EP3412590A1 - Behälter für die verpackung einer flüssigkeit mit tropfenspender mit umkehrbarer deformation durch lufteinlass - Google Patents

Behälter für die verpackung einer flüssigkeit mit tropfenspender mit umkehrbarer deformation durch lufteinlass Download PDF

Info

Publication number
EP3412590A1
EP3412590A1 EP18183420.1A EP18183420A EP3412590A1 EP 3412590 A1 EP3412590 A1 EP 3412590A1 EP 18183420 A EP18183420 A EP 18183420A EP 3412590 A1 EP3412590 A1 EP 3412590A1
Authority
EP
European Patent Office
Prior art keywords
container
liquid
drop
packaging
dispensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18183420.1A
Other languages
English (en)
French (fr)
Other versions
EP3412590B1 (de
Inventor
Michel Faurie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Thea SAS
Original Assignee
Laboratoires Thea SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Thea SAS filed Critical Laboratoires Thea SAS
Priority to SI200532298T priority Critical patent/SI3412590T1/sl
Priority to PL18183420T priority patent/PL3412590T3/pl
Publication of EP3412590A1 publication Critical patent/EP3412590A1/de
Application granted granted Critical
Publication of EP3412590B1 publication Critical patent/EP3412590B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/04—Deformable containers producing the flow, e.g. squeeze bottles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/32—Containers adapted to be temporarily deformed by external pressure to expel contents

Definitions

  • the invention is in the field of packaging and dispensing liquids, such as pharmaceutical solutions and especially eye drops. It relates to a container equipped with a dispensing head, which is organized to contain a liquid by protecting it from the outside environment and to deliver this liquid in a controlled manner, particularly drop by drop.
  • Containers for containing a liquid which are organized to preserve this liquid from the outside environment and to deliver it in a controlled manner, in particular drop by drop.
  • the applications of such containers are numerous, and a preferred application, but not restrictive as to the scope of the present invention, lies in the preservation and distribution of a pharmaceutical solution, especially eye drops.
  • the preservation of the liquid With regard to the preservation of the liquid, it must be protected from the outside environment by avoiding contact with the ambient air which is likely to contain pollutants, including bacteria.
  • the container For the distribution of the liquid, it is common to give the container a deformable character to reduce its capacity, at least temporarily, to evacuate the liquid it contains.
  • Such containers are more precisely flexible wall, to cause evacuation of the liquid from a compression exerted by the user on this wall, and they are equipped with a dispensing head, to achieve the two objectives that are the preservation and controlled distribution of the liquid.
  • a first approach it has been proposed to give the container an irreversible or almost irreversible deformable character.
  • An inner wall of the container defining the liquid receiving capacity is organized bellows, and is wrapped with an outer sheath.
  • This container further contains a filter membrane which has a character impervious to air, to prohibit an intake of outside air to the liquid in the container, under the effect of a withdrawal of liquid delivered.
  • patent documents may be referred to FR 2 661 401 and FR 2,770,495 (or US6,336,571 ), which describe such containers.
  • a microporous buffer acting as a flow regulator is disposed in the dispensing head of a rigidly irreversible deformation wall container.
  • An intermediate reserve is provided downstream of the buffer and upstream of an impervious membrane filter.
  • Such a container has a complex structure, and the manufacturing cost of both the reservoir for containing the liquid to be dispensed and the dispensing head is high.
  • the dispensing head of this container is simple. It contains a filter membrane that aims to preserve the liquid pollutants that may be present in the ambient air. It is further planned to preserve the liquid rigorously ambient environment before first use.
  • the dispensing head is movably mounted on the neck of the container, for the perforation of a cap extemporaneously to a first delivery operation.
  • the present invention is part of this search for compromise, and aims to provide a container for the packaging of a liquid to be dispensed drop by drop which offers a solution to such a compromise.
  • the invention more specifically relates to the packaging of a sensitive liquid, such as a pharmaceutical, biological or similar solution, especially eye drops.
  • the inventive step of the present invention consisted in its generality, to first choose a container of the type comprising a wall tank with elastically reversible deformation by admission of air inside the container.
  • This choice is intended to allow a delivery of the liquid under the effect of a pressure exerted against this wall, and to allow a spontaneous return of the container to its initial conformation after delivery of a dose of liquid.
  • a tank with reversible deformation wall already has in itself the advantage of a large simplicity of manufacture, compared to tanks with irreversible deformation of the prior art, which require a number of parts and assembly operations important.
  • such a container will be recognized according to the present invention in that it is equipped with a dispensing head comprising a hollow body which is provided with a nozzle for delivering the liquid and which contains a microporous pad of hydrophobic material. placed downstream of the tank across the body of the dispensing head. Said body is irreversibly assembled inside the neck of the container.
  • the passage of air is authorized by suction through the hydrophobic microporous pad to the storage capacity after delivery of a dose of liquid, this suction being caused by the elastic return of the vessel wall to its initial conformation , return by which the container returns to its original shape notwithstanding a withdrawal of a dose of liquid.
  • microporous pad is preferably made of polyethylene, or similar material, which gives it a hydrophobic character so that it is not wettable, its microporous nature nevertheless allowing the passage of the liquid through it provided that the differential of pressure, induced by the pressure exerted by the user, is sufficient.
  • Such a configuration of the container according to the invention, and more particularly the combination between the reversible deformation tank, the microporous pad and the sealing cap, is quite advantageous. Indeed, when the cap is returned to the sealed sealing position of the nozzle, after the air suction following the delivery of a dose of liquid and the elastic return of the container wall to its initial conformation, it a pressure difference is created between the parts upstream and downstream of the buffer through which a pressure drop is created. This pressure difference prevents the liquid contained in the container from passing through the buffer, even if it is accidentally pressed on the wall of the container, and it seals the bottle, while protecting the liquid contained therein from external contaminations . In addition, such a configuration avoids stagnation of liquid downstream of the buffer, since the non-expelled liquid is sucked back to the capacity of the container.
  • the container according to the invention advantageously meets an objective of the invention, which is to ensure optimum use of the entire contents of the tank, and this in two different ways.
  • the container thanks to its elastically reversible deformation wall, the container retains a capacity to expel the intact liquid to the last drop of liquid. Indeed, because air is sucked into the container to replace each dose of liquid expelled, the expulsion pressure available in the bottle is always the same throughout the use, and until the distribution of the last drop.
  • there is no downstream of the buffer any drop of liquid likely to be contaminated by external agents, and should be eliminated before any new distribution of a clean dose.
  • the microporous buffer plays a role of flow regulator, which promotes the controlled distribution of liquid doses.
  • it prevents the liquid contained in the bottle from flowing when the cap is removed, even when the bottle is in the inverted position, the dispensing head being directed downwards, as long as no pressure is exerted on the wall of the container.
  • the dispensing head is preferably equipped with a filtering membrane intended to protect the liquid from an intake of pollutants present in the ambient air, bacteria especially.
  • a membrane that is at least partly hydrophilic and at least partly hydrophobic is then chosen, to alternatively allow the passage of liquid and air through it, and which is disposed in the dispensing head in upstream of the nozzle, between it and the buffer.
  • the partially hydrophilic nature of the membrane allows the liquid to pass therethrough under the effect of the compression exerted in the container by deformation of the wall, whereas its partially hydrophobic nature allows an entry of the outside air into the container. when the latter elastically resumes its initial shape after each compression exerted by the user.
  • the membrane furthermore advantageously constitutes an additional pressure drop, which ensures, in combination with the hydrophobic microporous pad, that no leakage of liquid from the container occurs until the wall of the container is compressed.
  • the invention In order to promote the passage of air through the membrane, the invention then provides that it is possible to maintain this dry membrane between two liquid deliveries, when the container is in a rested position on its base, thanks to the presence an intermediate chamber arranged in interposition between the microporous pad and the membrane.
  • Such an intermediate chamber can also be used to constitute a regulation chamber of the delivery of the liquid.
  • it can advantageously give it a sufficient volume to collect at least one drop of liquid to be dispensed during a liquid delivery operation to let it drop out of the dispensing head.
  • the volume of the intermediate chamber is also advantageously an air reserve which, when the nozzle is closed by the cap, retains a pressure which tends to prevent the liquid from passing through the microporous pad. It should be noted that in combination with the intermediate chamber, the character hydrophobic microporous buffer promotes an obstacle role opposing the passage of liquid through it.
  • the intermediate chamber is also advantageously a capacity to accommodate the liquid that has not yet passed through the membrane when it ceases to exert pressure on the wall of the container. For this, it is advantageous to ensure that the intermediate chamber extends over the entire surface of the membrane and that it is located at an axial distance from it sufficient to promote the drying of the membrane when the pressure exerted on the wall of the container ceases after delivery of liquid, and that the container is returned to its rest position, resting on its base and the dispensing head at the top. As a result, any residue of liquid which, having not been expelled, remains contained in the intermediate chamber, does not persist in wetting the membrane by capillarity. It will be noted that the hydrophobic nature of the microporous buffer also promotes the drying of the membrane.
  • the invention has the advantage, in industrial practice, to overcome the complex systems of dynamic closure that was used previously. Thanks to the provisions of the invention, there is no need for a lid or other tear-off partition, or a valve of other shape, or a procedure for opening the bottle by translation or rotation of the dispensing head with respect to the liquid reservoir container to be dispensed drop by drop.
  • a microporous pad quite suitable for the purposes of the invention has, for the passage of the liquid in the longitudinal direction, microchannels whose average pore diameter is between 0.3 and 10 microns.
  • Such a range of values is particularly particularly suitable in the preferred field of application of the invention, which is the storage and distribution of a pharmaceutical solution, especially eye drops.
  • microporous buffer with a partially hydrophilic and partially hydrophobic membrane whose pore diameter is smaller than that of the buffer, in particular between 0.1 and 0.2 microns. This results in particular sealing properties and flow control of the improved dispensing head.
  • the membrane may be made of a polymeric material, based for example on polyamide resin or polyether sulfone, which gives it a hydrophilic character. It is then rendered partially hydrophobic by modifying its structure on part of its surface. Such a modification can be carried out in a conventional manner in itself, for example by grafting in the presence of an initiator of radical reactions. The treatment is advantageously carried out so as to render the membrane hydrophobic on a median strip occupying 20 to 50% of its surface which is wetted during the expulsion of the liquid.
  • the body is assembled inside the neck by interlocking in close contact.
  • the body is preferably elastically deformable for its introduction into force inside the neck of the container, a centering element being preferentially arranged at the base of the body to facilitate such an introduction. strength.
  • This centering member is preferably constituted by radial junction wings by interlocking the body of the dispensing head on the neck of the container, the flanges delimiting between them recessed areas.
  • the outer surface of the body of the dispensing head is advantageously equipped with a peripheral ring from said body with which it constitutes a unitary assembly, this ring being preferably in plurality and axially repeated on the body.
  • the body is advantageously obtained by molding, under conditions such that a rod, issuing from the joint plane, is radial to its general axis of extension, and in particular if appropriate parallel to the aforementioned peripheral ring.
  • This ring resulting from the joint plane is more particularly located at the distal end of the body, at the junction limit of the centering member, to promote the best seal between the dispensing head and the container.
  • the removable cap meanwhile is preferentially reported on the container by screwing to promote the clamping of the cap on the dispensing head, and therefore the seal between these bodies.
  • the cap advantageously comprises a combination of sealing members associating a picot penetrating inside the nozzle of the dispensing head and a skirt covering this nozzle.
  • the pin and the skirt are advantageously derived from the cap, when obtaining the latter in one piece, particularly by molding.
  • a container for the conditioning of a liquid 1 is of spontaneously reversible deformation, to allow a distribution of the liquid 1 from a manual compression exerted by a user of its wall 2 and spontaneous return to its initial form by admission of 'air.
  • This container has a liquid storage capacity 1, and is equipped with a dispensing head 3 of the liquid drop by drop.
  • This dispensing head 3 consists mainly of a hollow body 4 provided with a nozzle 5, and a removable cap 6 for closing off the nozzle 5.
  • An antibacterial, partially hydrophilic and partially hydrophobic filter membrane 7, therefore permeable to air but also to the liquid, is disposed upstream of the nozzle 5, to protect the liquid against an unwanted introduction of pollutants possibly present in the ambient air, including bacteria.
  • the body 4 of the dispensing head 3 houses in its inner recess a microporous pad 8 which is made of a hydrophobic material, especially polyethylene, to prevent the passage of the liquid 1 to the nozzle 5, in the absence of compression on the wall 2 of the container.
  • This microporous buffer 8 is disposed upstream and away from the membrane 7, so as to provide between itself 8 and the latter 7 an intermediate chamber 9.
  • the chamber 9 extends over the entire surface of the pad so as to constitute a reserve of air which exerts, when the nozzle 5 is closed by the cap 6, a pressure on the entire surface of the pad 8 preventing the liquid 1 to pass through the microporous pad 8 when the nozzle 5 is closed by the cap 6. More specifically, the cap 6 prevents an evacuation of air out of the container, and more particularly out of the intermediate chamber 9. The air being confined downstream of the microporous pad 8, the latter obstructs the passage of the liquid 1 through it as long as the nozzle 5 is closed by the cap 6. Conversely for delivery of the liquid 1, the microporous pad 8 does not prevent this. delivery as the air can be discharged out of the container through the nozzle 5.
  • the intermediate chamber 9 is used to allow spontaneous regularization the flow of the liquid 1 passing through the microporous pad 8, prior to its distribution through the nozzle 5.
  • the intermediate chamber 9 extends over the entire surface of the membrane so as to constitute a capacity to collect the liquid 1 away from the membrane 7 when it stops exerting pressure on the wall 2 of the container and thus to favor the drying of the membrane between two liquid deliveries.
  • the body 4 is assembled permanently inside the neck 10 of the container, by interlocking force. According to the various variants illustrated on the figure 1 and the figure 2 this interlocking is achieved either directly by close contact between the outer surfaces of the body 4 and the inside of the neck 10, as illustrated in FIG. figure 1 , and preferably via O-rings 11 formed at the periphery of the body 4, as illustrated in FIG. figure 2 .
  • a centering member 12 formed at the base of the body 4 to facilitate its introduction into the neck 10 of the container.
  • the centering member 12 illustrated for example consists generally of radial junction wings 13 by interlocking the body 4 on the neck 10, the wings 13 delimiting between them recessed areas, more particularly visible on the figure 3 .
  • the variants shown illustrate the assembly by screwing the cap 6 on the neck 10 of the container, through cooperating reliefs 14.
  • the cap 6 comprises a pin 15 penetrating inside the nozzle 5 of the dispensing head and a skirt 16 styling the nozzle.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Closures For Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
EP18183420.1A 2004-06-24 2005-06-24 Behälter für die verpackung einer flüssigkeit mit tropfenspender mit umkehrbarer deformation durch lufteinlass Active EP3412590B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI200532298T SI3412590T1 (sl) 2004-06-24 2005-06-24 Posoda za shranjevanje razpršila za tekočine, povratno deformirana z vstopom zraka
PL18183420T PL3412590T3 (pl) 2004-06-24 2005-06-24 Pojemnik do pakowania cieczy do dozownika, dozującego kropla po kropli, odkształcalny odwracalnie w wyniku dopływu powietrza

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0407042A FR2872137B1 (fr) 2004-06-24 2004-06-24 Recipient pour le conditionnement d'un liquide a distributeur goutte a goutte, a deformation reversible par admission d'air
EP05756044.3A EP1765513B1 (de) 2004-06-24 2005-06-24 Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit
PCT/IB2005/001791 WO2006000897A1 (fr) 2004-06-24 2005-06-24 Recipient pour le conditionnement d’un liquide a distribuer goutte a goutte, a deformation reversible par admission d’air

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP05756044.3A Division EP1765513B1 (de) 2004-06-24 2005-06-24 Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit
EP05756044.3A Division-Into EP1765513B1 (de) 2004-06-24 2005-06-24 Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit

Publications (2)

Publication Number Publication Date
EP3412590A1 true EP3412590A1 (de) 2018-12-12
EP3412590B1 EP3412590B1 (de) 2021-08-04

Family

ID=34949309

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18183420.1A Active EP3412590B1 (de) 2004-06-24 2005-06-24 Behälter für die verpackung einer flüssigkeit mit tropfenspender mit umkehrbarer deformation durch lufteinlass
EP05756044.3A Active EP1765513B1 (de) 2004-06-24 2005-06-24 Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP05756044.3A Active EP1765513B1 (de) 2004-06-24 2005-06-24 Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit

Country Status (27)

Country Link
US (1) US7971755B2 (de)
EP (2) EP3412590B1 (de)
JP (2) JP5080972B2 (de)
KR (1) KR100919520B1 (de)
CN (1) CN100475359C (de)
AR (1) AR051064A1 (de)
BR (1) BRPI0512387B8 (de)
CA (1) CA2572048C (de)
CY (2) CY1120837T1 (de)
DK (2) DK3412590T3 (de)
ES (2) ES2691721T3 (de)
FR (1) FR2872137B1 (de)
HK (1) HK1104253A1 (de)
HU (2) HUE056784T2 (de)
LT (2) LT1765513T (de)
MA (1) MA28671B1 (de)
MX (1) MXPA06014657A (de)
MY (1) MY164320A (de)
NO (1) NO343517B1 (de)
PL (2) PL3412590T3 (de)
PT (2) PT1765513T (de)
RU (1) RU2385774C2 (de)
SI (2) SI3412590T1 (de)
TN (1) TNSN06415A1 (de)
TR (1) TR201815132T4 (de)
WO (1) WO2006000897A1 (de)
ZA (1) ZA200700248B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2897599B1 (fr) * 2006-02-23 2010-08-27 Rexam Pharma Ensemble de conditionnement et de distribution de liquide.
FR2908043B1 (fr) * 2006-11-03 2009-01-23 Prevor Internat Sarl Dispositif portable individuel pour bain d'oeil
DE102008027146B4 (de) * 2008-06-02 2012-01-19 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
JP5224915B2 (ja) * 2008-06-03 2013-07-03 大成化工株式会社 フィルター付き吐出容器
FR2934572A1 (fr) * 2008-07-31 2010-02-05 Thea Lab Embout pour flacon de conditionnement de liquide a distribuer goutte a goutte.
FR2937018B1 (fr) * 2008-10-15 2012-06-01 Rexam Pharma La Verpilliere Dispositif de distribution de liquide muni d'un organe d'etancheite deplacable sous l'effet de la pression d'un utilisateur
SE533241C2 (sv) * 2009-10-22 2010-07-27 Mahbobeh-Taghinejad Sadabadi Doseringsanordning
FR2952040B1 (fr) 2009-10-29 2011-12-30 Rexam Pharma La Verpilliere Dispositif de distribution de liquide sous forme de gouttes
FR2955842B1 (fr) * 2010-02-04 2012-03-16 Thea Lab Flacon de conditionnement d'un liquide a tete de distribution goutte a goutte
FR2963329B1 (fr) * 2010-07-30 2013-06-28 Thea Lab Tete de distribution d'un liquide goutte a goutte
FR2974742B1 (fr) * 2011-05-04 2013-05-03 Rexam Healthcare La Verpillier Dispositif de distribution de liquide muni d'un canal de passage d'air
EP2739402B1 (de) 2011-08-01 2015-07-22 Colgate-Palmolive Company Ausgabebehälter mit verbessertem erscheinungsbild
FR2994162B1 (fr) * 2012-08-06 2014-09-05 Thea Lab Tete de distribution de liquide, notamment pour flacon de conditionnement d'un liquide a distribuer goutte a goutte
US9296525B2 (en) 2012-12-03 2016-03-29 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
US9096352B2 (en) 2012-12-03 2015-08-04 RLM Group Ltd. Enhanced dispensing and dosaging techniques for fluid containers
WO2015061632A2 (en) * 2013-10-23 2015-04-30 O'connell John F Antimicrobial compositions and articles
CN104097843B (zh) * 2014-07-28 2016-08-24 武汉五景药业有限公司 一种除菌过滤型瓶盖
WO2016156897A1 (fr) 2015-03-31 2016-10-06 Laboratoires Thea Dispositif de distribution de liquide hors d'un flacon de conditionnement sterile a membrane bi-fonctionnelle
FR3035080B1 (fr) * 2015-04-17 2019-08-09 Centre Hospitalier Universitaire D'amiens-Picardie Dispositif de bouchage pour permettre un prelevement d'une composition ensemble de conditionnement comprenant un tel dispositif de bouchage, procedes de prelevement et de conditionnement
CN105197383A (zh) * 2015-10-17 2015-12-30 李红彪 外挂式可吸可挤嘴
JP6763873B2 (ja) * 2015-11-05 2020-09-30 栄研化学株式会社 フィルタ付き注出部材
KR101968708B1 (ko) * 2016-02-12 2019-04-12 가부시키가이샤 도쿠에 휴대용 용기
EP3323753B1 (de) * 2016-11-17 2019-08-07 Aptar Radolfzell GmbH Austragkopf und flüssigkeitsspender mit einem solchen austragkopf
WO2018119066A1 (en) * 2016-12-21 2018-06-28 Stoneridge Kitchen & Bath Llc Glue gun
KR20190033359A (ko) * 2017-09-21 2019-03-29 주식회사 아이팩 튜브 용기 내의 액상 내용물을 방울 형태로 배출시키는 배출장치
US10788263B1 (en) * 2018-02-17 2020-09-29 Clearman Labs, LLC Drying, space-saving soap bar container methods, systems, and devices
CN108357805B (zh) * 2018-03-27 2023-05-12 郭思治 一种能够调节给药量的眼药水药瓶的使用方法
CN208264912U (zh) * 2018-03-28 2018-12-21 深圳市通产丽星股份有限公司 一种点滴软管
FR3080843B1 (fr) * 2018-05-07 2020-05-29 Horus Pharma Dispositif de conditionnement et distribution d'un produit ayant un embout doseur a extremite exterieurement propre
FR3080844B1 (fr) * 2018-05-07 2020-06-05 Horus Pharma Dispositif de conditionnement et distribution d'un produit avec flacon et embout doseur muni d'un filtre
GB201809627D0 (en) * 2018-06-12 2018-07-25 Biorelevant Com Ltd Methods for preparing buffer solutions suitable for in vitro drug dissolution testing, drug solubility testing and/or drug profiling
CN109620720A (zh) * 2018-12-29 2019-04-16 上海千盈实业有限公司 一种输液包装盖及其生产方法
US11618612B2 (en) 2019-02-27 2023-04-04 Container Packaging Systems, LLC Vented pour spout
US10723526B1 (en) * 2019-03-29 2020-07-28 Chubby Gorilla, Inc. Bottle and cap arrangement
CN110314804B (zh) * 2019-08-16 2021-08-24 台州锐祥机械设备有限公司 多晶硅片凝固装置
JP6976469B1 (ja) * 2021-04-26 2021-12-08 さち子 松山 目薬容器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0500249A1 (de) * 1991-02-19 1992-08-26 Pilkington Barnes Hind, Inc. Spender
US5249712A (en) * 1988-10-28 1993-10-05 Transphyto S.A. Packaging for altering the composition of a liquid
US6336571B1 (en) * 1997-11-04 2002-01-08 Laboratoires Thea S.A. Device for packaging a liquid to be dispensed drop by drop
US20040074925A1 (en) * 2000-11-13 2004-04-22 Michel Faurie Drip liquid dispenser

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149758A (en) * 1961-11-01 1964-09-22 Millipore Filter Corp Combination filter and flow divider for gas and liquid
US3189223A (en) * 1964-05-18 1965-06-15 Halkey Roberts Corp Liquid dispensing device
JPS62127063A (ja) * 1985-11-27 1987-06-09 ト−メ−産業株式会社 点眼容器
JPH063808Y2 (ja) * 1985-11-27 1994-02-02 ト−メ−産業株式会社 点眼用二次汚染防止キャップ
US4948505A (en) * 1986-01-27 1990-08-14 Cuno, Inc. Quick-change filter cartridge and head therefor
US5320254A (en) * 1988-10-07 1994-06-14 Ryder International Corp. Liquid dispenser nozzle assembly
US4938389A (en) * 1988-11-03 1990-07-03 Eye Research Institute Of Retina Foundation Filter bottle
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
FR2661401B1 (fr) * 1990-04-27 1992-07-24 Transphyto Sa Procede de conditionnement pour conserver et distribuer par portions du liquide sterile.
US5074440A (en) * 1990-07-16 1991-12-24 Alcon Laboratories, Inc. Container for dispensing preservative-free preparations
DE4027539A1 (de) * 1990-08-31 1992-03-05 Kautex Werke Gmbh Quetschflasche mit innenbeutel
JPH0478161U (de) * 1990-11-20 1992-07-08
US5310094A (en) * 1991-11-15 1994-05-10 Jsp Partners, L.P. Preservative free sterile fluid dispensing system
EP0631770B1 (de) * 1993-06-25 1998-07-22 Alcon Cusi, S.A. Neue Verwendung von polymeren Membranen zum Ausgeben von pharmazeutischen Lösungen, die quarternäre, als Konserviermittel dienende Ammoniumverbindungen enthalten und entsprechender Dosierbehälter
US5490938A (en) * 1993-12-20 1996-02-13 Biopolymerix, Inc. Liquid dispenser for sterile solutions
FR2729924B1 (fr) * 1995-02-01 1997-04-11 Kerplas Snc Flacon de distribution de produit
US5611464A (en) * 1995-05-30 1997-03-18 Ciba Geigy Corporation Container for preserving media in the tip of a solution dispenser
US5680969A (en) * 1995-12-18 1997-10-28 Aptargroup, Inc. Closure with dispensing valve and separate releasable internal shipping seal
US5676289A (en) * 1996-04-04 1997-10-14 Aptargroup, Inc. Valve-controlled dispensing closure with dispersion baffle
FR2761665B1 (fr) * 1997-04-02 1999-06-25 Sofab Dispositif pour la distribution et le conditionnement de produits liquides steriles
FR2769595B1 (fr) * 1997-10-10 1999-11-19 Oreal Tete de distribution a reprise d'air amelioree, et ensemble de conditionnement et de distribution equipe d'une telle tete
US7186045B2 (en) * 2000-02-16 2007-03-06 L'oreal S.A. Device and method for applying a cosmetic product
US6290108B1 (en) * 2000-04-14 2001-09-18 Seaquist Closures Foreign, Inc. Dispensing system with an internal releasable shipping seal and an extended tip containing a pressure openable valve
JP4580524B2 (ja) * 2000-09-12 2010-11-17 株式会社日本点眼薬研究所 フィルター付き吐出容器
JP4749572B2 (ja) * 2001-03-13 2011-08-17 大成化工株式会社 分与容器の口栓構造
JP4047617B2 (ja) * 2002-04-04 2008-02-13 ニプロ株式会社 薬液容器
US7427355B2 (en) * 2004-05-14 2008-09-23 Yiu Chau Chau Water treatment unit for bottle or pitcher

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5249712A (en) * 1988-10-28 1993-10-05 Transphyto S.A. Packaging for altering the composition of a liquid
EP0500249A1 (de) * 1991-02-19 1992-08-26 Pilkington Barnes Hind, Inc. Spender
US6336571B1 (en) * 1997-11-04 2002-01-08 Laboratoires Thea S.A. Device for packaging a liquid to be dispensed drop by drop
US20040074925A1 (en) * 2000-11-13 2004-04-22 Michel Faurie Drip liquid dispenser

Also Published As

Publication number Publication date
BRPI0512387B1 (pt) 2018-11-06
TR201815132T4 (tr) 2018-11-21
BRPI0512387B8 (pt) 2019-01-15
RU2385774C2 (ru) 2010-04-10
EP3412590B1 (de) 2021-08-04
EP1765513B1 (de) 2018-08-22
JP5080972B2 (ja) 2012-11-21
AR051064A1 (es) 2006-12-20
HUE039799T2 (hu) 2019-02-28
US7971755B2 (en) 2011-07-05
MA28671B1 (fr) 2007-06-01
MY164320A (en) 2017-12-15
MXPA06014657A (es) 2007-02-12
LT1765513T (lt) 2018-11-12
RU2007101567A (ru) 2008-07-27
HUE056784T2 (hu) 2022-03-28
HK1104253A1 (en) 2008-01-11
WO2006000897A1 (fr) 2006-01-05
FR2872137B1 (fr) 2009-01-23
PL1765513T3 (pl) 2019-01-31
LT3412590T (lt) 2021-11-10
DK3412590T3 (da) 2021-10-11
ES2891874T3 (es) 2022-01-31
KR100919520B1 (ko) 2009-09-28
CA2572048A1 (fr) 2006-01-05
BRPI0512387A (pt) 2008-03-11
JP2008503410A (ja) 2008-02-07
SI1765513T1 (sl) 2018-12-31
NO20070474L (no) 2007-03-26
TNSN06415A1 (fr) 2008-02-22
SI3412590T1 (sl) 2022-01-31
KR20070027738A (ko) 2007-03-09
FR2872137A1 (fr) 2005-12-30
NO343517B1 (no) 2019-04-01
ZA200700248B (en) 2008-05-28
PT1765513T (pt) 2018-11-20
CA2572048C (fr) 2011-01-04
US20080067194A1 (en) 2008-03-20
JP5307916B2 (ja) 2013-10-02
DK1765513T3 (en) 2018-11-26
CY1120837T1 (el) 2019-12-11
PT3412590T (pt) 2021-09-29
JP2012210979A (ja) 2012-11-01
CN1972755A (zh) 2007-05-30
PL3412590T3 (pl) 2022-01-24
ES2691721T3 (es) 2018-11-28
CY1124636T1 (el) 2022-07-22
CN100475359C (zh) 2009-04-08
EP1765513A1 (de) 2007-03-28

Similar Documents

Publication Publication Date Title
EP1765513B1 (de) Durch luftzuführung umgekehrt verformter behälter zur verpackung einer in tropfen abzugebenden flüssigkeit
EP0721573B1 (de) Dosiergerät zur abgabe von konstanten einheitlichen dosen
EP1048590B1 (de) Ventilbetätigungsvorrichtung und Einrichtung mit einer solchen Vorrichtung
EP1288142B1 (de) Einheit zur Aufbewahrung und Ausgabe eines unter Druck stehenden Produktes
EP2511196B1 (de) Abgabevorrichtung für ein flüssiges Produkt, die ein Füllventil umfasst
EP1572375B1 (de) Manuell betätigte dosierpumpe
FR2674747A1 (fr) Dispositif distributeur de gouttes de petit volume, notamment pour soins ophtalmologiques.
FR2749833A1 (fr) Recipient de distribution de produits
EP1312561A2 (de) Verpackungsvorrichtung, insbesondere für kosmetische Produkte
EP3999245A1 (de) Vorrichtung zum verschliessen eines behälters eines flüssigen bis pastösen produkts und mit einer solchen vorrichtung verschlossene nachfüllpackung
EP2879966A1 (de) Flüssigkeitsausgabekopf, im besonderen für eine flasche zum verpacken einer flüssigkeit mit tropfenspender
EP0960829B1 (de) Ventil sowie Aufbewahrungs- und Ausgabevorrichtung mit einem solchen Ventil
EP3206968B1 (de) Vorrichtung zur ausgabe eines kosmetischen produktes in aerosolform, zugehörige anordnung und verfahren
WO2017051127A1 (fr) Valve pour embout a obturateur
EP1789338A1 (de) Kappe für einen kopf zur abgabe von fluidprodukten
EP4061767B1 (de) Ausgusstülle für flüssigkeitsbehälter
WO2017202958A1 (fr) Embout de récipient de liquide destiné à s'adapter sur un embout de réservoir
FR3019476A1 (fr) Flacon distributeur de fluide
WO2014166933A1 (fr) Dispositif de conditionnement pour produit cosmétique, notamment pour produit cosmétique dégazant
FR2947431A3 (fr) Structure de contenant cosmetique de type a bille
FR2841538A1 (fr) Ensemble de conditionnement et de distribution d'un produit

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 1765513

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: HR LV YU

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20190419

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20190927

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602005057279

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: B65D0047180000

Ipc: B65D0001320000

RIC1 Information provided on ipc code assigned before grant

Ipc: B65D 1/32 20060101AFI20201028BHEP

Ipc: B65D 47/18 20060101ALI20201028BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20210126

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 1765513

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1416773

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210815

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602005057279

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REG Reference to a national code

Ref country code: RO

Ref legal event code: EPE

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 3412590

Country of ref document: PT

Date of ref document: 20210929

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20210923

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20211004

REG Reference to a national code

Ref country code: FI

Ref legal event code: FGE

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: EE

Ref legal event code: FG4A

Ref document number: E021365

Country of ref document: EE

Effective date: 20210930

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20210402795

Country of ref document: GR

Effective date: 20211111

REG Reference to a national code

Ref country code: SK

Ref legal event code: T3

Ref document number: E 38440

Country of ref document: SK

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2891874

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20220131

REG Reference to a national code

Ref country code: HU

Ref legal event code: AG4A

Ref document number: E056784

Country of ref document: HU

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602005057279

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20220506

REG Reference to a national code

Ref country code: AT

Ref legal event code: UEP

Ref document number: 1416773

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210804

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230512

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: RO

Payment date: 20230526

Year of fee payment: 19

Ref country code: PT

Payment date: 20230517

Year of fee payment: 19

Ref country code: NL

Payment date: 20230627

Year of fee payment: 19

Ref country code: MC

Payment date: 20230628

Year of fee payment: 19

Ref country code: LT

Payment date: 20230523

Year of fee payment: 19

Ref country code: IE

Payment date: 20230627

Year of fee payment: 19

Ref country code: FR

Payment date: 20230628

Year of fee payment: 19

Ref country code: EE

Payment date: 20230523

Year of fee payment: 19

Ref country code: DK

Payment date: 20230531

Year of fee payment: 19

Ref country code: DE

Payment date: 20230627

Year of fee payment: 19

Ref country code: CZ

Payment date: 20230524

Year of fee payment: 19

Ref country code: BG

Payment date: 20230530

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20230608

Year of fee payment: 19

Ref country code: SK

Payment date: 20230518

Year of fee payment: 19

Ref country code: SI

Payment date: 20230522

Year of fee payment: 19

Ref country code: SE

Payment date: 20230629

Year of fee payment: 19

Ref country code: PL

Payment date: 20230530

Year of fee payment: 19

Ref country code: LU

Payment date: 20230627

Year of fee payment: 19

Ref country code: IS

Payment date: 20230517

Year of fee payment: 19

Ref country code: HU

Payment date: 20230525

Year of fee payment: 19

Ref country code: GR

Payment date: 20230524

Year of fee payment: 19

Ref country code: FI

Payment date: 20230522

Year of fee payment: 19

Ref country code: AT

Payment date: 20230627

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20230627

Year of fee payment: 19

Ref country code: GB

Payment date: 20230711

Year of fee payment: 19

Ref country code: ES

Payment date: 20230727

Year of fee payment: 19

Ref country code: CY

Payment date: 20230517

Year of fee payment: 19

Ref country code: CH

Payment date: 20230702

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20230626

Year of fee payment: 19