EP3463359A4 - Agonistes du récepteur 1 associé à une amine à l'état de trace et agonistes partiels pour le traitement de la douleur - Google Patents

Agonistes du récepteur 1 associé à une amine à l'état de trace et agonistes partiels pour le traitement de la douleur Download PDF

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Publication number
EP3463359A4
EP3463359A4 EP17807608.9A EP17807608A EP3463359A4 EP 3463359 A4 EP3463359 A4 EP 3463359A4 EP 17807608 A EP17807608 A EP 17807608A EP 3463359 A4 EP3463359 A4 EP 3463359A4
Authority
EP
European Patent Office
Prior art keywords
agonists
pain treatment
associated receptor
trace amine
amine associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17807608.9A
Other languages
German (de)
English (en)
Other versions
EP3463359A1 (fr
Inventor
Michele HUMMEL
Laykea Tafesse
Donald J. Kyle
Garth WHITESIDE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Pharma LP
Original Assignee
Purdue Pharma LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma LP filed Critical Purdue Pharma LP
Publication of EP3463359A1 publication Critical patent/EP3463359A1/fr
Publication of EP3463359A4 publication Critical patent/EP3463359A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP17807608.9A 2016-06-02 2017-06-02 Agonistes du récepteur 1 associé à une amine à l'état de trace et agonistes partiels pour le traitement de la douleur Withdrawn EP3463359A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344833P 2016-06-02 2016-06-02
US201662440747P 2016-12-30 2016-12-30
PCT/US2017/035776 WO2017210616A1 (fr) 2016-06-02 2017-06-02 Agonistes du récepteur 1 associé à une amine à l'état de trace et agonistes partiels pour le traitement de la douleur

Publications (2)

Publication Number Publication Date
EP3463359A1 EP3463359A1 (fr) 2019-04-10
EP3463359A4 true EP3463359A4 (fr) 2020-08-26

Family

ID=60479002

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17807608.9A Withdrawn EP3463359A4 (fr) 2016-06-02 2017-06-02 Agonistes du récepteur 1 associé à une amine à l'état de trace et agonistes partiels pour le traitement de la douleur

Country Status (4)

Country Link
US (2) US20190201410A1 (fr)
EP (1) EP3463359A4 (fr)
JP (1) JP2019517524A (fr)
WO (1) WO2017210616A1 (fr)

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007085557A2 (fr) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Utilisation de 2-imidazole substitue de derives d'imidazoline
US20080119535A1 (en) * 2006-10-19 2008-05-22 Guido Galley Aminomethyl-4-imidazoles
WO2009016088A1 (fr) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag Utilisation de dérivés de benzamide pour le traitement de troubles du snc
US20090176843A1 (en) * 2008-01-09 2009-07-09 Sinha Santosh C Substituted-aryl-2-phenylethyl-1h-imidazole compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors
WO2009091735A1 (fr) * 2008-01-18 2009-07-23 Allergan.Inc Composes aryl-(imidazole)-methyl)-phenyle substitues servant de modulateurs selectifs des sous-types des recepteurs adrenergiques alpha 2b et/ou alpha 2c
WO2010010014A1 (fr) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag Dérivés de 4,5-dihydrooxazol-2-yle
US20100273814A1 (en) * 2007-05-14 2010-10-28 Sinha Santosh C ((phenyl)imidazolyl)methylheteroaryl compounds
EP2245019A1 (fr) * 2008-02-18 2010-11-03 F. Hoffmann-La Roche AG Dérivés de 4,5-dihydrooxazol-2-ylamine
US20110152245A1 (en) * 2009-12-22 2011-06-23 Katrin Groebke Zbinden Substituted benzamides
US20120196903A1 (en) * 2007-02-02 2012-08-02 Guido Galley 2-aminooxazolines as taar1 ligands
WO2015165085A1 (fr) * 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Dérivés de morpholine-pyridine
WO2015181061A1 (fr) * 2014-05-28 2015-12-03 F. Hoffmann-La Roche Ag Dérivés 5-oxa-2-azabicyclo[2.2.2]octan-4-yl et 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl en tant que modulateurs de taar1
WO2016016162A1 (fr) * 2014-07-30 2016-02-04 F. Hoffmann-La Roche Ag Dérivés 6-amino -5,6,7,8-tétrahydronaphtalène -2-yle ou 3-aminochroman -7-yl comme modulateurs de taar
WO2016015333A1 (fr) * 2014-08-01 2016-02-04 F.Hoffmann-La Roche Ag Dérivés de 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl
WO2017192858A1 (fr) * 2016-05-04 2017-11-09 Purdue Pharma L.P. Pseudodimères d'oxazoline, compositions pharmaceutiques et utilisation correspondantes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
KR101335845B1 (ko) * 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007085557A2 (fr) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Utilisation de 2-imidazole substitue de derives d'imidazoline
US20080119535A1 (en) * 2006-10-19 2008-05-22 Guido Galley Aminomethyl-4-imidazoles
US20120196903A1 (en) * 2007-02-02 2012-08-02 Guido Galley 2-aminooxazolines as taar1 ligands
US20100273814A1 (en) * 2007-05-14 2010-10-28 Sinha Santosh C ((phenyl)imidazolyl)methylheteroaryl compounds
WO2009016088A1 (fr) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag Utilisation de dérivés de benzamide pour le traitement de troubles du snc
US20090176843A1 (en) * 2008-01-09 2009-07-09 Sinha Santosh C Substituted-aryl-2-phenylethyl-1h-imidazole compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors
WO2009091735A1 (fr) * 2008-01-18 2009-07-23 Allergan.Inc Composes aryl-(imidazole)-methyl)-phenyle substitues servant de modulateurs selectifs des sous-types des recepteurs adrenergiques alpha 2b et/ou alpha 2c
EP2245019A1 (fr) * 2008-02-18 2010-11-03 F. Hoffmann-La Roche AG Dérivés de 4,5-dihydrooxazol-2-ylamine
WO2010010014A1 (fr) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag Dérivés de 4,5-dihydrooxazol-2-yle
US20110152245A1 (en) * 2009-12-22 2011-06-23 Katrin Groebke Zbinden Substituted benzamides
WO2015165085A1 (fr) * 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Dérivés de morpholine-pyridine
WO2015181061A1 (fr) * 2014-05-28 2015-12-03 F. Hoffmann-La Roche Ag Dérivés 5-oxa-2-azabicyclo[2.2.2]octan-4-yl et 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl en tant que modulateurs de taar1
WO2016016162A1 (fr) * 2014-07-30 2016-02-04 F. Hoffmann-La Roche Ag Dérivés 6-amino -5,6,7,8-tétrahydronaphtalène -2-yle ou 3-aminochroman -7-yl comme modulateurs de taar
WO2016015333A1 (fr) * 2014-08-01 2016-02-04 F.Hoffmann-La Roche Ag Dérivés de 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl
WO2017192858A1 (fr) * 2016-05-04 2017-11-09 Purdue Pharma L.P. Pseudodimères d'oxazoline, compositions pharmaceutiques et utilisation correspondantes

Non-Patent Citations (12)

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ANNIE DELAUNOIS ET AL: "Advantageous safety profile of a dual selective alpha 2C agonist/alpha 2A antagonist antinociceptive agent", FUNDAMENTAL & CLINICAL PHARMACOLOGY, vol. 28, no. 4, 11 August 2014 (2014-08-11), pages 423 - 438, XP055135961, ISSN: 0767-3981, DOI: 10.1111/fcp.12047 *
ANTTI PERTOVAARA ET AL: "The effect of medetomidine, an [alpha]2-adrenoceptor agonist, in various pain tests", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 179, no. 3, 1 April 1990 (1990-04-01), NL, pages 323 - 328, XP055710388, ISSN: 0014-2999, DOI: 10.1016/0014-2999(90)90172-3 *
DAVID M. BIONDI ET AL: "Is migraine a neuropathic pain syndrome?", CURRENT PAIN AND HEADACHE REPORTS, vol. 10, no. 3, 1 June 2006 (2006-06-01), US, pages 167 - 178, XP055495933, ISSN: 1531-3433, DOI: 10.1007/s11916-006-0042-y *
ERIC JNOFF ET AL: "Discovery of Selective Alpha 2C Adrenergic Receptor Agonists", CHEMMEDCHEM, vol. 7, no. 3, 5 March 2012 (2012-03-05), pages 385 - 390, XP055135969, ISSN: 1860-7179, DOI: 10.1002/cmdc.201100528 *
FARGHALY HANAN SAYED M ET AL: "Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-[alpha]", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 776, 16 February 2016 (2016-02-16), pages 139 - 145, XP029446158, ISSN: 0014-2999, DOI: 10.1016/J.EJPHAR.2016.02.046 *
GRAZIA RUTIGLIANO ET AL: "The Case for TAAR1 as a Modulator of Central Nervous System Function", FRONTIERS IN PHARMACOLOGY, vol. 8, 1 January 2018 (2018-01-01), CH, XP055653521, ISSN: 1663-9812, DOI: 10.3389/fphar.2017.00987 *
GUIDO GALLEY ET AL: "Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 2, 11 February 2016 (2016-02-11), US, pages 192 - 197, XP055377959, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00449 *
MARIA ELENA MANNI ET AL: "Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold : T1AM, a hyperalgic and memory-enhancing amine", BRITISH JOURNAL OF PHARMACOLOGY, vol. 168, no. 2, 1 January 2013 (2013-01-01), UK, pages 354 - 362, XP055653308, ISSN: 0007-1188, DOI: 10.1111/j.1476-5381.2012.02137.x *
See also references of WO2017210616A1 *
VONVOIGTLANDER P F ET AL: "Involvement of biogenic amines with the mechanisms of novel analgesics", PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, ELSEVIER, GB, vol. 7, no. 4-6, 1 January 1983 (1983-01-01), pages 651 - 656, XP025489404, ISSN: 0278-5846, [retrieved on 19830101], DOI: 10.1016/0278-5846(83)90040-4 *
YUTAKA MATSUOKA ET AL: "Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception.", JAPANESE JOURNAL OF PHARMACOLOGY., vol. 48, no. 2, 1 January 1988 (1988-01-01), KYOTO, JP, pages 263 - 272, XP055653397, ISSN: 0021-5198, DOI: 10.1254/jjp.48.263 *
ZUCCHI R ET AL: "Trace amine-associated receptors and their ligands", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 149, 6 November 2006 (2006-11-06), pages 967 - 978, XP002473114, ISSN: 0007-1188, DOI: 10.1038/SJ.BJP.0706948 *

Also Published As

Publication number Publication date
WO2017210616A1 (fr) 2017-12-07
US20220280527A1 (en) 2022-09-08
EP3463359A1 (fr) 2019-04-10
JP2019517524A (ja) 2019-06-24
US20190201410A1 (en) 2019-07-04

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