EP3349910A1 - Magnetische trennvorrichtung mit mechanischer aktivierung und deaktivierung - Google Patents
Magnetische trennvorrichtung mit mechanischer aktivierung und deaktivierungInfo
- Publication number
- EP3349910A1 EP3349910A1 EP16766295.6A EP16766295A EP3349910A1 EP 3349910 A1 EP3349910 A1 EP 3349910A1 EP 16766295 A EP16766295 A EP 16766295A EP 3349910 A1 EP3349910 A1 EP 3349910A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- tip
- magnetic
- separation device
- drive
- magnet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005291 magnetic effect Effects 0.000 title claims abstract description 139
- 230000009849 deactivation Effects 0.000 title description 2
- 238000004137 mechanical activation Methods 0.000 title description 2
- 230000033001 locomotion Effects 0.000 claims abstract description 72
- 230000005415 magnetization Effects 0.000 claims abstract description 60
- 239000000725 suspension Substances 0.000 claims abstract description 34
- 239000006249 magnetic particle Substances 0.000 claims abstract description 21
- 238000003780 insertion Methods 0.000 claims abstract description 8
- 230000037431 insertion Effects 0.000 claims abstract description 8
- 238000007654 immersion Methods 0.000 claims abstract description 6
- 238000007885 magnetic separation Methods 0.000 claims description 47
- 230000008878 coupling Effects 0.000 claims description 25
- 238000010168 coupling process Methods 0.000 claims description 25
- 238000005859 coupling reaction Methods 0.000 claims description 25
- 238000013459 approach Methods 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 11
- 230000005540 biological transmission Effects 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 230000001419 dependent effect Effects 0.000 claims description 3
- 230000010287 polarization Effects 0.000 claims description 3
- 230000005484 gravity Effects 0.000 description 7
- 239000000696 magnetic material Substances 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 239000006148 magnetic separator Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000003302 ferromagnetic material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000011553 magnetic fluid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/034—Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/284—Magnetic plugs and dipsticks with associated cleaning means, e.g. retractable non-magnetic sleeve
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/286—Magnetic plugs and dipsticks disposed at the inner circumference of a recipient, e.g. magnetic drain bolt
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Definitions
- the present invention relates to a magnetic separation device for separating magnetic particles from a suspension having a soft magnetic tip extending along a tip axis whose magnetization state is selectively changeable between a more magnetized state and a weaker magnetized state, wherein the tip is an immersion end to Introduction into the suspension and a magnetization section for changing the magnetization state of the tip, wherein the separation device comprises a movement drive and with this motion-communicating magnetic arrangement comprising at least one permanent magnet or at least one permanent magnet is formed and which by the movement drive to the magnetization section approachable and removable from, so that the magnetic field of the magnet assembly in the magnetization portion of the tip to change the magnetization and the tip is temporally variable.
- Such separation devices are used, for example, in chemical, biochemical and / or pharmaceutical laboratories to remove magnetic particles contained in a suspension from the suspension.
- Such suspensions with magnetic particles can be used for example for the purification of DNA.
- the magnetic particles serve merely as a means of transport and are usually coated in such a way that only a specific constituent of the suspension can and will attach to the outer surface of the coating pointing away from the particle, which can then be removed together with the particle from the suspension.
- the magnetic particles are thus usually magnetic only for the purpose of the planned removal of chemical or biological material from the suspension liquid.
- magnetic is meant a material which is either magnetizable or magnetised. In most applications of the magnetic separation device discussed herein, the magnetic particles will comprise ferromagnetic material or be made of ferromagnetic material.
- a generic magnetic separation device is known from US 7799281 B2. This document discloses a magnetic separator having a soft magnetic tip which is rigidly coupled at its longitudinal end remote from the dip end to a guide tube in which a permanent magnet is approachable along the tube axis to contact the soft magnetic tip and removable therefrom.
- the movable permanent magnet is polarized along its axis of motion so that one of its magnetic poles can be brought into contact contact with the soft magnetic tip.
- the soft magnetic tip is magnetized while, when the permanent magnet is spaced from the soft magnetic tip, it is substantially unmagnetized. That portion of the soft magnetic tip which makes contact with the movable permanent magnet is the magnetization portion of the known soft magnetic tip.
- the known generic magnetic separation device thus comes in the region of its soft magnetic tip without electrically energized components, in particular without an electromagnet, which often represents an undesirable heat source magnetic separation devices.
- the coincident with the axis of the guide tube relative movement direction of the permanent magnet is collinear with the tip axis to provide a radially as possible with respect to the tip axis as slim magnetic separation device.
- the permanent magnet is coupled with its movement drive via a rod accommodated in the guide tube and extending coaxially with the guide tube or via a cable received in the guide tube and running coaxially with the guide tube, and thus driven for movement within the guide tube. bar. Further mobility of the permanent magnet and the soft-elastic tip is not provided.
- a further magnetic separation device which, however, uses an electromagnet to be energized for the duration of the magnetization for the temporary magnetization of the soft-magnetic tip, is known, for example, from WO 02/40173 A1.
- a strong and correspondingly space-demanding electric ring magnet surrounds the soft-magnetic tip, which passes through the plane of extent of the electric ring magnet along the ring axis.
- soft magnetic tip acts as an anchor or iron core and is magnetized for the duration of energization of the electric ring magnet, so that the insertion end of the soft magnetic tip inserted into the respective suspension and then because of their magnetized state in the suspension contained magnetic particles attract until it rests against an outer surface of the soft magnetic tip and then can remove frictionally or non-positively from the remaining suspension liquid.
- the outer surface of the soft magnetic tip may be formed by the soft magnetic material itself or - depending on the requirements of the respective cleaning process - by a surrounding the insertion end of the soft magnetic tip protective cover.
- the magnetic separation device known from WO 02/40173 A1 is coupled to an electromotive rotary drive, by means of which the soft-magnetic tip is rotatable about its longitudinal axis.
- the coupling of the soft-magnetic tip with a rotary drive is readily possible for the magnetic separation device known from WO 02/40173 A1, since the magnetic ring magnet changing the magnetization state of the tip can interact with the tip without contact and thus does not disturb its rotational drive coupling.
- rotation of the soft magnetic tip can be supported by WO 02/40173 A1, the deposition of the particles at magnetized immersion end of the soft magnetic tip.
- the rotation may also be used to remove magnetic particles deposited from the immersion end of the soft magnetic tip and removed from the suspension liquid together with the soft magnetic tip from the dip end.
- a disadvantage of the known from WO 02/40173 A1 magnetic separation device is on the one hand their expansive space-demanding design in which the soft magnetic tip and the electric ring magnet are arranged coaxially and axially overlapping as the above-mentioned magnet assembly. Another device, in particular a further magnetic separation device can therefore not be approximated closer to the known separation device than the radius of the soft magnetic tip surrounding the electric ring magnet.
- the use of an electromagnet for temporary magnetization of the soft-magnetic tip can be questionable, in particular if the electromagnet for magnetizing the soft magnetic tip is to be arranged axially overlapping with this in the direction of its longitudinal axis. The electromagnet is thus arranged comparatively close to the suspension to be processed with the separating device. Since the electromagnet only provides its magnetic field when energized, heating of the electromagnet and thus at least the risk of thermal loading of the suspension to be processed occurs during operation of the magnetic separation device, which may be disadvantageous for thermally sensitive ingredients of the suspension.
- the object of the present invention is to further improve the functionality of the magnetic separation device mentioned above.
- a generic magnetic separation device in which the soft magnetic tip is rotatable about the tip axis. Due to the rotatability of the soft magnetic tip about the tip axis, centrifugal forces acting radially to the tip axis can be generated at the soft magnetic tip. As a result of these centrifugal forces, magnetic particles adhering to the soft-magnetic tip can be removed therefrom and / or residual magnetic fluid present on the magnetic particles adhering to the tip can be removed from the magnetic particles.
- the speed at which the tip axis is rotatable, adjustable or changeable to adjust the acting centrifugal forces.
- the soft magnetic tip may be rotatable when in its more magnetized magnetization state in which a higher magnetic force acts between the soft magnetic tip and magnetic particles adhered thereto, so that suspension liquid flows from the magnetic particles adhered to the tip by rotation of the soft magnetic tip can be deposited. This is successfully possible if the centrifugal forces acting thereon due to the rotation of the soft magnetic tip between it and the magnetic particles are less than the magnetic forces acting on the basis of the magnetization state of the tip.
- the soft-magnetic tip can be rotatable in its weakly magnetized magnetization state, wherein the weakly magnetized magnetization state can be, in particular, a state of missing magnetization, that is, an un- or demagnetized state.
- the centrifugal forces caused by rotation of the tip can outweigh those forces with which magnetic particles previously removed from a suspension adhere to the soft magnetic tip.
- these may be weak magnetic forces and / or adhesion forces due to still existing residues of suspension liquid.
- the movement drive can be both coupled with the magnet assembly to transmit these to their approach movement to the magnetization section and to their removal movement away from this, and is also coupled to the soft magnetic tip to transmit it in order to rotate around to drive the top axle.
- the magnetic separation device can manage with a single motion drive.
- the transmission may be suitable for converting a movement type of an output member of the movement drive into another type of movement of the movement desired by the magnet arrangement, for example converting a rotational movement of the output member into a translatory movement of the magnet arrangement.
- a preferred transmission which meets the above requirements and in addition allows a radially with respect to the tip axis slim design of the magnetic separation device is a screw drive.
- a screw drive allows the implementation of rotational movement of an output member of a motion drive, such as an output shaft and thereby allows the use of spatially compact motion drives.
- the thread pitch of the threaded drive By appropriate selection of the thread pitch of the threaded drive, the forces which act on the magnet arrangement as a function of the output values of the movement drive and the speeds which can be achieved by the latter can be set.
- the screw can be advantageously carried out self-locking, so that movement and force only from one side ago, in this case from the side of the movement drive ago, can be introduced into the device.
- the screw to achieve the above-mentioned desired radially slender design and to reduce the components required for forming the magnetic separation device may be formed such that it has a connected for common rotation with the soft-elastic tip threaded rod, which passes through the magnet assembly, said Magnetic arrangement can be coupled for common movement with a threaded nut of the screw drive or - preferably - part of the threaded nut of the screw drive is.
- the magnet arrangement can, for example, have one or more annular permanent magnets, which are coupled radially inward for common movement with a sleeve, on the inside of which an internal thread is formed.
- the internal thread can be screwed with the threaded rod.
- the magnetic separation device may have a frame, which is to serve for further discussion as a coordinate origin of a stationary coordinate system.
- the frame as a whole may in turn be movable relative to a superordinate structure, such as a machine carrying the magnetic separation device, for instance in order to lower the magnetic separation device into a suspension and lift it out of suspension.
- rotation prevention for example in the form of a slotted guide, is provided, as is customary in screw drives, which prevents relative rotation of the threaded nut about the threaded axis of the threaded rod. dert, so that a rotation of the threaded rod sure leads to a translational displacement of the threaded nut along the threaded axis.
- the magnet arrangement is provided separately from the threaded nut and is coupled thereto for common translatory movement, although this is not preferred.
- the soft elastic tip may be coupled to the threaded rod for common rotation with the interposition of another gear
- “common” is then broadly understood to mean that the soft elastic tip rotates at least when the threaded rod rotates, for the sake of simplicity Slender construction is preferred when the threaded rod is rigidly coupled to the soft-elastic tip for common rotation, so that the rotation of the tip and the rotation of the threaded rod in rotational speed and sense of rotation match and the tip only rotates when the threaded rod is rotated ,
- the tip axis runs in the direction of gravity, to which the surface of the suspension, into which the tip is lowered, is naturally orthogonal. Then, the approaching movement of the magnet assembly to the soft magnetic tip is usually assisted by gravity, while the removal movement of the magnet assembly must be to remove it from the soft magnetic tip against gravity.
- the location of the maximum distance of the magnet assembly from the tip may be determined by a mechanical stop against which the magnet assembly is moved. However, when using the gear drive preferred with a single motion drive, the use of an abutment to define this location may impede the rotatability of the threaded rod and thus, typically, the soft magnetic tip when the magnet assembly stops at the maximum removal location has reached and the magnet assembly is not to be approximated to the soft magnetic tip again.
- the location of the maximum removal of the magnet assembly can be easily defined using a threaded drive through the threaded end of the threaded rod itself.
- a mechanical end stop is therefore not needed at the point of maximum removal of the magnet assembly from the tip. Therefore, the rotatability of the soft magnetic tip can be maintained even if the magnet assembly is maximally remote therefrom, if the magnetic separation device is preferably configured such that the maximum distance of the magnet assembly from the tip is defined by a threaded end of the threaded rod, between Threaded end and the movement drive is arranged a rod intermediate portion at which the magnet assembly is out of engagement with a threaded portion of the threaded rod and remains with continued rotation of the threaded rod in the removal direction at substantially the same distance from the soft-elastic tip.
- Threaded nut of the screw drive and with this the magnet assembly are simply unscrewed from the threaded portion of the threaded rod, so that further rotation of the threaded rod in the sense of removal of the magnet assembly from the tip due to lack of engagement between the threaded rod and threaded nut to no further removal movement Threaded nut leads.
- the threaded rod can be made in one or more parts, for example comprising a threaded component with external thread and an idle component with the above-mentioned rod intermediate section.
- the threaded engagement between threaded rod and threaded nut can be restored when the direction of rotation of the threaded rod changes and the threaded nut and, with it, the magnet arrangement can be approximated to the soft-magnetic tip again.
- the threaded axis of the threaded rod has a component in the direction of gravity action, preferably in the direction of gravity action.
- a rod axis along which the threaded rod extends extends, collinear with the tip axis.
- the rod axis coincides with the aforementioned thread axis.
- the location of maximum approximation of the magnet arrangement to the tip can be formed by a stop on which the magnet arrangement rests in the more magnetized state of the tip.
- This stop can also be formed by a section, in particular the magnetization section, of the tip itself.
- it may also be formed by an intermediate component which is arranged between the magnet arrangement and the soft-magnetic tip.
- an intermediate member which is arranged between the magnet arrangement and the soft-magnetic tip.
- such intermediate member is preferably at least partially made of soft elastic material, preferably completely made of flexible material.
- the clutch can be designed such that it transmits force and / or torque on the threaded nut of the screw drive and / or on the magnet arrangement when falling below a predetermined release torque and that they are on the release torque no force and / or no torque on the Threaded nut and / or transfers to the magnet assembly.
- Such a coupling can be provided, for example, radially between the above-mentioned sleeve carrying an internal thread and the at least one ring-shaped permanent magnet of the magnet arrangement surrounding this sleeve radially on the outside.
- the clutch may be a slip clutch or the like.
- the magnet arrangement In order to provide a magnetic field which is as homogeneous as possible, it is preferable for the magnet arrangement to be rotationally symmetrical at least in sections, preferably completely.
- the magnet arrangement can cause its maximum magnetization at maximum approach to the soft magnetic tip, so that the magnetic field of the magnet assembly is the magnetic field magnetizing the soft magnetic tip.
- the magnetic field of the above-mentioned magnet arrangement is merely a control magnetic field which weakens a magnetization magnetic field of another magnet arrangement differently depending on the relative position of the first-mentioned movable magnet arrangement relative to the soft magnetic peak.
- the magnetization of the soft magnetic tip is caused by the magnetic field of the further magnet arrangement, wherein the magnetic field can be influenced by the magnetic field of the first-mentioned movable magnet arrangement.
- the magnetic separator may comprise a second magnet assembly permanently connected to the soft magnetic tip, wherein the tip-to-tip magnet assembly in the approximated magnetization portion weakens the magnetic field of the second magnet assembly more than in the farther tip distant condition.
- the second magnet arrangement is the above-mentioned further magnet arrangement.
- the so far described alone approachable and removable from this magnet assembly is referred to as a first magnet assembly.
- the permanent connection of the second magnet arrangement with the soft magnetic tip can then be advantageously designed for the intended magnetization of the soft magnetic tip, for example by the magnetization section of the soft magnetic tip surrounding, preferably pot-like, the second magnet arrangement at its end section closest to the soft magnetic tip.
- the second magnet arrangement is preferably configured at least in sections, particularly preferably completely rotationally symmetrical.
- the second magnet arrangement also preferably extends along an arrangement axis, which is preferably its rotational symmetry axis and which is collinear with the tip axis.
- a desired radially slender configuration of the magnetic separation device can be achieved in that the second magnet arrangement passes through the movable, ie the approachable and removable, first magnet arrangement.
- the second magnet assembly is part of the threaded rod.
- the second magnet arrangement may be surrounded as a cylindrical bar magnet by a radially outer cylindrical sleeve which carries an external thread.
- the external thread of the threaded rod directly on the second magnet arrangement, however, numerous are suitable for perma- Magnets preferred materials very brittle, so that a thread formation on the outside of a magnet assembly is likely to be associated with difficulties.
- a possible weakening of the magnetic field of the second magnet arrangement as a function of the relative position of the first magnet arrangement relative to the soft magnetic tip and thus also relative to the second magnet arrangement can be effected by arranging the first magnet arrangement and the second magnet arrangement coaxially with opposite polarization, with their respective magnetic field Poles follow each other along the common extension axis.
- poles of the first and the second magnet arrangement are in the position of closest approach of the first magnet assembly to the soft magnetic tip very close together, so that by the first magnet assembly, a magnetic inference can be effected and thus only a small part of the magnetic field of the second magnet assembly actually penetrates into the soft magnetic tip.
- the soft magnetic tip may have its magnetization state of greatest magnetization.
- the magnetic separation device comprises a separator head having a plurality of soft magnetic tips, all extending along a tip axis, the tip axes of the individual soft magnetic tips being arranged parallel to one another.
- the soft magnetic tips are arranged in a matrix-like manner in rows and columns, wherein an orthogonal row and column system is preferred.
- the magnetization state of at least part of the soft magnetic tips of the separating pre-emergence head can preferably be changed independently of another part of the soft magnetic tips. This independent variability of the magnetization state of soft magnetic tips in a separator head can be accomplished by individual movement of the magnet assembly that can be approached and removed from the soft magnetic tip.
- the magnetization state of each individual soft-magnetic tip of the separation pre-head is changeable independently of the magnetization state of each other soft-magnetic tip. Since the change in the magnetization state is preferably effected by energizing an electromotive movement drive of the movable magnet arrangement, the energization of individual movement drives can be effected in a simple and reliable manner by a corresponding control device, wherein the control device can also be designed to line up soft-magnetic tips of the separation device head. or / and column by column to jointly change the magnetization state summarize. In this case, the control device can change all soft magnetic peaks of a row and / or a column by common control of the respective movement drives the movable magnet assemblies in the same sense and simultaneously.
- Such magnetic separation devices can advantageously be provided on a pipetting device, in which case at least one pipetting channel of the pipetting device is replaced by a separating device as described above.
- the technical features presented above for forming a radially slimmest possible separation device make it possible to form the magnetic separation device of the present invention with a radial installation space requirement which does not exceed that of a pipetting channel in a pipetting device.
- the soft magnetic tip may be metallic bright or may have a coating.
- the coating may be fixedly connected to the magnetic tip or may be detachably provided thereon.
- the movement drive of the movable magnet arrangement is preferably provided with the greatest possible distance from the soft magnetic tip, and in particular from its insertion end, of the respective separation device. Therefore, the first and / or the second magnet arrangement is preferably arranged between the movement drive and the soft-magnetic tip.
- the heat source present by the preferred electromagnetic motion drive is negligible in its effect on the suspension to be processed not only because of the greatest possible distance of the motive drive from the plunge end of the soft magnetic tip, but also because the motive drive is only for the duration of the change in magnetization state the soft magnetic tip needs to be energized, but not for the duration of the magnetization state itself.
- FIG. 1 a is an elevational view of an embodiment according to the invention of a magnetic separation device of the present application
- FIG. 1 b is a longitudinal sectional view of the device of FIG. 1 a taken along the section plane Ib-Ib in FIG. 1 a, wherein the movable magnet arrangement is in its end position closest to the soft-magnetic tip
- Figure 2a is a view corresponding to the view of Figure 1 a same device, wherein the movable magnet assembly is in its off-peak end position
- Figure 2b is a longitudinal sectional view of the device of Figure 2a taken along the sectional plane llb-llb in Figure 2a.
- FIGS. 1 and 2 an embodiment according to the invention of a magnetic separating device with mechanical drive is generally designated 10.
- the separating device 10 extends along a device axis V, which is preferably oriented parallel to the direction of gravity of action in normal operation and intended arrangement.
- a container 12 in which a suspension 14 (see FIGS. 1 b and 2 b) is accommodated, in which magnetic particles are suspended in a suspension liquid for the purpose of biochemical analysis.
- the magnetic separator 10 comprises, in a manner known per se, a soft-magnetic tip 16 which extends along a tip axis S which is collinear with the device axis V.
- the soft-magnetic tip has a longitudinal end 16a located closer to the container 12 during normal operation, which is an insertion end 16a of the tip 16, since the tip 16 is immersed in the suspension 14 with this insertion end 16a, in order then to reach Magnetization of the tip 16 magnetic particles from the suspension 14 to remove.
- the magnetic particles of the suspension 14 are attracted by the increased magnetization of the soft magnetic tip 16 of this and can be removed under the action of the forces acting on the magnetic particles magnetic forces with the tip 16 at this adhering to the suspension 14.
- the protective cover 18 may be formed of plastic or of a non-magnetic metal.
- the longitudinal end 16b of the tip 16 opposite the plunging end 16a forms a magnetization section 16b of the soft magnetic tip since, as will be described in detail below, the temporary magnetization of the tip 16 is effected via this section 16b or longitudinal end.
- the magnetization section 16b is surrounded by a coupling component 20 which projects beyond the longitudinal end 16b, axially with respect to the device axis V, away from the insertion end 16a.
- the coupling member 20 couples the soft magnetic tip 16 for common rotation with a drive member 24 whose tip nearer longitudinal end 14 a is also surrounded by the coupling member 20.
- the drive member 24 has a stub shaft portion 24b, which is designed for coupling to a drive motor, not shown in Figures 1 and 2.
- the stub shaft portion 24b has an axial recess 26 into which a key for torque transmission from a hub of a drive motor, not shown in Figures 1 and 2 can be inserted to positively transfer torque to the stub shaft portion 24b and thus to the drive member 24.
- the drive member 24 is integrally formed in the example shown, but this need not be so.
- a portion 24c of the drive member 24 is provided with an external thread 28 and forms a threaded rod portion.
- Threaded rod portion 24c axially adjacent thereto immediately thereafter, there is an externally threaded intermediate rod portion 24d.
- Threaded rod portion 24c and the intermediate rod portion 24d preferably have a smaller diameter than the shaft stub portion 24b.
- the drive component 24 extends along a component axis B, which is also collinear with the device axis V.
- the drive member 24 - with the exception of the feather key recess 26 and the external thread 28 - rotationally symmetrical with respect to the device axis V is formed.
- the coupling component 20 is rotationally symmetrical to the device axis V.
- the coupling member 20 may connect the tip 16 and the drive member 24 by, for example, press-fitting both components in the central recess of the coupling member 20 for common rotation about the device axis V.
- the drive member 24 passes through a threaded nut 30, which is coupled for common movement with a permanent magnet assembly 32, for example by gluing.
- This positive engagement of the nose 30a in the slot recess 34 forms a rotation prevention of the threaded nut 30 about the device axis V, so that upon rotation of the drive member 24, the threaded nut 30 and with it the permanent magnet assembly 32 connected to it for co-movement securely translatable along the device axis V over the region of the threaded rod portion 24c away are displaced.
- the drive component is preferably non-magnetic in the example shown.
- the coupling component 20 can form a mechanical end stop for the threaded nut 30 or for a jointly movable arrangement of threaded nut 30 and permanent magnet arrangement 32. Then, when the threaded nut 30 is applied to the coupling member 20, as shown in Figure 1 b, in the example shown further rotation of the drive member 24 in an approximation of the threaded nut 30 to the soft magnetic tip 16 is impossible, since the nut 30 is already maximum is approximated to the top 16.
- the soft magnetic tip 16 can only be rotated when the drive member 24 is rotated in a distance sense in which the threaded nut 30 is removed from the tip 16 along the device axis V.
- the threaded nut 30 may have a torque-dependent coupling, such as a slip clutch or the like., Which allows further rotation of the drive member 24 in the proximity sense even when the threaded nut 30 abuts the end stop formed by the coupling member 20 and is at maximum approximate to the tip 16.
- the magnetic separation device 10 is shown at the demagnetized tip 16 or at the weaker magnetized tip 16.
- the Drive member 24 as long as the Vorhchtungsachse V in the sense of distance rotated until the gear nut 30 has been moved axially out of the threaded rod portion 24c and thus this is no longer in screw engagement with the threaded rod portion 24c.
- the drive component 24 can be further rotated in the direction of removal, without there being any further displacement of the threaded nut 30 and with this the permanent magnet arrangement 32 away from the soft-magnetic tip 16.
- the magnetic separation device 10 thus allows a radially extremely slim design, which is suitable for an arrangement of a plurality of separation devices 10 in a matrix structure with parallel device axes V. Further, the magnetic separator 10 not only permits the targeted change of the magnetization state of the soft magnetic tip 16 between a more magnetized state and a less strongly magnetized state, but moreover permits a rotation of the soft magnetic tip 16 about its tip axis S, which coincides with the device axis V.
- FIG. 1 b an alternative embodiment is briefly presented:
- a further permanent magnet arrangement 40 ' can be accommodated therein.
- the coupling section 24a of the drive component 24 is formed from soft magnetic material in order to achieve a magnetic closure of the second permanent magnet arrangement 40 'via the coupling longitudinal end 24a and the coupling component 20 with the magnetization section 16b.
- the coupling portion 24a touches Preferably, the magnetization portion 16b frontally, so that there is a direct magnetic circuit between these components.
- the coupling portion 24a formed of soft magnetic material therefore extends to the second permanent magnet assembly 40 'and is in contact with it.
- the entire threaded rod portion 24c or even the entire drive member 24 is formed of soft magnetic material.
- both the permanent magnet arrangement 32 which is then to be referred to as the first permanent magnet arrangement
- the second permanent magnet arrangement 40 ' are magnetized such that their magnetic poles follow one another along the device axis V.
- the first permanent magnet arrangement 32 weakens the magnetic field of the second permanent magnet arrangement 40 'in the region of the pole end closest to the tip 16 by field closure in the position approximated to the peak 16 shown in FIG.
- the unlike pole of the first permanent arrangement 32 lying close to the pole of the second permanent arrangement 40 'at the magnetization section 16b provides a magnetic inference for the magnetic field emanating from the pole of the second permanent arrangement 40'.
- the magnetization portion 16b of the tip 16 is thus penetrated to a lesser extent by the magnetic field of the second permanent assembly 40 'than when the first permanent magnet assembly 32 is located farther from the magnetization portion 16b.
- the soft magnetic tip is then magnetized less strongly than when the permanent magnet assembly 32 is disposed further away from the soft magnetic tip 16, in particular at a maximum distance, as shown in Figure 2b.
Landscapes
- Transmission Devices (AREA)
- Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102015218008.5A DE102015218008A1 (de) | 2015-09-18 | 2015-09-18 | Magnetische Trennvorrichtung mit mechanischer Aktivierung und Deaktivierung |
PCT/EP2016/071805 WO2017046235A1 (de) | 2015-09-18 | 2016-09-15 | Magnetische trennvorrichtung mit mechanischer aktivierung und deaktivierung |
Publications (2)
Publication Number | Publication Date |
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EP3349910A1 true EP3349910A1 (de) | 2018-07-25 |
EP3349910B1 EP3349910B1 (de) | 2021-11-17 |
Family
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Application Number | Title | Priority Date | Filing Date |
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EP16766295.6A Active EP3349910B1 (de) | 2015-09-18 | 2016-09-15 | Magnetische trennvorrichtung mit mechanischer aktivierung und deaktivierung |
Country Status (3)
Country | Link |
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EP (1) | EP3349910B1 (de) |
DE (1) | DE102015218008A1 (de) |
WO (1) | WO2017046235A1 (de) |
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CA3008660A1 (en) * | 2016-01-19 | 2017-08-24 | Shanxi Zdgsy Bio-Scientific Co., Ltd. | Multifunctional biological substance separation device |
CN114534911B (zh) * | 2022-02-25 | 2024-04-09 | 奥星制药设备(石家庄)有限公司 | 一种磁性分离器及清洗方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2554016B1 (fr) * | 1983-10-27 | 1986-08-08 | Pasteur Institut | Perfectionnements apportes aux moyens magnetiques destines a retirer des billes de gel magnetique d'un fluide de dosage |
SE8601143L (sv) * | 1986-03-12 | 1987-09-13 | Carbematrix Ab | Sett och anordning for samling och spridning av ferromagnetiska partiklar i ett fluidformigt medium |
DE4421058A1 (de) * | 1994-06-16 | 1995-12-21 | Boehringer Mannheim Gmbh | Verfahren zur magnetischen Abtrennung von Flüssigkeitskomponenten |
DE10057396C1 (de) | 2000-11-18 | 2002-04-04 | Karlsruhe Forschzent | Verfahren zum Abtrennen eines dispergierten oder gelösten Stoffes und Magnetseparator |
FI120863B (fi) * | 2002-10-18 | 2010-04-15 | Biocontrol Systems Inc | Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite |
US7799281B2 (en) | 2007-01-16 | 2010-09-21 | Festo Corporation | Flux concentrator for biomagnetic particle transfer device |
ATE471761T1 (de) * | 2007-08-14 | 2010-07-15 | Qiagen Gmbh | Verfahren zum suspendieren oder resuspendieren von partikeln in einer lösung sowie daran angepasste vorrichtung |
WO2014007074A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社 日立ハイテクノロジーズ | 核酸抽出用キット及び核酸抽出装置 |
-
2015
- 2015-09-18 DE DE102015218008.5A patent/DE102015218008A1/de not_active Withdrawn
-
2016
- 2016-09-15 EP EP16766295.6A patent/EP3349910B1/de active Active
- 2016-09-15 WO PCT/EP2016/071805 patent/WO2017046235A1/de active Application Filing
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WO2017046235A1 (de) | 2017-03-23 |
DE102015218008A1 (de) | 2017-03-23 |
EP3349910B1 (de) | 2021-11-17 |
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