EP3359284A1 - Dispositif de filtration à membrane à fibre creuse et son procédé de fabrication - Google Patents

Dispositif de filtration à membrane à fibre creuse et son procédé de fabrication

Info

Publication number
EP3359284A1
EP3359284A1 EP16805719.8A EP16805719A EP3359284A1 EP 3359284 A1 EP3359284 A1 EP 3359284A1 EP 16805719 A EP16805719 A EP 16805719A EP 3359284 A1 EP3359284 A1 EP 3359284A1
Authority
EP
European Patent Office
Prior art keywords
housing
extensions
fiber membrane
filtration device
locking means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16805719.8A
Other languages
German (de)
English (en)
Inventor
Jan Stanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serumwerk Bernburg AG
Original Assignee
Serumwerk Bernburg AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serumwerk Bernburg AG filed Critical Serumwerk Bernburg AG
Publication of EP3359284A1 publication Critical patent/EP3359284A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/022—Encapsulating hollow fibres
    • B01D63/0222—Encapsulating hollow fibres using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0233—Manufacturing thereof forming the bundle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/02—Specific tightening or locking mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/04—Specific sealing means
    • B01D2313/042—Adhesives or glues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/20—Specific housing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/21—Specific headers, end caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/44—Cartridge types

Definitions

  • the invention is based on the preamble of claim 1 of a hollow fiber membrane filtration device for body fluids, with a bundle of hollow fibers and with a longitudinally extending along the bundle of hollow fibers housing with a housing, which housing defines an interior in which the bundle is arranged hollow fibers, wherein the bundle of hollow fibers is cast into a potting compound at both ends, and wherein the housing has on the inside at least one positive locking means with a free end, which positive locking means is at least partially enclosed by the potting compound.
  • claim 15 of the invention further relates to a method for producing a hollow fiber membrane device.
  • a filtering device is known, the two-end disc-shaped curing potting compound is enclosed in each case by an intermediate ring to which the potting compound does not adhere.
  • said ring consists for example of polypropylene (PP)
  • the potting compound consists of, for example, polyurethane (PUR).
  • PP polypropylene
  • PUR polyurethane
  • the disk-shaped potting compounds are supported so that a movement of the same is prevented in the longitudinal direction. This is effected by a radially directed flange of said ring.
  • the tooth or crenellated projections may have radially outwardly directed projections at their ends.
  • the housing consists of a material, such as polypropylene (PP), which does not form a tight adhesive bond with the potting compound of eg polyurethane (PUR).
  • EP 1 926 546 B1 discloses a filtering device based on the above-described EP 0 844 015 B1 with tooth-shaped or crenellated projections of the housing of the filtration device formed by free-running axial notches or cuts, the housing being arranged between the toothed or crenellated teeth Having projections of these outgoing projections which extend to the adjacent tooth or crenellated projection.
  • a filtering device is known, the housing of which has a connecting element in the form of a so-called stop ring, which is cast in potting compound and whose thickness, starting from the housing wall, increases from radially outside to radially inside.
  • a filtration device with a housing is known, which has a ring with a radially inwardly directed and embedded in potting compound annular anchor element.
  • US 2015/0165106 A1 describes a filtering apparatus or a capillary dialyzer which has a respective support ring attached to the housing of the filtering device and cast in potting compound. On the support ring a plurality of evenly distributed over the circumference of the same arranged ribs are formed.
  • US Pat. No. 6,830,685 B2 describes a filtering device which has a ring with a ring-shaped armature attached at both ends to the housing of the same. The said anchor is cast in potting compound.
  • EP 1 616 617 A1 describes a filtering apparatus which has an annular body at both ends with an annular projection facing radially inwards.
  • the annular bodies are each distributed by means of a plurality distributed over the circumference of the same and pointing radially outward Protrusions, so to speak, at a distance supported on the housing of the filtration device to realize fluid passages or channels between the housing wall and the annular body. At least the radially inwardly facing annular projection is received by a sealing element not described in detail.
  • JP 20005161305 A describes a filtering device with a cylindrical housing which is formed on the cap side in the manner of an annular cage, with uniformly distributed over the circumference of the same axially aligned rod elements, which are mutually connected at both ends. Between the respective cage and a cap closing off the housing, an annular space is formed. The incisions of the cage formed between the rod elements are partially embedded in casting resin.
  • the object of the invention is therefore to provide a hollow-fiber membrane filtration apparatus improved with respect to the state of the art, which, while retaining the advantages of the prior art, ensures in a particularly simple and advantageous manner a firm bond between the housing of the filtration apparatus and the potting compound. It is another object of the invention to provide a method for producing such a hollow-fiber membrane filtration device, which is particularly simple and inexpensive to carry out.
  • the object is achieved in conjunction with the features in the preamble of claim 1, characterized in that the at least one positive locking means by two or more, seen in the circumferential direction of the housing spaced from each other and one end connected to the housing extensions formed, each starting are formed by an imaginary, the terminal portion of the relevant extension of the housing passing through orthogonal to a central longitudinal axis of the housing by a defined angle of inclination "a" in the interior of the housing into one or to the other end of the filtration device out inclined.
  • connection area which may also be referred to as the foot area of the respective extension
  • the end of the extension opposite the free end of the respective extension is understood, which is supported on the housing wall and represents, so to speak, the transition from the extension to the housing wall.
  • a filtering device which ensures the same with a simple production of a solid bond between the housing of the filtration device and the potting compound together with the bundled at its ends hollow fibers. Due to the deliberately inclined arrangement of the extensions of the applied to the cured potting compound resistance to axial withdrawal is increased, which is particularly advantageous if after pouring the ends of the hollow fiber bundle in said potting compound and curing the same hollow fibers by trimming the ends of the hollow fibers be opened transversely to the longitudinal extent of the same. In addition, the risk of damage to the hollow fibers is effectively avoided by excessive, acting on the hollow fibers tensile force due to said cut.
  • the at least one positive locking means is integrally formed with the housing, resulting in savings in particular material, manufacturing and assembly costs.
  • the invention is not limited to a one-piece design of the housing with the extensions according to the first preferred embodiment of the invention, but detected according to a second embodiment of the invention also extensions that summarized at least one separately manufactured, For example, form one-piece, annular attachment and fixed to the housing or the inner contour of the housing, preferably firmly bonded, in particular with the same / the same welded or glued.
  • the at least one attachment itself may also be formed two or more parts, for example, be formed by ring segments, which is accordingly also covered by the invention.
  • the extensions of the at least one positive locking means are resiliently formed at least in their connection region to the housing wall. Due to the resilient design of at least the terminal portions of said extensions and the inclined orientation of the extensions a simple production of the housing of the filtration device including the integrally formed with the same extensions according to, for example, a plastic injection molding in a single step in a simple design demolding possible. While the demolding give way to the extensions, but can then take advantage of their desired inclined arrangement again automatically.
  • the invention is not limited to the said plastic injection molding process, but covers any suitable, plastic processing method for producing the housing, such as the production of the same by 3D printing.
  • the angle of inclination "a" is preferably formed between the said orthogonal and an imaginary line, which line intersects the orthogonal to the housing wall in the connection area of the relevant extension and to the other the resulting intersection with one of the housing wall nearest Point at the free end of the extension connects.
  • the angle of inclination "he” is selected according to the relationship 0 ° ⁇ lal ⁇ 90 °.
  • an angle of inclination "a” has proven successful, which, starting from the orthogonal, ranges from preferably ⁇ 10 ° to ⁇ 80 °, more preferably from ⁇ 40 ° to ⁇ 70 °, even more preferably is selected from a range of ⁇ 50 ° to ⁇ 65 °.
  • connection regions of the extensions or all extensions of the respective positive locking means are preferably arranged in a common, aligned orthogonal to said central longitudinal axis of the housing first level.
  • connection areas of a first part of the extensions of the respective positive locking means in a orthogonal to said central longitudinal axis of the housing aligned first level and the terminal portions of at least a second part of said extensions in one of first level parallel second level are arranged.
  • a larger area of the housing wall is integrated into the introduction of force, as a result of which the local load on the housing wall is reduced and, as a consequence, this can be designed to be thinner-walled than is conventional. Furthermore, as a result, the most varied variants of the alignment and arrangement of the projections in one, two or more levels can be realized.
  • all extensions of the respective positive locking means can be arranged inclined to the one or to the other end of the housing.
  • extensions of the respective positive locking means may also be arranged regularly or irregularly alternately to the one or to the other end of the housing inclined. Which variant is specifically taken into account depends in particular on the materials used for the potting compound and the extensions and on the currently acting longitudinal or axial forces. For those skilled in the art, it goes without saying that directed against the direction of action of said longitudinal forces extensions the greatest resistance to axial withdrawal of hardened potting compound during the cutting of the bundle hollow fibers transverse to the longitudinal extent of the hollow fibers apply.
  • the extensions are uniform in the circumferential direction, i. arranged distributed with equal spacing to each other around the bundle of hollow fibers.
  • the forces acting on the potting compound can be optimally introduced into the housing by means of the extensions.
  • At least one of the extensions has at least one opening, a recess, a bead-like formation and / or an angling at the free end of the extension. Due to the above-described resilient design of at least the terminal portions of the extensions can in the manufacture of the housing after, for example, a plastic injection molding consuming slide etc. for the formation of said openings, recesses, undercuts and / or the like. Be more unnecessary.
  • the spacing between adjacent projections in the circumferential direction of the housing is taken up by an elastic wall element connecting at least partially the relevant extensions, wherein the elasticity of the wall element is greater than the elasticity the extensions is. It is thus a closed ring alternately formed with smaller sections and in relation to greater elasticity, whereby any tensile forces on the potting compound together with hollow fibers, which may arise when trimming the potting compound together with hollow fibers, better transferred to the total cross section of the potting compound together with hollow fibers and by the same Avoidance of damage can be effectively absorbed and / or introduced into the housing wall.
  • the housing together with extensions or the housing together with the at least one attachment with projections made of a material that does not receive an adhesive bond with the potting compound.
  • the housing including extensions or the housing together with the at least one attachment with extensions at least one polyolefin, in particular polypropylene (PP) or polyethylene (PE), and the potting compound polyurethane (PUR), resulting in particular savings in material costs compared to frequently used materials, such as polycarbonates (PC), which undergo better adhesion with the potting compound, result.
  • the housing together with extensions or the housing together with the at least one attachment with projections material of uniform design.
  • the invention is not limited to this preferred embodiment, but also covers a combination of different materials, which are processed for example by a multi-component plastic injection molding.
  • both ends of the housing introducing a potting compound into the housing such that, on the one hand, the ends of the bundle of hollow fibers are enclosed by the potting compound and, on the other hand, the potting compound at least partially surrounds the extensions, and d) after curing of the potting compound opening the ends of the hollow fibers by trimming the ends of the hollow fibers transverse to the longitudinal extent thereof.
  • This method has the advantage that when changing the materials used, in particular when using non-adhesive materials for the production of a filter device according to the invention, only a very small effort and the existing production processes and production equipment can be largely retained.
  • Fig. 1 is a side view of an inventive design
  • Fig. 2 is a sectional view of the housing of the filtration device according to Fig. 1 with a key element according to the invention in the form of several
  • FIG. 3 the housing of the filtration device of FIG. 2 completed by a bundle
  • FIG. 4 shows the detail , ⁇ ⁇ 'of FIG. 2 (first embodiment)
  • FIG. 6 shows the detail "Z 2" of FIG. 2 according to a second embodiment
  • Fig. 7 shows the detail "Z 3" of FIG. 2 according to a third embodiment
  • Fig. 8 shows the detail "Z 4" in FIG. 2 in accordance with 9 shows the detail "Z 5 " according to FIG. 2 according to a fifth embodiment variant
  • FIG. 10 shows the form-fitting element according to FIG. 9 in a perspective individual representation.
  • the hollow-fiber membrane filtration device 1 for body fluids consists of a tubular housing 2 with in the present example a circular cross-section.
  • the housing 2 consists of a plastic, preferably of polypropylene (PP).
  • the housing 2 has a central housing portion 2a and the respective end thereof depending on an end portion 2b, 2c with a respective larger in relation to the central housing portion 2a diameter.
  • the hollow fibers 4 are each formed by a semipermeable membrane and form by their non-illustrated tube or Kapillarröhren- passageways a first flow space 5 of the filtering device 1 for said body fluid, in particular for blood.
  • the housing 2 with its housing wall 6 extends along the bundle 3 hollow fibers 4 and defines an interior space 7 and thus a second flow space 8 of the filtration device 1, in which second flow space 8 a liquid, in the present case a dialysate is guided.
  • the ends of the bundle 3 hollow fibers 4 are each cast or embedded in a potting compound 9 preferably made of polyurethane (PUR). After curing of the potting compound 9 this is largely disc-shaped.
  • This disc-shaped shape of the two ends of the housing 2 arranged potting compound 9 is effected by centrifuging during the introduction of the potting compound 9 in the housing 2, preferably the same about a directed perpendicular to the central longitudinal axis 10 of the housing 2 axis.
  • the curing of the potting compound 9 takes place in temporarily provided and the respective end face of the housing 2 covering caps (not shown in the drawing), whereby the potting compound 9 circumferentially clings to the housing 6 and to the frontal caps. After curing of the respective potting compound 9, the end caps are removed.
  • the respective potting compound 9 together with the cast or embedded hollow fibers 4 is cut at its front side and transversely to the longitudinal extent of the hollow fibers 4, whereby the process-related sealed by the potting compound 9 tube or Kapillarröhren press sautician the hollow fibers 4 are opened again.
  • the steps of removing the caps and trimming the potting compound 9 together with hollow fibers 4 can be performed in one step by said trimming (not shown in the drawing).
  • a cap 11a, 11b with first connecting pieces 12a, 12b is attached to the front side of the housing 2, which ensures the flow of body fluid (for example blood) through the hollow fibers 4 or the first flow space 5 formed.
  • a cap 11a with connection piece 12a thus forms the inflow for the body fluid
  • the other cap 11b with connection stub 12b forms the outflow.
  • Inflow and outflow are involved according to this embodiment in a flow circuit of a known per se and thus not graphically illustrated dialysis machine.
  • the caps 1a, 11b together with connecting pieces 12a, 12b are in the present case non-positively connected by screwing to the housing 2.
  • a cohesive joint connection can be provided by welding or gluing.
  • Said inner space 7 of the housing also referred to as dialysate space
  • Said inner space 7 of the housing has in the region of its ends or in the region of the respective end section 2b, 2c each a second connecting piece 13a, 13b oriented orthogonally to the central longitudinal axis 10 of the housing 2.
  • the second connecting pieces 13a, 13b are used for supplying and discharging the dialysate flowing through the inner space 7 or the second flow space 8 and thus flowing around the hollow fibers 4.
  • These connecting pieces 13a, 13b are integrated in a flow circuit of the dialysis machine not shown in the drawing.
  • the potting compound 9 made of polyurethane (PUR) no adhesive bond and thus no tight joint connection with the housing 2 made of polypropylene (PP) and the screw connection of the embodiment causes no liquid seal, are in the region of the respective cap 11 a, 11 b two concentric with each other arranged ring seals 14, 15 are provided (see Fig .. 5).
  • the second, radially outer ring seal 15, seals the second flow chamber 8 against the outside atmosphere and is supported in particular axially on an end edge of the housing 2 and on the respectively adjacent cap 11a, 11b.
  • the ring seals 14, 15 are held within recesses of the housing 2, the potting compound 9 and the relevant cap 11a, 11b in such a way that they are fixed in the radial direction.
  • the ring seals 14, 15 may also be integrally formed and thereby seal the first flow space 5 against the second flow space 8 and the outside atmosphere (not shown in the drawing). Any other suitable, known per se embodiments of the sealing of the flow spaces 5, 8 to each other and the outside atmosphere are of course included by the invention.
  • the housing 2 in the region of its two end sections 2b, 2c each has a positive locking means 16 with a free end 16b.
  • the respective positive locking means 16 is formed by a plurality of extensions 16a, according to this embodiment by twelve extensions 16a. All projections 16a of the respective positive locking means 16 in the respective end portion 2b, 2c are connected at one end to the housing 6 of the housing 2 and arranged in a common, orthogonal to the central longitudinal axis 10 of the housing 2 aligned first level.
  • the extensions 16a are preferably uniformly distributed around the bundle 3 hollow fibers 4 and arranged at a distance from one another in the assembly of the housing 2 with the bundle 3 hollow fibers 4 and in the circumferential direction of the housing 2.
  • Said extensions 16a are produced according to this exemplary embodiment by a plastic injection molding method and formed integrally with the housing 2 or its housing wall 6. This is done for example by means of a known per se plastic Sp tzg confusetechniks with two concentric to each other arranged tensile cores for each side, which are movable only in the axial housing direction (not shown in the drawing).
  • all projections 16a of the respective positive locking means 16 in the respective end portion 2b, 2c according to a preferred first Design variant of the invention, starting from an imaginary, the terminal portion of the respective extension 16a to the housing 6 passing through orthogonal 20 on the central longitudinal axis 10 of the housing 2 by a defined angle of inclination "a" in the interior of the housing 2 into the respective adjacent end of the filtration device 1 and 4.
  • the projections 16a have a spring-elastic design at least in their connection region to the housing wall 6. Said spring elasticity of the extensions 16a formed integrally with the housing 2 can be brought about, for example, by a material thinning in said connection region. [Dem Dem]
  • the spring elasticity can also be effected by an elastomer, which is injection-molded according to a multi-component plastic injection molding process.
  • connection area which can also be referred to as the foot area of the extension 16a
  • the end 16b of the respective projection 16a opposite end of the extension 16a is understood, which is supported on the housing 6 and fixedly connected to the same and so to speak, the transition from Extension 16a to the housing 6 represents, in this case due to integral formation of the extension 16a with the housing 2 and the housing 6th
  • the angle of inclination "a” is selected on the basis of the orthogonal 20 according to the relationship 0 ° ⁇ lal ⁇ 90 ° In experiments on the subject of the application, an angle of inclination "a” has proven successful, which preferably starts from the orthogonal 20 from a range of ⁇ 10 ° to ⁇ 80 °, more preferably selected from a range of ⁇ 40 ° to ⁇ 70 °.
  • the extensions 16a are formed according to this embodiment, largely in the manner of a free end of the same 16b tapered cuboid and each have a radial opening 17 on.
  • the extensions 16a are embedded in the potting compound 9 and thus a positive connection between the potting compound 9 and the projections 16a causes.
  • the potting compound 9 passes through the extensions 16a through said openings 17, whereby the positive connection is further improved.
  • the invention is not limited to said openings 17, but also covers, for example, recesses on the projections 16a, bead-like formations, which may be directed to the interior of the housing 2 or to the outside of the housing 2, and / or one, two or more bends on free end 16b of the respective extension 16a, which may also be directed to the interior of the housing 2 or to the outside of the housing 2 (not shown in the drawing).
  • the invention is not limited to parallelepiped extensions 16a, but also covers extensions 16a, which for example have a shape that is similar to the basic shape of a trapezium, a triangle or a ring segment (not shown in the drawing).
  • Embodiment 2 (FIG. 6):
  • Fig. 6 shows a second embodiment of the invention, wherein
  • the above-described preferred first embodiment of the invention is based on a housing 2, in which all integrally formed with the housing 2 extensions 16a of the respective positive locking means 16 in the relevant End section 2b, 2c tilted by a selected angle of inclination "a" to the respective adjacent end of the filtration device 1 and to the respective adjacent cap 11a, 11b.
  • the invention also covers an embodiment of the invention, in which all according to FIG the housing 2 formed projections 16a of the respective positive locking means 16 in the respective end portion 2b, 2c by a defined respectively selected angle of inclination "a” not to the respective adjacent end of the filtration device 1 and the adjacent cap 11a, 11b, but respectively to the opposite end of the filtration device 1 or to each oppositely arranged cap 11 a, 11 b are inclined towards.
  • an arrangement of projections 16a of the respective positive locking means 16 in the respective end portion 2b, 2c detected in the extensions 16a regularly, ie alternately, or irregularly alternately inclined to the one or to the other end of the filtration device 1 out (not shown in the drawing ).
  • the term “alternating or alternating” is understood to mean that an equal number of extensions 16a are alternately directed or inclined in one direction or the other.
  • the term “irregular change" is understood to mean that an unequal number of extensions 16a are alternately directed or inclined in one direction or the other.
  • Embodiment 3 (FIG. 7):
  • Fig. 7 shows a third embodiment of the invention, wherein functionally identical parts with the same reference numerals as in the previous drawings
  • Fig. 7 shows an embodiment of the invention, in which at least one of the end portions 2 b, 2 c of the housing 2 parallel to each other, a first and a second orthogonal to Center longitudinal axis 10 of the housing 2 aligned plane with a plurality of projections 16a are provided.
  • the extensions 16a of the two mutually parallel planes are arranged offset to each other such that the extensions 16a of a plane in the longitudinal direction of the housing 2 seen in the region of the spacing between the Fortsa 16a of the other level are arranged.
  • Embodiment 4 (FIG. 8):
  • Fig. 8 shows a fourth embodiment of the invention, wherein
  • the spacing between adjacent extensions 16a seen in the circumferential direction of the housing 2 is occupied by an elastic wall element 18 connecting at least partially the relevant projections 16a.
  • the elasticity of the wall element 18 is set greater than the elasticity of the projections 16a.
  • a closed ring is formed alternately with portions less and in relation to greater elasticity. Any tensile forces acting on the potting compound 9 together with hollow fibers 4 when trimming the potting compound 9, together with hollow fibers 4, can be better transferred into the overall cross section of the potting compound 9 together with hollow fibers 4 and effectively absorbed by the same while avoiding damage and / / or be introduced into the housing 6.
  • the wall elements 18 connected to the extensions 16a which preferably occupy the entire spacing between the extensions 16a, also act as additional centering means in combination with the extensions 16a, which effectively prevent hollow fibers 4 from widening the ends of the bundle 3 and generally the fixation of the bundle 3 hollow fibers 4 in the housing 2 improve. Due to the relatively greater elasticity of the wall element 18 to the extensions 16a, following the demolding of the housing 2 with the projections 16a, a spring-elastic recoil of the projections 16a in the desired inclined arrangement is not hindered.
  • Embodiment 5 (FIGS. 9 and 10):
  • FIGs. 9 and 10 show a fifth embodiment of the invention, wherein functionally identical parts with the same reference numerals as in the previous
  • the exemplary embodiment according to FIGS. 9 and 10 differs from those described above only in that the projections 16a of the respective positive locking means 16 are formed in the relevant end section 2b, 2c by at least one separately produced attachment 19 fixed to the housing 2.
  • the abovementioned attachment 19 is illustratively designed in one piece as well as annular and can be fastened or fastened to the housing 2 or the inner contour of the housing wall 6. All projections 16a are presently arranged in a common plane.
  • the ring-shaped attachment 19 in this case has an annular base body 19a, to which the extensions 16a are connected at one end.
  • the base body 19a forms, as it were, a fastening region of the form-fitting means 16 or its extensions 16a to the housing wall 6 and is connected or connectable to the housing wall 6 preferably by material bonding by welding or gluing.
  • the at least one attachment 19 may also be formed in several parts, for example, be formed by two or more ring segments, which is accordingly also covered by the invention.
  • the extensions 16a may be arranged in two or more planes based on the above-described embodiment of variant 3 of the invention (not shown in the drawing).
  • the preferred embodiment for the above Federelastische training at least the terminal portions of said extensions 16a is not mandatory. Otherwise, it may behave due to the preferred plastic injection molding process, if said attachment 19 has extensions 16a, which are arranged distributed over two or more levels. In this case, it may be advantageous to design the projections 16a, at least in their connection region to the housing wall 6, in the present case indirectly realized via the interposed and acting as a fastening region and fixed to the housing 6 main body 19a, resilient.
  • the base body 19a in this case has a wall thickness and accordingly a strength and / or rigidity, which is the function of the positive locking means 16 justice.
  • an optimal function of the positive locking means 16 has resulted when the wall thickness of the body 19a directly connected to the housing wall 6 largely corresponds to the material thickness of the extensions 16a (FIG. 10).

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  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne entre autre un dispositif de filtration à membrane à fibre creuse (1) pour des fluides corporels, comprenant un faisceau (3) de fibres creuses (4) et un boîtier (2) s'étendant le long du faisceau (3) de fibres creuses (4). Le boîtier (2) définit un espace intérieur (7) pour le faisceau (3) de fibres creuses (4), lequel faisceau est scellé par les deux extrémités dans une masse de scellement (9). Le boîtier (2) comprend au moins un moyen à coopération de formes (16) présentant une extrémité libre (16b), lequel moyen à coopération de formes (16) est entouré au moins en partie par la masse de scellement (9). Le moyen à coopération de formes (16) est formé par deux prolongements (16a) ou plus espacés les uns des autres et raccordés par une extrémité à la paroi (6) de boîtier. À partir d'une orthogonale (20) sur un axe longitudinal médian (10) du boîtier (2), les prolongements (16a) sont inclinés selon un angle d'inclinaison « α » à l'intérieur du boîtier (2) en direction de l'une des extrémités ou de l'autre extrémité du dispositif de filtration (1).
EP16805719.8A 2015-11-25 2016-11-16 Dispositif de filtration à membrane à fibre creuse et son procédé de fabrication Withdrawn EP3359284A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015015149.5A DE102015015149B3 (de) 2015-11-25 2015-11-25 Hohlfasermembran-Filtriervorrichtung und Verfahren zur Herstellung derselben
PCT/DE2016/000398 WO2017088845A1 (fr) 2015-11-25 2016-11-16 Dispositif de filtration à membrane à fibre creuse et son procédé de fabrication

Publications (1)

Publication Number Publication Date
EP3359284A1 true EP3359284A1 (fr) 2018-08-15

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EP16805719.8A Withdrawn EP3359284A1 (fr) 2015-11-25 2016-11-16 Dispositif de filtration à membrane à fibre creuse et son procédé de fabrication

Country Status (6)

Country Link
EP (1) EP3359284A1 (fr)
JP (1) JP2018536537A (fr)
CN (1) CN108463281A (fr)
DE (1) DE102015015149B3 (fr)
RU (1) RU2018122635A (fr)
WO (1) WO2017088845A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6780785B2 (ja) * 2018-07-27 2020-11-04 東レ株式会社 中空糸膜モジュール及び中空糸膜モジュールの製造方法
EP3620228B1 (fr) * 2018-09-04 2022-02-09 Gambro Lundia AB Procédé de fabrication d'un dispositif de filtration et/ou de diffusion
CN114939347A (zh) * 2022-06-15 2022-08-26 广州康盛生物科技股份有限公司 一种壳体结构

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454847B (sv) 1987-08-31 1988-06-06 Gambro Dialysatoren Anordning for diffusion och/eller filtrering samt forfarande for tillverkning av denna anordning
JPH0549875A (ja) * 1991-08-12 1993-03-02 Mitsubishi Rayon Co Ltd 中空糸膜モジユール
JPH06296834A (ja) 1993-04-20 1994-10-25 Kanegafuchi Chem Ind Co Ltd 中空糸型フィルター
US6074559A (en) 1996-11-21 2000-06-13 Fresenius Medical Care Deutschland Gmbh Filter device having a hollow fiber bundle and associated sealing devices
US6830685B2 (en) 2001-12-05 2004-12-14 Fresenius Usa, Inc. Filtering device with associated sealing design and method
JP4381957B2 (ja) * 2003-11-10 2009-12-09 日機装株式会社 中空糸型モジュール
CN1922461B (zh) * 2003-12-22 2012-12-26 安格斯公司 封装的交换装置及其制造方法
US7264725B2 (en) * 2004-03-04 2007-09-04 Celgard Inc. Hollow fiber membrane contactor and method of making same
ITMO20040180A1 (it) * 2004-07-14 2004-10-14 Gambo Lidia Ab Dispositivo di separazione e supporto per un dispositivo di separazione.
DE102005043321A1 (de) * 2005-09-12 2007-03-22 Fresenius Medical Care Deutschland Gmbh Hohlfasermembrantrennvorrichtung
CN202740496U (zh) * 2012-06-21 2013-02-20 甘布罗伦迪亚股份公司 毛细管透析器

Also Published As

Publication number Publication date
WO2017088845A1 (fr) 2017-06-01
JP2018536537A (ja) 2018-12-13
CN108463281A (zh) 2018-08-28
DE102015015149B3 (de) 2017-01-26
RU2018122635A (ru) 2019-12-26

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