EP3454947A1

EP3454947A1 - Peroxide-free whitening gel

Info

Publication number: EP3454947A1
Application number: EP17730840.0A
Authority: EP
Inventors: Stephane Bochenek
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-13
Filing date: 2017-05-12
Publication date: 2019-03-20
Also published as: FR3051113A1; WO2017194901A1; FR3051113B1

Abstract

The invention relates to a peroxide-free dental whitening gel comprising sodium bicarbonate combined with one or more humectants, one or more gelling agents, and one or more emulsifiers, and to a method for preparing the gel. The invention also relates to a cosmetic tooth-whitening method and to a tooth-whitening kit using said gel.

Description

Bleaching gel without peroxides

The present invention relates to a dental bleaching gel.

Dental whitening aims to lighten the coloring of teeth for aesthetic purposes. The defects of staining of the teeth can be of natural or physiological origin (for example related to the aging of the tooth), or to come from exogenous factors (for example taking of tetracycline during the formation of the tooth, important consumption of coffee, tea, or tobacco, etc.).

Various types of dental whitening treatments are currently available; they are mainly based on the use of peroxide compounds (especially hydrogen peroxide or carbamide peroxide) as bleaching agents.

Some of these treatments are performed in the dental office, in one or more sessions. A gutter conforming to the shape of the dental arch, made to measure and filled with a whitening product highly concentrated in whitening agent is applied to the jaw to be treated for a duration of the order of a few tens of minutes, variable according to the initial coloring of the tooth. If necessary, the lightening process can be activated by the use of a laser lamp. These in-office treatments can be replaced or supplemented by an outpatient treatment prescribed by the dentist, using the same gutters with a less-dosed whitening product. The gutters are applied daily for a time varying from a few minutes to an hour per day, until the desired lightening is achieved. In addition to treatments that are intended to be performed under the supervision of a dentist, there are also treatments that can be used at home and are sold without a prescription in the form of ready-to-use kits. Like the previous ones, these treatments use peroxide whiteners, but these are used at much lower concentrations. They come in different forms, combining a whitening composition to an applicator device. These include: applicators in the form of brush or pen: they allow a precise application of the whitening product, for localized use on a few teeth; self-adhesive strips coated with whitening composition, which can be positioned on the teeth to be treated; preformed mouth gutters, which can be filled with whitening composition. A problem with these dental bleaching methods is the use of peroxide bleaches. Indeed, it has been reported that peroxides can induce an increase in tooth sensitivity in some people, as well as gingival irritation. The risk of such undesirable effects is increased in the case of non-prescription treatments for home use, as it is difficult to control whether the recommended treatment modalities are actually followed.

The present invention provides novel teeth whitening means to prevent these problems by avoiding the use of peroxidized derivatives.

More specifically, the present invention is based on the use of dental bleaching compositions in which the bleaching agent is sodium bicarbonate.

These compositions are in the form of gels, in which the sodium bicarbonate is associated with one or more humectant (s), one or more gelling agent (s), and one or more emulsifying agent (s). (s).

In the context of the present invention, preferred humectants are polyols, or mixtures of polyols. These include glycerol, sorbitol and xylitol, which can be used singly or in combination. Advantageously, a mixture of these three polyols will be used.

Preferred gelling agents include in particular polyacrylic acid derivatives (carbomers) gelled by neutralization using a base. A preferred base for gelation is triethanolamine. The texture of the gel obtained can be adjusted by varying the carbomer / triethanolamine ratio.

Advantageously, another type of gelling agent, preferably a gelling polysaccharide, in particular a carrageenan, will also be used.

Preferred emulsifying agents include amphoteric surfactants, especially betaines, especially cocamidopropyl betaine. Preferably, a dental bleaching gel according to the invention further comprises a plant extract, obtained from one or more plants having a beneficial action on the gingival mucosa. These may include plants with softening, anti-inflammatory and / or antioxidant properties. Advantageously, said plant extract comprises a mixture of an extract of aloe leaf, a pomegranate extract, and an extract of chamomile flowers. Generally, a dental bleaching gel according to the invention will also comprise one or more flavoring agent (s), making its use more pleasant for the skin. consumer. It may be for example a mint flavor, or any other flavor that can be used in dental hygiene products. It may also include one or more dyes, the nature of which will depend on the color that is desired to give to the preparation.

Usually, a dental whitening gel according to the invention will comprise: - between 20 and 35% by weight of a 9% solution of sodium bicarbonate in water; between 60 and 70% by weight of humectant agent (s); if this humectant is a mixture of glycerol, sorbitol and xylitol, this mixture will advantageously comprise from 98.8% to 99.8% by weight of glycerol, from 0.2 to 1% by weight of sorbitol, and from 0.5 to 0.2% by weight of xylitol. between 1 and 2% by weight of gelling agent (s), preferably comprising between 1 and 1.5% by weight of carbomer, and between 0.1 and 0.5% by weight of carrageenan; preferably between 0.02% and 0.1% by weight of agent (s) emulsifier (s) between 0.1 and 0.5% by weight of plant extract.

When flavorings and / or dyes are used, their dosage will depend mainly on their nature, as well as the intensity of the taste and / or color that is desired to confer on the final product. For example, if peppermint oil is used as a flavor, it will be used in a proportion of 0.05 to 0.2% by weight of the final product.

The present invention also relates to a method for preparing a dental whitening gel according to the invention. This process comprises the following steps: a) the preparation of the polyol or polyol mixture used as humectant agent (s); b) incorporation in said humectant agent (s), carbomer, carrageenan, and cocamidopropyl betaine, with constant stirring until complete dispersion; c) maintaining the mixture obtained in step b) with intermittent stirring for 12 to 48 hours; d) adding the sodium bicarbonate in solution in water, and triethanolamine, with constant stirring until a gel is formed. If the dental bleaching gel contains an extract of plant (s), this extract is added, with stirring, to the gel obtained at the end of step d) and stirring is continued for a few minutes to allow its incorporation.

If it is desired to add flavors and / or dyes, they are added, still with stirring, after the plant extract, and stirring is continued to allow their incorporation into the mixture. The present invention also relates to an aesthetic tooth whitening method characterized in that it comprises the application to teeth whose appearance is to improve a tooth whitening gel according to the invention.

Generally, the dental bleaching gel according to the invention will be used in daily or twice-daily applications, of at least 5 minutes, and preferably of 10 to 60 minutes. However, the frequency of applications, and the duration of each application can, if necessary, be increased or decreased. Applications may be continued until the desired degree of lightening is achieved. Because of the absence of peroxides, prolonged treatment does not run the risk of tooth sensitization or irritation of the gingival mucosa.

The present invention also relates to a kit for whitening teeth, comprising a dental whitening gel according to the invention, and a device for the application of said gel.

The applicator device may for example be in the form of a brush, a pen or a stick provided with a foam nozzle, it may also be a self-adhesive strip coated with the bleaching gel according to the invention, or a mouth gutter that can be filled with said gel.

The present invention will be better understood with the aid of the additional description which follows, which refers to a non-limiting example illustrating the preparation of a tooth whitening gel according to the invention.

Example:

Ingredients:

The ingredients used for the preparation of the gel are listed in the table below:

Ingredient CAS # Percent by Weight

Glycerol CAS 56-81-5 65.35%

Sodium bicarbonate CAS 144-55-8 32%

(9% solution)

Carbomer 940 CAS 9007-20-9 1.3%

Sorbitol (70% solution) CAS 50-70-4 0.5%

Carrageenan (CAS Powder 9000-07-1 0.3%

Chondrus Crispus)

Xylitol (Solution in CAS 87-99-0 0.2%

the water)

Triethanolamine CAS 102-71-6 0.2% to 0.8% depending on the desired texture

Peppermint oil CAS 8006-90-4 0.1%

(Mentha Piperita)

Extract of aloe leaves CAS 85507-69-3 0.1% (Aloe Arborescens)

Pomegranate extract CAS 84961-57-9 0.05%

(Punica Granatum)

Chamomile Extract CAS 84082-60-0 0.05%

(Chamomilla Recutita)

Cocamidopropyl CAS 61789-40-0 0.05%

betaine

Cl dye 42090 CAS 3844-45-9 (few drops)

Cl dye 19140 CAS 1934-21-0 (A few drops)

The ingredients used come from SPECTRUM CHEMICAL, except for the following:

Peppermint oil and pomegranate extract (NATURES FLAVORS)

Chamomile extract (BOTANIC CHOICE) Cl dyes 42090 and Cl 19140

The Xylitol solution used was prepared as follows: ¼ to ½ cups (54 to 108 g) of xylitol powder was added to one cup (236.59 ml) of hot water, stirring to dissolve. After adding a pinch of salt, the mixture was boiled for 3 minutes. After removing the mixture from the heat, ¼ to ½ teaspoon of xanthan gum was added to the hot mixture while whisking until fully incorporated.

The sodium bicarbonate solution was prepared as follows: Hot water temperature in a large pot. Set aside the pot. 54 grams of sodium bicarbonate was added to 0.6 liters of hot water in a stainless steel beaker, and the mixture was stirred until the bicarbonate granules were completely dissolved. For the preparation of the gel, the glycerol is placed in a stainless steel container. Stirring is started, and the speed set to form a vortex. Coolant is circulated around the tank to reduce heat build-up, so that the temperature of the preparation does not exceed 40 ° C.

The sorbitol and xylitol solutions are added in the vortex, continuing to mix for at least 30 minutes.

The powdered ingredients (carbomer, Chondrus crispus powder and cocamidopropyl betaine are added by dusting into the vortex and mixing is continued until the powders are completely dispersed.

Intermittently mixed for 3 days using the above protocol. On day 3, add the sodium bicarbonate solution and triethanolamine while mixing at medium speed. A thick gel is formed quickly.

Once the desired consistency is achieved, the speed of the mixer is adjusted to keep the preparation in motion, and mixing is continued for 3 to 5 minutes.

Aloe gel, pomegranate extract and chamomile extract are added to the preparation and mixing is continued for 3 to 5 minutes. The peppermint oil is then added and mixing is continued for 3 to 5 minutes. Finally, 7 drops of Cl 42090 dye and 1 drop of Cl 19140 dye are added per gallon (3.79 liters) of gel, and mixing is continued for 10 minutes.

Claims

1) A peroxy-free tooth whitening gel, comprising: sodium bicarbonate as a bleaching agent; one or more humectant (s) comprising at least one polyol selected from glycerol, sorbitol, and xylitol, or a mixture of at least two of said polyols; one or more gelling agent (s) comprising at least one carbomer triethanolamine neutralized, and at least one carrageenan; one or more emulsifying agent (s) comprising at least cocamidopropyl betaine.

2) dental bleaching gel according to claim 1, characterized in that it further comprises at least one extract of one or more plants.

3) dental bleaching gel according to claim 2, characterized in that said plant extract comprises a mixture of an extract of aloe leaves, a pomegranate extract, and an extract of chamomile flowers.

4) dental bleaching gel according to one of claims 1 to 3, characterized in that the humectants are a mixture of glycerol, sorbitol and xylitol.

5) dental bleaching gel according to one of claims 1 to 4, characterized in that it comprises: between 20 and 35% by weight of a 9% solution of sodium bicarbonate in water; between 60 and 70% by weight of humectant agent (s); between 1 and 2% by weight of gelling agent (s); between 0.02% and 0.1% by weight of emulsifying agent (s).

6) dental bleaching gel according to one of claims 1 to 5, characterized in that it further contains one or more flavoring agent (s) and one or more agent (s) dye (s).

7) A method for preparing a dental bleaching gel according to one of claims 1 to 6, characterized in that it comprises the following steps: e) the preparation of the polyol or mixture of polyols used as agent (s) humectant (s); f) incorporation in said humectant agent (s), carbomer, carrageenan, and cocamidopropyl betaine, with constant stirring until complete dispersion; g) maintaining the mixture obtained in step b) with intermittent stirring for 12 to 48 hours; h) adding the sodium bicarbonate in solution in water, and triethanolamine, with constant stirring until a gel is formed.

8) Process according to claim 7, characterized in that it further comprises: i) adding, with stirring, the plant extract (s) to the gel obtained at the end of step d); j) Optionally, adding, with stirring, the flavoring agent (s) and the dye (s).

9) aesthetic tooth whitening method characterized in that it comprises the application to the teeth whose appearance is to improve a tooth whitening gel according to one of claims 1 to 6.

10) Kit for whitening teeth, characterized in that it comprises a dental bleaching gel according to one of claims 1 to 6, and a device for applying said gel to teeth whose appearance is to improve.