EP3361942A1 - Procédé et appareil pour l'enregistrement continu d'un électrocardiogramme - Google Patents

Procédé et appareil pour l'enregistrement continu d'un électrocardiogramme

Info

Publication number
EP3361942A1
EP3361942A1 EP16801305.0A EP16801305A EP3361942A1 EP 3361942 A1 EP3361942 A1 EP 3361942A1 EP 16801305 A EP16801305 A EP 16801305A EP 3361942 A1 EP3361942 A1 EP 3361942A1
Authority
EP
European Patent Office
Prior art keywords
band
electrodes
electronic circuit
patient
lateral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16801305.0A
Other languages
German (de)
English (en)
Inventor
Pietro Rossi
Giancarlo Monari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miocardio Srl
Original Assignee
Miocardio Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITUB2015A004646A external-priority patent/ITUB20154646A1/it
Priority claimed from ITUB2015A004645A external-priority patent/ITUB20154645A1/it
Application filed by Miocardio Srl filed Critical Miocardio Srl
Publication of EP3361942A1 publication Critical patent/EP3361942A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6831Straps, bands or harnesses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • A61B5/271Arrangements of electrodes with cords, cables or leads, e.g. single leads or patient cord assemblies
    • A61B5/273Connection of cords, cables or leads to electrodes
    • A61B5/274Connection of cords, cables or leads to electrodes using snap or button fasteners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30Input circuits therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6823Trunk, e.g., chest, back, abdomen, hip

Definitions

  • the present invention relates to the production of electro-medical devices, in the specific case diagnostic devices, and in particular refers to a method and apparatus for the continuous acquisition of an electrocardiogram (ECG), the latter including a detecting device, composed of a band and an amplification circuit with attenuation of the interferences caused by the thermal shift.
  • ECG electrocardiogram
  • arrhythmias tachyarrhythmias and bradyarrhythmias
  • the apparatus allows recording all the heartbeats during 24 hours in all various situations of everyday life. This allows recording the whole heart activity and a correlation thereof with possible symptoms reported by the patient.
  • the obtained recording is processed and visualized on a monitor or printed, thus allowing to study a possible alteration of the heartbeat or the presence of symptoms of ischemic heart disease, that is possible conditions which can be referred to the symptoms reported by the patient.
  • the Holter recorders have been greatly improved, however, the present systems suffer from troubles which make the detected cardiographic signals difficult to read and interpret.
  • the known devices just because of their constructive configuration, involve also the risk of very probable recording of unrelated signals, generated especially during the movement.
  • the most common thermal noise is produced in any real dissipating system, at a temperature different from the absolute zero.
  • the noise moves according to the relation 1 /f, where f is the frequency, in practice indirectly proportional to the frequency.
  • the representation of the thermal noise is statistically composed of a Gaussian curve, having null average value, which derives, according to the central limit theorem, from the "infinite" independent basic contributions of the single particles moved by the thermal agitation.
  • the electric thermal noise can be noticed by detecting that across a resistor, to which no voltage is applied, a noise voltage variable over time is present, depending on the temperature T: v n ( t ) .
  • this noise voltage that obviously produces a direct current i n i t ⁇ — v n (i) /H across an open circuit resistor, can be statistically calculated as RMS value according to the following equation:
  • T is the temperature in Kelvin degrees
  • ⁇ f is the observation frequency band.
  • the maximum noise power that a resistor can supply (that is the power supplied in conditions of adapted load) does not depend on the resistance, but only on the temperature, as the Nyquist formula describes: In practice, the thermal noise makes the signal fluctuate as in figure 3.
  • Another source of interference derives from the fact that the signal to be amplified has a very low level and the transducer, in this case constituted by each of the adhesive electrodes, is not very distant from the amplifier.
  • shielded cables are used, which however are capable of filtering the radio frequency interferences, but they can do very little against the low frequency interferences.
  • the parasitic resistance and capacitances produced by the cables contribute to the increase of the interferences, inducing voltages that propagate with not negligible phase difference up to the terminals of the amplifier.
  • a method for overcoming this problem includes the application of an auxiliary voltage Vco / w to the shielding sheath of the cables.
  • this technique does not eliminate the interferences, but prevents the cable from displacing them out of phase.
  • a counter-reaction is applied so as to minimise the interference.
  • This technique is used for example in the medical field in the observation of the electrocardiogram, as shown in figure 5.
  • FIG. 6 A typical electrical diagram of an ECG with reference to the right leg to reduce the interferences caused by thermal shift, is shown in figure 6.
  • the VR is buffered, inverted and sent to the reference electrode for the active drive.
  • the object of the 100 ⁇ final resistance is to keep the current circulating on the patient within the limits provided by the regulations, which must be less than 10 ⁇ .
  • the object of the present invention is to overcome the above mentioned undesirable problems in order to record a signal of better quality, reducing noises, interferences and electrical shifts.
  • Another object of the invention is to propose an apparatus so configured as to obtain a substantial improvement of the quality of the detected signal, without illegible pieces referred to conditions and situations in which the check of the cardiac activity is of vital importance for the correct diagnosis and an effective prevention.
  • a further object of the invention is to propose a recording apparatus which is comfortable for the person who wears it and is easy to install.
  • a further object of the invention is to propose an apparatus which adapts perfectly and stably to the user's anatomy.
  • a still further object of the invention is to propose the above mentioned system obtained by means of a solution which is as simple as possible and whose production and subsequent implementation do not require high costs.
  • a method and apparatus for the continuous acquisition of an electrocardiogram including a band adapted to wrap the chest of a patient and a unit for collecting the signals corresponding to the heart electric activity, provided in the band.
  • An amplifier electronic circuit and a plurality of electrodes are provided inside the collecting unit, placed in the band at as many terminals touching the skin, adapted to be applied to the patient's chest for detecting the heart electrical activity and connected to the unit for collecting signals.
  • the contact terminals include aligned lateral terminals and a central reference terminal, which is not aligned with the lateral terminals; the central reference contact terminal is connected to the amplifier electronic circuit at the last stage of the amplifier, in such a way that the difference between the signal detected by the reference electrode, situated on the central terminal and the electrical signal detected by the other lateral electrodes situated on the lateral terminals reduces substantially the thermal shift to obtain more readable and interpretable ECG traces, thus facilitating the arrhythmologic diagnosis.
  • figure 1 and figure 2 illustrate a band type apparatus for the continuous acquisition of an electrocardiogram, which integrates the present invention, seen from the side and from the opposite side, respectively;
  • figure 3 illustrates a representation of the detected electrical signal disturbed by the thermal noise;
  • figure 4 and figure 5 illustrate simplified representations for the correction of the disturbed signal according to the prior art
  • figure 6 shows a typical electrical diagram of the ECG recorder, with the configuration adapted to reduce the interferences caused by the thermal shift according to the prior art
  • figure 7 shows the simplified diagram of the additional configuration of the electronic circuit according to the invention which allows to limit the interference caused by thermal shift, when applied in an apparatus for
  • figure 8 illustrates the simplified diagram of the electronic circuit which implements the method proposed by the present invention and comprises the additional layout of figure 6;
  • figure 9 is a perspective view of a different and preferred embodiment of the apparatus for the continuous acquisition of an electrocardiogram, proposed by the invention.
  • figure 10 is a top view of the apparatus of figure 9;
  • figure 10 is a front view of the apparatus of figure 9, which shows the inner part of the band.
  • reference numeral 1 indicates a band of an apparatus for continuous and prolonged acquisition of an electrocardiogram (ECG) developed by the Applicant and proposed by the present invention.
  • ECG electrocardiogram
  • the band 1 is adapted to wrap the patient's chest and is kept close by connecting means consisting of a portion of Velcro 10 (figure 2) adapted to adhere to the opposite end of the band 1 .
  • the band 1 includes a first portion A of an inelastic material and a second portion E of an elastic material.
  • the band 1 can be made of fabric or in a single structure of a synthetic or rubber plastic material, without excluding the use of other suitable materials.
  • Velcro other known ways can be used to make the connecting means, for example, strips or buckles, or snap or hook fastening means, according to different needs, which can occur case by case.
  • the band 1 can have an average width of 3.5 cm, a thickness included in the range of 3 to 6 mm and a length of about 100 cm, or in any case as necessary to wrap a chest.
  • a wave-shaped projection 7, whose function will be set forth later, is provided along the upper edge 1 1 of the band 1 , that is the one intended to remain turned upwards, when the band is worn.
  • the proposed apparatus includes a unit for collecting the signals corresponding to the heart electrical activity, consisting of an electronic circuit 2 situated along the inelastic portion A of the band 1 , approximately in a longitudinally central position and near the lower border 6 of the band.
  • the electronic circuit 2 can be, for example, introduced between two layers of the fabric that forms the band 1 , or embedded therein, if composed of a synthetic plastic material or rubber. Consequently, the area of the band 1 with the electronic circuit 2 has a bigger thickness, for example of 6 mm.
  • An opening for the access to a USB port associated to the circuit 2 is provided on the rear face of the band 1 or along the lower border 6 thereof.
  • the heart electrical activity is detected by the collecting unit (electronic circuit 2) using a plurality of electrodes applied to the patient's chest (not shown) connected to the collecting unit by connecting means 3, 4, 5, in this case constituted by connection buttons 3, 4, 5, called also terminal snaps, connected to said electronic circuit 2 by corresponding conductors 13, 14, 15.
  • connection buttons 3, 4, 5, called also terminal snaps are fastened to the fabric of the band or are embedded in the synthetic or rubber plastic material thereof.
  • the buttons or snaps are fastened to the band by means of elastic supports 23, 24, 25 that support resiliently the buttons, almost as a damper, so as to prevent the adhesive electrodes from being pulled away.
  • This support system of the buttons or snaps allows to avoid, or at least substantially reduce the production of artefacts caused by the movement of the buttons or snaps, due to the mechanical traction of the band, which can provoke the partial or total detachment of the electrodes during the patient's movement.
  • Two lateral connection buttons or snaps 3, 4 are arranged at or in proximity of the lower border 6, with respect to the width of the band 1 , being spaced by such a distance as to remain situated at the sides of the patient's chest, while a third central connection button or snap 5 is situated in an intermediate portion between the two lateral connection buttons or snaps 3, 4 and vertically spaced from the horizontal plane passing therebetween, for example by about 3 cm.
  • the central connection button or snap 5 is situated at the upper pole of the area of the band 1 defined by a wave- shaped projection 7.
  • buttons or snaps can be provided in order to detect other electrical signals, so as to have more electrocardiographic sources at the same time.
  • other buttons or snaps can be advantageously arranged on the same line of the lateral buttons or snaps 3,4, in order to obtain more precise readings.
  • the central connection button or snap 5 is situated at the upper pole of the area of the band 1 defined by a wave- shaped projection 7.
  • the central connection button or snap 5 can be provided at an extroversion 7a made in the band 1 and more precisely in the above mentioned projection 7 (see figures 9 and 10).
  • the central snap 5 which during the operations is positioned at the top of the patient's breastbone, generally having a concave morphology, and even more marked in subjects with "pectus escavatum", provides more stable and precise contact with the patient's skin.
  • the central connection button or snap 5 is used as reference electrode, while the two lateral connection buttons or snaps 3, 4 are used as recording electrodes.
  • the recording mode of the heart electrical activity uses strips of highly conductive material, for example graphite, applied to the band and intended to be positioned directly in contact with the patient's skin, when the belt is worn.
  • the width of the strips is equal to the width of the band and they are 5-8 cm long.
  • power means 8 are provided, in this case composed of one or more batteries applied in suitable positions to the band 1 and connected to the electronic circuit 2 by relative cable 18 with a suitable connector.
  • the battery 8, or the battery pack since in fact there are more batteries connected together, is joined removably to the band 1 , for example, it can be introduced in a bag of a waterproofed fabric (not shown) made adhere to the band 1 by means of a portion of fabric like Velcro, or by other suitable adhesion systems.
  • This system allows to replace the battery pack, when it is discharged, or to introduce a pack with batteries having different characteristics, for example more or less powerful, as needed.
  • Non removable batteries can also be used, for example, of the dedicated type having a very reduced thickness (2-3 mm), and the width slightly smaller than the width of the band (about 3 cm) and the length equal to about 5-6 cm or as required, for constructive technique reasons.
  • Such batteries can be introduced or embedded into the material that composes the thickness of the band (fabric, plastic, rubber or other suitable materials, as well seen in figures 9 and 1 1 ).
  • the batteries can be placed in different areas along the inelastic part of the band (on one side or on both sides), as illustrated by way of a not limiting example in the above mentioned figures 9 and 1 1 .
  • the batteries 8 can have a curved conformation (the embodiment illustrated in figures 9 and 10), so as to better adapt to anatomy of the patient's chest, when the band 1 is applied. This allows to minimize the nuisance experienced by the patient when the electrocardiogram is carried out, especially at night.
  • the embodiment of the band 1 illustrated in figures 9, 10 and 1 1 includes a front part 1 a of the band, illustrated in the figures, which houses the above described devices, and a belt, not shown since readily understood, adapted to connect the two ends of the front part of the band 1 a by means of slots 30a, 30b made therein.
  • An opening for a switch 17 and a window for a LED 16, provided on the front face of the band 1 at the electronic circuit, are adapted to operate the system and to signal its correct operation, respectively.
  • a further feature, illustrated in figures 9 and 1 1 provides a pair of bends 31 a, 31 b on the upper side of the band 1 , substantially symmetrical with respect to the band center and thus to the projection 7 thereof. This allows to obtain better comfort for the user of the band 1 , especially if the user is a woman, since these areas of the band 1 adapt to the conformation of the lower part of the user's breasts.
  • the inner face of the band, at the terminal snap is provided with a portion of Velcro material, and a corresponding portion of Velcro material, of complementary type, is fixed to the non conductive surface of the electrodes.
  • the mechanical stresses, which merge in three points of the metallic snaps are distributed on the whole surface of the adhesive electrode.
  • the electrodes are placed very close to the differential amplifier, so as to reduce the difference of the path and reduce the effects of the low frequency interferences.
  • a surface electrical signal detected by the reference electrode is measured.
  • Such surface electrical signal contains the level of human body potential as well as known interferences, like those caused by the electromagnetic, thermal fields and others, coming from the surrounding environment.
  • the signal of the reference electrode is introduced in the final stage of the amplifier, in a central point between the two gain resistors (see figure 7) so as to dynamically adjust the amplifier gain of the final stage.
  • the modulation section of the final stage is connected in the circuit to the differential amplifier in order to calculate the difference with respect to the signal detected by the other two electrodes placed beside the circuit.
  • the reference electrode is placed exactly in the middle between the two lateral electrodes and not on the same conduction line of the two lateral electrodes.
  • the reference electrode is situated at the level of the band wave (about 3-4 cm above the line that connects the two lateral electrodes).
  • a terminal contacting the skin, of the "Patch" type picks up a signal of thermal interference, which is differentiated in the last stage of the amplification, so that the difference between the interference signal and the detected signal corresponding to the heart electrical activity applied in the last stage of amplification substantially reduces the thermal shift, to obtain more readable and interpretable ECG traces, thus facilitating the arrhythmologic diagnosis.
  • the electrode used to detect the signal of thermal interference can be, for example, the one connected to the third central connection button or snap 5, used also as reference electrode, while the other two electrodes act as real detectors of the cardiographic signal.
  • the common mode voltage « i ⁇ Zl is also available, which will be used to minimize the effect of thermal interferences, as will be shown in the following.
  • the difference between the prior art and the circuit of the invention and the method implemented thereby is that the signal of thermal interference, taken by the reference electrode, is connected to the final stage of the amplifier in a central point between the two gain resistors, to dynamically adjust the amplifier gain and so as to substantially reduce the thermal shift.
  • the electronic circuit begins immediately to collect the detected signals corresponding to the surface electrocardiographic signal and to record them. They can be sent automatically to a cardiology data center every hour or with a programmable frequency, wireless interacting with a dedicated software downloadable on the mobile electronic devices (Telephone, PC, Tablet or yet other electronic systems of graphic visualization) or directly by a data SIM introduced into the system circuitry.
  • the patient who wears the band 1 will be able to visualize the ECG trace on his/her mobile phone or tablet, and send it directly to his/her cardiologist and reporting medical center.
  • the band allows recordal of one or more branches (three branches) without using electrical cables coming out from the system, and its thickness includes therein the whole circuitry aimed at recording the electrical signal, as well as the power supply, by means of 'thin' batteries.
  • the quality of the signal is improved because the used devices reduce the artefacts caused by the electrodes traction and the configuration of the adhesive electrodes under the band which allows a constant compression thereof, prevent the electrodes from detaching. These devices, together with the circuital measures mentioned above, allow to use the system also for recording a good quality of the signal also during the sport activity.
  • the possibility to replace the battery pack provides functional flexibility which allows to apply the batteries with different power and which can allow variable recording time depending on clinical needs, for example, for short, medium and long term recording, that is hours, days or weeks.
  • the apparatus assures the functional interactivity, to make the arrhythmias detection rapid, with the possibility to send automatically the recorded data to a cardiology data center every hour or with a programmable frequency, interacting wireless or directly by a data SIM.
  • the patient who wears the recording band recognizes symptoms of arrhythmia, besides storing the data, he/she will be able to visualize the ECG trace on his/her mobile phone or tablet and send it directly to his/her cardiologist and reporting medical center.
  • the apparatus allows the patient to wear in an independent way the band and all the components associated thereto, he/she can temporarily remove it, for example, to take a shower.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un appareil pour l'acquisition continue d'un électrocardiogramme qui comprend une bande (1) adaptée pour envelopper le thorax d'un patient et une unité de collecte (2) disposée dans la bande (1) pour collecter des signaux correspondant à l'activité électrique cardiaque. Un circuit électronique d'amplificateur et une pluralité d'électrodes sont disposés à l'intérieur de ladite unité de collecte (2), placée dans la bande (1) en connexion avec autant de bornes (3, 4, 5) en contact avec la peau, adaptées pour être appliquées sur le thorax du patient pour détecter l'activité électrique cardiaque et reliées à ladite unité de collecte de signaux (2). Dans la bande (1), les bornes de contact (3, 4, 5) comprennent des bornes latérales (3, 4) disposées en alignement avec celui-ci, et une borne de référence (5) centrale, non alignée avec les bornes latérales (3, 4) ; la borne de contact de référence centrale (5) est connectée au circuit électronique d'amplificateur au dernier étage de l'amplificateur, de telle manière que la différence entre le signal détecté par l'électrode de référence, disposée en connexion avec la borne centrale (5) et le signal électrique détecté par les autres électrodes latérales disposées en connexion avec les bornes latérales (3, 4) réduit sensiblement le décalage thermique pour obtenir des tracés d'ECG plus lisibles et interprétables, de manière à faciliter le diagnostic arythmologique.
EP16801305.0A 2015-10-13 2016-10-13 Procédé et appareil pour l'enregistrement continu d'un électrocardiogramme Withdrawn EP3361942A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITUB2015A004646A ITUB20154646A1 (it) 2015-10-13 2015-10-13 Metodo e circuito di amplificazione con attenuazione dei disturbi da deriva termica in un sistema per la registrazione ecg prolungata e continua
ITUB2015A004645A ITUB20154645A1 (it) 2015-10-13 2015-10-13 Sistema a fascia per la registrazione prolungata e continua di un elettrocardiogramma
PCT/IB2016/056133 WO2017064643A1 (fr) 2015-10-13 2016-10-13 Procédé et appareil pour l'enregistrement continu d'un électrocardiogramme

Publications (1)

Publication Number Publication Date
EP3361942A1 true EP3361942A1 (fr) 2018-08-22

Family

ID=57394618

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16801305.0A Withdrawn EP3361942A1 (fr) 2015-10-13 2016-10-13 Procédé et appareil pour l'enregistrement continu d'un électrocardiogramme

Country Status (2)

Country Link
EP (1) EP3361942A1 (fr)
WO (1) WO2017064643A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112741633A (zh) * 2019-10-31 2021-05-04 深圳市理邦精密仪器股份有限公司 心电信号检测系统以及心电信号检测设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2070438A (en) * 1980-02-26 1981-09-09 Anderson J Physiological electric signals monitoring electrode
US5002063A (en) * 1990-03-29 1991-03-26 The Scott Fetzer Company Electronic physiological data monitoring
AU2003902187A0 (en) * 2003-05-08 2003-05-22 Aimedics Pty Ltd Patient monitor
US20050049515A1 (en) * 2003-07-31 2005-03-03 Dale Julian Misczynski Electrode belt for acquisition, processing and transmission of cardiac (ECG) signals
US8620402B2 (en) * 2003-10-30 2013-12-31 Halthion Medical Technologies, Inc. Physiological sensor device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112741633A (zh) * 2019-10-31 2021-05-04 深圳市理邦精密仪器股份有限公司 心电信号检测系统以及心电信号检测设备
CN112741633B (zh) * 2019-10-31 2024-04-05 深圳市理邦精密仪器股份有限公司 心电信号检测系统以及心电信号检测设备

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