CN115998417A

CN115998417A - Selective skin treatment using laser equivalent intense pulsed light device

Info

Publication number: CN115998417A
Application number: CN202310077226.0A
Authority: CN
Inventors: Y·多麦克维特兹; I·舒斯特
Original assignee: Rumex Be Co ltd
Current assignee: Rumex Be Co ltd
Priority date: 2016-06-24
Filing date: 2017-06-22
Publication date: 2023-04-25
Also published as: CN109788946A; IL263143A; EP3474762A1; IL303752A; CA3026197A1; IL263143B2; WO2017223331A1; CN109788946B; EP3474762A4; IL263143B1

Abstract

The present application relates to selective skin treatment using a laser equivalent intense pulsed light device. For example, cosmetic methods of providing light treatment to skin tissue include: providing an Intense Pulsed Light (IPL) source; inserting a band pass filter between the IPL source and skin tissue; the band-pass filter passes light in a selected wavelength range, and the average absorption coefficient of the band-pass filter is equivalent to that of the selected laser source; the method includes activating and applying the IPL source to skin tissue, wherein filtering of the illumination on the skin tissue provides treatment equivalent to the selected laser source.

Description

Selective skin treatment using laser equivalent intense pulsed light device

Case division information

The present application is a divisional application of patent application No. 201780038674.2 entitled "selective skin treatment with laser equivalent intense pulsed light device" filed on 22 th month 6 of 2017.

Technical Field

The present application relates to light treatment applied to human skin tissue, and more particularly to light treatment using selective bandpass filters in intense pulsed light devices.

Background

Optical energy radiation is a known means for the treatment of dermatological disorders. In order to obtain a clinical effect in the skin, the irradiated light energy is preferably absorbed in the skin.

Light absorption in the skin is dominated by three endogenous chromophores: water, melanin and hemoglobin. The correct matching between the wavelength or spectrum of wavelengths and the target chromophore may result in optical energy absorption, which may be a clinical effect caused by one or more photo-thermal, photochemical or opto-mechanical effects. When light energy impinges on the skin, light scattering effects may affect the depth of penetration of the light rays through the tissue. This effect, if any, is more dominant in the dermis than in the epidermis due to the higher concentration of collagen fibers in the dermis. Generally, up to the mid-infrared region of light energy, the amount of scattering is inversely proportional to the wavelength of the light. "Selective photothermal decomposition" as in Anderson and Parrish: precise microsurgery by selective absorption of pulsed radiation "Science, 29, 4, 1983; 220 (4596): 524-7, selective laser treatment may be achieved by selecting the appropriate wavelength to the appropriate chromophore, by applying an energy pulse that is shorter than or equal to the thermal relaxation time of the target chromophore, and by delivering energy above a threshold to the target tissue, as described above. Different various laser and Intense Pulsed Light (IPL) devices use these principles to provide a wide range of optical treatments for dermatological disorders.

IPL devices emit polychromatic, incoherent and non-collimated light in the spectral range of about 400nm to about 1,400nm and are typically delivered in various pulse durations. Accordingly, IPL selectivity is lower because different chromophores can be targeted within this range. One option to increase the selectivity of the light energy produced by the IPL is to use a filter. A cut-off filter is used at the lower end of the emission spectrum of the IPL device and a cut-in filter is used at the upper end of the emission spectrum. Such filters may improve process selectivity or reduce spurious wavelengths, which may put the patient at risk, such as ultraviolet light or increased overall heating, such as the presence of infrared components in the emitted light. Common medical IPL cut-off filters include 550, 560, 570, 590, 615, 645, 695, 755, and 780nm filters. A cut-off filter and a cut-in filter may be used together to create a so-called bandpass filter.

Bandpass filters are provided by some suppliers (e.g., alma Lasers, etc.), for example, providing IPL-based narrow spectrum processing in the 500nm-600nm range for treating vascular lesions for larger blood vessels. Another narrow band pass filter is provided in the range 550nm-600nm for skin regeneration. One of the problems with such filters is that they also remove part of the optical energy generated by the light source, which is an IPL light source, during the filtering process. Thus, in order to produce a clinical effect by meeting the above-described threshold energy requirements, only a limited amount of the spectrum may be removed.

In the laser domain, vascular lesions were treated by targeting the intravascular chromophore of oxyhemoglobin, which has light absorption peaks at 418nm, 542nm and 577 nm. The most common vascular lasers are KTP,532nm, pulse Dye Lasers (PDL) 585nm-595nm, emerald 755nm, diode lasers 940-980nm and Nd: YAG 532 or 1,064nm. PDL is known as the "dominant" vascular laser.

As described above, IPL light sources can also be used for the treatment of vascular lesions, using filters comprising at least one of these absorption peaks and removing damaging UV wavelengths and/or infrared wavelengths that may cause collateral thermal damage. Two companies, lumenis and Palomar, provide such a dual band filter. For example, in a vessel dual band filter, shorter wavelengths are used for smaller superficial vessels, while longer wavelengths are used for larger deeper vessels.

Pigment damage is also treated by laser light, using lasers such as KTP (532 nn), ruby (694 nm), emerald (755 nm), etc., with melanin in the melanosome as the target chromophore, using various pulse durations, starting from millisecond to picosecond. IPL can also be used for some pigmentation disorders, such as pigmentation disorders or solar nevi. Likewise, by selecting a filter that produces the appropriate spectral energy, the IPL-driven device can be used to treat at least some pigmentation disorders, provided the spectrum is broad enough so that a sufficient amount of energy density reaches the target tissue. However, the broader the spectrum, the different chromophores can be targeted and the selectivity can be reduced. Furthermore, to avoid the side effects of scarring or discoloration, short pulses may be required to limit the area or volume of any thermal effects in the targeted tissue. These short pulses may be in the range of nanoseconds or less, while IPL provides pulses in the millisecond range only.

The flexibility of using a single light source IPL in a device for treating various types of skin disorders on various types of skin remains very attractive. Thus, there is a need for a more advanced system to provide IPL-based processing with higher effective selectivity or higher absorbance, similar to its equivalent known laser wavelength designed for simulation.

Disclosure of Invention

In one aspect, a device for cosmetic treatment of vascular lesions on skin tissue equivalent to a laser operating at 532nm, comprises: a pulsed intense light (IPL) source, said IPL source being activatable; further comprising a bandpass filter that, when activated, blocks substantially all light emitted from the IPL source except for substantially one wavelength range; the bandpass filter, when activated, allows transmission of light from the IPL source in the range of about 525nm to about 585 nm; the IPL with the bandpass filter provides a cosmetic treatment equivalent to a laser operating at a wavelength of 532 nm.

In another aspect, there is provided a cosmetic treatment method equivalent to a 532nm laser on a body vessel region, comprising: providing an Intense Pulsed Light (IPL) source; inserting a band pass filter between the IPL source and the body vessel region; the type of bandpass filter is substantially light-transmitting in the range of about 525nm to about 585 nm; the method further comprises activating the IPL source; the filtering of the illumination on the vascular body part provides a cosmetic treatment equivalent to a 532nm laser.

In another aspect, a cosmetic method of providing light treatment to skin tissue includes providing a source of Intense Pulsed Light (IPL); inserting a band pass filter between the IPL source and the body vessel region; the bandpass filter passes light in the range of about 525nm to about 585 nm; the method further includes activating and applying the IPL source to the skin tissue, wherein filtering of the illumination on the skin tissue provides treatment equivalent to a 532nm laser.

In another aspect, a bandpass filter equivalent to a 532nm laser that impinges on skin tissue is configured such that light passing through the filter is substantially in the range of 525nm to 585 nm.

In a further aspect, a cosmetic method of providing light treatment to skin tissue includes the steps of providing a source of Intense Pulsed Light (IPL); inserting a band pass filter between the IPL source and the skin tissue; the band-pass filter passes light in a selected wavelength range, and the average absorption coefficient of the band-pass filter is equal to that of the selected laser light source; the method further includes activating and applying an IPL source to the skin tissue, wherein filtering of the illumination on the skin tissue provides a treatment equivalent to the selected laser light source.

In another aspect, a cosmetic method of providing a strong pulsed light (IPL) source equivalent to the treatment effect of a selected laser light source includes determining an average absorption coefficient for a particular wavelength in skin tissue for the selected particular wavelength laser light source; and selecting a bandpass filter having a substantially equivalent average absorption coefficient in the skin tissue. The skin tissue may be one or more of the following: blood absorption and melanin absorption.

In another aspect, the IPL source further comprises a body section comprising the IPL source and an opening in the body section to receive one or more bandpass filters, and wherein the one or more bandpass filters are filters that pass different ranges of light from the IPL source to skin tissue. The one or more bandpass filters may be in one or more of the following ranges: 560-690nm;675-900nm;700-800nm;725-775nm;940-980nm.

In one aspect, a method of selecting an IPL light source having a bandpass filter for providing cosmetic treatment of skin tissue, the bandpass filter being equivalent to a laser light source of a specified wavelength, the method comprising the steps of: selecting a laser light source of a specified wavelength; activating the laser light source; directing a laser light source to a target; measuring an average absorption coefficient of the laser selected in the target; storing the measured coefficients; selecting a bandpass filter; activating the IPL light source; measuring the average absorption coefficient of the band-pass filter selected in the target; comparing the measurement coefficients of the band pass filter with stored measurement coefficients of the selected laser source; if the measurement coefficients substantially match, it is determined that the selected laser source and the IPL source with the selected bandpass filter are equivalent. The target may be skin tissue.

In one aspect, a method of selecting an IPL light source having a bandpass filter for providing cosmetic treatment of skin tissue, the bandpass filter being equivalent to a laser light source of a specified wavelength, the method comprising the steps of: selecting a laser light source of a specified wavelength; activating the laser light source; directing the laser light source to a target; measuring the average penetration depth of the selected laser in the target; storing said penetration depth; selecting a bandpass filter; activating the IPL light source; measuring the average penetration depth of the selected bandpass filter in the target; comparing the measured average penetration of the band pass filter with the stored measured average penetration of the selected laser light source; if the measured average penetration depths substantially match, then it is determined that the selected laser light source and the IPL light source with the selected bandpass filter are equivalent.

In one aspect, a bandpass filter equivalent to a 595nm laser that impinges on skin tissue; the bandpass filter is configured such that light passing through the filter is substantially in the range of 560nm to 690 nm. The light may be an IPL light source.

In one aspect, a bandpass filter equivalent to a 755nm laser that impinges on skin tissue; the bandpass filter is configured such that light passing through the filter is substantially in the range 700nm to 800 nm. The light may be an IPL light source.

In another aspect, a device for cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 595nm, comprising a source of Intense Pulsed Light (IPL), said IPL source being activatable; a band pass filter that, when activated, blocks substantially all light emitted from the IPL source except for one wavelength range; the bandpass filter, when activated, allows transmission of light from the IPL source in the range of about 560nm to about 690nm; the IPL with the bandpass filter provides a cosmetic treatment equivalent to a laser operating at 595 nm.

In yet another aspect, a device for cosmetic treatment of vascular lesions on skin tissue, wherein the device is an equivalent of a laser having an operating wavelength of 755nm, comprising a source of Intense Pulsed Light (IPL), said IPL source being activatable; a band pass filter that, when activated, blocks substantially all light emitted from the IPL source except for one wavelength range; the bandpass filter, when activated, allows transmission of light from the IPL source in the range of about 700nm to about 800nm; the IPL with the bandpass filter provides a cosmetic treatment equivalent to a laser operating at 755 nm.

Drawings

Fig. 1 illustrates the absorption of blood by light of different wavelengths.

Fig. 2 shows the absorption coefficient shown in fig. 1 by means of a table.

Fig. 3 graphically illustrates the absorption of melanin by light of different wavelengths.

Fig. 4 shows the absorption coefficient shown in fig. 3 by a table.

Figure 5 graphically illustrates the ratio of melanin to the absorption coefficient of light in blood as a function of wavelength.

Figure 6 graphically illustrates the penetration depth of light into tissue at various wavelengths.

Fig. 7 illustrates the relative efficiency of an IPL light source at different wavelengths.

Figures 8 and 9 show in tabular form typical values of optical absorption at different wavelengths for different chromophores.

Detailed Description

The absorption coefficient of light in a tissue or chromophore is a function of wavelength. Referring now to FIG. 1, a graph of light absorption in whole blood as a function of wavelength for a "532 laser filter" indicated by a "solid line" and a "dye laser filter" indicated by a "dashed line" is shown. In this non-limiting example, it is assumed that the blood average consists of approximately 70% oxyhemoglobin and 30% deoxyhemoglobin. It can be seen that the absorption level varies with wavelength.

Fig. 2 shows a table containing selected values derived from the chart of fig. 1. Alternatively, fig. 3 shows a graph of the absorbance of light in melanin as a function of wavelength, and fig. 4 provides selected values from the graph of fig. 3. Figures 8 and 9 list typical values for the optical absorption of different chromophores at different wavelengths. The average absorption calculation to be given below as an example is based on these values.

For example, as can be seen from FIG. 2, the absorption coefficient of blood at a wavelength of 532nm is about 232l/cm. Thus, according to this aspect of the invention, a bandpass filter for an IPL system may be provided in the range of 525 to 585nm, as shown in fig. 1 as a "532 laser filter" for vascular lesion treatment, and as shown in fig. 9, fig. 9 shows an embodiment of a wavelength range selectable to provide an equivalent average absorption coefficient provided by a laser. The average absorption coefficient refers to all wavelengths in the blood within this range, equal to 232l/cm, which characterizes the absorption of 532KTP laser light in blood. Accordingly, IPL systems with such bandpass filters are expected to have similar tissue interactions on the skin as 532nm lasers and may be as effective as 532nm lasers in treating vascular lesions.

As another example shown in FIG. 2, a dye laser having a wavelength of about 595nm has an absorption coefficient in blood of about 60l/cm. Band pass filter average absorption coefficient values between 560nm and 690nm have the same average absorption coefficient in blood as dye lasers, therefore, according to this aspect of the invention, an IPL system with a 560nm to 690nm band pass filter, as shown in fig. 2, "dye laser filter", can be used to treat vascular lesions.

As another example, referring now to fig. 3, an emerald laser (755 nm) has an absorption coefficient in melanin of about 172l/cm, as shown in fig. 3. For example, a bandpass filter from 700nm to 800nm passes through the spectrum with an average melanin absorption coefficient of 173l/cm, and thus, according to this aspect of the invention, an IPL system is provided with a bandpass filter between 700nm and 800nm, which is equivalent to an emerald laser, and is referred to herein as an "emerald laser filter". Similar results can be provided by bandpass filters of the 675nm to 900nm spectrum.

Fig. 8 is a table of embodiments having wavelength ranges that can be selected to provide an average absorption coefficient equivalent to an emerald laser in an IPL device. Such IPL systems can be considered to have the same or very similar clinical effects as emerald lasers used to treat pigmentation disorders.

According to another aspect of the invention, there may be provided an IPL system having an IPL handpiece with a permanently embedded filter configured to receive a bandpass filter that transmits a spectrum having an average absorption coefficient that is approximately similar to that of a known laser, such as KTP,532nm, pulse Dye Laser (PDL) 585nm-595nm, emerald 755nm, diode laser 800-810nm, and Nd: YAG 532, ruby 694nm or 1,064nm or more.

According to yet another aspect of the invention, an IPL system with an IPL handpiece can be configured to accept different filters according to the invention such that a single handpiece can interchangeably transmit spectra having an average absorption coefficient on a target tissue or chromophore similar to an equivalent known laser. The device manufactured and sold by the assignee of the present invention, lumenis LTD, designated M22Universal IPL, of israel, is one embodiment of such a device that accepts different filters.

The average calculation of a series of absorption values associated with a certain spectrum passing through a band pass filter as described above may be performed in different ways. In the above embodiment, the calculation of the average is a basic arithmetic average calculation in which the "weights" for each wavelength are similar.

However, as shown in fig. 6, the penetration depth of light into tissue (e.g., skin) varies and is also a function of wavelength. Thus, according to another aspect of the invention, the average absorption coefficient of the spectrum passing through the band pass filter according to the invention may be calculated based on a weighted average calculation.

Furthermore, due to the wavelength dependence of penetration depth, spots of different depths in the skin will experience different effective wavelength intensity profiles. Typically, as depth increases, the spectrum shifts to the red and mid-infrared directions. Thus, according to this aspect of the invention, there is provided an IPL system having an IPL band pass filter configured to transmit a spectrum having an average absorption coefficient of a target tissue or chromophore that is similar to the absorption coefficient of a known laser at a predetermined depth in the skin.

For example, on the skin surface, a 755nm emerald laser has an absorption value of about 172l/cm in melanin, as shown in fig. 4. As can be seen from fig. 3, the spectrum having an absorption value similar to that of the emerald laser in melanin on average may be a band-pass filter of 700nm to 800 nm. It should be noted that different bandpass filters may also produce, on average, a spectrum having an average absorption coefficient similar to that of an emerald laser, such as a 725nm to 775nm bandpass filter.

As mentioned above, it is also preferable to reach a critical energy threshold in order to achieve the desired clinical effect. The bandpass filter should therefore be selected based on the lamp performance and intensity in order to not only provide a spectrum with an average light absorption in the target tissue or chromophore similar to known lasers, but also to provide at least a threshold energy to achieve a clinical effect. Turning attention now to an embodiment regarding the depth of target tissue in the skin, an emerald laser filter for pigmentary lesions, which, due to movement in the mid-infrared direction, is intended for deeper melanin in the skin, may need to transmit a slightly different spectrum moving in the blue direction in order to keep the average absorption value of the transmitted spectrum around 172l/cm+ at this deeper position.

According to another aspect of the invention, as shown in fig. 7, the energy emitted by the lamp is also a function of wavelength. At different wavelengths, the efficiency of the lamp is different, thus illuminating and delivering different amounts of energy. Thus, as described above, a weighted average calculation may be performed to compensate for the non-uniform energy distribution of the lamp. An IPL system and an appropriate band pass filter configured to transmit a spectrum having absorption coefficient values in the skin or anywhere within the skin on a weighted average basis that are similar to absorption coefficient values of known lasers in the target tissue or chromophore that are also an aspect of the invention.

Fig. 5 shows the ratio of melanin to the absorption coefficient of light in blood as a function of wavelength. It can be seen that this ratio is higher than 10 in the wavelength range of 600nm to 900 nm. Thus, according to this aspect of the invention, the bandpass filter of the invention may be configured to pass a wavelength spectrum wherein the ratio of light absorption in melanin to light absorption in blood is at least greater than 10l/cm. Ratios above 10l/cm are expected to give good selectivity for the treatment of pigmentary lesions. According to another embodiment, the IPL system may be configured to transmit spectra having a ratio of greater than 20l/cm, greater than 30l/cm, greater than 40l/cm, or greater than 50l/cm to further enhance selectivity. According to this and other aspects of the invention, lamps with high brightness are configured to deliver high energy flux, and therefore, even with relatively narrow bandpass filters, threshold energy sufficient to produce clinical effects can be achieved.

One embodiment of a suitable flash for practicing the present invention may be the flash configuration described in U.S. provisional application Ser. No. 62/465,210, filed on day 3/1 in 2017.

Claims

1. A bandpass filter configured to block substantially all light except a range of wavelengths when activated and when inserted into a light beam during operation,

wherein, when activated, the band pass filter allows:

light transmission in the range of 525nm to 585nm, in order to provide a cosmetic treatment effect equivalent in absorption coefficient and/or penetration depth to a laser operating at 532nm,

light transmission in the range 560nm to 690nm to provide a cosmetic treatment effect equivalent in absorption coefficient and/or penetration depth to a laser operating at 595 nm.

2. The bandpass filter of claim 1, wherein the light is from an IPL light source.

3. A method for adjusting an IPL system to produce an IPL beam, comprising:

for a selected specific wavelength laser light source, determining an average absorption coefficient of the specific wavelength in a target; and

a bandpass filter is selected having a substantially equivalent average absorption coefficient in the target,

wherein the IPL beam is capable of inducing a cosmetic treatment effect equivalent to the selected laser light source.

4. The method of claim 3, wherein the selected laser light source has an operating wavelength of 755nm, 595nm, or 532nm, the method further comprising:

providing an IPL source/lamp having a high brightness configured to deliver a high energy flux;

a band pass filter is inserted into the beam, the band pass filter being configured to transmit a spectrum having absorption coefficient values in the human skin or anywhere within the skin on a weighted average basis that are similar to the absorption coefficient values of selected lasers in the target tissue or chromophore.

5. The method of claim 4, the method further comprising:

inserting a bandpass filter into the light beam, wherein the bandpass filter transmits light in the range of 525nm to 585 nm;

wherein the filtering provides an equivalent treatment effect to a 532nm laser to human skin.

6. A method according to claim 3, comprising:

providing an IPL source/lamp;

inserting a bandpass filter into the beam;

wherein the band pass filter is of a type that substantially transmits light in the range of 525nm to 585 nm;

activating the IPL source;

wherein the filtering provides a treatment effect equivalent to a 532nm laser to the vascular part of the human body.

7. A method according to claim 3, comprising:

providing an IPL source/lamp;

inserting a bandpass filter into the beam;

wherein the band pass filter is of a type that transmits substantially light in the range 560nm to 690nm;

activating the IPL source;

wherein the filtering provides an equivalent treatment effect to a 595nm laser to the vascular portion of the human body.

8. A method according to claim 3, comprising:

providing an IPL source/lamp;

inserting a bandpass filter into the beam;

wherein the band pass filter is of a type that transmits substantially light in the range 700nm to 800nm;

activating the IPL source;

wherein the filtering provides a treatment effect equivalent to a 755nm laser to the vascular segment of the human body.