2001-05-22 Applied Optronics Corporation Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
US6514254B1 (en) * 2000-09-25 2003-02-04 John W. Falls Clamp device for orthopedic external fixator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2045931U (en) * 1987-09-29 1989-10-18 中国科学院武汉物理研究所 Electronic hair-removing device
US6162211A (en) * 1996-12-05 2000-12-19 Thermolase Corporation Skin enhancement using laser light
IL122840A (en) * 1997-12-31 2002-04-21 Radiancy Inc Apparatus and methods for removing hair

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235015B1 (en) * 1997-05-14 2001-05-22 Applied Optronics Corporation Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
US6168590B1 (en) * 1997-08-12 2001-01-02 Y-Beam Technologies, Inc. Method for permanent hair removal
US6514254B1 (en) * 2000-09-25 2003-02-04 John W. Falls Clamp device for orthopedic external fixator

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