EP3395811A4 - Kristalle eines chinazolinderivats und herstellungsverfahren dafür - Google Patents

Kristalle eines chinazolinderivats und herstellungsverfahren dafür Download PDF

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Publication number
EP3395811A4
EP3395811A4 EP16877796.9A EP16877796A EP3395811A4 EP 3395811 A4 EP3395811 A4 EP 3395811A4 EP 16877796 A EP16877796 A EP 16877796A EP 3395811 A4 EP3395811 A4 EP 3395811A4
Authority
EP
European Patent Office
Prior art keywords
crystals
preparation
method therefor
quinazoline derivative
quinazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16877796.9A
Other languages
English (en)
French (fr)
Other versions
EP3395811B1 (de
EP3395811A1 (de
Inventor
Chutian Shu
Jinyuan Wang
Zhenhua Wang
Yuzhen FENG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong Xuanzhu Pharma Co Ltd
Original Assignee
Xuanzhu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xuanzhu Pharma Co Ltd filed Critical Xuanzhu Pharma Co Ltd
Publication of EP3395811A1 publication Critical patent/EP3395811A1/de
Publication of EP3395811A4 publication Critical patent/EP3395811A4/de
Application granted granted Critical
Publication of EP3395811B1 publication Critical patent/EP3395811B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP16877796.9A 2015-12-25 2016-12-23 Kristalle eines chinazolinderivats und herstellungsverfahren dafür Active EP3395811B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201510999109 2015-12-25
CN201510997569 2015-12-25
CN201510999065 2015-12-25
PCT/CN2016/111774 WO2017107986A1 (zh) 2015-12-25 2016-12-23 喹唑啉衍生物的晶体及其制备方法

Publications (3)

Publication Number Publication Date
EP3395811A1 EP3395811A1 (de) 2018-10-31
EP3395811A4 true EP3395811A4 (de) 2019-06-26
EP3395811B1 EP3395811B1 (de) 2020-05-13

Family

ID=59089149

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16877796.9A Active EP3395811B1 (de) 2015-12-25 2016-12-23 Kristalle eines chinazolinderivats und herstellungsverfahren dafür

Country Status (6)

Country Link
US (1) US10689359B2 (de)
EP (1) EP3395811B1 (de)
JP (1) JP6674027B2 (de)
CN (1) CN108430990B (de)
HK (1) HK1252375A1 (de)
WO (1) WO2017107986A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200143361A (ko) * 2018-02-08 2020-12-23 뉴파마, 인크. 특정 화학 물질, 조성물, 및 방법
EP3858830B1 (de) * 2018-09-27 2022-11-16 Shanghai Yingli Pharmaceutical Co. Ltd. Kristallform der morpholino-chinazolinverbindung, verfahren zu ihrer herstellung und ihre verwendung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3395810A1 (de) * 2015-12-25 2018-10-31 Xuanzhu Pharma Co., Ltd. Kristalle eines chinazolinderivats und herstellungsverfahren dafür

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031971A1 (de) * 2000-06-30 2002-01-10 Goedecke Ag Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung
DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
CN102382106A (zh) 2010-08-30 2012-03-21 黄振华 苯胺取代的喹唑啉衍生物
CN102382065B (zh) 2010-08-30 2014-05-28 山东轩竹医药科技有限公司 苯胺取代的喹唑啉衍生物
JP5808818B2 (ja) 2010-11-25 2015-11-10 ラツィオファーム・ゲーエムベーハー アファチニブの新規塩及び多形形態
EP2716633B1 (de) * 2011-05-26 2017-05-17 Xuanzhu Pharma Co., Ltd. Chinazolinderivat als tyrosinkinasehemmer, verfahren zu seiner herstellung und seine anwendung
CN103965119B (zh) * 2013-02-02 2016-07-06 通化济达医药有限公司 含有锌结合基的不可逆egfr酪氨酸激酶抑制剂

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3395810A1 (de) * 2015-12-25 2018-10-31 Xuanzhu Pharma Co., Ltd. Kristalle eines chinazolinderivats und herstellungsverfahren dafür

Also Published As

Publication number Publication date
HK1252375A1 (zh) 2019-05-24
WO2017107986A1 (zh) 2017-06-29
JP2018538348A (ja) 2018-12-27
EP3395811B1 (de) 2020-05-13
CN108430990A (zh) 2018-08-21
EP3395811A1 (de) 2018-10-31
US10689359B2 (en) 2020-06-23
JP6674027B2 (ja) 2020-04-01
US20190002434A1 (en) 2019-01-03
CN108430990B (zh) 2020-08-25

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